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Q9UN73

- PCDA6_HUMAN

UniProt

Q9UN73 - PCDA6_HUMAN

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Protein
Protocadherin alpha-6
Gene
PCDHA6, CNRS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. homophilic cell adhesion Source: InterPro
  3. nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-6
Short name:
PCDH-alpha-6
Gene namesi
Name:PCDHA6
Synonyms:CNRS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8672. PCDHA6.

Subcellular locationi

Isoform 2 : Secreted Reviewed prediction

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 697668Extracellular Reviewed prediction
Add
BLAST
Transmembranei698 – 71821Helical; Reviewed prediction
Add
BLAST
Topological domaini719 – 950232Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 950921Protocadherin alpha-6
PRO_0000003894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi257 – 2571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi548 – 5481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UN73.
PRIDEiQ9UN73.

PTM databases

PhosphoSiteiQ9UN73.

Expressioni

Gene expression databases

BgeeiQ9UN73.
CleanExiHS_PCDHA6.
GenevestigatoriQ9UN73.

Organism-specific databases

HPAiHPA008712.

Interactioni

Protein-protein interaction databases

BioGridi121082. 2 interactions.
IntActiQ9UN73. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UN73.
SMRiQ9UN73. Positions 27-681.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 133100Cadherin 1
Add
BLAST
Domaini157 – 24286Cadherin 2
Add
BLAST
Domaini243 – 350108Cadherin 3
Add
BLAST
Domaini351 – 455105Cadherin 4
Add
BLAST
Domaini456 – 565110Cadherin 5
Add
BLAST
Domaini581 – 67898Cadherin 6
Add
BLAST
Repeati799 – 8024PXXP 1
Repeati832 – 8354PXXP 2
Repeati873 – 8764PXXP 3
Repeati891 – 8944PXXP 4

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni799 – 894964 X 4 AA repeats of P-X-X-P
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi923 – 9308Poly-Lys

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267459.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN73.
KOiK16493.
OMAiEGACTAD.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN73.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9UN73-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVFTPEDRLG KQCLLLPLLL LAAWKVGSGQ LHYSVPEEAK HGTFVGRIAQ    50
DLGLELAELV PRLFRMASKD REDLLEVNLQ NGILFVNSRI DREELCGRSA 100
ECSIHLEVIV DRPLQVFHVD VEVRDINDNP PLFPVEEQRV LIYESRLPDS 150
VFPLEGASDA DVGSNSILTY KLSSSEYFGL DVKINSDDNK QIGLLLKKSL 200
DREEAPAHNL FLTATDGGKP ELTGTVQLLV TVLDVNDNAP TFEQSEYEVR 250
IFENADNGTT VIRLNASDRD EGANGAISYS FNSLVAAMVI DHFSIDRNTG 300
EIVIRGNLDF EQENLYKILI DATDKGHPPM AGHCTVLVRI LDKNDNVPEI 350
ALTSLSLPVR EDAQFGTVIA LISVNDLDSG ANGQVNCSLT PHVPFKLVST 400
FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS LSVEVADMND 450
NAPAFAQPEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG 500
ERALSSYISV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT 550
LQVFVLDEND NAPALLAPRV GGTGGAVSEL VPRSLGAGQV VAKVRAVDAD 600
SGYNAWLSYE LQPPASSARF PFRVGLYTGE ISTTRVLDEA DSPRHRLLVL 650
VKDHGEPALT ATATVLVSLV ESGQAPKASS RASVGAAGPE AALVDVNVYL 700
IIAICAVSSL LVLTLLLYTA LRCSAPPTEG ACTADKPTLV CSSAVGSWSY 750
SQQRRQRVCS GEGPPKMDLM AFSPSLSPCP IMMGKAENQD LNEDHDAKPR 800
QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE 850
AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR 900
QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ 950
Length:950
Mass (Da):102,716
Last modified:May 1, 2000 - v1
Checksum:i894B97B9737C52B9
GO
Isoform 2 (identifier: Q9UN73-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-798: Missing.

Show »
Length:686
Mass (Da):75,250
Checksum:i683E33D08C967700
GO
Isoform 3 (identifier: Q9UN73-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     799-803: PRQPN → VSEFS
     804-950: Missing.

Show »
Length:803
Mass (Da):86,845
Checksum:iD95B0E37DD1B0F17
GO

Sequence cautioni

The sequence AAF89691.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti585 – 5851L → V.
Corresponds to variant rs60309716 [ dbSNP | Ensembl ].
VAR_061061

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei535 – 798264Missing in isoform 2.
VSP_000681Add
BLAST
Alternative sequencei799 – 8035PRQPN → VSEFS in isoform 3.
VSP_000682
Alternative sequencei804 – 950147Missing in isoform 3.
VSP_000683Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152314 mRNA. Translation: AAD43708.1.
AF152484 mRNA. Translation: AAD43745.1.
AF169694 mRNA. Translation: AAF89691.1. Different initiation.
AC005609 Genomic DNA. Translation: AAC34320.1.
BC036674 mRNA. Translation: AAH36674.1.
CCDSiCCDS47281.1. [Q9UN73-1]
CCDS47282.1. [Q9UN73-2]
RefSeqiNP_061732.1. NM_018909.3. [Q9UN73-1]
NP_114036.1. NM_031848.2. [Q9UN73-3]
NP_114037.1. NM_031849.2. [Q9UN73-2]
UniGeneiHs.199343.
Hs.570901.
Hs.599714.
Hs.621225.

Genome annotation databases

EnsembliENST00000527624; ENSP00000434113; ENSG00000081842. [Q9UN73-2]
ENST00000529310; ENSP00000433378; ENSG00000081842. [Q9UN73-1]
ENST00000608670; ENSP00000477179; ENSG00000273256. [Q9UN73-1]
ENST00000608977; ENSP00000477064; ENSG00000273256. [Q9UN73-2]
GeneIDi56142.
KEGGihsa:56142.
UCSCiuc003lhn.2. human. [Q9UN73-2]
uc003lho.2. human. [Q9UN73-1]
uc011dab.2. human. [Q9UN73-3]

Polymorphism databases

DMDMi13878423.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152314 mRNA. Translation: AAD43708.1 .
AF152484 mRNA. Translation: AAD43745.1 .
AF169694 mRNA. Translation: AAF89691.1 . Different initiation.
AC005609 Genomic DNA. Translation: AAC34320.1 .
BC036674 mRNA. Translation: AAH36674.1 .
CCDSi CCDS47281.1. [Q9UN73-1 ]
CCDS47282.1. [Q9UN73-2 ]
RefSeqi NP_061732.1. NM_018909.3. [Q9UN73-1 ]
NP_114036.1. NM_031848.2. [Q9UN73-3 ]
NP_114037.1. NM_031849.2. [Q9UN73-2 ]
UniGenei Hs.199343.
Hs.570901.
Hs.599714.
Hs.621225.

3D structure databases

ProteinModelPortali Q9UN73.
SMRi Q9UN73. Positions 27-681.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121082. 2 interactions.
IntActi Q9UN73. 2 interactions.

PTM databases

PhosphoSitei Q9UN73.

Polymorphism databases

DMDMi 13878423.

Proteomic databases

PaxDbi Q9UN73.
PRIDEi Q9UN73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000527624 ; ENSP00000434113 ; ENSG00000081842 . [Q9UN73-2 ]
ENST00000529310 ; ENSP00000433378 ; ENSG00000081842 . [Q9UN73-1 ]
ENST00000608670 ; ENSP00000477179 ; ENSG00000273256 . [Q9UN73-1 ]
ENST00000608977 ; ENSP00000477064 ; ENSG00000273256 . [Q9UN73-2 ]
GeneIDi 56142.
KEGGi hsa:56142.
UCSCi uc003lhn.2. human. [Q9UN73-2 ]
uc003lho.2. human. [Q9UN73-1 ]
uc011dab.2. human. [Q9UN73-3 ]

Organism-specific databases

CTDi 56142.
GeneCardsi GC05P140439.
HGNCi HGNC:8672. PCDHA6.
HPAi HPA008712.
MIMi 604966. gene.
606312. gene.
neXtProti NX_Q9UN73.
PharmGKBi PA33018.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267459.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
InParanoidi Q9UN73.
KOi K16493.
OMAi EGACTAD.
OrthoDBi EOG7KSX80.
PhylomeDBi Q9UN73.
TreeFami TF332299.

Miscellaneous databases

GeneWikii PCDHA6.
GenomeRNAii 56142.
NextBioi 61718.
PROi Q9UN73.
SOURCEi Search...

Gene expression databases

Bgeei Q9UN73.
CleanExi HS_PCDHA6.
Genevestigatori Q9UN73.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  2. "Alternative splicing within the human CNR family of protocadherins (PCDH-alpha) produces transcripts encoding secreted proteins."
    Kools P.F.J., van Roy F.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiPCDA6_HUMAN
AccessioniPrimary (citable) accession number: Q9UN73
Secondary accession number(s): O75283, Q9NRT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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