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Q9UN76

- S6A14_HUMAN

UniProt

Q9UN76 - S6A14_HUMAN

Protein

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Gene

SLC6A14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.1 Publication

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: ProtInc
    2. neurotransmitter:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. amino acid transmembrane transport Source: GOC
    2. amino acid transport Source: Reactome
    3. cellular amino acid metabolic process Source: ProtInc
    4. ion transport Source: Reactome
    5. response to toxic substance Source: UniProtKB
    6. transmembrane transport Source: Reactome
    7. transport Source: ProtInc

    Keywords - Biological processi

    Amino-acid transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
    REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Protein family/group databases

    TCDBi2.A.22.2.3. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
    Alternative name(s):
    Amino acid transporter ATB0+
    Solute carrier family 6 member 14
    Gene namesi
    Name:SLC6A14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11047. SLC6A14.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: ProtInc
    4. plasma membrane Source: Reactome
    5. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.

    Keywords - Diseasei

    Obesity

    Organism-specific databases

    PharmGKBiPA35910.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 642642Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)PRO_0000214795Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9UN76.
    PaxDbiQ9UN76.
    PRIDEiQ9UN76.

    PTM databases

    PhosphoSiteiQ9UN76.

    Expressioni

    Tissue specificityi

    Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.1 Publication

    Gene expression databases

    BgeeiQ9UN76.
    CleanExiHS_SLC6A14.
    GenevestigatoriQ9UN76.

    Organism-specific databases

    HPAiHPA003193.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000360967.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UN76.
    SMRiQ9UN76. Positions 35-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini131 – 234104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini584 – 64259CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei450 – 47728Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei528 – 54821Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei563 – 58321Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ9UN76.
    KOiK05038.
    OMAiNCSYWAD.
    OrthoDBiEOG793B71.
    PhylomeDBiQ9UN76.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UN76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI    50
    GYAVGLGNVW RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA 100
    SLGPVSVWRI LPLFQGVGIT MVLISIFVTI YYNVIIAYSL YYMFASFQSE 150
    LPWKNCSSWS DKNCSRSPIV THCNVSTVNK GIQEIIQMNK SWVDINNFTC 200
    INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA LCLLLAWLIV 250
    GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ 300
    SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV 350
    CLTNCLTSVF AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA 400
    QLPGGPFWSI LFFFMLLTLG LDSQFASIET ITTTIQDLFP KVMKKMRVPI 450
    TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF CAGWGILIAA ILELVGIIWI 500
    YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI FIWSLVQFHR 550
    PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 600
    RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE 642
    Length:642
    Mass (Da):72,153
    Last modified:May 1, 2000 - v1
    Checksum:iE0FCDD5F173128C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151978 mRNA. Translation: AAD49223.1.
    Z96810, AL034411 Genomic DNA. Translation: CAI42799.1.
    AL034411, Z96810 Genomic DNA. Translation: CAI43081.1.
    BC093710 mRNA. Translation: AAH93710.1.
    BC093712 mRNA. Translation: AAH93712.1.
    CCDSiCCDS14570.1.
    RefSeqiNP_009162.1. NM_007231.4.
    UniGeneiHs.522109.

    Genome annotation databases

    EnsembliENST00000598581; ENSP00000470801; ENSG00000268104.
    GeneIDi11254.
    KEGGihsa:11254.
    UCSCiuc004eqi.3. human.

    Polymorphism databases

    DMDMi41018156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151978 mRNA. Translation: AAD49223.1 .
    Z96810 , AL034411 Genomic DNA. Translation: CAI42799.1 .
    AL034411 , Z96810 Genomic DNA. Translation: CAI43081.1 .
    BC093710 mRNA. Translation: AAH93710.1 .
    BC093712 mRNA. Translation: AAH93712.1 .
    CCDSi CCDS14570.1.
    RefSeqi NP_009162.1. NM_007231.4.
    UniGenei Hs.522109.

    3D structure databases

    ProteinModelPortali Q9UN76.
    SMRi Q9UN76. Positions 35-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000360967.

    Chemistry

    DrugBanki DB00172. L-Proline.
    GuidetoPHARMACOLOGYi 937.

    Protein family/group databases

    TCDBi 2.A.22.2.3. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei Q9UN76.

    Polymorphism databases

    DMDMi 41018156.

    Proteomic databases

    MaxQBi Q9UN76.
    PaxDbi Q9UN76.
    PRIDEi Q9UN76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000598581 ; ENSP00000470801 ; ENSG00000268104 .
    GeneIDi 11254.
    KEGGi hsa:11254.
    UCSCi uc004eqi.3. human.

    Organism-specific databases

    CTDi 11254.
    GeneCardsi GC0XP115481.
    HGNCi HGNC:11047. SLC6A14.
    HPAi HPA003193.
    MIMi 300444. gene.
    neXtProti NX_Q9UN76.
    PharmGKBi PA35910.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q9UN76.
    KOi K05038.
    OMAi NCSYWAD.
    OrthoDBi EOG793B71.
    PhylomeDBi Q9UN76.
    TreeFami TF343812.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.
    REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Miscellaneous databases

    GeneWikii SLC6A14.
    GenomeRNAii 11254.
    NextBioi 42826.
    PROi Q9UN76.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UN76.
    CleanExi HS_SLC6A14.
    Genevestigatori Q9UN76.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)."
      Sloan J.L., Mager S.
      J. Biol. Chem. 274:23740-23745(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Mammary gland.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Do allelic variants of SLC6A14 predispose to obesity?"
      Tiwari H.K., Allison D.B.
      J. Clin. Invest. 112:1633-1636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO OBESITY.
    5. Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO OBESITY.

    Entry informationi

    Entry nameiS6A14_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN76
    Secondary accession number(s): Q5H942
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3