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Protein

Protocadherin alpha-7

Gene

PCDHA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-7Curated
Short name:
PCDH-alpha-7Curated
Gene namesi
Name:PCDHA7Imported
Synonyms:CNRS4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8673. PCDHA7.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 697ExtracellularBy similarityAdd BLAST668
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 937CytoplasmicBy similarityAdd BLAST219

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204963.
PharmGKBiPA33019.

Polymorphism and mutation databases

BioMutaiPCDHA7.
DMDMi13878422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000389630 – 937Protocadherin alpha-7Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi96 ↔ 102By similarity
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UN72.
PeptideAtlasiQ9UN72.
PRIDEiQ9UN72.

PTM databases

iPTMnetiQ9UN72.
PhosphoSitePlusiQ9UN72.

Expressioni

Gene expression databases

GenevisibleiQ9UN72. HS.

Interactioni

Subunit structurei

Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins.By similarity

Protein-protein interaction databases

BioGridi121081. 4 interactors.
IntActiQ9UN72. 2 interactors.
MINTiMINT-7241677.
STRINGi9606.ENSP00000436426.

Structurei

3D structure databases

ProteinModelPortaliQ9UN72.
SMRiQ9UN72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini581 – 678Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Repeati774 – 777PXXP 14
Repeati786 – 789PXXP 24
Repeati819 – 822PXXP 34
Repeati860 – 863PXXP 44
Repeati878 – 881PXXP 54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni774 – 8815 X 4 AA repeats of P-X-X-PAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi910 – 917Poly-LysSequence analysis8

Domaini

Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN72.
KOiK16493.
OMAiMVCPNGY.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9UN72.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UN72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCPNGYDPG GRHLLLFIII LAAWEAGRGQ LHYSVPEEAK HGNFVGRIAQ
60 70 80 90 100
DLGLELAELV PRLFRAVCKF RGDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV ERPLQVFHVD VEVKDINDNP PVFPATQRNL FIAESRPLDS
160 170 180 190 200
RFPLEGASDA DIGENALLTY RLSPNEYFFL DVPTSNQQVK PLGLVLRKLL
210 220 230 240 250
DREETPELHL LLTATDGGKP ELTGTVQLLI TVLDNNDNAP VFDRTLYTVK
260 270 280 290 300
LPENVSIGTL VIHPNASDLD EGLNGDIIYS FSSDVSPDIK SKFHMDPLSG
310 320 330 340 350
AITVIGHMDF EESRAHKIPV EAVDKGFPPL AGHCTVLVEV VDVNDNAPQL
360 370 380 390 400
TLTSLSLPIP EDAQPGTVIT LISVFDRDFG VNGQVTCSLT PRVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GCHIFTVSAG DADAQKNALV SYSLVELRVG
510 520 530 540 550
ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLAPRV GGTGGAVREL VPRSVGAGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQPVAAGASI PFRVGLYTGE ISTTRALDET DAPRHRLLVL
660 670 680 690 700
VKDHGEPSLT ATATVLVSLV ESGQAPKASS RASLGIAGPE TELVDVNVYL
710 720 730 740 750
IIAICAVSSL LVLTLLLYTA LRCSAPSSEG ACSLVKPTLV CSSAVGSWSF
760 770 780 790 800
SQQRRQRVCS GEGPPKTDLM AFSPSLPQGP SSTDNPRQPN PDWRYSASLR
810 820 830 840 850
AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE VSPPVGAGVN
860 870 880 890 900
SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP TNSQIDKSDF
910 920 930
ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ
Length:937
Mass (Da):100,865
Last modified:May 1, 2000 - v1
Checksum:i1BBF0D4DF89BCD8D
GO
Isoform 2 (identifier: Q9UN72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-789: PRQP → VSHK
     790-937: Missing.

Show »
Length:789
Mass (Da):84,896
Checksum:i5A820CAAF34855AD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048527138R → K.Corresponds to variant rs10067182dbSNPEnsembl.1
Natural variantiVAR_048528663A → G.Corresponds to variant rs6880234dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000684786 – 789PRQP → VSHK in isoform 2. 1 Publication4
Alternative sequenceiVSP_000685790 – 937Missing in isoform 2. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152315 mRNA. Translation: AAD43709.1.
AF152485 mRNA. Translation: AAD43746.1.
AC005609 Genomic DNA. Translation: AAC34319.1.
CCDSiCCDS54918.1. [Q9UN72-1]
RefSeqiNP_061733.1. NM_018910.2. [Q9UN72-1]
NP_114040.1. NM_031852.1. [Q9UN72-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000356878; ENSP00000349344; ENSG00000204963. [Q9UN72-2]
ENST00000525929; ENSP00000436426; ENSG00000204963. [Q9UN72-1]
GeneIDi56141.
KEGGihsa:56141.
UCSCiuc003lhq.2. human. [Q9UN72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152315 mRNA. Translation: AAD43709.1.
AF152485 mRNA. Translation: AAD43746.1.
AC005609 Genomic DNA. Translation: AAC34319.1.
CCDSiCCDS54918.1. [Q9UN72-1]
RefSeqiNP_061733.1. NM_018910.2. [Q9UN72-1]
NP_114040.1. NM_031852.1. [Q9UN72-2]
UniGeneiHs.199343.

3D structure databases

ProteinModelPortaliQ9UN72.
SMRiQ9UN72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121081. 4 interactors.
IntActiQ9UN72. 2 interactors.
MINTiMINT-7241677.
STRINGi9606.ENSP00000436426.

PTM databases

iPTMnetiQ9UN72.
PhosphoSitePlusiQ9UN72.

Polymorphism and mutation databases

BioMutaiPCDHA7.
DMDMi13878422.

Proteomic databases

PaxDbiQ9UN72.
PeptideAtlasiQ9UN72.
PRIDEiQ9UN72.

Protocols and materials databases

DNASUi56141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356878; ENSP00000349344; ENSG00000204963. [Q9UN72-2]
ENST00000525929; ENSP00000436426; ENSG00000204963. [Q9UN72-1]
GeneIDi56141.
KEGGihsa:56141.
UCSCiuc003lhq.2. human. [Q9UN72-1]

Organism-specific databases

CTDi56141.
GeneCardsiPCDHA7.
HGNCiHGNC:8673. PCDHA7.
MIMi604966. gene.
606313. gene.
neXtProtiNX_Q9UN72.
OpenTargetsiENSG00000204963.
PharmGKBiPA33019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN72.
KOiK16493.
OMAiMVCPNGY.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9UN72.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56141.
PROiQ9UN72.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ9UN72. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDA7_HUMAN
AccessioniPrimary (citable) accession number: Q9UN72
Secondary accession number(s): O75282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.