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Q9UN67 (PCDBA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin beta-10

Short name=PCDH-beta-10
Gene names
Name:PCDHB10
ORF Names:UNQ1906/PRO4352
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length800 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.5
Chain27 – 800774Protocadherin beta-10
PRO_0000003932

Regions

Topological domain27 – 692666Extracellular Potential
Transmembrane693 – 71321Helical; Potential
Topological domain714 – 80087Cytoplasmic Potential
Domain35 – 13399Cadherin 1
Domain138 – 242105Cadherin 2
Domain247 – 347101Cadherin 3
Domain352 – 451100Cadherin 4
Domain456 – 561106Cadherin 5
Domain568 – 671104Cadherin 6

Amino acid modifications

Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5431R → S in AAK51616. Ref.2
Sequence conflict6601L → V in AAK51616. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9UN67 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7DF4CE8467502B91

FASTA80087,621
        10         20         30         40         50         60 
MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK DLGLAEGELA 

        70         80         90        100        110        120 
ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE PCMLYFQILM DDPFQIYRAE 

       130        140        150        160        170        180 
LRVRDINDHA PVFQDKETVL KISENTAEGT AFRLERAQDP DGGLNGIQNY TISPNSFFHI 

       190        200        210        220        230        240 
NISGGDEGMI YPELVLDKAL DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP 

       250        260        270        280        290        300 
QFAQALYETQ APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE 

       310        320        330        340        350        360 
IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS SFSNSVAENS 

       370        380        390        400        410        420 
PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF YILITEGALD REIRAEYNIT 

       430        440        450        460        470        480 
ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS 

       490        500        510        520        530        540 
GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA 

       550        560        570        580        590        600 
LSREALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 

       610        620        630        640        650        660 
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHL 

       670        680        690        700        710        720 
LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS SLFLLSVLLF VAVRLCRRSR 

       730        740        750        760        770        780 
AASVGRCSVP EGPFPGHLVD VRGAETLSQS YQYEVCLTGG PGTSEFKFLK PVISDIQAQG 

       790        800 
PGRKGEENST FRNSFGFNIQ 

« Hide

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-41.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152489 mRNA. Translation: AAD43750.1.
AF217748 mRNA. Translation: AAK51616.1.
AY358720 mRNA. Translation: AAQ89082.1.
BC031837 mRNA. Translation: AAH31837.1.
CCDSCCDS4252.1.
RefSeqNP_061753.1. NM_018930.3.
UniGeneHs.657953.

3D structure databases

ProteinModelPortalQ9UN67.
SMRQ9UN67. Positions 33-690.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121066. 2 interactions.
IntActQ9UN67. 1 interaction.
STRING9606.ENSP00000239446.

Polymorphism databases

DMDM13431371.

Proteomic databases

PRIDEQ9UN67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000239446; ENSP00000239446; ENSG00000120324.
ENST00000599465; ENSP00000476802; ENSG00000268060.
GeneID56126.
KEGGhsa:56126.
UCSCuc003lix.3. human.

Organism-specific databases

CTD56126.
GeneCardsGC05P141281.
HGNCHGNC:8681. PCDHB10.
HPAHPA013445.
HPA029441.
MIM604967. gene.
606336. gene.
neXtProtNX_Q9UN67.
PharmGKBPA33026.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000220892.
HOVERGENHBG054878.
InParanoidQ9UN67.
KOK16494.
OMAFQILMDN.
OrthoDBEOG7KSX80.
PhylomeDBQ9UN67.
TreeFamTF332299.

Gene expression databases

ArrayExpressQ9UN67.
BgeeQ9UN67.
CleanExHS_PCDHB10.
GenevestigatorQ9UN67.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHB10.
GenomeRNAi56126.
NextBio61636.
PROQ9UN67.
SOURCESearch...

Entry information

Entry namePCDBA_HUMAN
AccessionPrimary (citable) accession number: Q9UN67
Secondary accession number(s): Q96T99
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM