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Protein

Protocadherin beta-8

Gene

PCDHB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-8Curated
Short name:
PCDH-beta-8Curated
Alternative name(s):
Protocadherin-3I
Gene namesi
Name:PCDHB8Imported
Synonyms:PCDH3I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8693. PCDHB8.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 691ExtracellularBy similarityAdd BLAST662
Transmembranei692 – 710HelicalSequence analysisAdd BLAST19
Topological domaini711 – 801CytoplasmicBy similarityAdd BLAST91

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56128.
PharmGKBiPA33042.

Polymorphism and mutation databases

BioMutaiPCDHB8.
DMDMi145559514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000000392830 – 801Protocadherin beta-8Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 103By similarity
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UN66.
MaxQBiQ9UN66.
PaxDbiQ9UN66.
PeptideAtlasiQ9UN66.
PRIDEiQ9UN66.

PTM databases

iPTMnetiQ9UN66.
PhosphoSitePlusiQ9UN66.

Expressioni

Gene expression databases

BgeeiENSG00000273227.
CleanExiHS_PCDHB8.
GenevisibleiQ9UN66. HS.

Organism-specific databases

HPAiHPA057773.

Interactioni

Subunit structurei

Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins.By similarity

Protein-protein interaction databases

BioGridi121068. 1 interactor.
STRINGi9606.ENSP00000239444.

Structurei

3D structure databases

ProteinModelPortaliQ9UN66.
SMRiQ9UN66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 134Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini139 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini248 – 348Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini353 – 452Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini457 – 562Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini569 – 672Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Domaini

Cadherin 1 to cadherin 4 domains mediate homophilic trans-interaction, the interaction with an identical protocadherin expressed by a neighboring cell. This is a head-to-tail interaction, the cadherin 1 domain interacting with the cadherin 4 domain and the cadherin 2 domain interacting the cadherin 3 domain of the other protocadherin. The cadherin 6 domain mediates promiscuous interactions with protocadherins on the same cell membrane. Each cadherin domain binds three calcium ions.By similarity

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN66.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9UN66.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASGKLICR QRQVLFSFLL LGLSLAGAAE PRSYSVVEET EGSSFVTNLA
60 70 80 90 100
KDLGLEQREF SRRGVRVVSR GNKLHLQLNQ ETADLLLNEK LDREDLCGHT
110 120 130 140 150
EPCVLRFQVL LESPFEFFQA ELQVIDINDH SPVFLDKQML VKVSESSPPG
160 170 180 190 200
TAFPLKNAED LDIGQNNIEN YIISPNSYFR VLTRKRSDGR KYPELVLDKA
210 220 230 240 250
LDREEEAELR LTLTALDGGS PPRSGTAQVY IEVVDVNDNA PEFEQPFYRV
260 270 280 290 300
QISEDSPISF LVVKVSATDV DTGVNGEISY SLFQASDEIS KTFKVDFLTG
310 320 330 340 350
EIRLKKQLDF EKFQSYEVNI EARDAGGFSG KCTVLIQVID VNDHAPEVTM
360 370 380 390 400
SAFTSPIPEN APETVVALFS VSDLDSGENG KISCSIQEDL PFLLKSSVGN
410 420 430 440 450
FYTLLTETPL DRESRAEYNV TITVTDLGTP RLTTHLNMTV LVSDVNDNAP
460 470 480 490 500
AFTQTSYTLF VRENNSPALH IGSVSATDRD SGTNAQVTYS LLPPQDPHLP
510 520 530 540 550
LASLVSINTD NGHLFALRSL DYEALQAFEF RVGASDRGSP ALSSEALVRV
560 570 580 590 600
LVLDANDNSP FVLYPLQNGS APCTELVPRA AEPGYLVTKV VAVDGDSGQN
610 620 630 640 650
AWLSYQLLKA TEPGLFGVWA HNGEVRTARL LSERDAAKQR LVVLVKDNGE
660 670 680 690 700
PPCSATATLH LLLVDGFSQP YLPLPEAAPA QGQADSLTVY LVVALASVSS
710 720 730 740 750
LFLFSVLLFV AVLLCRRSRA ASVGRCSVPE GPFPGHLVDV RGTGSLSQNY
760 770 780 790 800
QYEVCLAGGS GTNEFQFLKP VLPNIQGHSF GPEMEQNSNF RNGFGFSLQL

K
Length:801
Mass (Da):87,639
Last modified:April 17, 2007 - v3
Checksum:i5BFB3C62B19E9CE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234V → L in AAG10031 (PubMed:11322959).Curated1
Sequence conflicti569G → S in AAG10031 (PubMed:11322959).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031619199K → N.1 PublicationCorresponds to variant rs2950845dbSNPEnsembl.1
Natural variantiVAR_055581232E → G.Corresponds to variant rs17096954dbSNPEnsembl.1
Natural variantiVAR_031620244E → Q.1 PublicationCorresponds to variant rs2950844dbSNPEnsembl.1
Natural variantiVAR_021880305K → E.Corresponds to variant rs3733694dbSNPEnsembl.1
Natural variantiVAR_024392322A → V.Corresponds to variant rs7700833dbSNPEnsembl.1
Natural variantiVAR_055582382I → T.Corresponds to variant rs3733693dbSNPEnsembl.1
Natural variantiVAR_055583639Q → H.1 PublicationCorresponds to variant rs2740582dbSNPEnsembl.1
Natural variantiVAR_055584661L → V.2 PublicationsCorresponds to variant rs2697541dbSNPEnsembl.1
Natural variantiVAR_055585745S → N.Corresponds to variant rs17096961dbSNPEnsembl.1
Natural variantiVAR_055586759G → V.Corresponds to variant rs35245446dbSNPEnsembl.1
Natural variantiVAR_024393767F → L.2 PublicationsCorresponds to variant rs2740583dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152501 mRNA. Translation: AAD43762.2.
BC136801 mRNA. Translation: AAI36802.1.
AF282973 Genomic DNA. Translation: AAG10031.1.
CCDSiCCDS4250.1.
RefSeqiNP_061993.3. NM_019120.4.
UniGeneiHs.283803.
Hs.287793.

Genome annotation databases

EnsembliENST00000239444; ENSP00000239444; ENSG00000120322.
GeneIDi56128.
KEGGihsa:56128.
UCSCiuc011dai.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152501 mRNA. Translation: AAD43762.2.
BC136801 mRNA. Translation: AAI36802.1.
AF282973 Genomic DNA. Translation: AAG10031.1.
CCDSiCCDS4250.1.
RefSeqiNP_061993.3. NM_019120.4.
UniGeneiHs.283803.
Hs.287793.

3D structure databases

ProteinModelPortaliQ9UN66.
SMRiQ9UN66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121068. 1 interactor.
STRINGi9606.ENSP00000239444.

PTM databases

iPTMnetiQ9UN66.
PhosphoSitePlusiQ9UN66.

Polymorphism and mutation databases

BioMutaiPCDHB8.
DMDMi145559514.

Proteomic databases

EPDiQ9UN66.
MaxQBiQ9UN66.
PaxDbiQ9UN66.
PeptideAtlasiQ9UN66.
PRIDEiQ9UN66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239444; ENSP00000239444; ENSG00000120322.
GeneIDi56128.
KEGGihsa:56128.
UCSCiuc011dai.3. human.

Organism-specific databases

CTDi56128.
DisGeNETi56128.
GeneCardsiPCDHB8.
H-InvDBHIX0031984.
HGNCiHGNC:8693. PCDHB8.
HPAiHPA057773.
MIMi604967. gene.
606334. gene.
neXtProtiNX_Q9UN66.
PharmGKBiPA33042.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN66.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9UN66.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120322-MONOMER.

Miscellaneous databases

GenomeRNAii56128.
PROiQ9UN66.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000273227.
CleanExiHS_PCDHB8.
GenevisibleiQ9UN66. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB8_HUMAN
AccessioniPrimary (citable) accession number: Q9UN66
Secondary accession number(s): B9EGV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.