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Protein

Protocadherin gamma-B4

Gene

PCDHGB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-B4
Short name:
PCDH-gamma-B4
Alternative name(s):
Cadherin-20
Fibroblast cadherin-2
Gene namesi
Name:PCDHGB4
Synonyms:CDH20, FIB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000253953.2
HGNCiHGNC:8711 PCDHGB4
MIMi603058 gene
604968 gene
neXtProtiNX_Q9UN71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 689ExtracellularSequence analysisAdd BLAST659
Transmembranei690 – 710HelicalSequence analysisAdd BLAST21
Topological domaini711 – 923CytoplasmicSequence analysisAdd BLAST213

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253953
PharmGKBiPA33059

Polymorphism and mutation databases

BioMutaiPCDHGB4
DMDMi37999814

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000397731 – 923Protocadherin gamma-B4Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN71
PaxDbiQ9UN71
PeptideAtlasiQ9UN71
PRIDEiQ9UN71
ProteomicsDBi85257
85258 [Q9UN71-2]

PTM databases

iPTMnetiQ9UN71
PhosphoSitePlusiQ9UN71

Expressioni

Gene expression databases

BgeeiENSG00000253953
CleanExiHS_CDH20
GenevisibleiQ9UN71 HS

Organism-specific databases

HPAiHPA008755
HPA010580

Interactioni

Protein-protein interaction databases

BioGridi114193, 58 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9UN71
SMRiQ9UN71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST103
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 345Cadherin 3PROSITE-ProRule annotationAdd BLAST103
Domaini346 – 450Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini451 – 560Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini568 – 673Cadherin 6PROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000148964
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9UN71
KOiK16496
OMAiGMIAQCT
OrthoDBiEOG091G01ZQ
PhylomeDBiQ9UN71
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UN71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL
60 70 80 90 100
ATDLGFSVQE LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP
110 120 130 140 150
ACALEFEAVA ENPLNFYHVN VEIEDINDHT PKFTQNSFEL QISESAQPGT
160 170 180 190 200
RFILGSAHDA DIGSNTLQNY QLSPSDHFSL INKEKSDGSK YPEMVLKTPL
210 220 230 240 250
DREKQKSYHL TLTALDFGAP PLSSTAQIHV LVTDANDNAP VFSQDVYRVS
260 270 280 290 300
LSENVYPGTT VLQVTATDQD EGVNAEITFS FSEASQITQF DLNSNTGEIT
310 320 330 340 350
VLNTLDFEEV KEYSIVLEAR DGGGMIAQCT VEVEVIDEND NAPEVIFQSL
360 370 380 390 400
PNLIMEDAEL GTHIALLKVR DKDSRHNGEV TCKLEGDVPF KILTSSRNTY
410 420 430 440 450
KLVTDAVLDR EQNPEYNITV TATDRGKPPL SSSSSITLHI GDVNDNAPVF
460 470 480 490 500
SQSSYIVHVA ENNPPGASIS QVRASDPDLG PNGQVSYCIM ASDLEQRELS
510 520 530 540 550
SYVSISAESG VVFAQRAFDH EQLRAFELTL QARDQGSPAL SANVSLRVLV
560 570 580 590 600
DDRNDNAPRV LYPALGPDGS ALFDMVPHAA EPGYLVTKVV AVDADSGHNA
610 620 630 640 650
WLSYHVLQAS EPGLFSLGLR TGEVRTARAL GDRDAVRQRL LVAVRDGGQP
660 670 680 690 700
PLSATATLHL VFADSLQEVL PDITDRPDPS DLQAELQFYL VVALALISVL
710 720 730 740 750
FLVAMILAIA LRLRRSSSPA SWSCFQPGLC VKSESVVPPN YSEGTLPYSY
760 770 780 790 800
NLCVAHTGKT EFNFLKCSEQ LSSGQDILCG DSSGALFPLC NSSELTSHQQ
810 820 830 840 850
APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ AMILASASEA
860 870 880 890 900
ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG
910 920
KRDGKAPAGG NGNKKKSGKK EKK
Length:923
Mass (Da):99,927
Last modified:May 1, 2000 - v1
Checksum:i649A8F509CE1B31A
GO
Isoform 2 (identifier: Q9UN71-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     800-803: QAPP → VSFL
     804-923: Missing.

Show »
Length:803
Mass (Da):87,447
Checksum:i635DD22BAB37A0B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008690800 – 803QAPP → VSFL in isoform 2. 2 Publications4
Alternative sequenceiVSP_008691804 – 923Missing in isoform 2. 2 PublicationsAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152333 mRNA Translation: AAD43727.1
AF152520 mRNA Translation: AAD43780.1
CH471062 Genomic DNA Translation: EAW61927.1
BC112088 mRNA Translation: AAI12089.1
BC113607 mRNA Translation: AAI13608.1
AB000896 mRNA Translation: BAA21134.1
CCDSiCCDS54928.1 [Q9UN71-1]
CCDS75337.1 [Q9UN71-2]
PIRiPC4298
RefSeqiNP_003727.1, NM_003736.2 [Q9UN71-1]
NP_115269.1, NM_032098.1 [Q9UN71-2]
UniGeneiHs.368160

Genome annotation databases

EnsembliENST00000519479; ENSP00000428288; ENSG00000253953 [Q9UN71-1]
ENST00000615384; ENSP00000484560; ENSG00000253953 [Q9UN71-2]
GeneIDi8641
KEGGihsa:8641
UCSCiuc003lkc.3 human [Q9UN71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPCDGG_HUMAN
AccessioniPrimary (citable) accession number: Q9UN71
Secondary accession number(s): O15099, Q2M267, Q9UN64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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