Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UN70 (PCDGK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin gamma-C3

Short name=PCDH-gamma-C3
Alternative name(s):
Protocadherin-2
Protocadherin-43
Short name=PC-43
Gene names
Name:PCDHGC3
Synonyms:PCDH2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Sequence caution

The sequence AAA75391.1 differs from that shown. Reason: Frameshift at position 905.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcalcium-dependent cell-cell adhesion

Non-traceable author statement Ref.1. Source: UniProtKB

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Non-traceable author statement Ref.1. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UN70-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UN70-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     811-863: QAPPNTDWRF...ILASASEAAD → VRFSKSCLTL...ALPRSKLVPL
     864-934: Missing.
Isoform 3 (identifier: Q9UN70-3)

Also known as: PC43-11;

The sequence of this isoform differs from the canonical sequence as follows:
     811-837: QAPPNTDWRFSQAQRPGTSGSQNGDDT → VRFSKSCLTLLVPFYSYIILRRLELFF
     838-934: Missing.
Isoform 4 (identifier: Q9UN70-4)

Also known as: PC43-12;

The sequence of this isoform differs from the canonical sequence as follows:
     683-683: P → S
     684-934: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 934903Protocadherin gamma-C3
PRO_0000003985

Regions

Topological domain32 – 693662Extracellular Potential
Transmembrane694 – 71421Helical; Potential
Topological domain715 – 934220Cytoplasmic Potential
Domain32 – 135104Cadherin 1
Domain136 – 244109Cadherin 2
Domain245 – 352108Cadherin 3
Domain353 – 457105Cadherin 4
Domain458 – 567110Cadherin 5
Domain572 – 685114Cadherin 6

Amino acid modifications

Glycosylation2451N-linked (GlcNAc...) Potential
Glycosylation4241N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation5501N-linked (GlcNAc...) Potential
Glycosylation6151N-linked (GlcNAc...) Potential
Glycosylation6891N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence6831P → S in isoform 4.
VSP_009673
Alternative sequence684 – 934251Missing in isoform 4.
VSP_009674
Alternative sequence811 – 86353QAPPN…SEAAD → VRFSKSCLTLLVLFYSYIIL RKEWSCFFSDEDVFLVMHSH FQLALPRSKLVPL in isoform 2.
VSP_008698
Alternative sequence811 – 83727QAPPN…NGDDT → VRFSKSCLTLLVPFYSYIIL RRLELFF in isoform 3.
VSP_009675
Alternative sequence838 – 93497Missing in isoform 3.
VSP_009676
Alternative sequence864 – 93471Missing in isoform 2.
VSP_008699

Experimental info

Sequence conflict671R → P in AAA75391. Ref.1
Sequence conflict1641V → L in AAA75391. Ref.1
Sequence conflict254 – 2585LEDAP → PGGCT in AAA75391. Ref.1
Sequence conflict366 – 3672PL → S in AAA75391. Ref.1
Sequence conflict6111L → F in AAA75391. Ref.1
Sequence conflict768 – 7692RS → PG in AAC08350. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1C8E1EADD485AB10

FASTA934101,077
        10         20         30         40         50         60 
MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV VANLGLDLGS 

        70         80         90        100        110        120 
LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT LPSCTVTLEL VVENPLELFS 

       130        140        150        160        170        180 
VEVVIQDIND NNPAFPTQEM KLEISEAVAP GTRFPLESAH DPDVGSNSLQ TYELSRNEYF 

       190        200        210        220        230        240 
ALRVQTREDS TKYAELVLER ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN 

       250        260        270        280        290        300 
APVFNQSLYR ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV 

       310        320        330        340        350        360 
TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP EITVTSVYSP 

       370        380        390        400        410        420 
VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT SSLKNYFTLK TSADLDRETV 

       430        440        450        460        470        480 
PEYNLSITAR DAGTPSLSAL TIVRVQVSDI NDNPPQSSQS SYDVYIEENN LPGAPILNLS 

       490        500        510        520        530        540 
VWDPDAPQNA RLSFFLLEQG AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS 

       550        560        570        580        590        600 
DGGTPVLATN ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA 

       610        620        630        640        650        660 
GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD NGEPSLSTTA 

       670        680        690        700        710        720 
TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL VSVGFVVTVF GVIIFKVYKW 

       730        740        750        760        770        780 
KQSRDLYRAP VSSLYRTPGP SLHADAVRGG LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS 

       790        800        810        820        830        840 
PLASRQNTLR SCDPVFYRQV LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW 

       850        860        870        880        890        900 
PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP 

       910        920        930 
GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 884E5FF5A1F227A2
Show »

FASTA86394,458
Isoform 3 (PC43-11) [UniParc].

Checksum: 187309C9134B4BB3
Show »

FASTA83791,458
Isoform 4 (PC43-12) [UniParc].

Checksum: 749733C5F280BE03
Show »

FASTA68373,954

References

« Hide 'large scale' references
[1]"Protocadherins: a large family of cadherin-related molecules in central nervous system."
Sano K., Tanihara H., Heimark R.L., Obata S., Davidson M., St John T., Taketani S., Suzuki S.
EMBO J. 12:2249-2256(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4).
Tissue: Brain.
[2]"Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous."
Lynch E.D., Lee M.K., Morrow J.E., Welcsh P.L., Leon P.E., King M.-C.
Science 278:1315-1318(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11371 mRNA. Translation: AAA36420.1.
L11372 mRNA. Translation: AAA36421.1.
L11373 mRNA. Translation: AAA75391.1. Frameshift.
AF052685, AF052683, AF052684 Genomic DNA. Translation: AAC08350.1.
AF152337 mRNA. Translation: AAD43731.1.
AF152524 mRNA. Translation: AAD43784.1.
BC019299 mRNA. Translation: AAH19299.1.
BC026218 mRNA. Translation: AAH26218.1.
RefSeqNP_002579.2. NM_002588.3.
NP_115778.1. NM_032402.1.
UniGeneHs.368160.

3D structure databases

ProteinModelPortalQ9UN70.
SMRQ9UN70. Positions 33-691.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111131. 4 interactions.
IntActQ9UN70. 3 interactions.

PTM databases

PhosphoSiteQ9UN70.

Polymorphism databases

DMDM37999813.

Proteomic databases

PaxDbQ9UN70.
PeptideAtlasQ9UN70.
PRIDEQ9UN70.

Protocols and materials databases

DNASU5098.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308177; ENSP00000312070; ENSG00000240184. [Q9UN70-1]
GeneID5098.
KEGGhsa:5098.
UCSCuc003lku.1. human. [Q9UN70-2]
uc003lkv.2. human. [Q9UN70-1]

Organism-specific databases

CTD5098.
GeneCardsGC05P141338.
HGNCHGNC:8716. PCDHGC3.
HPAHPA008755.
MIM603627. gene.
604968. gene.
neXtProtNX_Q9UN70.
PharmGKBPA33064.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316473.
HOGENOMHOG000220892.
HOVERGENHBG054878.
KOK16497.
OMAFELTAHV.
OrthoDBEOG7J445X.
PhylomeDBQ9UN70.
TreeFamTF332299.

Gene expression databases

ArrayExpressQ9UN70.
BgeeQ9UN70.
CleanExHS_PCDHGC3.
GenevestigatorQ9UN70.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHGC3.
GenomeRNAi5098.
NextBio19670.
PROQ9UN70.
SOURCESearch...

Entry information

Entry namePCDGK_HUMAN
AccessionPrimary (citable) accession number: Q9UN70
Secondary accession number(s): O60622, Q08192, Q9Y5C4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM