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Q9UN42 (AT1B4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene names
Name:ATP1B4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. Ref.4

Subunit structure

Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1 By similarity. According to Ref.4, does not associate with known Na,K-ATPase alpha-subunits.

Subcellular location

Nucleus inner membrane; Single-pass type II membrane protein By similarity. Note: Detected in nuclear envelops. Ref.3 Ref.4

Tissue specificity

Highly expressed in skeletal muscle and at a lower level in heart. Ref.1

Sequence similarities

Belongs to the X(+)/potassium ATPases subunit beta family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9UN42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9UN42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-110: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Protein ATP1B4
PRO_0000219122

Regions

Topological domain1 – 110110Nuclear Potential
Transmembrane111 – 13121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain132 – 357226Perinuclear space Potential
Compositional bias35 – 7238Glu-rich

Natural variations

Alternative sequence107 – 1104Missing in isoform B.
VSP_000351
Natural variant481V → A.
Corresponds to variant rs2072452 [ dbSNP | Ensembl ].
VAR_055535

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 94926EB1BB637ACA

FASTA35741,598
        10         20         30         40         50         60 
MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK SEEEEEEEEK 

        70         80         90        100        110        120 
EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM FLARTGQSWS LILLIYFFFY 

       130        140        150        160        170        180 
ASLAAVITLC MYTLFLTISP YIPTFTERVK PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI 

       190        200        210        220        230        240 
SLNGFLQGYN DSLQEEMNVD CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY 

       250        260        270        280        290        300 
STGQPCILLK MNRIVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRYYPYYG 

       310        320        330        340        350 
KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGVINDV INDRFVGRVI FTLNIET 

« Hide

Isoform B [UniParc].

Checksum: 393BEDAF2FD45D96
Show »

FASTA35341,109

References

« Hide 'large scale' references
[1]"Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles."
Pestov N.B., Adams G., Shakhparonov M.I., Modyanov N.N.
FEBS Lett. 456:243-248(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), TISSUE SPECIFICITY.
Tissue: Skeletal muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
[3]"Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.
Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[4]"Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals."
Pestov N.B., Ahmad N., Korneenko T.V., Zhao H., Radkov R., Schaer D., Roy S., Bibert S., Geering K., Modyanov N.N.
Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF158383 mRNA. Translation: AAD49692.1.
AF158384 mRNA. Translation: AAD49693.1.
BC117227 mRNA. Translation: AAI17228.1.
RefSeqNP_001135919.1. NM_001142447.2.
NP_036201.1. NM_012069.4.
UniGeneHs.292599.

3D structure databases

ProteinModelPortalQ9UN42.
SMRQ9UN42. Positions 95-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000218008.

PTM databases

PhosphoSiteQ9UN42.

Polymorphism databases

DMDM17367154.

Proteomic databases

PaxDbQ9UN42.
PRIDEQ9UN42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000218008; ENSP00000218008; ENSG00000101892. [Q9UN42-1]
ENST00000361319; ENSP00000355346; ENSG00000101892. [Q9UN42-2]
GeneID23439.
KEGGhsa:23439.
UCSCuc004esq.3. human. [Q9UN42-2]
uc004esr.3. human. [Q9UN42-1]

Organism-specific databases

CTD23439.
GeneCardsGC0XP119495.
HGNCHGNC:808. ATP1B4.
HPAHPA044128.
neXtProtNX_Q9UN42.
PharmGKBPA410.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259814.
HOGENOMHOG000039248.
HOVERGENHBG050603.
InParanoidQ9UN42.
KOK01540.
OMAPTGNAWW.
OrthoDBEOG7M6D85.
PhylomeDBQ9UN42.
TreeFamTF314618.

Gene expression databases

ArrayExpressQ9UN42.
BgeeQ9UN42.
CleanExHS_ATP1B4.
GenevestigatorQ9UN42.

Family and domain databases

InterProIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERPTHR11523. PTHR11523. 1 hit.
PfamPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23439.
NextBio45709.
PROQ9UN42.

Entry information

Entry nameAT1B4_HUMAN
AccessionPrimary (citable) accession number: Q9UN42
Secondary accession number(s): Q17RR0, Q9UN41
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM