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Q9UN67

- PCDBA_HUMAN

UniProt

Q9UN67 - PCDBA_HUMAN

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Protein

Protocadherin beta-10

Gene

PCDHB10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: UniProtKB
  2. homophilic cell adhesion Source: InterPro
  3. synapse assembly Source: UniProtKB
  4. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-10
Short name:
PCDH-beta-10
Gene namesi
Name:PCDHB10
ORF Names:UNQ1906/PRO4352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8681. PCDHB10.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 800774Protocadherin beta-10PRO_0000003932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9UN67.

Expressioni

Gene expression databases

BgeeiQ9UN67.
CleanExiHS_PCDHB10.
ExpressionAtlasiQ9UN67. baseline and differential.
GenevestigatoriQ9UN67.

Organism-specific databases

HPAiHPA013445.
HPA029441.

Interactioni

Protein-protein interaction databases

BioGridi121066. 2 interactions.
IntActiQ9UN67. 1 interaction.
STRINGi9606.ENSP00000239446.

Structurei

3D structure databases

ProteinModelPortaliQ9UN67.
SMRiQ9UN67. Positions 33-690.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 692666ExtracellularSequence AnalysisAdd
BLAST
Topological domaini714 – 80087CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei693 – 71321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN67.
KOiK16494.
OMAiFQILMDN.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN67.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK
60 70 80 90 100
DLGLAEGELA ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE
110 120 130 140 150
PCMLYFQILM DDPFQIYRAE LRVRDINDHA PVFQDKETVL KISENTAEGT
160 170 180 190 200
AFRLERAQDP DGGLNGIQNY TISPNSFFHI NISGGDEGMI YPELVLDKAL
210 220 230 240 250
DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP QFAQALYETQ
260 270 280 290 300
APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE
310 320 330 340 350
IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS
360 370 380 390 400
SFSNSVAENS PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF
410 420 430 440 450
YILITEGALD REIRAEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSREALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHL LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS
710 720 730 740 750
SLFLLSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGHLVD VRGAETLSQS
760 770 780 790 800
YQYEVCLTGG PGTSEFKFLK PVISDIQAQG PGRKGEENST FRNSFGFNIQ
Length:800
Mass (Da):87,621
Last modified:May 1, 2000 - v1
Checksum:i7DF4CE8467502B91
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti543 – 5431R → S in AAK51616. (PubMed:11322959)Curated
Sequence conflicti660 – 6601L → V in AAK51616. (PubMed:11322959)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152489 mRNA. Translation: AAD43750.1.
AF217748 mRNA. Translation: AAK51616.1.
AY358720 mRNA. Translation: AAQ89082.1.
BC031837 mRNA. Translation: AAH31837.1.
CCDSiCCDS4252.1.
RefSeqiNP_061753.1. NM_018930.3.
UniGeneiHs.657953.

Genome annotation databases

EnsembliENST00000239446; ENSP00000239446; ENSG00000120324.
GeneIDi56126.
KEGGihsa:56126.
UCSCiuc003lix.3. human.

Polymorphism databases

DMDMi13431371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152489 mRNA. Translation: AAD43750.1 .
AF217748 mRNA. Translation: AAK51616.1 .
AY358720 mRNA. Translation: AAQ89082.1 .
BC031837 mRNA. Translation: AAH31837.1 .
CCDSi CCDS4252.1.
RefSeqi NP_061753.1. NM_018930.3.
UniGenei Hs.657953.

3D structure databases

ProteinModelPortali Q9UN67.
SMRi Q9UN67. Positions 33-690.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121066. 2 interactions.
IntActi Q9UN67. 1 interaction.
STRINGi 9606.ENSP00000239446.

Polymorphism databases

DMDMi 13431371.

Proteomic databases

PRIDEi Q9UN67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239446 ; ENSP00000239446 ; ENSG00000120324 .
GeneIDi 56126.
KEGGi hsa:56126.
UCSCi uc003lix.3. human.

Organism-specific databases

CTDi 56126.
GeneCardsi GC05P141363.
HGNCi HGNC:8681. PCDHB10.
HPAi HPA013445.
HPA029441.
MIMi 604967. gene.
606336. gene.
neXtProti NX_Q9UN67.
PharmGKBi PA33026.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118847.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
InParanoidi Q9UN67.
KOi K16494.
OMAi FQILMDN.
OrthoDBi EOG7KSX80.
PhylomeDBi Q9UN67.
TreeFami TF332299.

Miscellaneous databases

GeneWikii PCDHB10.
GenomeRNAii 56126.
NextBioi 61636.
PROi Q9UN67.
SOURCEi Search...

Gene expression databases

Bgeei Q9UN67.
CleanExi HS_PCDHB10.
ExpressionAtlasi Q9UN67. baseline and differential.
Genevestigatori Q9UN67.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41.

Entry informationi

Entry nameiPCDBA_HUMAN
AccessioniPrimary (citable) accession number: Q9UN67
Secondary accession number(s): Q96T99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3