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Q9UN36

- NDRG2_HUMAN

UniProt

Q9UN36 - NDRG2_HUMAN

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Protein

Protein NDRG2

Gene

NDRG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.3 Publications

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of cytokine production Source: Ensembl
  3. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  4. negative regulation of smooth muscle cell proliferation Source: Ensembl
  5. regulation of platelet-derived growth factor production Source: Ensembl
  6. regulation of vascular endothelial growth factor production Source: Ensembl
  7. substantia nigra development Source: UniProt
  8. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG2
Alternative name(s):
N-myc downstream-regulated gene 2 protein
Protein Syld709613
Gene namesi
Name:NDRG2
Synonyms:KIAA1248, SYLD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14460. NDRG2.

Subcellular locationi

Cytoplasm. Cytoplasmperinuclear region. Cell projectiongrowth cone By similarity
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. centrosome Source: HPA
  3. cytoplasm Source: HPA
  4. cytosol Source: UniProtKB
  5. extracellular vesicular exosome Source: UniProt
  6. Golgi apparatus Source: LIFEdb
  7. microtubule organizing center Source: HPA
  8. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi186 – 1861L → D: Decreased interaction with CTNNB1. Abolishes down-regulation of Wnt signaling. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA31483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 371370Protein NDRG2PRO_0000159575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei328 – 3281Phosphoserine1 Publication
Modified residuei330 – 3301PhosphothreonineBy similarity
Modified residuei332 – 3321Phosphoserine1 Publication
Modified residuei334 – 3341PhosphothreonineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei338 – 3381Phosphoserine2 Publications
Modified residuei348 – 3481Phosphothreonine1 Publication
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei357 – 3571PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9UN36.
PaxDbiQ9UN36.
PRIDEiQ9UN36.

PTM databases

PhosphoSiteiQ9UN36.

Expressioni

Tissue specificityi

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).7 Publications

Developmental stagei

Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.2 Publications

Gene expression databases

BgeeiQ9UN36.
ExpressionAtlasiQ9UN36. baseline and differential.
GenevestigatoriQ9UN36.

Organism-specific databases

HPAiCAB017491.
HPA002896.
HPA003590.

Interactioni

Subunit structurei

Interacts with CTNNB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-3895741,EBI-78473
RABAC1Q9UI147EBI-8084503,EBI-712367

Protein-protein interaction databases

BioGridi121520. 6 interactions.
IntActiQ9UN36. 3 interactions.
MINTiMINT-3082604.

Structurei

Secondary structure

1
371
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 456Combined sources
Beta strandi48 – 5710Combined sources
Beta strandi64 – 685Combined sources
Helixi75 – 784Combined sources
Helixi80 – 845Combined sources
Helixi86 – 927Combined sources
Beta strandi97 – 1015Combined sources
Helixi121 – 1255Combined sources
Helixi128 – 1358Combined sources
Beta strandi140 – 1456Combined sources
Helixi147 – 15812Combined sources
Helixi160 – 1623Combined sources
Beta strandi163 – 1708Combined sources
Helixi178 – 18710Combined sources
Turni188 – 1903Combined sources
Helixi193 – 2019Combined sources
Helixi204 – 2096Combined sources
Helixi212 – 22211Combined sources
Helixi227 – 23812Combined sources
Beta strandi249 – 2513Combined sources
Beta strandi257 – 2626Combined sources
Helixi268 – 2758Combined sources
Turni280 – 2823Combined sources
Beta strandi283 – 2886Combined sources
Helixi295 – 2984Combined sources
Helixi300 – 31415Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XMQX-ray2.81A/B/C40-318[»]
2XMRX-ray2.00A/B/C40-318[»]
2XMSX-ray2.15A40-318[»]
ProteinModelPortaliQ9UN36.
SMRiQ9UN36. Positions 38-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UN36.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

eggNOGiNOG310435.
GeneTreeiENSGT00390000001874.
HOVERGENiHBG052591.
InParanoidiQ9UN36.
OMAiFQFGDMQ.
OrthoDBiEOG7KH9JS.
PhylomeDBiQ9UN36.
TreeFamiTF313168.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UN36-1) [UniParc]FASTAAdd to Basket

Also known as: NDRG2ins

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV
60 70 80 90 100
TFTVYGTPKP KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV
110 120 130 140 150
DAPGMEEGAP VFPLGYQYPS LDQLADMIPC VLQYLNFSTI IGVGVGAGAY
160 170 180 190 200
ILARYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH
210 220 230 240 250
LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR RDLNFERGGD
260 270 280 290 300
ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP
310 320 330 340 350
GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS
360 370
QSSESGTLSS GPPGHTMEVS C
Length:371
Mass (Da):40,798
Last modified:January 23, 2002 - v2
Checksum:i7B49B0B12BD3F595
GO
Isoform 2 (identifier: Q9UN36-2) [UniParc]FASTAAdd to Basket

Also known as: NDRG2var

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.

Show »
Length:357
Mass (Da):39,289
Checksum:iDD793CDC7173704A
GO
Isoform 3 (identifier: Q9UN36-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-272: Missing.

Show »
Length:360
Mass (Da):39,679
Checksum:iCB10621C98F95CED
GO
Isoform 4 (identifier: Q9UN36-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.
     157-185: Missing.

Show »
Length:328
Mass (Da):36,052
Checksum:i3B2E97F79C3E2875
GO
Isoform 5 (identifier: Q9UN36-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.
     272-287: Missing.

Show »
Length:341
Mass (Da):37,497
Checksum:i0A213AAB643816C8
GO
Isoform 6 (identifier: Q9UN36-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MENGGSMQATM
     26-39: Missing.

Note: No experimental confirmation available.

Show »
Length:367
Mass (Da):40,297
Checksum:i26CE96CF6F63D0D6
GO

Sequence cautioni

The sequence BAA86562.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAD62350.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541V → A in AAL08624. (PubMed:11936845)Curated
Sequence conflicti123 – 1231Q → E in AAH93038. (PubMed:15489334)Curated
Sequence conflicti172 – 1721D → G in AAK50340. (PubMed:12845671)Curated
Sequence conflicti250 – 2501D → N in AAL08624. (PubMed:11936845)Curated
Sequence conflicti282 – 2821Q → R in AAH93038. (PubMed:15489334)Curated
Sequence conflicti296 – 2961Q → R in AAK50340. (PubMed:12845671)Curated
Sequence conflicti306 – 3061A → V in AAL08624. (PubMed:11936845)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451T → S.
Corresponds to variant rs36007455 [ dbSNP | Ensembl ].
VAR_050236
Natural varianti48 – 481G → V.1 Publication
Corresponds to variant rs11552412 [ dbSNP | Ensembl ].
VAR_026572

