Reviewed,
UniProtKB/Swiss-Prot Q9UN42 (AT1B4_HUMAN)
Last modified
December 15, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: X/potassium-transporting ATPase subunit beta-m Alternative name(s): X,K-ATPase subunit beta-m | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 357 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This is the non-catalytic component of a yet unknown sodium or proton exchange ATPase. |
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Tissue specificity | Highly expressed in skeletal muscle and at a lower level in heart. |
| Sequence similarities | Belongs to the X(+)/potassium ATPases subunit beta family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Hydrogen ion transport Ion transport Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal-anchor Transmembrane |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ATP biosynthetic process Inferred from electronic annotation. Source: InterPro potassium ion transportInferred from electronic annotation. Source: InterPro proton transportInferred from electronic annotation. Source: UniProtKB-KW sodium ion transportInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | monovalent inorganic cation transmembrane transporter activity Ref.1 Traceable author statement. Source: ProtInc sodium:potassium-exchanging ATPase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform A (identifier: Q9UN42-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform B (identifier: Q9UN42-2) The sequence of this isoform differs from the canonical sequence as follows: 107-110: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 357 | 357 | X/potassium-transporting ATPase subunit beta-m | PRO_0000219122 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 110 | 110 | Cytoplasmic Potential | ||||||||
| Transmembrane | 111 – 131 | 21 | Signal-anchor for type II membrane protein Potential | ||||||||
| Topological domain | 132 – 357 | 226 | Extracellular Potential | ||||||||
| Compositional bias | 35 – 72 | 38 | Glu-rich | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 168 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 190 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 229 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 306 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 201 ↔ 220 | By similarity | |||||||||
| Disulfide bond | 230 ↔ 246 | By similarity | |||||||||
| Disulfide bond | 269 ↔ 329 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 107 – 110 | 4 | Missing in isoform B. | VSP_000351 | |||||||
| Natural variant | 48 | 1 | V → A: dbSNP rs2072452. | VAR_055535 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles." Pestov N.B., Adams G., Shakhparonov M.I., Modyanov N.N. FEBS Lett. 456:243-248(1999) [PubMed: 10456317] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Tissue: Skeletal muscle. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF158383 mRNA. Translation: AAD49692.1. AF158384 mRNA. Translation: AAD49693.1. BC117227 mRNA. Translation: AAI17228.1. | |
| IPI | IPI00013724. IPI00220387. |
| RefSeq | NP_001135919.1. NP_036201.1. |
| UniGene | Hs.662608 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9UN42. |
Proteomic databases | |
| PRIDE | Q9UN42. |
Genome annotation databases | |
| Ensembl | ENST00000218008; ENSP00000218008; ENSG00000101892; Homo sapiens. [Genome view] |
| GeneID | 23439. |
| KEGG | hsa:23439. |
| UCSC | uc004esq.1. human. uc004esr.1. human. |
Organism-specific databases | |
| CTD | 23439. |
| GeneCards | GC0XP119379. |
| HGNC | HGNC:808. ATP1B4. |
| PharmGKB | PA410. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG446583. |
| HOVERGEN | Q9UN42. |
| InParanoid | Q9UN42. |
| OMA | GNAWWQK. |
| OrthoDB | EOG9J9QJ4. |
Gene expression databases | |
| ArrayExpress | Q9UN42. |
| Bgee | Q9UN42. |
| CleanEx | HS_ATP1B4. |
| Genevestigator | Q9UN42. |
| GermOnline | ENSG00000101892. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view] |
| PANTHER | PTHR11523. ATPase_H_Na/K_b. 1 hit. |
| Pfam | PF00287. Na_K-ATPase. 1 hit. [Graphical view] |
| PROSITE | PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 45709. |
Entry information
| Entry name | AT1B4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UN42 Secondary accession number(s): Q17RR0, Q9UN41 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


