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Q9UN74 (PCDA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin alpha-4

Short name=PCDH-alpha-4
Gene names
Name:PCDHA4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length947 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subunit structure

Interacts with FYN By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Traceable author statement Ref.1. Source: ProtInc

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

nervous system development

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UN74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UN74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     796-798: PRQ → VSV
     799-947: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 947918Protocadherin alpha-4
PRO_0000003890

Regions

Topological domain30 – 697668Extracellular Potential
Transmembrane698 – 71821Helical; Potential
Topological domain719 – 947229Cytoplasmic Potential
Domain30 – 133104Cadherin 1
Domain134 – 242109Cadherin 2
Domain243 – 350108Cadherin 3
Domain351 – 455105Cadherin 4
Domain456 – 565110Cadherin 5
Domain588 – 67891Cadherin 6
Repeat734 – 7374PXXP 1
Repeat774 – 7774PXXP 2
Repeat796 – 7994PXXP 3
Repeat829 – 8324PXXP 4
Repeat870 – 8734PXXP 5
Repeat888 – 8914PXXP 6
Region734 – 8911586 X 4 AA repeats of P-X-X-P
Compositional bias920 – 9278Poly-Lys

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation5481N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence796 – 7983PRQ → VSV in isoform 2.
VSP_000677
Alternative sequence799 – 947149Missing in isoform 2.
VSP_000678
Natural variant551E → D.
Corresponds to variant rs11167605 [ dbSNP | Ensembl ].
VAR_059180
Natural variant1841P → S.
Corresponds to variant rs3822346 [ dbSNP | Ensembl ].
VAR_024390

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2B06F20872D731D8

FASTA947102,293
        10         20         30         40         50         60 
MEFSWGSGQE SRRLLLLLLL LAAWEAGNGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV 

        70         80         90        100        110        120 
PRLFRVASKG RGGLLEVNLQ NGILFVNSRI DREELCRRSA ECSIHLEVIV DRPLQVFHVD 

       130        140        150        160        170        180 
VEVRDINDNP PVFPATQKNL SIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFSL 

       190        200        210        220        230        240 
EKPPDDELVK GLGLILRKSL DREEAPEIFL VLTATDGGKP ELTGTVQLLI TVLDANDNAP 

       250        260        270        280        290        300 
AFDRTIYKVR LLENVPNGTL VIKLNASDLD EGLNGDIVYS FSNDISPNVK SKFHIDPITG 

       310        320        330        340        350        360 
QIIVKGYIDF EESKSYEIIV EGIDKGQLPL SGHCRVIVEV EDNNDNVPDL EFKSLSLPIR 

       370        380        390        400        410        420 
EDAPLGTVIA LISVSDKDMG VNGLVTCSLT SHVPFKLVST FKNYYSLVLD SALDRESVSA 

       430        440        450        460        470        480 
YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW 

       490        500        510        520        530        540 
DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVTARDA 

       550        560        570        580        590        600 
GVPPLGSNVT LQVFVLDEND NAPALLAPRA GGTGGAVSEL VPWSVGVGHV VAKVRAVDAD 

       610        620        630        640        650        660 
SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDET DAPRHRLLVL VKDHGEPALT 

       670        680        690        700        710        720 
ATATVLVSLV ESGQAPKASS RALVGAVGPD AALVDVNVYL IIAICAVSSL LVLTLLLYTA 

       730        740        750        760        770        780 
LRCSALPTEG ACAPGKPTLV CSSAVGSWSY SQQRRPRVCS GEGPPKTDLM AFSPSLPDSR 

       790        800        810        820        830        840 
DREDQLQTTE ESFAKPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS 

       850        860        870        880        890        900 
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP 

       910        920        930        940 
TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ 

« Hide

Isoform 2 [UniParc].

Checksum: 9EF890C30F48A77F
Show »

FASTA79886,158

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152312 mRNA. Translation: AAD43706.1.
AF152482 mRNA. Translation: AAD43743.1.
AC005609 Genomic DNA. Translation: AAC34322.1.
BC112102 mRNA. Translation: AAI12103.1.
BC113609 mRNA. Translation: AAI13610.1.
CCDSCCDS54916.1. [Q9UN74-1]
RefSeqNP_061730.1. NM_018907.3. [Q9UN74-1]
NP_113688.1. NM_031500.2. [Q9UN74-2]
UniGeneHs.199343.

3D structure databases

ProteinModelPortalQ9UN74.
SMRQ9UN74. Positions 27-667.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121084. 13 interactions.
IntActQ9UN74. 13 interactions.
MINTMINT-1368168.
STRING9606.ENSP00000349344.

PTM databases

PhosphoSiteQ9UN74.

Polymorphism databases

DMDM13878424.

Proteomic databases

PaxDbQ9UN74.
PRIDEQ9UN74.

Protocols and materials databases

DNASU56144.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356878; ENSP00000349344; ENSG00000204967. [Q9UN74-2]
ENST00000530339; ENSP00000435300; ENSG00000204967. [Q9UN74-1]
ENST00000609250; ENSP00000477235; ENSG00000272756. [Q9UN74-1]
ENST00000609302; ENSP00000476794; ENSG00000272756. [Q9UN74-2]
GeneID56144.
KEGGhsa:56144.
UCSCuc003lhi.2. human. [Q9UN74-1]
uc011daa.2. human. [Q9UN74-2]

Organism-specific databases

CTD56144.
GeneCardsGC05P140186.
HGNCHGNC:8670. PCDHA4.
HPAHPA008712.
HPA043180.
MIM604966. gene.
606310. gene.
neXtProtNX_Q9UN74.
PharmGKBPA33016.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267459.
HOGENOMHOG000220892.
HOVERGENHBG054878.
InParanoidQ9UN74.
KOK16493.
OMADNVPDLE.
OrthoDBEOG7KSX80.
PhylomeDBQ9UN74.
TreeFamTF332299.

Gene expression databases

BgeeQ9UN74.
GenevestigatorQ9UN74.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHA4.
GenomeRNAi56144.
NextBio61732.
PROQ9UN74.
SOURCESearch...

Entry information

Entry namePCDA4_HUMAN
AccessionPrimary (citable) accession number: Q9UN74
Secondary accession number(s): O75285, Q2M253
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM