Protocadherin beta-10 precursor - Homo sapiens (Human)

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Q9UN67 (PCDBA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

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Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protocadherin beta-10
Short name=PCDH-beta-10

Gene names

Name:	PCDHB10
ORF Names:	UNQ1906/PRO4352

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	800 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Non-traceable author statement Ref.2. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro synapse assembly Traceable author statement PubMed 12231349. Source: UniProtKB synaptic transmission Traceable author statement PubMed 12231349. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement Ref.2. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

26

Chain

774

Protocadherin beta-10

PRO_0000003932

Regions

Topological domain

666

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

87

Cytoplasmic Potential

Domain

99

Cadherin 1

Domain

105

Cadherin 2

Domain

101

Cadherin 3

Domain

100

Cadherin 4

Domain

106

Cadherin 5

Domain

104

Cadherin 6

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

1

R → S in AAK51616. Ref.2

Sequence conflict

1

L → V in AAK51616. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UN67 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7DF4CE8467502B91
Show »

800

87,621

        10         20         30         40         50         60 
MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK DLGLAEGELA 

        70         80         90        100        110        120 
ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE PCMLYFQILM DDPFQIYRAE 

       130        140        150        160        170        180 
LRVRDINDHA PVFQDKETVL KISENTAEGT AFRLERAQDP DGGLNGIQNY TISPNSFFHI 

       190        200        210        220        230        240 
NISGGDEGMI YPELVLDKAL DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP 

       250        260        270        280        290        300 
QFAQALYETQ APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE 

       310        320        330        340        350        360 
IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS SFSNSVAENS 

       370        380        390        400        410        420 
PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF YILITEGALD REIRAEYNIT 

       430        440        450        460        470        480 
ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS 

       490        500        510        520        530        540 
GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA 

       550        560        570        580        590        600 
LSREALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 

       610        620        630        640        650        660 
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHL 

       670        680        690        700        710        720 
LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS SLFLLSVLLF VAVRLCRRSR 

       730        740        750        760        770        780 
AASVGRCSVP EGPFPGHLVD VRGAETLSQS YQYEVCLTGG PGTSEFKFLK PVISDIQAQG 

       790        800 
PGRKGEENST FRNSFGFNIQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 27-41.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152489 mRNA. Translation: AAD43750.1. AF217748 mRNA. Translation: AAK51616.1. AY358720 mRNA. Translation: AAQ89082.1. BC031837 mRNA. Translation: AAH31837.1.
IPI	IPI00009034.
RefSeq	NP_061753.1. NM_018930.3.
UniGene	Hs.657953.
3D structure databases
ProteinModelPortal	Q9UN67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UN67. 1 interaction.
STRING	9606.ENSP00000239446.
Polymorphism databases
DMDM	13431371.
Proteomic databases
PRIDE	Q9UN67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000239446; ENSP00000239446; ENSG00000120324.
GeneID	56126.
KEGG	hsa:56126.
UCSC	uc003lix.3. human.
Organism-specific databases
CTD	56126.
GeneCards	GC05P140577.
HGNC	HGNC:8681. PCDHB10.
HPA	HPA013445. HPA029441.
MIM	604967. gene. 606336. gene.
neXtProt	NX_Q9UN67.
PharmGKB	PA33026.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000220892.
HOVERGEN	HBG054878.
InParanoid	Q9UN67.
KO	K16494.
OMA	ENFYILM.
PhylomeDB	Q9UN67.
Gene expression databases
ArrayExpress	Q9UN67.
Bgee	Q9UN67.
CleanEx	HS_PCDHB10.
Genevestigator	Q9UN67.
GermOnline	ENSG00000120324. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56126.
NextBio	61636.
SOURCE	Search...

Entry information

Entry name

PCDBA_HUMAN

Accession

Primary (citable) accession number: Q9UN67
Secondary accession number(s): Q96T99

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents