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Protein

Protocadherin alpha-12

Gene

PCDHA12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-12
Short name:
PCDH-alpha-12
Gene namesi
Name:PCDHA12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8666. PCDHA12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 697ExtracellularSequence analysisAdd BLAST668
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 941CytoplasmicSequence analysisAdd BLAST223

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000251664.
PharmGKBiPA33012.

Polymorphism and mutation databases

BioMutaiPCDHA12.
DMDMi13878425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000390630 – 941Protocadherin alpha-12Add BLAST912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN75.
PaxDbiQ9UN75.
PeptideAtlasiQ9UN75.
PRIDEiQ9UN75.

PTM databases

iPTMnetiQ9UN75.
PhosphoSitePlusiQ9UN75.

Expressioni

Gene expression databases

BgeeiENSG00000251664.
GenevisibleiQ9UN75. HS.

Organism-specific databases

HPAiHPA035812.

Interactioni

Protein-protein interaction databases

BioGridi121077. 32 interactors.
IntActiQ9UN75. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9UN75.
SMRiQ9UN75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini581 – 678Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Repeati734 – 737PXXP 14
Repeati790 – 793PXXP 24
Repeati823 – 826PXXP 34
Repeati863 – 866PXXP 44
Repeati882 – 885PXXP 54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni734 – 8855 X 4 AA repeats of P-X-X-PAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi914 – 921Poly-Lys8

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN75.
KOiK16493.
OMAiPNDTRVI.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9UN75.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UN75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVIIGPRGPG SQRLLLSLLL LAAWEVGSGQ LHYSVYEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELAELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREKLCGRSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVD VEVKDINDNP PVFREREQKV PVSESAPLDS
160 170 180 190 200
HFPLEGASDA DIGVNSLLTY ALSLNENFEL KIKTKKDKSI LPELVLRKLL
210 220 230 240 250
DREQTPKLNL LLMVIDGGKP ELTGSVQIQI TVLDVNDNGP AFDKPSYKVV
260 270 280 290 300
LSENVQNDTR VIQLNASDPD EGLNGEISYG IKMILPVSEK CMFSINPDTG
310 320 330 340 350
EIRIYGELDF EENNAYEIQV NAIDKGIPSM AGHSMVLVEV LDVNDNVPEV
360 370 380 390 400
MVTSLSLPVQ EDAQVGTVIA LISVSDRDSG ANGQVICSLT PHVPFKLVST
410 420 430 440 450
YKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAR VSVEVADVND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQKNALV SYSLVERRVG
510 520 530 540 550
EHALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLATPA GSAGGAVSEL VPRSVGAGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQPAAVGAHI PFHVGLYTGE ISTTRILDEA DAPRHRLLVL
660 670 680 690 700
VKDHGEPALT STATVLVSLV ENGQAPKTSS RASVGAVDPE AALVDINVYL
710 720 730 740 750
IIAICAVSSL LVLTLLLYTA LRCSAPPTVS RCAPGKPTLV CSSAVGSWSY
760 770 780 790 800
SQQRRQRVCS AESPPKTDLM AFSPSLQLSR EDCLNPPSEP RQPNPDWRYS
810 820 830 840 850
ASLRAGMHSS VHLEEAGILR AGPGGPDQQW PTVSSATPEP EAGEVSPPVG
860 870 880 890 900
AGVNSNSWTF KYGPGNPKQS GPGELPDKFI IPGSPAIISI RQEPTNSQID
910 920 930 940
KSDFITFGKK EETKKKKKKK KGNKTQEKKE KGNSTTDNSD Q
Length:941
Mass (Da):101,652
Last modified:May 1, 2000 - v1
Checksum:i284D4DE7333E10CA
GO
Isoform 2 (identifier: Q9UN75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     790-792: PRQ → VSY
     793-941: Missing.

Show »
Length:792
Mass (Da):85,581
Checksum:iB906EEDDE42364EC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000695790 – 792PRQ → VSY in isoform 2. 2 Publications3
Alternative sequenceiVSP_000696793 – 941Missing in isoform 2. 2 PublicationsAdd BLAST149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152308 mRNA. Translation: AAD43702.1.
AF152477 mRNA. Translation: AAD43738.1.
AC005609 Genomic DNA. Translation: AAC34315.1.
BC112280 mRNA. Translation: AAI12281.1.
BC113372 mRNA. Translation: AAI13373.1.
CCDSiCCDS47285.1. [Q9UN75-1]
CCDS75327.1. [Q9UN75-2]
RefSeqiNP_061726.1. NM_018903.3. [Q9UN75-1]
NP_114070.1. NM_031864.2. [Q9UN75-2]
UniGeneiHs.199343.
Hs.608548.

Genome annotation databases

EnsembliENST00000398631; ENSP00000381628; ENSG00000251664. [Q9UN75-1]
ENST00000613593; ENSP00000481404; ENSG00000251664. [Q9UN75-2]
GeneIDi56137.
KEGGihsa:56137.
UCSCiuc003lic.4. human. [Q9UN75-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152308 mRNA. Translation: AAD43702.1.
AF152477 mRNA. Translation: AAD43738.1.
AC005609 Genomic DNA. Translation: AAC34315.1.
BC112280 mRNA. Translation: AAI12281.1.
BC113372 mRNA. Translation: AAI13373.1.
CCDSiCCDS47285.1. [Q9UN75-1]
CCDS75327.1. [Q9UN75-2]
RefSeqiNP_061726.1. NM_018903.3. [Q9UN75-1]
NP_114070.1. NM_031864.2. [Q9UN75-2]
UniGeneiHs.199343.
Hs.608548.

3D structure databases

ProteinModelPortaliQ9UN75.
SMRiQ9UN75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121077. 32 interactors.
IntActiQ9UN75. 1 interactor.

PTM databases

iPTMnetiQ9UN75.
PhosphoSitePlusiQ9UN75.

Polymorphism and mutation databases

BioMutaiPCDHA12.
DMDMi13878425.

Proteomic databases

EPDiQ9UN75.
PaxDbiQ9UN75.
PeptideAtlasiQ9UN75.
PRIDEiQ9UN75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398631; ENSP00000381628; ENSG00000251664. [Q9UN75-1]
ENST00000613593; ENSP00000481404; ENSG00000251664. [Q9UN75-2]
GeneIDi56137.
KEGGihsa:56137.
UCSCiuc003lic.4. human. [Q9UN75-1]

Organism-specific databases

CTDi56137.
GeneCardsiPCDHA12.
HGNCiHGNC:8666. PCDHA12.
HPAiHPA035812.
MIMi604966. gene.
606318. gene.
neXtProtiNX_Q9UN75.
OpenTargetsiENSG00000251664.
PharmGKBiPA33012.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN75.
KOiK16493.
OMAiPNDTRVI.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9UN75.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHA12.
GenomeRNAii56137.
PROiQ9UN75.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000251664.
GenevisibleiQ9UN75. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDAC_HUMAN
AccessioniPrimary (citable) accession number: Q9UN75
Secondary accession number(s): O75278, Q2M1N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.