Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UN74

- PCDA4_HUMAN

UniProt

Q9UN74 - PCDA4_HUMAN

Protein

Protocadherin alpha-4

Gene

PCDHA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. homophilic cell adhesion Source: InterPro
    3. nervous system development Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin alpha-4
    Short name:
    PCDH-alpha-4
    Gene namesi
    Name:PCDHA4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8670. PCDHA4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 947918Protocadherin alpha-4PRO_0000003890Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9UN74.
    PRIDEiQ9UN74.

    PTM databases

    PhosphoSiteiQ9UN74.

    Expressioni

    Gene expression databases

    BgeeiQ9UN74.
    GenevestigatoriQ9UN74.

    Organism-specific databases

    HPAiHPA008712.
    HPA043180.

    Interactioni

    Subunit structurei

    Interacts with FYN.By similarity

    Protein-protein interaction databases

    BioGridi121084. 13 interactions.
    IntActiQ9UN74. 13 interactions.
    MINTiMINT-1368168.
    STRINGi9606.ENSP00000349344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UN74.
    SMRiQ9UN74. Positions 27-667.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 697668ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini719 – 947229CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei698 – 71821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 350108Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini351 – 455105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 565110Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini588 – 67891Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Repeati734 – 7374PXXP 1
    Repeati774 – 7774PXXP 2
    Repeati796 – 7994PXXP 3
    Repeati829 – 8324PXXP 4
    Repeati870 – 8734PXXP 5
    Repeati888 – 8914PXXP 6

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni734 – 8911586 X 4 AA repeats of P-X-X-PAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi920 – 9278Poly-Lys

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267459.
    HOGENOMiHOG000220892.
    HOVERGENiHBG054878.
    InParanoidiQ9UN74.
    KOiK16493.
    OMAiDNVPDLE.
    OrthoDBiEOG7KSX80.
    PhylomeDBiQ9UN74.
    TreeFamiTF332299.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UN74-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFSWGSGQE SRRLLLLLLL LAAWEAGNGQ LHYSVSEEAK HGTFVGRIAQ    50
    DLGLELAELV PRLFRVASKG RGGLLEVNLQ NGILFVNSRI DREELCRRSA 100
    ECSIHLEVIV DRPLQVFHVD VEVRDINDNP PVFPATQKNL SIAESRPLDS 150
    RFPLEGASDA DIGENALLTY RLSPNEYFSL EKPPDDELVK GLGLILRKSL 200
    DREEAPEIFL VLTATDGGKP ELTGTVQLLI TVLDANDNAP AFDRTIYKVR 250
    LLENVPNGTL VIKLNASDLD EGLNGDIVYS FSNDISPNVK SKFHIDPITG 300
    QIIVKGYIDF EESKSYEIIV EGIDKGQLPL SGHCRVIVEV EDNNDNVPDL 350
    EFKSLSLPIR EDAPLGTVIA LISVSDKDMG VNGLVTCSLT SHVPFKLVST 400
    FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND 450
    NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQENALV SYSLVERRVG 500
    ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVTARDA GVPPLGSNVT 550
    LQVFVLDEND NAPALLAPRA GGTGGAVSEL VPWSVGVGHV VAKVRAVDAD 600
    SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDET DAPRHRLLVL 650
    VKDHGEPALT ATATVLVSLV ESGQAPKASS RALVGAVGPD AALVDVNVYL 700
    IIAICAVSSL LVLTLLLYTA LRCSALPTEG ACAPGKPTLV CSSAVGSWSY 750
    SQQRRPRVCS GEGPPKTDLM AFSPSLPDSR DREDQLQTTE ESFAKPRQPN 800
    PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE 850
    VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP 900
    TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ 947
    Length:947
    Mass (Da):102,293
    Last modified:May 1, 2000 - v1
    Checksum:i2B06F20872D731D8
    GO
    Isoform 2 (identifier: Q9UN74-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         796-798: PRQ → VSV
         799-947: Missing.

    Show »
    Length:798
    Mass (Da):86,158
    Checksum:i9EF890C30F48A77F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551E → D.
    Corresponds to variant rs11167605 [ dbSNP | Ensembl ].
    VAR_059180
    Natural varianti184 – 1841P → S.
    Corresponds to variant rs3822346 [ dbSNP | Ensembl ].
    VAR_024390

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei796 – 7983PRQ → VSV in isoform 2. 2 PublicationsVSP_000677
    Alternative sequencei799 – 947149Missing in isoform 2. 2 PublicationsVSP_000678Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152312 mRNA. Translation: AAD43706.1.
    AF152482 mRNA. Translation: AAD43743.1.
    AC005609 Genomic DNA. Translation: AAC34322.1.
    BC112102 mRNA. Translation: AAI12103.1.
    BC113609 mRNA. Translation: AAI13610.1.
    CCDSiCCDS54916.1. [Q9UN74-1]
    RefSeqiNP_061730.1. NM_018907.3. [Q9UN74-1]
    NP_113688.1. NM_031500.2. [Q9UN74-2]
    UniGeneiHs.199343.

    Genome annotation databases

    EnsembliENST00000530339; ENSP00000435300; ENSG00000204967. [Q9UN74-1]
    GeneIDi56144.
    KEGGihsa:56144.
    UCSCiuc003lhi.2. human. [Q9UN74-1]
    uc011daa.2. human. [Q9UN74-2]

    Polymorphism databases

    DMDMi13878424.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152312 mRNA. Translation: AAD43706.1 .
    AF152482 mRNA. Translation: AAD43743.1 .
    AC005609 Genomic DNA. Translation: AAC34322.1 .
    BC112102 mRNA. Translation: AAI12103.1 .
    BC113609 mRNA. Translation: AAI13610.1 .
    CCDSi CCDS54916.1. [Q9UN74-1 ]
    RefSeqi NP_061730.1. NM_018907.3. [Q9UN74-1 ]
    NP_113688.1. NM_031500.2. [Q9UN74-2 ]
    UniGenei Hs.199343.

    3D structure databases

    ProteinModelPortali Q9UN74.
    SMRi Q9UN74. Positions 27-667.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121084. 13 interactions.
    IntActi Q9UN74. 13 interactions.
    MINTi MINT-1368168.
    STRINGi 9606.ENSP00000349344.

    PTM databases

    PhosphoSitei Q9UN74.

    Polymorphism databases

    DMDMi 13878424.

    Proteomic databases

    PaxDbi Q9UN74.
    PRIDEi Q9UN74.

    Protocols and materials databases

    DNASUi 56144.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000530339 ; ENSP00000435300 ; ENSG00000204967 . [Q9UN74-1 ]
    GeneIDi 56144.
    KEGGi hsa:56144.
    UCSCi uc003lhi.2. human. [Q9UN74-1 ]
    uc011daa.2. human. [Q9UN74-2 ]

    Organism-specific databases

    CTDi 56144.
    GeneCardsi GC05P140186.
    HGNCi HGNC:8670. PCDHA4.
    HPAi HPA008712.
    HPA043180.
    MIMi 604966. gene.
    606310. gene.
    neXtProti NX_Q9UN74.
    PharmGKBi PA33016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267459.
    HOGENOMi HOG000220892.
    HOVERGENi HBG054878.
    InParanoidi Q9UN74.
    KOi K16493.
    OMAi DNVPDLE.
    OrthoDBi EOG7KSX80.
    PhylomeDBi Q9UN74.
    TreeFami TF332299.

    Miscellaneous databases

    GeneWikii PCDHA4.
    GenomeRNAii 56144.
    NextBioi 61732.
    PROi Q9UN74.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UN74.
    Genevestigatori Q9UN74.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.

    Entry informationi

    Entry nameiPCDA4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN74
    Secondary accession number(s): O75285, Q2M253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3