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Protein

Protocadherin gamma-B4

Gene

PCDHGB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-B4
Short name:
PCDH-gamma-B4
Alternative name(s):
Cadherin-20
Fibroblast cadherin-2
Gene namesi
Name:PCDHGB4
Synonyms:CDH20, FIB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8711. PCDHGB4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 689659ExtracellularSequence analysisAdd
BLAST
Transmembranei690 – 71021HelicalSequence analysisAdd
BLAST
Topological domaini711 – 923213CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33059.

Polymorphism and mutation databases

BioMutaiPCDHGB4.
DMDMi37999814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 923893Protocadherin gamma-B4PRO_0000003977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis
Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UN71.
PRIDEiQ9UN71.

PTM databases

iPTMnetiQ9UN71.
PhosphoSiteiQ9UN71.

Expressioni

Gene expression databases

BgeeiQ9UN71.
CleanExiHS_CDH20.
GenevisibleiQ9UN71. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi114193. 55 interactions.
STRINGi9606.ENSP00000428288.

Structurei

3D structure databases

ProteinModelPortaliQ9UN71.
SMRiQ9UN71. Positions 32-664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 133103Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 345103Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini346 – 450105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini451 – 560110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 673106Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN71.
KOiK16496.
OMAiGMIAQCT.
OrthoDBiEOG7J70DX.
PhylomeDBiQ9UN71.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UN71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL
60 70 80 90 100
ATDLGFSVQE LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP
110 120 130 140 150
ACALEFEAVA ENPLNFYHVN VEIEDINDHT PKFTQNSFEL QISESAQPGT
160 170 180 190 200
RFILGSAHDA DIGSNTLQNY QLSPSDHFSL INKEKSDGSK YPEMVLKTPL
210 220 230 240 250
DREKQKSYHL TLTALDFGAP PLSSTAQIHV LVTDANDNAP VFSQDVYRVS
260 270 280 290 300
LSENVYPGTT VLQVTATDQD EGVNAEITFS FSEASQITQF DLNSNTGEIT
310 320 330 340 350
VLNTLDFEEV KEYSIVLEAR DGGGMIAQCT VEVEVIDEND NAPEVIFQSL
360 370 380 390 400
PNLIMEDAEL GTHIALLKVR DKDSRHNGEV TCKLEGDVPF KILTSSRNTY
410 420 430 440 450
KLVTDAVLDR EQNPEYNITV TATDRGKPPL SSSSSITLHI GDVNDNAPVF
460 470 480 490 500
SQSSYIVHVA ENNPPGASIS QVRASDPDLG PNGQVSYCIM ASDLEQRELS
510 520 530 540 550
SYVSISAESG VVFAQRAFDH EQLRAFELTL QARDQGSPAL SANVSLRVLV
560 570 580 590 600
DDRNDNAPRV LYPALGPDGS ALFDMVPHAA EPGYLVTKVV AVDADSGHNA
610 620 630 640 650
WLSYHVLQAS EPGLFSLGLR TGEVRTARAL GDRDAVRQRL LVAVRDGGQP
660 670 680 690 700
PLSATATLHL VFADSLQEVL PDITDRPDPS DLQAELQFYL VVALALISVL
710 720 730 740 750
FLVAMILAIA LRLRRSSSPA SWSCFQPGLC VKSESVVPPN YSEGTLPYSY
760 770 780 790 800
NLCVAHTGKT EFNFLKCSEQ LSSGQDILCG DSSGALFPLC NSSELTSHQQ
810 820 830 840 850
APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ AMILASASEA
860 870 880 890 900
ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG
910 920
KRDGKAPAGG NGNKKKSGKK EKK
Length:923
Mass (Da):99,927
Last modified:May 1, 2000 - v1
Checksum:i649A8F509CE1B31A
GO
Isoform 2 (identifier: Q9UN71-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     800-803: QAPP → VSFL
     804-923: Missing.

Show »
Length:803
Mass (Da):87,447
Checksum:i635DD22BAB37A0B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei800 – 8034QAPP → VSFL in isoform 2. 2 PublicationsVSP_008690
Alternative sequencei804 – 923120Missing in isoform 2. 2 PublicationsVSP_008691Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152333 mRNA. Translation: AAD43727.1.
AF152520 mRNA. Translation: AAD43780.1.
CH471062 Genomic DNA. Translation: EAW61927.1.
BC112088 mRNA. Translation: AAI12089.1.
BC113607 mRNA. Translation: AAI13608.1.
AB000896 mRNA. Translation: BAA21134.1.
CCDSiCCDS54928.1. [Q9UN71-1]
CCDS75337.1. [Q9UN71-2]
PIRiPC4298.
RefSeqiNP_003727.1. NM_003736.2. [Q9UN71-1]
NP_115269.1. NM_032098.1. [Q9UN71-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000519479; ENSP00000428288; ENSG00000253953. [Q9UN71-1]
ENST00000615384; ENSP00000484560; ENSG00000253953. [Q9UN71-2]
GeneIDi8641.
KEGGihsa:8641.
UCSCiuc003lkc.3. human. [Q9UN71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152333 mRNA. Translation: AAD43727.1.
AF152520 mRNA. Translation: AAD43780.1.
CH471062 Genomic DNA. Translation: EAW61927.1.
BC112088 mRNA. Translation: AAI12089.1.
BC113607 mRNA. Translation: AAI13608.1.
AB000896 mRNA. Translation: BAA21134.1.
CCDSiCCDS54928.1. [Q9UN71-1]
CCDS75337.1. [Q9UN71-2]
PIRiPC4298.
RefSeqiNP_003727.1. NM_003736.2. [Q9UN71-1]
NP_115269.1. NM_032098.1. [Q9UN71-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9UN71.
SMRiQ9UN71. Positions 32-664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114193. 55 interactions.
STRINGi9606.ENSP00000428288.

PTM databases

iPTMnetiQ9UN71.
PhosphoSiteiQ9UN71.

Polymorphism and mutation databases

BioMutaiPCDHGB4.
DMDMi37999814.

Proteomic databases

PaxDbiQ9UN71.
PRIDEiQ9UN71.

Protocols and materials databases

DNASUi8641.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519479; ENSP00000428288; ENSG00000253953. [Q9UN71-1]
ENST00000615384; ENSP00000484560; ENSG00000253953. [Q9UN71-2]
GeneIDi8641.
KEGGihsa:8641.
UCSCiuc003lkc.3. human. [Q9UN71-1]

Organism-specific databases

CTDi8641.
GeneCardsiPCDHGB4.
HGNCiHGNC:8711. PCDHGB4.
HPAiHPA008755.
MIMi603058. gene.
604968. gene.
neXtProtiNX_Q9UN71.
PharmGKBiPA33059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN71.
KOiK16496.
OMAiGMIAQCT.
OrthoDBiEOG7J70DX.
PhylomeDBiQ9UN71.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii8641.
PROiQ9UN71.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UN71.
CleanExiHS_CDH20.
GenevisibleiQ9UN71. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  4. "Multiple cadherins are expressed in human fibroblasts."
    Matsuyoshi N., Imamura S.
    Biochem. Biophys. Res. Commun. 235:355-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 94-234.

Entry informationi

Entry nameiPCDGG_HUMAN
AccessioniPrimary (citable) accession number: Q9UN71
Secondary accession number(s): O15099, Q2M267, Q9UN64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.