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Protein

Protocadherin gamma-C3

Gene

PCDHGC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-C3
Short name:
PCDH-gamma-C3
Alternative name(s):
Protocadherin-2
Protocadherin-43
Short name:
PC-43
Gene namesi
Name:PCDHGC3
Synonyms:PCDH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8716. PCDHGC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 693662ExtracellularSequence analysisAdd
BLAST
Transmembranei694 – 71421HelicalSequence analysisAdd
BLAST
Topological domaini715 – 934220CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33064.

Polymorphism and mutation databases

BioMutaiPCDHGC3.
DMDMi37999813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 934903Protocadherin gamma-C3PRO_0000003985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence analysis
Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence analysis
Glycosylationi550 – 5501N-linked (GlcNAc...)Sequence analysis
Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence analysis
Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN70.
MaxQBiQ9UN70.
PaxDbiQ9UN70.
PeptideAtlasiQ9UN70.
PRIDEiQ9UN70.

PTM databases

iPTMnetiQ9UN70.
PhosphoSiteiQ9UN70.

Expressioni

Gene expression databases

BgeeiQ9UN70.
CleanExiHS_PCDHGC3.
ExpressionAtlasiQ9UN70. baseline and differential.
GenevisibleiQ9UN70. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi111131. 36 interactions.
IntActiQ9UN70. 3 interactions.
STRINGi9606.ENSP00000312070.

Structurei

3D structure databases

ProteinModelPortaliQ9UN70.
SMRiQ9UN70. Positions 33-691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 135104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 244109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini245 – 352108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini353 – 457105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini458 – 567110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini572 – 685114Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN70.
KOiK16497.
OMAiWRQSKEL.
OrthoDBiEOG7J445X.
PhylomeDBiQ9UN70.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030728. PCDHGC3.
[Graphical view]
PANTHERiPTHR24028:SF70. PTHR24028:SF70. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UN70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV
60 70 80 90 100
VANLGLDLGS LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT
110 120 130 140 150
LPSCTVTLEL VVENPLELFS VEVVIQDIND NNPAFPTQEM KLEISEAVAP
160 170 180 190 200
GTRFPLESAH DPDVGSNSLQ TYELSRNEYF ALRVQTREDS TKYAELVLER
210 220 230 240 250
ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN APVFNQSLYR
260 270 280 290 300
ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV
310 320 330 340 350
TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP
360 370 380 390 400
EITVTSVYSP VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT
410 420 430 440 450
SSLKNYFTLK TSADLDRETV PEYNLSITAR DAGTPSLSAL TIVRVQVSDI
460 470 480 490 500
NDNPPQSSQS SYDVYIEENN LPGAPILNLS VWDPDAPQNA RLSFFLLEQG
510 520 530 540 550
AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS DGGTPVLATN
560 570 580 590 600
ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA
610 620 630 640 650
GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD
660 670 680 690 700
NGEPSLSTTA TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL
710 720 730 740 750
VSVGFVVTVF GVIIFKVYKW KQSRDLYRAP VSSLYRTPGP SLHADAVRGG
760 770 780 790 800
LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS PLASRQNTLR SCDPVFYRQV
810 820 830 840 850
LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML
860 870 880 890 900
QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP
910 920 930
GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK
Length:934
Mass (Da):101,077
Last modified:May 1, 2000 - v1
Checksum:i1C8E1EADD485AB10
GO
Isoform 2 (identifier: Q9UN70-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     811-863: QAPPNTDWRF...ILASASEAAD → VRFSKSCLTL...ALPRSKLVPL
     864-934: Missing.

