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Q9UN67

- PCDBA_HUMAN

UniProt

Q9UN67 - PCDBA_HUMAN

Protein

Protocadherin beta-10

Gene

PCDHB10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. calcium-dependent cell-cell adhesion Source: UniProtKB
    2. homophilic cell adhesion Source: InterPro
    3. synapse assembly Source: UniProtKB
    4. synaptic transmission Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin beta-10
    Short name:
    PCDH-beta-10
    Gene namesi
    Name:PCDHB10
    ORF Names:UNQ1906/PRO4352
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8681. PCDHB10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 800774Protocadherin beta-10PRO_0000003932Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9UN67.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UN67.
    BgeeiQ9UN67.
    CleanExiHS_PCDHB10.
    GenevestigatoriQ9UN67.

    Organism-specific databases

    HPAiHPA013445.
    HPA029441.

    Interactioni

    Protein-protein interaction databases

    BioGridi121066. 2 interactions.
    IntActiQ9UN67. 1 interaction.
    STRINGi9606.ENSP00000239446.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UN67.
    SMRiQ9UN67. Positions 33-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 692666ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini714 – 80087CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei693 – 71321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000220892.
    HOVERGENiHBG054878.
    InParanoidiQ9UN67.
    KOiK16494.
    OMAiFQILMDN.
    OrthoDBiEOG7KSX80.
    PhylomeDBiQ9UN67.
    TreeFamiTF332299.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UN67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK    50
    DLGLAEGELA ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE 100
    PCMLYFQILM DDPFQIYRAE LRVRDINDHA PVFQDKETVL KISENTAEGT 150
    AFRLERAQDP DGGLNGIQNY TISPNSFFHI NISGGDEGMI YPELVLDKAL 200
    DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP QFAQALYETQ 250
    APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE 300
    IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS 350
    SFSNSVAENS PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF 400
    YILITEGALD REIRAEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA 450
    FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL 500
    ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSREALVRVL 550
    VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 600
    WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP 650
    PRSATATLHL LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS 700
    SLFLLSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGHLVD VRGAETLSQS 750
    YQYEVCLTGG PGTSEFKFLK PVISDIQAQG PGRKGEENST FRNSFGFNIQ 800
    Length:800
    Mass (Da):87,621
    Last modified:May 1, 2000 - v1
    Checksum:i7DF4CE8467502B91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti543 – 5431R → S in AAK51616. (PubMed:11322959)Curated
    Sequence conflicti660 – 6601L → V in AAK51616. (PubMed:11322959)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152489 mRNA. Translation: AAD43750.1.
    AF217748 mRNA. Translation: AAK51616.1.
    AY358720 mRNA. Translation: AAQ89082.1.
    BC031837 mRNA. Translation: AAH31837.1.
    CCDSiCCDS4252.1.
    RefSeqiNP_061753.1. NM_018930.3.
    UniGeneiHs.657953.

    Genome annotation databases

    EnsembliENST00000239446; ENSP00000239446; ENSG00000120324.
    GeneIDi56126.
    KEGGihsa:56126.
    UCSCiuc003lix.3. human.

    Polymorphism databases

    DMDMi13431371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152489 mRNA. Translation: AAD43750.1 .
    AF217748 mRNA. Translation: AAK51616.1 .
    AY358720 mRNA. Translation: AAQ89082.1 .
    BC031837 mRNA. Translation: AAH31837.1 .
    CCDSi CCDS4252.1.
    RefSeqi NP_061753.1. NM_018930.3.
    UniGenei Hs.657953.

    3D structure databases

    ProteinModelPortali Q9UN67.
    SMRi Q9UN67. Positions 33-690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121066. 2 interactions.
    IntActi Q9UN67. 1 interaction.
    STRINGi 9606.ENSP00000239446.

    Polymorphism databases

    DMDMi 13431371.

    Proteomic databases

    PRIDEi Q9UN67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239446 ; ENSP00000239446 ; ENSG00000120324 .
    GeneIDi 56126.
    KEGGi hsa:56126.
    UCSCi uc003lix.3. human.

    Organism-specific databases

    CTDi 56126.
    GeneCardsi GC05P141281.
    HGNCi HGNC:8681. PCDHB10.
    HPAi HPA013445.
    HPA029441.
    MIMi 604967. gene.
    606336. gene.
    neXtProti NX_Q9UN67.
    PharmGKBi PA33026.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000220892.
    HOVERGENi HBG054878.
    InParanoidi Q9UN67.
    KOi K16494.
    OMAi FQILMDN.
    OrthoDBi EOG7KSX80.
    PhylomeDBi Q9UN67.
    TreeFami TF332299.

    Miscellaneous databases

    GeneWikii PCDHB10.
    GenomeRNAii 56126.
    NextBioi 61636.
    PROi Q9UN67.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UN67.
    Bgeei Q9UN67.
    CleanExi HS_PCDHB10.
    Genevestigatori Q9UN67.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
      Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
      FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-41.

    Entry informationi

    Entry nameiPCDBA_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN67
    Secondary accession number(s): Q96T99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3