Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin alpha-6

Gene

PCDHA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-6
Short name:
PCDH-alpha-6
Gene namesi
Name:PCDHA6
Synonyms:CNRS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8672. PCDHA6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 697ExtracellularSequence analysisAdd BLAST668
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 950CytoplasmicSequence analysisAdd BLAST232

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56142.
OpenTargetsiENSG00000081842.
PharmGKBiPA33018.

Polymorphism and mutation databases

BioMutaiPCDHA6.
DMDMi13878423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000389430 – 950Protocadherin alpha-6Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN73.
PaxDbiQ9UN73.
PeptideAtlasiQ9UN73.
PRIDEiQ9UN73.

PTM databases

iPTMnetiQ9UN73.
PhosphoSitePlusiQ9UN73.

Expressioni

Gene expression databases

BgeeiENSG00000081842.
CleanExiHS_PCDHA6.
GenevisibleiQ9UN73. HS.

Organism-specific databases

HPAiCAB000052.
CAB002800.
CAB056154.
CAB068221.

Interactioni

Protein-protein interaction databases

BioGridi121082. 3 interactors.
IntActiQ9UN73. 2 interactors.
STRINGi9606.ENSP00000433378.

Structurei

3D structure databases

ProteinModelPortaliQ9UN73.
SMRiQ9UN73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST100
Domaini157 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST86
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini581 – 678Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Repeati799 – 802PXXP 14
Repeati832 – 835PXXP 24
Repeati873 – 876PXXP 34
Repeati891 – 894PXXP 44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni799 – 8944 X 4 AA repeats of P-X-X-PAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi923 – 930Poly-Lys8

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN73.
KOiK16493.
OMAiSNEYFAL.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9UN73.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9UN73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFTPEDRLG KQCLLLPLLL LAAWKVGSGQ LHYSVPEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELAELV PRLFRMASKD REDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVD VEVRDINDNP PLFPVEEQRV LIYESRLPDS
160 170 180 190 200
VFPLEGASDA DVGSNSILTY KLSSSEYFGL DVKINSDDNK QIGLLLKKSL
210 220 230 240 250
DREEAPAHNL FLTATDGGKP ELTGTVQLLV TVLDVNDNAP TFEQSEYEVR
260 270 280 290 300
IFENADNGTT VIRLNASDRD EGANGAISYS FNSLVAAMVI DHFSIDRNTG
310 320 330 340 350
EIVIRGNLDF EQENLYKILI DATDKGHPPM AGHCTVLVRI LDKNDNVPEI
360 370 380 390 400
ALTSLSLPVR EDAQFGTVIA LISVNDLDSG ANGQVNCSLT PHVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS LSVEVADMND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG
510 520 530 540 550
ERALSSYISV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLAPRV GGTGGAVSEL VPRSLGAGQV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQPPASSARF PFRVGLYTGE ISTTRVLDEA DSPRHRLLVL
660 670 680 690 700
VKDHGEPALT ATATVLVSLV ESGQAPKASS RASVGAAGPE AALVDVNVYL
710 720 730 740 750
IIAICAVSSL LVLTLLLYTA LRCSAPPTEG ACTADKPTLV CSSAVGSWSY
760 770 780 790 800
SQQRRQRVCS GEGPPKMDLM AFSPSLSPCP IMMGKAENQD LNEDHDAKPR
810 820 830 840 850
QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE
860 870 880 890 900
AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR
910 920 930 940 950
QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ
Length:950
Mass (Da):102,716
Last modified:May 1, 2000 - v1
Checksum:i894B97B9737C52B9
GO
Isoform 2 (identifier: Q9UN73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-798: Missing.

Show »
Length:686
Mass (Da):75,250
Checksum:i683E33D08C967700
GO
Isoform 3 (identifier: Q9UN73-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     799-803: PRQPN → VSEFS
     804-950: Missing.