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MENGGSMQATM in isoform 6. 1 PublicationVSP_054583
Alternative sequencei26 – 3914Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 6 PublicationsVSP_003417Add
BLAST
Alternative sequencei157 – 18529Missing in isoform 4. 1 PublicationVSP_019007Add
BLAST
Alternative sequencei262 – 27211Missing in isoform 3. 1 PublicationVSP_003418Add
BLAST
Alternative sequencei272 – 28716Missing in isoform 5. 1 PublicationVSP_019008Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF304051 mRNA. Translation: AAL08624.1.
AF159092 mRNA. Translation: AAD43131.2.
AY028430 Genomic DNA. Translation: AAK50340.1.
AB033074 mRNA. Translation: BAA86562.1. Different initiation.
AL136574 mRNA. Translation: CAB66509.1.
BX247987 mRNA. Translation: CAD62321.1.
BX248031 mRNA. Translation: CAD62350.1. Different initiation.
AK096999 mRNA. Translation: BAG53405.1.
AK293514 mRNA. Translation: BAG56997.1.
CR749252 mRNA. Translation: CAH18108.1.
AL161668 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66423.1.
CH471078 Genomic DNA. Translation: EAW66422.1.
CH471078 Genomic DNA. Translation: EAW66424.1.
CH471078 Genomic DNA. Translation: EAW66425.1.
CH471078 Genomic DNA. Translation: EAW66426.1.
CH471078 Genomic DNA. Translation: EAW66427.1.
CH471078 Genomic DNA. Translation: EAW66428.1.
CH471078 Genomic DNA. Translation: EAW66429.1.
CH471078 Genomic DNA. Translation: EAW66430.1.
BC010458 mRNA. Translation: AAH10458.1.
BC011240 mRNA. Translation: AAH11240.1.
BC093038 mRNA. Translation: AAH93038.1.
CCDSiCCDS61384.1. [Q9UN36-3]
CCDS61386.1. [Q9UN36-6]
CCDS73613.1. [Q9UN36-5]
CCDS9564.1. [Q9UN36-2]
CCDS9565.1. [Q9UN36-1]
RefSeqiNP_001269140.1. NM_001282211.1. [Q9UN36-6]
NP_001269141.1. NM_001282212.1. [Q9UN36-5]
NP_001269142.1. NM_001282213.1. [Q9UN36-2]
NP_001269143.1. NM_001282214.1. [Q9UN36-2]
NP_001269144.1. NM_001282215.1. [Q9UN36-3]
NP_001269145.1. NM_001282216.1.
NP_057334.1. NM_016250.2. [Q9UN36-2]
NP_963293.1. NM_201535.1. [Q9UN36-1]
NP_963294.1. NM_201536.1. [Q9UN36-2]
NP_963831.1. NM_201537.1. [Q9UN36-1]
NP_963832.1. NM_201538.1. [Q9UN36-2]
NP_963833.1. NM_201539.1. [Q9UN36-1]
NP_963834.1. NM_201540.1. [Q9UN36-1]
NP_963835.1. NM_201541.1. [Q9UN36-2]
UniGeneiHs.525205.

Genome annotation databases

EnsembliENST00000298684; ENSP00000298684; ENSG00000165795. [Q9UN36-4]
ENST00000298687; ENSP00000298687; ENSG00000165795. [Q9UN36-1]
ENST00000350792; ENSP00000344620; ENSG00000165795. [Q9UN36-2]
ENST00000360463; ENSP00000353649; ENSG00000165795. [Q9UN36-2]
ENST00000397844; ENSP00000380943; ENSG00000165795. [Q9UN36-5]
ENST00000397847; ENSP00000380945; ENSG00000165795. [Q9UN36-3]
ENST00000397851; ENSP00000380949; ENSG00000165795. [Q9UN36-1]
ENST00000397853; ENSP00000380951; ENSG00000165795. [Q9UN36-1]
ENST00000397858; ENSP00000380956; ENSG00000165795. [Q9UN36-1]
ENST00000403829; ENSP00000385889; ENSG00000165795. [Q9UN36-6]
ENST00000553503; ENSP00000452306; ENSG00000165795. [Q9UN36-2]
ENST00000554143; ENSP00000452006; ENSG00000165795. [Q9UN36-2]
ENST00000555158; ENSP00000452038; ENSG00000165795. [Q9UN36-2]
ENST00000556147; ENSP00000451712; ENSG00000165795. [Q9UN36-1]
GeneIDi57447.
KEGGihsa:57447.
UCSCiuc001vyt.3. human. [Q9UN36-1]
uc001vyu.3. human. [Q9UN36-4]
uc001vyv.3. human. [Q9UN36-2]
uc001vzc.3. human. [Q9UN36-5]
uc010aig.3. human. [Q9UN36-3]

Polymorphism databases

DMDMi20141615.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF304051 mRNA. Translation: AAL08624.1 .
AF159092 mRNA. Translation: AAD43131.2 .
AY028430 Genomic DNA. Translation: AAK50340.1 .
AB033074 mRNA. Translation: BAA86562.1 . Different initiation.
AL136574 mRNA. Translation: CAB66509.1 .
BX247987 mRNA. Translation: CAD62321.1 .
BX248031 mRNA. Translation: CAD62350.1 . Different initiation.
AK096999 mRNA. Translation: BAG53405.1 .
AK293514 mRNA. Translation: BAG56997.1 .
CR749252 mRNA. Translation: CAH18108.1 .
AL161668 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66423.1 .
CH471078 Genomic DNA. Translation: EAW66422.1 .
CH471078 Genomic DNA. Translation: EAW66424.1 .
CH471078 Genomic DNA. Translation: EAW66425.1 .
CH471078 Genomic DNA. Translation: EAW66426.1 .
CH471078 Genomic DNA. Translation: EAW66427.1 .
CH471078 Genomic DNA. Translation: EAW66428.1 .
CH471078 Genomic DNA. Translation: EAW66429.1 .
CH471078 Genomic DNA. Translation: EAW66430.1 .
BC010458 mRNA. Translation: AAH10458.1 .
BC011240 mRNA. Translation: AAH11240.1 .
BC093038 mRNA. Translation: AAH93038.1 .
CCDSi CCDS61384.1. [Q9UN36-3 ]
CCDS61386.1. [Q9UN36-6 ]
CCDS73613.1. [Q9UN36-5 ]
CCDS9564.1. [Q9UN36-2 ]
CCDS9565.1. [Q9UN36-1 ]
RefSeqi NP_001269140.1. NM_001282211.1. [Q9UN36-6 ]
NP_001269141.1. NM_001282212.1. [Q9UN36-5 ]
NP_001269142.1. NM_001282213.1. [Q9UN36-2 ]
NP_001269143.1. NM_001282214.1. [Q9UN36-2 ]
NP_001269144.1. NM_001282215.1. [Q9UN36-3 ]
NP_001269145.1. NM_001282216.1.
NP_057334.1. NM_016250.2. [Q9UN36-2 ]
NP_963293.1. NM_201535.1. [Q9UN36-1 ]
NP_963294.1. NM_201536.1. [Q9UN36-2 ]
NP_963831.1. NM_201537.1. [Q9UN36-1 ]
NP_963832.1. NM_201538.1. [Q9UN36-2 ]
NP_963833.1. NM_201539.1. [Q9UN36-1 ]
NP_963834.1. NM_201540.1. [Q9UN36-1 ]
NP_963835.1. NM_201541.1. [Q9UN36-2 ]
UniGenei Hs.525205.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XMQ X-ray 2.81 A/B/C 40-318 [» ]
2XMR X-ray 2.00 A/B/C 40-318 [» ]
2XMS X-ray 2.15 A 40-318 [» ]
ProteinModelPortali Q9UN36.
SMRi Q9UN36. Positions 38-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121520. 6 interactions.
IntActi Q9UN36. 3 interactions.
MINTi MINT-3082604.

PTM databases

PhosphoSitei Q9UN36.

Polymorphism databases

DMDMi 20141615.

Proteomic databases

MaxQBi Q9UN36.
PaxDbi Q9UN36.
PRIDEi Q9UN36.

Protocols and materials databases

DNASUi 57447.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298684 ; ENSP00000298684 ; ENSG00000165795 . [Q9UN36-4 ]
ENST00000298687 ; ENSP00000298687 ; ENSG00000165795 . [Q9UN36-1 ]
ENST00000350792 ; ENSP00000344620 ; ENSG00000165795 . [Q9UN36-2 ]
ENST00000360463 ; ENSP00000353649 ; ENSG00000165795 . [Q9UN36-2 ]
ENST00000397844 ; ENSP00000380943 ; ENSG00000165795 . [Q9UN36-5 ]
ENST00000397847 ; ENSP00000380945 ; ENSG00000165795 . [Q9UN36-3 ]
ENST00000397851 ; ENSP00000380949 ; ENSG00000165795 . [Q9UN36-1 ]
ENST00000397853 ; ENSP00000380951 ; ENSG00000165795 . [Q9UN36-1 ]
ENST00000397858 ; ENSP00000380956 ; ENSG00000165795 . [Q9UN36-1 ]
ENST00000403829 ; ENSP00000385889 ; ENSG00000165795 . [Q9UN36-6 ]
ENST00000553503 ; ENSP00000452306 ; ENSG00000165795 . [Q9UN36-2 ]
ENST00000554143 ; ENSP00000452006 ; ENSG00000165795 . [Q9UN36-2 ]
ENST00000555158 ; ENSP00000452038 ; ENSG00000165795 . [Q9UN36-2 ]
ENST00000556147 ; ENSP00000451712 ; ENSG00000165795 . [Q9UN36-1 ]
GeneIDi 57447.
KEGGi hsa:57447.
UCSCi uc001vyt.3. human. [Q9UN36-1 ]
uc001vyu.3. human. [Q9UN36-4 ]
uc001vyv.3. human. [Q9UN36-2 ]
uc001vzc.3. human. [Q9UN36-5 ]
uc010aig.3. human. [Q9UN36-3 ]

Organism-specific databases

CTDi 57447.
GeneCardsi GC14M021484.
HGNCi HGNC:14460. NDRG2.
HPAi CAB017491.
HPA002896.
HPA003590.
MIMi 605272. gene.
neXtProti NX_Q9UN36.
PharmGKBi PA31483.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310435.
GeneTreei ENSGT00390000001874.
HOVERGENi HBG052591.
InParanoidi Q9UN36.
OMAi FQFGDMQ.
OrthoDBi EOG7KH9JS.
PhylomeDBi Q9UN36.
TreeFami TF313168.

Miscellaneous databases

ChiTaRSi NDRG2. human.
EvolutionaryTracei Q9UN36.
GeneWikii NDRG2.
GenomeRNAii 57447.
NextBioi 35471146.
PROi Q9UN36.
SOURCEi Search...

Gene expression databases

Bgeei Q9UN36.
ExpressionAtlasi Q9UN36. baseline and differential.
Genevestigatori Q9UN36.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR004142. NDRG.
[Graphical view ]
PANTHERi PTHR11034. PTHR11034. 1 hit.
Pfami PF03096. Ndr. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart."
    Zhou R.-H., Kokame K., Tsukamoto Y., Yutani C., Kato H., Miyata T.
    Genomics 73:86-97(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family."
    Qu X., Zhai Y., Wei H., Zhang C., Xing G., Yu Y., He F.
    Mol. Cell. Biochem. 229:35-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation."
    Deng Y., Yao L., Chau L., Ng S.S.-M., Peng Y., Liu X., Au W.-S., Wang J., Li F., Ji S., Han H., Nie X., Li Q., Kung H.-F., Leung S.-Y., Lin M.C.-M.
    Int. J. Cancer 106:342-347(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Neuroblastoma.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    Tissue: Cerebellum and Small intestine.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  9. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT VAL-48.
    Tissue: Brain.
  12. "Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells."
    Choi S.-C., Kim K.D., Kim J.-T., Kim J.-W., Yoon D.-Y., Choe Y.-K., Chang Y.-S., Paik S.-G., Lim J.-S.
    FEBS Lett. 553:413-418(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  13. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  14. "NDRG2 expression and mutation in human liver and pancreatic cancers."
    Hu X.-L., Liu X.-P., Lin S.-X., Deng Y.-C., Liu N., Li X., Yao L.-B.
    World J. Gastroenterol. 10:3518-3521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  15. "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma."
    Lusis E.A., Watson M.A., Chicoine M.R., Lyman M., Roerig P., Reifenberger G., Gutmann D.H., Perry A.
    Cancer Res. 65:7121-7126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328; SER-332; SER-338 AND THR-348, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor."
    Hwang J., Kim Y., Kang H.B., Jaroszewski L., Deacon A.M., Lee H., Choi W.C., Kim K.J., Kim C.H., Kang B.S., Lee J.O., Oh T.K., Kim J.W., Wilson I.A., Kim M.H.
    J. Biol. Chem. 286:12450-12460(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 40-318, FUNCTION, INTERACTION WITH CTNNB1, MUTAGENESIS OF LEU-186, ABSENCE OF HYDROLASE ACTIVITY.

Entry informationi

Entry nameiNDRG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UN36
Secondary accession number(s): B3KUE3
, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3