Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UN42

- AT1B4_HUMAN

UniProt

Q9UN42 - AT1B4_HUMAN

Protein

Protein ATP1B4

Gene

ATP1B4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.1 Publication

    GO - Molecular functioni

    1. monovalent inorganic cation transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. monovalent inorganic cation transport Source: GOC
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. transport Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ATP1B4
    Alternative name(s):
    X,K-ATPase subunit beta-m
    X/potassium-transporting ATPase subunit beta-m
    Gene namesi
    Name:ATP1B4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:808. ATP1B4.

    Subcellular locationi

    Nucleus inner membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Detected in nuclear envelops.2 Publications

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. nuclear inner membrane Source: UniProtKB
    3. sodium:potassium-exchanging ATPase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA410.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Protein ATP1B4PRO_0000219122Add
    BLAST

    Proteomic databases

    PaxDbiQ9UN42.
    PRIDEiQ9UN42.

    PTM databases

    PhosphoSiteiQ9UN42.

    Expressioni

    Tissue specificityi

    Highly expressed in skeletal muscle and at a lower level in heart.1 Publication

    Gene expression databases

    ArrayExpressiQ9UN42.
    BgeeiQ9UN42.
    CleanExiHS_ATP1B4.
    GenevestigatoriQ9UN42.

    Organism-specific databases

    HPAiHPA044128.

    Interactioni

    Subunit structurei

    Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1 By similarity. According to PubMed:17592128, does not associate with known Na,K-ATPase alpha-subunits.By similarity

    Protein-protein interaction databases

    DIPiDIP-60961N.
    STRINGi9606.ENSP00000218008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UN42.
    SMRiQ9UN42. Positions 95-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 110110NuclearSequence AnalysisAdd
    BLAST
    Topological domaini132 – 357226Perinuclear spaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 7238Glu-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259814.
    HOGENOMiHOG000039248.
    HOVERGENiHBG050603.
    InParanoidiQ9UN42.
    KOiK01540.
    OMAiPTGNAWW.
    OrthoDBiEOG7M6D85.
    PhylomeDBiQ9UN42.
    TreeFamiTF314618.

    Family and domain databases

    InterProiIPR000402. Na/K_ATPase_sub_beta.
    [Graphical view]
    PANTHERiPTHR11523. PTHR11523. 1 hit.
    PfamiPF00287. Na_K-ATPase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
    PS00391. ATPASE_NA_K_BETA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9UN42-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK    50
    SEEEEEEEEK EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM 100
    FLARTGQSWS LILLIYFFFY ASLAAVITLC MYTLFLTISP YIPTFTERVK 150
    PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI SLNGFLQGYN DSLQEEMNVD 200
    CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY STGQPCILLK 250
    MNRIVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRYYPYYG 300
    KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGVINDV INDRFVGRVI 350
    FTLNIET 357
    Length:357
    Mass (Da):41,598
    Last modified:May 1, 2000 - v1
    Checksum:i94926EB1BB637ACA
    GO
    Isoform B (identifier: Q9UN42-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         107-110: Missing.

    Show »
    Length:353
    Mass (Da):41,109
    Checksum:i393BEDAF2FD45D96
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481V → A.
    Corresponds to variant rs2072452 [ dbSNP | Ensembl ].
    VAR_055535

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei107 – 1104Missing in isoform B. 1 PublicationVSP_000351

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF158383 mRNA. Translation: AAD49692.1.
    AF158384 mRNA. Translation: AAD49693.1.
    BC117227 mRNA. Translation: AAI17228.1.
    CCDSiCCDS14598.1. [Q9UN42-2]
    CCDS48158.1. [Q9UN42-1]
    RefSeqiNP_001135919.1. NM_001142447.2. [Q9UN42-1]
    NP_036201.1. NM_012069.4. [Q9UN42-2]
    UniGeneiHs.292599.

    Genome annotation databases

    EnsembliENST00000218008; ENSP00000218008; ENSG00000101892. [Q9UN42-1]
    ENST00000361319; ENSP00000355346; ENSG00000101892. [Q9UN42-2]
    GeneIDi23439.
    KEGGihsa:23439.
    UCSCiuc004esq.3. human. [Q9UN42-2]
    uc004esr.3. human. [Q9UN42-1]

    Polymorphism databases

    DMDMi17367154.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF158383 mRNA. Translation: AAD49692.1 .
    AF158384 mRNA. Translation: AAD49693.1 .
    BC117227 mRNA. Translation: AAI17228.1 .
    CCDSi CCDS14598.1. [Q9UN42-2 ]
    CCDS48158.1. [Q9UN42-1 ]
    RefSeqi NP_001135919.1. NM_001142447.2. [Q9UN42-1 ]
    NP_036201.1. NM_012069.4. [Q9UN42-2 ]
    UniGenei Hs.292599.

    3D structure databases

    ProteinModelPortali Q9UN42.
    SMRi Q9UN42. Positions 95-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60961N.
    STRINGi 9606.ENSP00000218008.

    PTM databases

    PhosphoSitei Q9UN42.

    Polymorphism databases

    DMDMi 17367154.

    Proteomic databases

    PaxDbi Q9UN42.
    PRIDEi Q9UN42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218008 ; ENSP00000218008 ; ENSG00000101892 . [Q9UN42-1 ]
    ENST00000361319 ; ENSP00000355346 ; ENSG00000101892 . [Q9UN42-2 ]
    GeneIDi 23439.
    KEGGi hsa:23439.
    UCSCi uc004esq.3. human. [Q9UN42-2 ]
    uc004esr.3. human. [Q9UN42-1 ]

    Organism-specific databases

    CTDi 23439.
    GeneCardsi GC0XP119495.
    HGNCi HGNC:808. ATP1B4.
    HPAi HPA044128.
    neXtProti NX_Q9UN42.
    PharmGKBi PA410.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259814.
    HOGENOMi HOG000039248.
    HOVERGENi HBG050603.
    InParanoidi Q9UN42.
    KOi K01540.
    OMAi PTGNAWW.
    OrthoDBi EOG7M6D85.
    PhylomeDBi Q9UN42.
    TreeFami TF314618.

    Miscellaneous databases

    GenomeRNAii 23439.
    NextBioi 45709.
    PROi Q9UN42.

    Gene expression databases

    ArrayExpressi Q9UN42.
    Bgeei Q9UN42.
    CleanExi HS_ATP1B4.
    Genevestigatori Q9UN42.

    Family and domain databases

    InterProi IPR000402. Na/K_ATPase_sub_beta.
    [Graphical view ]
    PANTHERi PTHR11523. PTHR11523. 1 hit.
    Pfami PF00287. Na_K-ATPase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
    PS00391. ATPASE_NA_K_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles."
      Pestov N.B., Adams G., Shakhparonov M.I., Modyanov N.N.
      FEBS Lett. 456:243-248(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), TISSUE SPECIFICITY.
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    3. "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
      Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.
      Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    4. "Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals."
      Pestov N.B., Ahmad N., Korneenko T.V., Zhao H., Radkov R., Schaer D., Roy S., Bibert S., Geering K., Modyanov N.N.
      Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAT1B4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN42
    Secondary accession number(s): Q17RR0, Q9UN41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3