Show »
Length:803
Mass (Da):86,845
Checksum:iD95B0E37DD1B0F17
GO

Sequence cautioni

The sequence AAF89691 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061061585L → V.Corresponds to variant rs60309716dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000681535 – 798Missing in isoform 2. 1 PublicationAdd BLAST264
Alternative sequenceiVSP_000682799 – 803PRQPN → VSEFS in isoform 3. 1 Publication5
Alternative sequenceiVSP_000683804 – 950Missing in isoform 3. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152314 mRNA. Translation: AAD43708.1.
AF152484 mRNA. Translation: AAD43745.1.
AF169694 mRNA. Translation: AAF89691.1. Different initiation.
AC005609 Genomic DNA. Translation: AAC34320.1.
BC036674 mRNA. Translation: AAH36674.1.
CCDSiCCDS47281.1. [Q9UN73-1]
CCDS47282.1. [Q9UN73-2]
RefSeqiNP_061732.1. NM_018909.3. [Q9UN73-1]
NP_114036.1. NM_031848.2. [Q9UN73-3]
NP_114037.1. NM_031849.2. [Q9UN73-2]
UniGeneiHs.199343.
Hs.570901.
Hs.599714.
Hs.621225.

Genome annotation databases

EnsembliENST00000378126; ENSP00000367366; ENSG00000081842. [Q9UN73-3]
ENST00000527624; ENSP00000434113; ENSG00000081842. [Q9UN73-2]
ENST00000529310; ENSP00000433378; ENSG00000081842. [Q9UN73-1]
GeneIDi56142.
KEGGihsa:56142.
UCSCiuc003lhn.4. human. [Q9UN73-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152314 mRNA. Translation: AAD43708.1.
AF152484 mRNA. Translation: AAD43745.1.
AF169694 mRNA. Translation: AAF89691.1. Different initiation.
AC005609 Genomic DNA. Translation: AAC34320.1.
BC036674 mRNA. Translation: AAH36674.1.
CCDSiCCDS47281.1. [Q9UN73-1]
CCDS47282.1. [Q9UN73-2]
RefSeqiNP_061732.1. NM_018909.3. [Q9UN73-1]
NP_114036.1. NM_031848.2. [Q9UN73-3]
NP_114037.1. NM_031849.2. [Q9UN73-2]
UniGeneiHs.199343.
Hs.570901.
Hs.599714.
Hs.621225.

3D structure databases

ProteinModelPortaliQ9UN73.
SMRiQ9UN73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121082. 3 interactors.
IntActiQ9UN73. 2 interactors.
STRINGi9606.ENSP00000433378.

PTM databases

iPTMnetiQ9UN73.
PhosphoSitePlusiQ9UN73.

Polymorphism and mutation databases

BioMutaiPCDHA6.
DMDMi13878423.

Proteomic databases

EPDiQ9UN73.
PaxDbiQ9UN73.
PeptideAtlasiQ9UN73.
PRIDEiQ9UN73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378126; ENSP00000367366; ENSG00000081842. [Q9UN73-3]
ENST00000527624; ENSP00000434113; ENSG00000081842. [Q9UN73-2]
ENST00000529310; ENSP00000433378; ENSG00000081842. [Q9UN73-1]
GeneIDi56142.
KEGGihsa:56142.
UCSCiuc003lhn.4. human. [Q9UN73-1]

Organism-specific databases

CTDi56142.
DisGeNETi56142.
GeneCardsiPCDHA6.
HGNCiHGNC:8672. PCDHA6.
HPAiCAB000052.
CAB002800.
CAB056154.
CAB068221.
MIMi604966. gene.
606312. gene.
neXtProtiNX_Q9UN73.
OpenTargetsiENSG00000081842.
PharmGKBiPA33018.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN73.
KOiK16493.
OMAiSNEYFAL.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9UN73.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHA6.
GenomeRNAii56142.
PROiQ9UN73.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081842.
CleanExiHS_PCDHA6.
GenevisibleiQ9UN73. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDA6_HUMAN
AccessioniPrimary (citable) accession number: Q9UN73
Secondary accession number(s): O75283, Q9NRT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.