Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UN42

- AT1B4_HUMAN

UniProt

Q9UN42 - AT1B4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein ATP1B4

Gene

ATP1B4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.1 Publication

GO - Molecular functioni

  1. monovalent inorganic cation transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. monovalent inorganic cation transport Source: GOC
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene namesi
Name:ATP1B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:808. ATP1B4.

Subcellular locationi

Nucleus inner membrane By similarity; Single-pass type II membrane protein By similarity
Note: Detected in nuclear envelops.2 Publications

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. nuclear inner membrane Source: UniProtKB
  3. sodium:potassium-exchanging ATPase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Protein ATP1B4PRO_0000219122Add
BLAST

Proteomic databases

PaxDbiQ9UN42.
PRIDEiQ9UN42.

PTM databases

PhosphoSiteiQ9UN42.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and at a lower level in heart.1 Publication

Gene expression databases

BgeeiQ9UN42.
CleanExiHS_ATP1B4.
ExpressionAtlasiQ9UN42. baseline and differential.
GenevestigatoriQ9UN42.

Organism-specific databases

HPAiHPA044128.

Interactioni

Subunit structurei

Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1 (By similarity). According to PubMed:17592128, does not associate with known Na,K-ATPase alpha-subunits.By similarity

Protein-protein interaction databases

BioGridi117007. 36 interactions.
DIPiDIP-60961N.
STRINGi9606.ENSP00000218008.

Structurei

3D structure databases

ProteinModelPortaliQ9UN42.
SMRiQ9UN42. Positions 95-356.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 110110NuclearSequence AnalysisAdd
BLAST
Topological domaini132 – 357226Perinuclear spaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei111 – 13121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 7238Glu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259814.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ9UN42.
KOiK01540.
OMAiPTGNAWW.
OrthoDBiEOG7M6D85.
PhylomeDBiQ9UN42.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9UN42) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK
60 70 80 90 100
SEEEEEEEEK EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM
110 120 130 140 150
FLARTGQSWS LILLIYFFFY ASLAAVITLC MYTLFLTISP YIPTFTERVK
160 170 180 190 200
PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI SLNGFLQGYN DSLQEEMNVD
210 220 230 240 250
CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY STGQPCILLK
260 270 280 290 300
MNRIVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRYYPYYG
310 320 330 340 350
KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGVINDV INDRFVGRVI

FTLNIET
Length:357
Mass (Da):41,598
Last modified:May 1, 2000 - v1
Checksum:i94926EB1BB637ACA
GO
Isoform B (identifier: Q9UN42-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-110: Missing.

Show »
Length:353
Mass (Da):41,109
Checksum:i393BEDAF2FD45D96
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481V → A.
Corresponds to variant rs2072452 [ dbSNP | Ensembl ].
VAR_055535

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 1104Missing in isoform B. 1 PublicationVSP_000351

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF158383 mRNA. Translation: AAD49692.1.
AF158384 mRNA. Translation: AAD49693.1.
BC117227 mRNA. Translation: AAI17228.1.
CCDSiCCDS14598.1. [Q9UN42-2]
CCDS48158.1. [Q9UN42-1]
RefSeqiNP_001135919.1. NM_001142447.2. [Q9UN42-1]
NP_036201.1. NM_012069.4. [Q9UN42-2]
UniGeneiHs.292599.

Genome annotation databases

EnsembliENST00000218008; ENSP00000218008; ENSG00000101892. [Q9UN42-1]
ENST00000361319; ENSP00000355346; ENSG00000101892. [Q9UN42-2]
GeneIDi23439.
KEGGihsa:23439.
UCSCiuc004esq.3. human. [Q9UN42-2]
uc004esr.3. human. [Q9UN42-1]

Polymorphism databases

DMDMi17367154.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF158383 mRNA. Translation: AAD49692.1 .
AF158384 mRNA. Translation: AAD49693.1 .
BC117227 mRNA. Translation: AAI17228.1 .
CCDSi CCDS14598.1. [Q9UN42-2 ]
CCDS48158.1. [Q9UN42-1 ]
RefSeqi NP_001135919.1. NM_001142447.2. [Q9UN42-1 ]
NP_036201.1. NM_012069.4. [Q9UN42-2 ]
UniGenei Hs.292599.

3D structure databases

ProteinModelPortali Q9UN42.
SMRi Q9UN42. Positions 95-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117007. 36 interactions.
DIPi DIP-60961N.
STRINGi 9606.ENSP00000218008.

PTM databases

PhosphoSitei Q9UN42.

Polymorphism databases

DMDMi 17367154.

Proteomic databases

PaxDbi Q9UN42.
PRIDEi Q9UN42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000218008 ; ENSP00000218008 ; ENSG00000101892 . [Q9UN42-1 ]
ENST00000361319 ; ENSP00000355346 ; ENSG00000101892 . [Q9UN42-2 ]
GeneIDi 23439.
KEGGi hsa:23439.
UCSCi uc004esq.3. human. [Q9UN42-2 ]
uc004esr.3. human. [Q9UN42-1 ]

Organism-specific databases

CTDi 23439.
GeneCardsi GC0XP119495.
HGNCi HGNC:808. ATP1B4.
HPAi HPA044128.
neXtProti NX_Q9UN42.
PharmGKBi PA410.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259814.
GeneTreei ENSGT00550000074530.
HOGENOMi HOG000039248.
HOVERGENi HBG050603.
InParanoidi Q9UN42.
KOi K01540.
OMAi PTGNAWW.
OrthoDBi EOG7M6D85.
PhylomeDBi Q9UN42.
TreeFami TF314618.

Miscellaneous databases

GenomeRNAii 23439.
NextBioi 45709.
PROi Q9UN42.

Gene expression databases

Bgeei Q9UN42.
CleanExi HS_ATP1B4.
ExpressionAtlasi Q9UN42. baseline and differential.
Genevestigatori Q9UN42.

Family and domain databases

InterProi IPR000402. Na/K_ATPase_sub_beta.
[Graphical view ]
PANTHERi PTHR11523. PTHR11523. 1 hit.
Pfami PF00287. Na_K-ATPase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles."
    Pestov N.B., Adams G., Shakhparonov M.I., Modyanov N.N.
    FEBS Lett. 456:243-248(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), TISSUE SPECIFICITY.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
  3. "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
    Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.
    Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals."
    Pestov N.B., Ahmad N., Korneenko T.V., Zhao H., Radkov R., Schaer D., Roy S., Bibert S., Geering K., Modyanov N.N.
    Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAT1B4_HUMAN
AccessioniPrimary (citable) accession number: Q9UN42
Secondary accession number(s): Q17RR0, Q9UN41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3