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Protein

Protocadherin beta-10

Gene

PCDHB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-10
Short name:
PCDH-beta-10
Gene namesi
Name:PCDHB10
ORF Names:UNQ1906/PRO4352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120324.7
HGNCiHGNC:8681 PCDHB10
MIMi604967 gene
606336 gene
neXtProtiNX_Q9UN67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 692ExtracellularSequence analysisAdd BLAST666
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 800CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120324
PharmGKBiPA33026

Polymorphism and mutation databases

BioMutaiPCDHB10
DMDMi13431371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000393227 – 800Protocadherin beta-10Add BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN67
PaxDbiQ9UN67
PeptideAtlasiQ9UN67
PRIDEiQ9UN67

PTM databases

iPTMnetiQ9UN67
PhosphoSitePlusiQ9UN67

Expressioni

Gene expression databases

BgeeiENSG00000120324
CleanExiHS_PCDHB10
GenevisibleiQ9UN67 HS

Organism-specific databases

HPAiHPA013445
HPA029441

Interactioni

Protein-protein interaction databases

BioGridi121066, 5 interactors
IntActiQ9UN67, 3 interactors
STRINGi9606.ENSP00000239446

Structurei

3D structure databases

ProteinModelPortaliQ9UN67
SMRiQ9UN67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000143986
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9UN67
KOiK16494
OMAiQILMDNP
PhylomeDBiQ9UN67
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK
60 70 80 90 100
DLGLAEGELA ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE
110 120 130 140 150
PCMLYFQILM DDPFQIYRAE LRVRDINDHA PVFQDKETVL KISENTAEGT
160 170 180 190 200
AFRLERAQDP DGGLNGIQNY TISPNSFFHI NISGGDEGMI YPELVLDKAL
210 220 230 240 250
DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP QFAQALYETQ
260 270 280 290 300
APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE
310 320 330 340 350
IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS
360 370 380 390 400
SFSNSVAENS PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF
410 420 430 440 450
YILITEGALD REIRAEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSREALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHL LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS
710 720 730 740 750
SLFLLSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGHLVD VRGAETLSQS
760 770 780 790 800
YQYEVCLTGG PGTSEFKFLK PVISDIQAQG PGRKGEENST FRNSFGFNIQ
Length:800
Mass (Da):87,621
Last modified:May 1, 2000 - v1
Checksum:i7DF4CE8467502B91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti543R → S in AAK51616 (PubMed:11322959).Curated1
Sequence conflicti660L → V in AAK51616 (PubMed:11322959).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152489 mRNA Translation: AAD43750.1
AF217748 mRNA Translation: AAK51616.1
AY358720 mRNA Translation: AAQ89082.1
BC031837 mRNA Translation: AAH31837.1
CCDSiCCDS4252.1
RefSeqiNP_061753.1, NM_018930.3
UniGeneiHs.657953

Genome annotation databases

EnsembliENST00000239446; ENSP00000239446; ENSG00000120324
GeneIDi56126
KEGGihsa:56126
UCSCiuc003lix.4 human

Similar proteinsi

Entry informationi

Entry nameiPCDBA_HUMAN
AccessioniPrimary (citable) accession number: Q9UN67
Secondary accession number(s): Q96T99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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