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Protein

Protocadherin alpha-7

Gene

PCDHA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-7
Short name:
PCDH-alpha-7
Gene namesi
Name:PCDHA7
Synonyms:CNRS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8673. PCDHA7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 697668ExtracellularSequence analysisAdd
BLAST
Transmembranei698 – 71821HelicalSequence analysisAdd
BLAST
Topological domaini719 – 937219CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33019.

Polymorphism and mutation databases

BioMutaiPCDHA7.
DMDMi13878422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 937908Protocadherin alpha-7PRO_0000003896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UN72.
PRIDEiQ9UN72.

PTM databases

iPTMnetiQ9UN72.
PhosphoSiteiQ9UN72.

Expressioni

Gene expression databases

BgeeiQ9UN72.
GenevisibleiQ9UN72. HS.

Interactioni

Protein-protein interaction databases

BioGridi121081. 4 interactions.
IntActiQ9UN72. 2 interactions.
MINTiMINT-7241677.
STRINGi9606.ENSP00000436426.

Structurei

3D structure databases

ProteinModelPortaliQ9UN72.
SMRiQ9UN72. Positions 27-697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 350108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 455105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 565110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini581 – 67898Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Repeati774 – 7774PXXP 1
Repeati786 – 7894PXXP 2
Repeati819 – 8224PXXP 3
Repeati860 – 8634PXXP 4
Repeati878 – 8814PXXP 5

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni774 – 8811085 X 4 AA repeats of P-X-X-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi910 – 9178Poly-Lys

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN72.
KOiK16493.
OMAiMVCPNGY.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN72.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UN72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCPNGYDPG GRHLLLFIII LAAWEAGRGQ LHYSVPEEAK HGNFVGRIAQ
60 70 80 90 100
DLGLELAELV PRLFRAVCKF RGDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV ERPLQVFHVD VEVKDINDNP PVFPATQRNL FIAESRPLDS
160 170 180 190 200
RFPLEGASDA DIGENALLTY RLSPNEYFFL DVPTSNQQVK PLGLVLRKLL
210 220 230 240 250
DREETPELHL LLTATDGGKP ELTGTVQLLI TVLDNNDNAP VFDRTLYTVK
260 270 280 290 300
LPENVSIGTL VIHPNASDLD EGLNGDIIYS FSSDVSPDIK SKFHMDPLSG
310 320 330 340 350
AITVIGHMDF EESRAHKIPV EAVDKGFPPL AGHCTVLVEV VDVNDNAPQL
360 370 380 390 400
TLTSLSLPIP EDAQPGTVIT LISVFDRDFG VNGQVTCSLT PRVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GCHIFTVSAG DADAQKNALV SYSLVELRVG
510 520 530 540 550
ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLAPRV GGTGGAVREL VPRSVGAGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQPVAAGASI PFRVGLYTGE ISTTRALDET DAPRHRLLVL
660 670 680 690 700
VKDHGEPSLT ATATVLVSLV ESGQAPKASS RASLGIAGPE TELVDVNVYL
710 720 730 740 750
IIAICAVSSL LVLTLLLYTA LRCSAPSSEG ACSLVKPTLV CSSAVGSWSF
760 770 780 790 800
SQQRRQRVCS GEGPPKTDLM AFSPSLPQGP SSTDNPRQPN PDWRYSASLR
810 820 830 840 850
AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE VSPPVGAGVN
860 870 880 890 900
SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP TNSQIDKSDF
910 920 930
ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ
Length:937
Mass (Da):100,865
Last modified:May 1, 2000 - v1
Checksum:i1BBF0D4DF89BCD8D
GO
Isoform 2 (identifier: Q9UN72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-789: PRQP → VSHK
     790-937: Missing.

Show »
Length:789
Mass (Da):84,896
Checksum:i5A820CAAF34855AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381R → K.
Corresponds to variant rs10067182 [ dbSNP | Ensembl ].
VAR_048527
Natural varianti663 – 6631A → G.
Corresponds to variant rs6880234 [ dbSNP | Ensembl ].
VAR_048528

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei786 – 7894PRQP → VSHK in isoform 2. 1 PublicationVSP_000684
Alternative sequencei790 – 937148Missing in isoform 2. 1 PublicationVSP_000685Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152315 mRNA. Translation: AAD43709.1.
AF152485 mRNA. Translation: AAD43746.1.
AC005609 Genomic DNA. Translation: AAC34319.1.
CCDSiCCDS54918.1. [Q9UN72-1]
RefSeqiNP_061733.1. NM_018910.2. [Q9UN72-1]
NP_114040.1. NM_031852.1. [Q9UN72-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000356878; ENSP00000349344; ENSG00000204963. [Q9UN72-2]
ENST00000525929; ENSP00000436426; ENSG00000204963. [Q9UN72-1]
GeneIDi56141.
KEGGihsa:56141.
UCSCiuc003lhq.2. human. [Q9UN72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152315 mRNA. Translation: AAD43709.1.
AF152485 mRNA. Translation: AAD43746.1.
AC005609 Genomic DNA. Translation: AAC34319.1.
CCDSiCCDS54918.1. [Q9UN72-1]
RefSeqiNP_061733.1. NM_018910.2. [Q9UN72-1]
NP_114040.1. NM_031852.1. [Q9UN72-2]
UniGeneiHs.199343.

3D structure databases

ProteinModelPortaliQ9UN72.
SMRiQ9UN72. Positions 27-697.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121081. 4 interactions.
IntActiQ9UN72. 2 interactions.
MINTiMINT-7241677.
STRINGi9606.ENSP00000436426.

PTM databases

iPTMnetiQ9UN72.
PhosphoSiteiQ9UN72.

Polymorphism and mutation databases

BioMutaiPCDHA7.
DMDMi13878422.

Proteomic databases

PaxDbiQ9UN72.
PRIDEiQ9UN72.

Protocols and materials databases

DNASUi56141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356878; ENSP00000349344; ENSG00000204963. [Q9UN72-2]
ENST00000525929; ENSP00000436426; ENSG00000204963. [Q9UN72-1]
GeneIDi56141.
KEGGihsa:56141.
UCSCiuc003lhq.2. human. [Q9UN72-1]

Organism-specific databases

CTDi56141.
GeneCardsiPCDHA7.
HGNCiHGNC:8673. PCDHA7.
MIMi604966. gene.
606313. gene.
neXtProtiNX_Q9UN72.
PharmGKBiPA33019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN72.
KOiK16493.
OMAiMVCPNGY.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN72.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56141.
NextBioi61712.
PROiQ9UN72.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UN72.
GenevisibleiQ9UN72. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPCDA7_HUMAN
AccessioniPrimary (citable) accession number: Q9UN72
Secondary accession number(s): O75282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.