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Q9UN76 (S6A14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Alternative name(s):
Amino acid transporter ATB0+
Solute carrier family 6 member 14
Gene names
Name:SLC6A14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis. Ref.1

Involvement in disease

Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.

Miscellaneous

Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
PRO_0000214795

Regions

Topological domain1 – 4444Cytoplasmic Potential
Transmembrane45 – 6521Helical; Name=1; Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Transmembrane110 – 13021Helical; Name=3; Potential
Topological domain131 – 234104Extracellular Potential
Transmembrane235 – 25521Helical; Name=4; Potential
Transmembrane261 – 28121Helical; Name=5; Potential
Transmembrane315 – 33521Helical; Name=6; Potential
Transmembrane348 – 36821Helical; Name=7; Potential
Transmembrane399 – 41921Helical; Name=8; Potential
Transmembrane450 – 47728Helical; Name=9; Potential
Transmembrane480 – 50021Helical; Name=10; Potential
Transmembrane528 – 54821Helical; Name=11; Potential
Transmembrane563 – 58321Helical; Name=12; Potential
Topological domain584 – 64259Cytoplasmic Potential

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9UN76 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E0FCDD5F173128C0

FASTA64272,153
        10         20         30         40         50         60 
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW 

        70         80         90        100        110        120 
RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT 

       130        140        150        160        170        180 
MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK 

       190        200        210        220        230        240 
GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA 

       250        260        270        280        290        300 
LCLLLAWLIV GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ 

       310        320        330        340        350        360 
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV CLTNCLTSVF 

       370        380        390        400        410        420 
AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG 

       430        440        450        460        470        480 
LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF 

       490        500        510        520        530        540 
CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI 

       550        560        570        580        590        600 
FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 

       610        620        630        640 
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)."
Sloan J.L., Mager S.
J. Biol. Chem. 274:23740-23745(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Mammary gland.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Do allelic variants of SLC6A14 predispose to obesity?"
Tiwari H.K., Allison D.B.
J. Clin. Invest. 112:1633-1636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO OBESITY.
[5]"The SLC6A14 gene shows evidence of association with obesity."
Suviolahti E., Oksanen L.J., Oehman M., Cantor R.M., Ridderstrale M., Tuomi T., Kaprio J., Rissanen A., Mustajoki P., Jousilahti P., Vartiainen E., Silander K., Kilpikari R., Salomaa V., Groop L., Kontula K., Peltonen L., Pajukanta P.
J. Clin. Invest. 112:1762-1772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO OBESITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151978 mRNA. Translation: AAD49223.1.
Z96810, AL034411 Genomic DNA. Translation: CAI42799.1.
AL034411, Z96810 Genomic DNA. Translation: CAI43081.1.
BC093710 mRNA. Translation: AAH93710.1.
BC093712 mRNA. Translation: AAH93712.1.
RefSeqNP_009162.1. NM_007231.4.
UniGeneHs.522109.

3D structure databases

ProteinModelPortalQ9UN76.
SMRQ9UN76. Positions 35-602.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000360967.

Chemistry

DrugBankDB00172. L-Proline.
GuidetoPHARMACOLOGY937.

Protein family/group databases

TCDB2.A.22.2.3. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteQ9UN76.

Polymorphism databases

DMDM41018156.

Proteomic databases

PaxDbQ9UN76.
PRIDEQ9UN76.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371900; ENSP00000360967; ENSG00000087916.
GeneID11254.
KEGGhsa:11254.
UCSCuc004eqi.3. human.

Organism-specific databases

CTD11254.
GeneCardsGC0XP115481.
HGNCHGNC:11047. SLC6A14.
HPAHPA003193.
MIM300444. gene.
neXtProtNX_Q9UN76.
PharmGKBPA35910.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ9UN76.
KOK05038.
OMASSGMNET.
OrthoDBEOG793B71.
PhylomeDBQ9UN76.
TreeFamTF343812.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

BgeeQ9UN76.
CleanExHS_SLC6A14.
GenevestigatorQ9UN76.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC6A14.
GenomeRNAi11254.
NextBio42826.
PROQ9UN76.
SOURCESearch...

Entry information

Entry nameS6A14_HUMAN
AccessionPrimary (citable) accession number: Q9UN76
Secondary accession number(s): Q5H942
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM