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Protein

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Gene

SLC6A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: ProtInc
  • neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  • amino acid transmembrane transport Source: GOC
  • amino acid transport Source: Reactome
  • cellular amino acid metabolic process Source: ProtInc
  • ion transport Source: Reactome
  • response to toxic substance Source: UniProtKB
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.2.3. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Alternative name(s):
Amino acid transporter ATB0+
Solute carrier family 6 member 14
Gene namesi
Name:SLC6A14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11047. SLC6A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 234104ExtracellularSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei315 – 33521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei348 – 36821Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei450 – 47728Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei480 – 50021Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei528 – 54821Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei563 – 58321Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini584 – 64259CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • brush border membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.

Keywords - Diseasei

Obesity

Organism-specific databases

PharmGKBiPA35910.

Chemistry

DrugBankiDB00172. L-Proline.
DB00577. Valaciclovir.
DB01610. Valganciclovir.

Polymorphism and mutation databases

DMDMi41018156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)PRO_0000214795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UN76.
PaxDbiQ9UN76.
PRIDEiQ9UN76.

PTM databases

PhosphoSiteiQ9UN76.

Expressioni

Tissue specificityi

Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.1 Publication

Gene expression databases

BgeeiQ9UN76.
CleanExiHS_SLC6A14.
GenevestigatoriQ9UN76.

Organism-specific databases

HPAiHPA003193.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360967.

Structurei

3D structure databases

ProteinModelPortaliQ9UN76.
SMRiQ9UN76. Positions 35-602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9UN76.
KOiK05038.
OMAiSSGMNET.
OrthoDBiEOG793B71.
PhylomeDBiQ9UN76.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UN76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI
60 70 80 90 100
GYAVGLGNVW RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA
110 120 130 140 150
SLGPVSVWRI LPLFQGVGIT MVLISIFVTI YYNVIIAYSL YYMFASFQSE
160 170 180 190 200
LPWKNCSSWS DKNCSRSPIV THCNVSTVNK GIQEIIQMNK SWVDINNFTC
210 220 230 240 250
INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA LCLLLAWLIV
260 270 280 290 300
GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ
310 320 330 340 350
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV
360 370 380 390 400
CLTNCLTSVF AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA
410 420 430 440 450
QLPGGPFWSI LFFFMLLTLG LDSQFASIET ITTTIQDLFP KVMKKMRVPI
460 470 480 490 500
TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF CAGWGILIAA ILELVGIIWI
510 520 530 540 550
YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI FIWSLVQFHR
560 570 580 590 600
PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC
610 620 630 640
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE
Length:642
Mass (Da):72,153
Last modified:May 1, 2000 - v1
Checksum:iE0FCDD5F173128C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151978 mRNA. Translation: AAD49223.1.
Z96810, AL034411 Genomic DNA. Translation: CAI42799.1.
AL034411, Z96810 Genomic DNA. Translation: CAI43081.1.
BC093710 mRNA. Translation: AAH93710.1.
BC093712 mRNA. Translation: AAH93712.1.
CCDSiCCDS14570.1.
RefSeqiNP_009162.1. NM_007231.4.
UniGeneiHs.522109.

Genome annotation databases

EnsembliENST00000598581; ENSP00000470801; ENSG00000268104.
GeneIDi11254.
KEGGihsa:11254.
UCSCiuc004eqi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151978 mRNA. Translation: AAD49223.1.
Z96810, AL034411 Genomic DNA. Translation: CAI42799.1.
AL034411, Z96810 Genomic DNA. Translation: CAI43081.1.
BC093710 mRNA. Translation: AAH93710.1.
BC093712 mRNA. Translation: AAH93712.1.
CCDSiCCDS14570.1.
RefSeqiNP_009162.1. NM_007231.4.
UniGeneiHs.522109.

3D structure databases

ProteinModelPortaliQ9UN76.
SMRiQ9UN76. Positions 35-602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360967.

Chemistry

DrugBankiDB00172. L-Proline.
DB00577. Valaciclovir.
DB01610. Valganciclovir.
GuidetoPHARMACOLOGYi937.

Protein family/group databases

TCDBi2.A.22.2.3. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteiQ9UN76.

Polymorphism and mutation databases

DMDMi41018156.

Proteomic databases

MaxQBiQ9UN76.
PaxDbiQ9UN76.
PRIDEiQ9UN76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000598581; ENSP00000470801; ENSG00000268104.
GeneIDi11254.
KEGGihsa:11254.
UCSCiuc004eqi.3. human.

Organism-specific databases

CTDi11254.
GeneCardsiGC0XP115481.
HGNCiHGNC:11047. SLC6A14.
HPAiHPA003193.
MIMi300444. gene.
neXtProtiNX_Q9UN76.
PharmGKBiPA35910.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9UN76.
KOiK05038.
OMAiSSGMNET.
OrthoDBiEOG793B71.
PhylomeDBiQ9UN76.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSiSLC6A14. human.
GeneWikiiSLC6A14.
GenomeRNAii11254.
NextBioi42826.
PROiQ9UN76.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UN76.
CleanExiHS_SLC6A14.
GenevestigatoriQ9UN76.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)."
    Sloan J.L., Mager S.
    J. Biol. Chem. 274:23740-23745(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Mammary gland.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Do allelic variants of SLC6A14 predispose to obesity?"
    Tiwari H.K., Allison D.B.
    J. Clin. Invest. 112:1633-1636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO OBESITY.
  5. Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO OBESITY.

Entry informationi

Entry nameiS6A14_HUMAN
AccessioniPrimary (citable) accession number: Q9UN76
Secondary accession number(s): Q5H942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.