Reviewed, UniProtKB/Swiss-Prot Q9UN67 (PCDBA_HUMAN)

Names and origin

Protein names

Recommended name:
    Protocadherin beta-10
      Short name=PCDH-beta-10

Gene names

Name:	PCDHB10
ORF Names:	UNQ1906/PRO4352

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	800 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	calcium-dependent cell-cell adhesion Ref.2 Non-traceable author statement. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro synapse assembly Traceable author statement. Source: UniProtKB synaptic transmission Traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.2 Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Ref.5
	Chain	27 – 800	774	Protocadherin beta-10		PRO_0000003932
Regions
	Topological domain	27 – 692	666	Extracellular Potential
	Transmembrane	693 – 713	21	Potential
	Topological domain	714 – 800	87	Cytoplasmic Potential
	Domain	35 – 133	99	Cadherin 1
	Domain	138 – 242	105	Cadherin 2
	Domain	247 – 347	101	Cadherin 3
	Domain	352 – 451	100	Cadherin 4
	Domain	456 – 561	106	Cadherin 5
	Domain	568 – 671	104	Cadherin 6
Amino acid modifications
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	418	1	N-linked (GlcNAc...) Potential
	Glycosylation	436	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	543	1	R → S in AAK51616. Ref.2
	Sequence conflict	660	1	L → V in AAK51616. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UN67-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7DF4CE8467502B91	FASTA	800	87,621
	10 20 30 40 50 60 MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK DLGLAEGELA 70 80 90 100 110 120 ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE PCMLYFQILM DDPFQIYRAE 130 140 150 160 170 180 LRVRDINDHA PVFQDKETVL KISENTAEGT AFRLERAQDP DGGLNGIQNY TISPNSFFHI 190 200 210 220 230 240 NISGGDEGMI YPELVLDKAL DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP 250 260 270 280 290 300 QFAQALYETQ APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE 310 320 330 340 350 360 IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS SFSNSVAENS 370 380 390 400 410 420 PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF YILITEGALD REIRAEYNIT 430 440 450 460 470 480 ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS 490 500 510 520 530 540 GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA 550 560 570 580 590 600 LSREALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 610 620 630 640 650 660 WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHL 670 680 690 700 710 720 LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS SLFLLSVLLF VAVRLCRRSR 730 740 750 760 770 780 AASVGRCSVP EGPFPGHLVD VRGAETLSQS YQYEVCLTGG PGTSEFKFLK PVISDIQAQG 790 800 PGRKGEENST FRNSFGFNIQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed: 10380929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed: 11322959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 27-41.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152489 mRNA. Translation: AAD43750.1. AF217748 mRNA. Translation: AAK51616.1. AY358720 mRNA. Translation: AAQ89082.1. BC031837 mRNA. Translation: AAH31837.1.
IPI	IPI00009034.
RefSeq	NP_061753.1.
UniGene	Hs.657953
3D structure databases
SMR	Q9UN67. Positions 22-138, 140-339, 355-553.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UN67.
Proteomic databases
PRIDE	Q9UN67.
Genome annotation databases
Ensembl	ENST00000239446; ENSP00000239446; ENSG00000120324; Homo sapiens. [Genome view]
GeneID	56126.
KEGG	hsa:56126.
UCSC	uc003lix.1. human.
Organism-specific databases
CTD	56126.
GeneCards	GC05P140552.
H-InvDB	HIX0005249. HIX0005250. HIX0031985.
HGNC	HGNC:8681. PCDHB10.
HPA	HPA013445.
MIM	604967. gene. 606336. gene.
PharmGKB	PA33026.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG447181.
HOVERGEN	Q9UN67.
InParanoid	Q9UN67.
OMA	MLYFQIL.
OrthoDB	EOG9KPWZ0.
PhylomeDB	Q9UN67.
Gene expression databases
ArrayExpress	Q9UN67.
Bgee	Q9UN67.
CleanEx	HS_PCDHB10.
Genevestigator	Q9UN67.
GermOnline	ENSG00000120324. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. IPR015493. Protocad_beta. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
PANTHER	PTHR10596:SF94. Protocad_beta. 1 hit.
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	61636.
SOURCE	Search...

Entry information

Entry name

PCDBA_HUMAN

Accession

Primary (citable) accession number: Q9UN67
Secondary accession number(s): Q96T99

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.