Show »
Length:863
Mass (Da):94,458
Checksum:i884E5FF5A1F227A2
GO

Sequence cautioni

Isoform 2 : The sequence AAA36420.1 differs from that shown. Reason: Frameshift at position 832. Curated
The sequence AAA36421.1 differs from that shown.Contaminating sequence. The C-terminus matches chromosome 8 region.Curated
The sequence AAA75391.1 differs from that shown. Reason: Frameshift at positions 254, 259, 905, 914, 918 and 930. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671R → P in AAA75391 (PubMed:8508762).Curated
Sequence conflicti164 – 1641V → L in AAA75391 (PubMed:8508762).Curated
Sequence conflicti366 – 3672PL → S in AAA75391 (PubMed:8508762).Curated
Sequence conflicti611 – 6111L → F in AAA75391 (PubMed:8508762).Curated
Sequence conflicti768 – 7692RS → PG in AAC08350 (PubMed:9360932).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei811 – 86353QAPPN…SEAAD → VRFSKSCLTLLVLFYSYIIL RKEWSCFFSDEDVFLVMHSH FQLALPRSKLVPL in isoform 2. 1 PublicationVSP_008698Add
BLAST
Alternative sequencei864 – 93471Missing in isoform 2. 1 PublicationVSP_008699Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11371 mRNA. Translation: AAA36420.1. Frameshift.
L11372 mRNA. Translation: AAA36421.1. Sequence problems.
L11373 mRNA. Translation: AAA75391.1. Frameshift.
AF052685, AF052683, AF052684 Genomic DNA. Translation: AAC08350.1.
AF152337 mRNA. Translation: AAD43731.1.
AF152524 mRNA. Translation: AAD43784.1.
BC019299 mRNA. Translation: AAH19299.1.
BC026218 mRNA. Translation: AAH26218.1.
CCDSiCCDS4261.1. [Q9UN70-1]
CCDS75348.1. [Q9UN70-2]
RefSeqiNP_002579.2. NM_002588.3. [Q9UN70-1]
NP_115778.1. NM_032402.1. [Q9UN70-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000308177; ENSP00000312070; ENSG00000240184. [Q9UN70-1]
ENST00000611950; ENSP00000481219; ENSG00000240184. [Q9UN70-2]
GeneIDi5098.
KEGGihsa:5098.
UCSCiuc003lku.2. human. [Q9UN70-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11371 mRNA. Translation: AAA36420.1. Frameshift.
L11372 mRNA. Translation: AAA36421.1. Sequence problems.
L11373 mRNA. Translation: AAA75391.1. Frameshift.
AF052685, AF052683, AF052684 Genomic DNA. Translation: AAC08350.1.
AF152337 mRNA. Translation: AAD43731.1.
AF152524 mRNA. Translation: AAD43784.1.
BC019299 mRNA. Translation: AAH19299.1.
BC026218 mRNA. Translation: AAH26218.1.
CCDSiCCDS4261.1. [Q9UN70-1]
CCDS75348.1. [Q9UN70-2]
RefSeqiNP_002579.2. NM_002588.3. [Q9UN70-1]
NP_115778.1. NM_032402.1. [Q9UN70-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9UN70.
SMRiQ9UN70. Positions 33-691.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111131. 36 interactions.
IntActiQ9UN70. 3 interactions.
STRINGi9606.ENSP00000312070.

PTM databases

iPTMnetiQ9UN70.
PhosphoSiteiQ9UN70.

Polymorphism and mutation databases

BioMutaiPCDHGC3.
DMDMi37999813.

Proteomic databases

EPDiQ9UN70.
MaxQBiQ9UN70.
PaxDbiQ9UN70.
PeptideAtlasiQ9UN70.
PRIDEiQ9UN70.

Protocols and materials databases

DNASUi5098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308177; ENSP00000312070; ENSG00000240184. [Q9UN70-1]
ENST00000611950; ENSP00000481219; ENSG00000240184. [Q9UN70-2]
GeneIDi5098.
KEGGihsa:5098.
UCSCiuc003lku.2. human. [Q9UN70-1]

Organism-specific databases

CTDi5098.
GeneCardsiPCDHGC3.
HGNCiHGNC:8716. PCDHGC3.
HPAiHPA008755.
MIMi603627. gene.
604968. gene.
neXtProtiNX_Q9UN70.
PharmGKBiPA33064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN70.
KOiK16497.
OMAiWRQSKEL.
OrthoDBiEOG7J445X.
PhylomeDBiQ9UN70.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHGC3.
GenomeRNAii5098.
NextBioi19670.
PROiQ9UN70.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UN70.
CleanExiHS_PCDHGC3.
ExpressionAtlasiQ9UN70. baseline and differential.
GenevisibleiQ9UN70. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030728. PCDHGC3.
[Graphical view]
PANTHERiPTHR24028:SF70. PTHR24028:SF70. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Protocadherins: a large family of cadherin-related molecules in central nervous system."
    Sano K., Tanihara H., Heimark R.L., Obata S., Davidson M., St John T., Taketani S., Suzuki S.
    EMBO J. 12:2249-2256(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous."
    Lynch E.D., Lee M.K., Morrow J.E., Welcsh P.L., Leon P.E., King M.-C.
    Science 278:1315-1318(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Skin.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPCDGK_HUMAN
AccessioniPrimary (citable) accession number: Q9UN70
Secondary accession number(s): O60622, Q08192, Q9Y5C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.