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Protein

Protocadherin beta-10

Gene

PCDHB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120324-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-10
Short name:
PCDH-beta-10
Gene namesi
Name:PCDHB10
ORF Names:UNQ1906/PRO4352
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8681. PCDHB10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 692ExtracellularSequence analysisAdd BLAST666
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 800CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120324.
PharmGKBiPA33026.

Polymorphism and mutation databases

BioMutaiPCDHB10.
DMDMi13431371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000393227 – 800Protocadherin beta-10Add BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN67.
PaxDbiQ9UN67.
PeptideAtlasiQ9UN67.
PRIDEiQ9UN67.

PTM databases

iPTMnetiQ9UN67.
PhosphoSitePlusiQ9UN67.

Expressioni

Gene expression databases

BgeeiENSG00000120324.
CleanExiHS_PCDHB10.
GenevisibleiQ9UN67. HS.

Organism-specific databases

HPAiHPA013445.
HPA029441.

Interactioni

Protein-protein interaction databases

BioGridi121066. 2 interactors.
IntActiQ9UN67. 3 interactors.
STRINGi9606.ENSP00000239446.

Structurei

3D structure databases

ProteinModelPortaliQ9UN67.
SMRiQ9UN67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN67.
KOiK16494.
PhylomeDBiQ9UN67.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK
60 70 80 90 100
DLGLAEGELA ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE
110 120 130 140 150
PCMLYFQILM DDPFQIYRAE LRVRDINDHA PVFQDKETVL KISENTAEGT
160 170 180 190 200
AFRLERAQDP DGGLNGIQNY TISPNSFFHI NISGGDEGMI YPELVLDKAL
210 220 230 240 250
DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP QFAQALYETQ
260 270 280 290 300
APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE
310 320 330 340 350
IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS
360 370 380 390 400
SFSNSVAENS PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF
410 420 430 440 450
YILITEGALD REIRAEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSREALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHL LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS
710 720 730 740 750
SLFLLSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGHLVD VRGAETLSQS
760 770 780 790 800
YQYEVCLTGG PGTSEFKFLK PVISDIQAQG PGRKGEENST FRNSFGFNIQ
Length:800
Mass (Da):87,621
Last modified:May 1, 2000 - v1
Checksum:i7DF4CE8467502B91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti543R → S in AAK51616 (PubMed:11322959).Curated1
Sequence conflicti660L → V in AAK51616 (PubMed:11322959).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152489 mRNA. Translation: AAD43750.1.
AF217748 mRNA. Translation: AAK51616.1.
AY358720 mRNA. Translation: AAQ89082.1.
BC031837 mRNA. Translation: AAH31837.1.
CCDSiCCDS4252.1.
RefSeqiNP_061753.1. NM_018930.3.
UniGeneiHs.657953.

Genome annotation databases

EnsembliENST00000239446; ENSP00000239446; ENSG00000120324.
GeneIDi56126.
KEGGihsa:56126.
UCSCiuc003lix.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152489 mRNA. Translation: AAD43750.1.
AF217748 mRNA. Translation: AAK51616.1.
AY358720 mRNA. Translation: AAQ89082.1.
BC031837 mRNA. Translation: AAH31837.1.
CCDSiCCDS4252.1.
RefSeqiNP_061753.1. NM_018930.3.
UniGeneiHs.657953.

3D structure databases

ProteinModelPortaliQ9UN67.
SMRiQ9UN67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121066. 2 interactors.
IntActiQ9UN67. 3 interactors.
STRINGi9606.ENSP00000239446.

PTM databases

iPTMnetiQ9UN67.
PhosphoSitePlusiQ9UN67.

Polymorphism and mutation databases

BioMutaiPCDHB10.
DMDMi13431371.

Proteomic databases

EPDiQ9UN67.
PaxDbiQ9UN67.
PeptideAtlasiQ9UN67.
PRIDEiQ9UN67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239446; ENSP00000239446; ENSG00000120324.
GeneIDi56126.
KEGGihsa:56126.
UCSCiuc003lix.4. human.

Organism-specific databases

CTDi56126.
GeneCardsiPCDHB10.
HGNCiHGNC:8681. PCDHB10.
HPAiHPA013445.
HPA029441.
MIMi604967. gene.
606336. gene.
neXtProtiNX_Q9UN67.
OpenTargetsiENSG00000120324.
PharmGKBiPA33026.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN67.
KOiK16494.
PhylomeDBiQ9UN67.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120324-MONOMER.

Miscellaneous databases

GeneWikiiPCDHB10.
GenomeRNAii56126.
PROiQ9UN67.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120324.
CleanExiHS_PCDHB10.
GenevisibleiQ9UN67. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBA_HUMAN
AccessioniPrimary (citable) accession number: Q9UN67
Secondary accession number(s): Q96T99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.