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Q9UN74

- PCDA4_HUMAN

UniProt

Q9UN74 - PCDA4_HUMAN

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Protein
Protocadherin alpha-4
Gene
PCDHA4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. homophilic cell adhesion Source: InterPro
  3. nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-4
Short name:
PCDH-alpha-4
Gene namesi
Name:PCDHA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8670. PCDHA4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 697668Extracellular Reviewed prediction
Add
BLAST
Transmembranei698 – 71821Helical; Reviewed prediction
Add
BLAST
Topological domaini719 – 947229Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 947918Protocadherin alpha-4
PRO_0000003890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi257 – 2571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi548 – 5481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UN74.
PRIDEiQ9UN74.

PTM databases

PhosphoSiteiQ9UN74.

Expressioni

Gene expression databases

BgeeiQ9UN74.
GenevestigatoriQ9UN74.

Organism-specific databases

HPAiHPA008712.
HPA043180.

Interactioni

Subunit structurei

Interacts with FYN By similarity.

Protein-protein interaction databases

BioGridi121084. 13 interactions.
IntActiQ9UN74. 13 interactions.
MINTiMINT-1368168.
STRINGi9606.ENSP00000349344.

Structurei

3D structure databases

ProteinModelPortaliQ9UN74.
SMRiQ9UN74. Positions 27-667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1
Add
BLAST
Domaini134 – 242109Cadherin 2
Add
BLAST
Domaini243 – 350108Cadherin 3
Add
BLAST
Domaini351 – 455105Cadherin 4
Add
BLAST
Domaini456 – 565110Cadherin 5
Add
BLAST
Domaini588 – 67891Cadherin 6
Add
BLAST
Repeati734 – 7374PXXP 1
Repeati774 – 7774PXXP 2
Repeati796 – 7994PXXP 3
Repeati829 – 8324PXXP 4
Repeati870 – 8734PXXP 5
Repeati888 – 8914PXXP 6

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni734 – 8911586 X 4 AA repeats of P-X-X-P
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi920 – 9278Poly-Lys

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267459.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN74.
KOiK16493.
OMAiDNVPDLE.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN74.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UN74-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEFSWGSGQE SRRLLLLLLL LAAWEAGNGQ LHYSVSEEAK HGTFVGRIAQ    50
DLGLELAELV PRLFRVASKG RGGLLEVNLQ NGILFVNSRI DREELCRRSA 100
ECSIHLEVIV DRPLQVFHVD VEVRDINDNP PVFPATQKNL SIAESRPLDS 150
RFPLEGASDA DIGENALLTY RLSPNEYFSL EKPPDDELVK GLGLILRKSL 200
DREEAPEIFL VLTATDGGKP ELTGTVQLLI TVLDANDNAP AFDRTIYKVR 250
LLENVPNGTL VIKLNASDLD EGLNGDIVYS FSNDISPNVK SKFHIDPITG 300
QIIVKGYIDF EESKSYEIIV EGIDKGQLPL SGHCRVIVEV EDNNDNVPDL 350
EFKSLSLPIR EDAPLGTVIA LISVSDKDMG VNGLVTCSLT SHVPFKLVST 400
FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND 450
NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQENALV SYSLVERRVG 500
ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVTARDA GVPPLGSNVT 550
LQVFVLDEND NAPALLAPRA GGTGGAVSEL VPWSVGVGHV VAKVRAVDAD 600
SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDET DAPRHRLLVL 650
VKDHGEPALT ATATVLVSLV ESGQAPKASS RALVGAVGPD AALVDVNVYL 700
IIAICAVSSL LVLTLLLYTA LRCSALPTEG ACAPGKPTLV CSSAVGSWSY 750
SQQRRPRVCS GEGPPKTDLM AFSPSLPDSR DREDQLQTTE ESFAKPRQPN 800
PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE 850
VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP 900
TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ 947
Length:947
Mass (Da):102,293
Last modified:May 1, 2000 - v1
Checksum:i2B06F20872D731D8
GO
Isoform 2 (identifier: Q9UN74-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     796-798: PRQ → VSV
     799-947: Missing.

Show »
Length:798
Mass (Da):86,158
Checksum:i9EF890C30F48A77F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551E → D.
Corresponds to variant rs11167605 [ dbSNP | Ensembl ].
VAR_059180
Natural varianti184 – 1841P → S.
Corresponds to variant rs3822346 [ dbSNP | Ensembl ].
VAR_024390

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei796 – 7983PRQ → VSV in isoform 2.
VSP_000677
Alternative sequencei799 – 947149Missing in isoform 2.
VSP_000678Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152312 mRNA. Translation: AAD43706.1.
AF152482 mRNA. Translation: AAD43743.1.
AC005609 Genomic DNA. Translation: AAC34322.1.
BC112102 mRNA. Translation: AAI12103.1.
BC113609 mRNA. Translation: AAI13610.1.
CCDSiCCDS54916.1. [Q9UN74-1]
RefSeqiNP_061730.1. NM_018907.3. [Q9UN74-1]
NP_113688.1. NM_031500.2. [Q9UN74-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000356878; ENSP00000349344; ENSG00000204967. [Q9UN74-2]
ENST00000530339; ENSP00000435300; ENSG00000204967. [Q9UN74-1]
ENST00000609250; ENSP00000477235; ENSG00000272756. [Q9UN74-1]
ENST00000609302; ENSP00000476794; ENSG00000272756. [Q9UN74-2]
GeneIDi56144.
KEGGihsa:56144.
UCSCiuc003lhi.2. human. [Q9UN74-1]
uc011daa.2. human. [Q9UN74-2]

Polymorphism databases

DMDMi13878424.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152312 mRNA. Translation: AAD43706.1 .
AF152482 mRNA. Translation: AAD43743.1 .
AC005609 Genomic DNA. Translation: AAC34322.1 .
BC112102 mRNA. Translation: AAI12103.1 .
BC113609 mRNA. Translation: AAI13610.1 .
CCDSi CCDS54916.1. [Q9UN74-1 ]
RefSeqi NP_061730.1. NM_018907.3. [Q9UN74-1 ]
NP_113688.1. NM_031500.2. [Q9UN74-2 ]
UniGenei Hs.199343.

3D structure databases

ProteinModelPortali Q9UN74.
SMRi Q9UN74. Positions 27-667.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121084. 13 interactions.
IntActi Q9UN74. 13 interactions.
MINTi MINT-1368168.
STRINGi 9606.ENSP00000349344.

PTM databases

PhosphoSitei Q9UN74.

Polymorphism databases

DMDMi 13878424.

Proteomic databases

PaxDbi Q9UN74.
PRIDEi Q9UN74.

Protocols and materials databases

DNASUi 56144.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356878 ; ENSP00000349344 ; ENSG00000204967 . [Q9UN74-2 ]
ENST00000530339 ; ENSP00000435300 ; ENSG00000204967 . [Q9UN74-1 ]
ENST00000609250 ; ENSP00000477235 ; ENSG00000272756 . [Q9UN74-1 ]
ENST00000609302 ; ENSP00000476794 ; ENSG00000272756 . [Q9UN74-2 ]
GeneIDi 56144.
KEGGi hsa:56144.
UCSCi uc003lhi.2. human. [Q9UN74-1 ]
uc011daa.2. human. [Q9UN74-2 ]

Organism-specific databases

CTDi 56144.
GeneCardsi GC05P140186.
HGNCi HGNC:8670. PCDHA4.
HPAi HPA008712.
HPA043180.
MIMi 604966. gene.
606310. gene.
neXtProti NX_Q9UN74.
PharmGKBi PA33016.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267459.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
InParanoidi Q9UN74.
KOi K16493.
OMAi DNVPDLE.
OrthoDBi EOG7KSX80.
PhylomeDBi Q9UN74.
TreeFami TF332299.

Miscellaneous databases

GeneWikii PCDHA4.
GenomeRNAii 56144.
NextBioi 61732.
PROi Q9UN74.
SOURCEi Search...

Gene expression databases

Bgeei Q9UN74.
Genevestigatori Q9UN74.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.

Entry informationi

Entry nameiPCDA4_HUMAN
AccessioniPrimary (citable) accession number: Q9UN74
Secondary accession number(s): O75285, Q2M253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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