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Protein

Protocadherin beta-8

Gene

PCDHB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-8
Short name:
PCDH-beta-8
Alternative name(s):
Protocadherin-3I
Gene namesi
Name:PCDHB8
Synonyms:PCDH3I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8693. PCDHB8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 691663ExtracellularSequence analysisAdd
BLAST
Transmembranei692 – 71019HelicalSequence analysisAdd
BLAST
Topological domaini711 – 80191CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33042.

Polymorphism and mutation databases

BioMutaiPCDHB8.
DMDMi145559514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 801773Protocadherin beta-8PRO_0000003928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UN66.
MaxQBiQ9UN66.
PaxDbiQ9UN66.
PRIDEiQ9UN66.

PTM databases

iPTMnetiQ9UN66.
PhosphoSiteiQ9UN66.

Expressioni

Gene expression databases

BgeeiQ9UN66.
CleanExiHS_PCDHB8.
GenevisibleiQ9UN66. HS.

Organism-specific databases

HPAiHPA057773.

Interactioni

Protein-protein interaction databases

BioGridi121068. 1 interaction.
STRINGi9606.ENSP00000239444.

Structurei

3D structure databases

ProteinModelPortaliQ9UN66.
SMRiQ9UN66. Positions 33-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 13499Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 243105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini248 – 348101Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini353 – 452100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini457 – 562106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 672104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN66.
KOiK16494.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN66.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASGKLICR QRQVLFSFLL LGLSLAGAAE PRSYSVVEET EGSSFVTNLA
60 70 80 90 100
KDLGLEQREF SRRGVRVVSR GNKLHLQLNQ ETADLLLNEK LDREDLCGHT
110 120 130 140 150
EPCVLRFQVL LESPFEFFQA ELQVIDINDH SPVFLDKQML VKVSESSPPG
160 170 180 190 200
TAFPLKNAED LDIGQNNIEN YIISPNSYFR VLTRKRSDGR KYPELVLDKA
210 220 230 240 250
LDREEEAELR LTLTALDGGS PPRSGTAQVY IEVVDVNDNA PEFEQPFYRV
260 270 280 290 300
QISEDSPISF LVVKVSATDV DTGVNGEISY SLFQASDEIS KTFKVDFLTG
310 320 330 340 350
EIRLKKQLDF EKFQSYEVNI EARDAGGFSG KCTVLIQVID VNDHAPEVTM
360 370 380 390 400
SAFTSPIPEN APETVVALFS VSDLDSGENG KISCSIQEDL PFLLKSSVGN
410 420 430 440 450
FYTLLTETPL DRESRAEYNV TITVTDLGTP RLTTHLNMTV LVSDVNDNAP
460 470 480 490 500
AFTQTSYTLF VRENNSPALH IGSVSATDRD SGTNAQVTYS LLPPQDPHLP
510 520 530 540 550
LASLVSINTD NGHLFALRSL DYEALQAFEF RVGASDRGSP ALSSEALVRV
560 570 580 590 600
LVLDANDNSP FVLYPLQNGS APCTELVPRA AEPGYLVTKV VAVDGDSGQN
610 620 630 640 650
AWLSYQLLKA TEPGLFGVWA HNGEVRTARL LSERDAAKQR LVVLVKDNGE
660 670 680 690 700
PPCSATATLH LLLVDGFSQP YLPLPEAAPA QGQADSLTVY LVVALASVSS
710 720 730 740 750
LFLFSVLLFV AVLLCRRSRA ASVGRCSVPE GPFPGHLVDV RGTGSLSQNY
760 770 780 790 800
QYEVCLAGGS GTNEFQFLKP VLPNIQGHSF GPEMEQNSNF RNGFGFSLQL

K
Length:801
Mass (Da):87,639
Last modified:April 17, 2007 - v3
Checksum:i5BFB3C62B19E9CE2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341V → L in AAG10031 (PubMed:11322959).Curated
Sequence conflicti569 – 5691G → S in AAG10031 (PubMed:11322959).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991K → N.1 Publication
Corresponds to variant rs2950845 [ dbSNP | Ensembl ].
VAR_031619
Natural varianti232 – 2321E → G.
Corresponds to variant rs17096954 [ dbSNP | Ensembl ].
VAR_055581
Natural varianti244 – 2441E → Q.1 Publication
Corresponds to variant rs2950844 [ dbSNP | Ensembl ].
VAR_031620
Natural varianti305 – 3051K → E.
Corresponds to variant rs3733694 [ dbSNP | Ensembl ].
VAR_021880
Natural varianti322 – 3221A → V.
Corresponds to variant rs7700833 [ dbSNP | Ensembl ].
VAR_024392
Natural varianti382 – 3821I → T.
Corresponds to variant rs3733693 [ dbSNP | Ensembl ].
VAR_055582
Natural varianti639 – 6391Q → H.1 Publication
Corresponds to variant rs2740582 [ dbSNP | Ensembl ].
VAR_055583
Natural varianti661 – 6611L → V.2 Publications
Corresponds to variant rs2697541 [ dbSNP | Ensembl ].
VAR_055584
Natural varianti745 – 7451S → N.
Corresponds to variant rs17096961 [ dbSNP | Ensembl ].
VAR_055585
Natural varianti759 – 7591G → V.
Corresponds to variant rs35245446 [ dbSNP | Ensembl ].
VAR_055586
Natural varianti767 – 7671F → L.2 Publications
Corresponds to variant rs2740583 [ dbSNP | Ensembl ].
VAR_024393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152501 mRNA. Translation: AAD43762.2.
BC136801 mRNA. Translation: AAI36802.1.
AF282973 Genomic DNA. Translation: AAG10031.1.
CCDSiCCDS4250.1.
RefSeqiNP_061993.3. NM_019120.4.
UniGeneiHs.283803.
Hs.287793.

Genome annotation databases

EnsembliENST00000239444; ENSP00000239444; ENSG00000120322.
GeneIDi56128.
KEGGihsa:56128.
UCSCiuc011dai.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152501 mRNA. Translation: AAD43762.2.
BC136801 mRNA. Translation: AAI36802.1.
AF282973 Genomic DNA. Translation: AAG10031.1.
CCDSiCCDS4250.1.
RefSeqiNP_061993.3. NM_019120.4.
UniGeneiHs.283803.
Hs.287793.

3D structure databases

ProteinModelPortaliQ9UN66.
SMRiQ9UN66. Positions 33-699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121068. 1 interaction.
STRINGi9606.ENSP00000239444.

PTM databases

iPTMnetiQ9UN66.
PhosphoSiteiQ9UN66.

Polymorphism and mutation databases

BioMutaiPCDHB8.
DMDMi145559514.

Proteomic databases

EPDiQ9UN66.
MaxQBiQ9UN66.
PaxDbiQ9UN66.
PRIDEiQ9UN66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239444; ENSP00000239444; ENSG00000120322.
GeneIDi56128.
KEGGihsa:56128.
UCSCiuc011dai.3. human.

Organism-specific databases

CTDi56128.
GeneCardsiPCDHB8.
H-InvDBHIX0031984.
HGNCiHGNC:8693. PCDHB8.
HPAiHPA057773.
MIMi604967. gene.
606334. gene.
neXtProtiNX_Q9UN66.
PharmGKBiPA33042.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9UN66.
KOiK16494.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9UN66.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56128.
PROiQ9UN66.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UN66.
CleanExiHS_PCDHB8.
GenevisibleiQ9UN66. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-199 AND GLN-244.
  2. Wu Q., Maniatis T.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-661 AND LEU-767.
    Tissue: Testis.
  4. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-801, VARIANTS HIS-639; VAL-661 AND LEU-767.

Entry informationi

Entry nameiPCDB8_HUMAN
AccessioniPrimary (citable) accession number: Q9UN66
Secondary accession number(s): B9EGV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.