Reviewed, UniProtKB/Swiss-Prot Q9UN42 (AT1B4_HUMAN)

Names and origin

Protein names

Recommended name:
    X/potassium-transporting ATPase subunit beta-m
Alternative name(s):
    X,K-ATPase subunit beta-m

Gene names

Name:

ATP1B4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This is the non-catalytic component of a yet unknown sodium or proton exchange ATPase.
Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Tissue specificity	Highly expressed in skeletal muscle and at a lower level in heart.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal-anchor Transmembrane
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro potassium ion transport Inferred from electronic annotation. Source: InterPro proton transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	monovalent inorganic cation transmembrane transporter activity Ref.1 Traceable author statement. Source: ProtInc sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9UN42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9UN42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     107-110: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	X/potassium-transporting ATPase subunit beta-m		PRO_0000219122
Regions
	Topological domain	1 – 110	110	Cytoplasmic Potential
	Transmembrane	111 – 131	21	Signal-anchor for type II membrane protein Potential
	Topological domain	132 – 357	226	Extracellular Potential
	Compositional bias	35 – 72	38	Glu-rich
Amino acid modifications
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Disulfide bond	201 ↔ 220		By similarity
	Disulfide bond	230 ↔ 246		By similarity
	Disulfide bond	269 ↔ 329		By similarity
Natural variations
	Alternative sequence	107 – 110	4	Missing in isoform B.		VSP_000351
	Natural variant	48	1	V → A: dbSNP rs2072452.		VAR_055535

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 94926EB1BB637ACA	FASTA	357	41,598
	10 20 30 40 50 60 MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK SEEEEEEEEK 70 80 90 100 110 120 EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM FLARTGQSWS LILLIYFFFY 130 140 150 160 170 180 ASLAAVITLC MYTLFLTISP YIPTFTERVK PPGVMIRPFA HSLNFNFNVS EPDTWQHYVI 190 200 210 220 230 240 SLNGFLQGYN DSLQEEMNVD CPPGQYFIQD GNEDEDKKAC QFKRSFLKNC SGLEDPTFGY 250 260 270 280 290 300 STGQPCILLK MNRIVGFRPE LGDPVKVSCK VQRGDENDIR SISYYPESAS FDLRYYPYYG 310 320 330 340 350 KLTHVNYTSP LVAMHFTDVV KNQAVPVQCQ LKGKGVINDV INDRFVGRVI FTLNIET
	Isoform B. Checksum: 393BEDAF2FD45D96	FASTA	353	41,109
	10 20 30 40 50 60 MRRQLRSRRA PSFPYSYRYR LDDPDEANQN YLADEEEEAE EEARVTVVPK SEEEEEEEEK 70 80 90 100 110 120 EEEEEEEKEE EEGQGQPTGN AWWQKLQIMS EYLWDPERRM FLARTGLILL IYFFFYASLA 130 140 150 160 170 180 AVITLCMYTL FLTISPYIPT FTERVKPPGV MIRPFAHSLN FNFNVSEPDT WQHYVISLNG 190 200 210 220 230 240 FLQGYNDSLQ EEMNVDCPPG QYFIQDGNED EDKKACQFKR SFLKNCSGLE DPTFGYSTGQ 250 260 270 280 290 300 PCILLKMNRI VGFRPELGDP VKVSCKVQRG DENDIRSISY YPESASFDLR YYPYYGKLTH 310 320 330 340 350 VNYTSPLVAM HFTDVVKNQA VPVQCQLKGK GVINDVINDR FVGRVIFTLN IET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles." Pestov N.B., Adams G., Shakhparonov M.I., Modyanov N.N. FEBS Lett. 456:243-248(1999) [PubMed: 10456317] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Tissue: Skeletal muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF158383 mRNA. Translation: AAD49692.1. AF158384 mRNA. Translation: AAD49693.1. BC117227 mRNA. Translation: AAI17228.1.
IPI	IPI00013724. IPI00220387.
RefSeq	NP_001135919.1. NP_036201.1.
UniGene	Hs.662608
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UN42.
Proteomic databases
PRIDE	Q9UN42.
Genome annotation databases
Ensembl	ENST00000218008; ENSP00000218008; ENSG00000101892; Homo sapiens. [Genome view]
GeneID	23439.
KEGG	hsa:23439.
UCSC	uc004esq.1. human. uc004esr.1. human.
Organism-specific databases
CTD	23439.
GeneCards	GC0XP119379.
HGNC	HGNC:808. ATP1B4.
PharmGKB	PA410.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG446583.
HOVERGEN	Q9UN42.
InParanoid	Q9UN42.
OMA	GNAWWQK.
OrthoDB	EOG9J9QJ4.
Gene expression databases
ArrayExpress	Q9UN42.
Bgee	Q9UN42.
CleanEx	HS_ATP1B4.
Genevestigator	Q9UN42.
GermOnline	ENSG00000101892. Homo sapiens.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	45709.

Entry information

Entry name

AT1B4_HUMAN

Accession

Primary (citable) accession number: Q9UN42
Secondary accession number(s): Q17RR0, Q9UN41

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	May 1, 2000
Last modified:	December 15, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.