Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UN36

- NDRG2_HUMAN

UniProt

Q9UN36 - NDRG2_HUMAN

Protein

Protein NDRG2

Gene

NDRG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.3 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of cytokine production Source: Ensembl
    3. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    4. negative regulation of smooth muscle cell proliferation Source: Ensembl
    5. regulation of platelet-derived growth factor production Source: Ensembl
    6. regulation of vascular endothelial growth factor production Source: Ensembl
    7. substantia nigra development Source: UniProt
    8. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NDRG2
    Alternative name(s):
    N-myc downstream-regulated gene 2 protein
    Protein Syld709613
    Gene namesi
    Name:NDRG2
    Synonyms:KIAA1248, SYLD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:14460. NDRG2.

    Subcellular locationi

    Cytoplasm. Cytoplasmperinuclear region. Cell projectiongrowth cone By similarity
    Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. cytoplasm Source: HPA
    3. cytosol Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. Golgi apparatus Source: LIFEdb
    6. growth cone Source: UniProtKB-SubCell
    7. microtubule organizing center Source: HPA
    8. nucleus Source: HPA
    9. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi186 – 1861L → D: Decreased interaction with CTNNB1. Abolishes down-regulation of Wnt signaling. 1 Publication

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA31483.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 371370Protein NDRG2PRO_0000159575Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei326 – 3261PhosphoserineBy similarity
    Modified residuei328 – 3281Phosphoserine1 Publication
    Modified residuei330 – 3301PhosphothreonineBy similarity
    Modified residuei332 – 3321Phosphoserine1 Publication
    Modified residuei334 – 3341PhosphothreonineBy similarity
    Modified residuei335 – 3351PhosphoserineBy similarity
    Modified residuei338 – 3381Phosphoserine2 Publications
    Modified residuei348 – 3481Phosphothreonine1 Publication
    Modified residuei350 – 3501PhosphoserineBy similarity
    Modified residuei357 – 3571PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UN36.
    PaxDbiQ9UN36.
    PRIDEiQ9UN36.

    PTM databases

    PhosphoSiteiQ9UN36.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).7 Publications

    Developmental stagei

    Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.2 Publications

    Gene expression databases

    ArrayExpressiQ9UN36.
    BgeeiQ9UN36.
    GenevestigatoriQ9UN36.

    Organism-specific databases

    HPAiCAB017491.
    HPA002896.
    HPA003590.

    Interactioni

    Subunit structurei

    Interacts with CTNNB1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ESR1P033722EBI-3895741,EBI-78473
    RABAC1Q9UI147EBI-8084503,EBI-712367

    Protein-protein interaction databases

    BioGridi121520. 2 interactions.
    IntActiQ9UN36. 3 interactions.
    MINTiMINT-3082604.

    Structurei

    Secondary structure

    1
    371
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi40 – 456
    Beta strandi48 – 5710
    Beta strandi64 – 685
    Helixi75 – 784
    Helixi80 – 845
    Helixi86 – 927
    Beta strandi97 – 1015
    Helixi121 – 1255
    Helixi128 – 1358
    Beta strandi140 – 1456
    Helixi147 – 15812
    Helixi160 – 1623
    Beta strandi163 – 1708
    Helixi178 – 18710
    Turni188 – 1903
    Helixi193 – 2019
    Helixi204 – 2096
    Helixi212 – 22211
    Helixi227 – 23812
    Beta strandi249 – 2513
    Beta strandi257 – 2626
    Helixi268 – 2758
    Turni280 – 2823
    Beta strandi283 – 2886
    Helixi295 – 2984
    Helixi300 – 31415

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XMQX-ray2.81A/B/C40-318[»]
    2XMRX-ray2.00A/B/C40-318[»]
    2XMSX-ray2.15A40-318[»]
    ProteinModelPortaliQ9UN36.
    SMRiQ9UN36. Positions 38-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UN36.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDRG family.Curated

    Phylogenomic databases

    eggNOGiNOG310435.
    HOVERGENiHBG052591.
    InParanoidiQ9UN36.
    OMAiFQFGDMQ.
    OrthoDBiEOG7KH9JS.
    PhylomeDBiQ9UN36.
    TreeFamiTF313168.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR004142. NDRG.
    [Graphical view]
    PANTHERiPTHR11034. PTHR11034. 1 hit.
    PfamiPF03096. Ndr. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UN36-1) [UniParc]FASTAAdd to Basket

    Also known as: NDRG2ins

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV    50
    TFTVYGTPKP KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV 100
    DAPGMEEGAP VFPLGYQYPS LDQLADMIPC VLQYLNFSTI IGVGVGAGAY 150
    ILARYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH 200
    LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR RDLNFERGGD 250
    ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP 300
    GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS 350
    QSSESGTLSS GPPGHTMEVS C 371
    Length:371
    Mass (Da):40,798
    Last modified:January 23, 2002 - v2
    Checksum:i7B49B0B12BD3F595
    GO
    Isoform 2 (identifier: Q9UN36-2) [UniParc]FASTAAdd to Basket

    Also known as: NDRG2var

    The sequence of this isoform differs from the canonical sequence as follows:
         26-39: Missing.

    Show »
    Length:357
    Mass (Da):39,289
    Checksum:iDD793CDC7173704A
    GO
    Isoform 3 (identifier: Q9UN36-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         262-272: Missing.

    Show »
    Length:360
    Mass (Da):39,679
    Checksum:iCB10621C98F95CED
    GO
    Isoform 4 (identifier: Q9UN36-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-39: Missing.
         157-185: Missing.

    Show »
    Length:328
    Mass (Da):36,052
    Checksum:i3B2E97F79C3E2875
    GO
    Isoform 5 (identifier: Q9UN36-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-39: Missing.
         272-287: Missing.

    Show »
    Length:341
    Mass (Da):37,497
    Checksum:i0A213AAB643816C8
    GO
    Isoform 6 (identifier: Q9UN36-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MENGGSMQATM
         26-39: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:367
    Mass (Da):40,297
    Checksum:i26CE96CF6F63D0D6
    GO

    Sequence cautioni

    The sequence BAA86562.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAD62350.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541V → A in AAL08624. (PubMed:11936845)Curated
    Sequence conflicti123 – 1231Q → E in AAH93038. (PubMed:15489334)Curated
    Sequence conflicti172 – 1721D → G in AAK50340. (PubMed:12845671)Curated
    Sequence conflicti250 – 2501D → N in AAL08624. (PubMed:11936845)Curated
    Sequence conflicti282 – 2821Q → R in AAH93038. (PubMed:15489334)Curated
    Sequence conflicti296 – 2961Q → R in AAK50340. (PubMed:12845671)Curated
    Sequence conflicti306 – 3061A → V in AAL08624. (PubMed:11936845)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451T → S.
    Corresponds to variant rs36007455 [ dbSNP | Ensembl ].
    VAR_050236
    Natural varianti48 – 481G → V.1 Publication
    Corresponds to variant rs11552412 [ dbSNP | Ensembl ].
    VAR_026572

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MENGGSMQATM in isoform 6. 1 PublicationVSP_054583
    Alternative sequencei26 – 3914Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 6 PublicationsVSP_003417Add
    BLAST
    Alternative sequencei157 – 18529Missing in isoform 4. 1 PublicationVSP_019007Add
    BLAST
    Alternative sequencei262 – 27211Missing in isoform 3. 1 PublicationVSP_003418Add
    BLAST
    Alternative sequencei272 – 28716Missing in isoform 5. 1 PublicationVSP_019008Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF304051 mRNA. Translation: AAL08624.1.
    AF159092 mRNA. Translation: AAD43131.2.
    AY028430 Genomic DNA. Translation: AAK50340.1.
    AB033074 mRNA. Translation: BAA86562.1. Different initiation.
    AL136574 mRNA. Translation: CAB66509.1.
    BX247987 mRNA. Translation: CAD62321.1.
    BX248031 mRNA. Translation: CAD62350.1. Different initiation.
    AK096999 mRNA. Translation: BAG53405.1.
    AK293514 mRNA. Translation: BAG56997.1.
    CR749252 mRNA. Translation: CAH18108.1.
    AL161668 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66423.1.
    CH471078 Genomic DNA. Translation: EAW66422.1.
    CH471078 Genomic DNA. Translation: EAW66424.1.
    CH471078 Genomic DNA. Translation: EAW66425.1.
    CH471078 Genomic DNA. Translation: EAW66426.1.
    CH471078 Genomic DNA. Translation: EAW66427.1.
    CH471078 Genomic DNA. Translation: EAW66428.1.
    CH471078 Genomic DNA. Translation: EAW66429.1.
    CH471078 Genomic DNA. Translation: EAW66430.1.
    BC010458 mRNA. Translation: AAH10458.1.
    BC011240 mRNA. Translation: AAH11240.1.
    BC093038 mRNA. Translation: AAH93038.1.
    CCDSiCCDS61384.1. [Q9UN36-3]
    CCDS61386.1. [Q9UN36-6]
    CCDS9564.1. [Q9UN36-2]
    CCDS9565.1. [Q9UN36-1]
    RefSeqiNP_001269140.1. NM_001282211.1. [Q9UN36-6]
    NP_001269141.1. NM_001282212.1. [Q9UN36-5]
    NP_001269142.1. NM_001282213.1. [Q9UN36-2]
    NP_001269143.1. NM_001282214.1. [Q9UN36-2]
    NP_001269144.1. NM_001282215.1. [Q9UN36-3]
    NP_001269145.1. NM_001282216.1.
    NP_057334.1. NM_016250.2. [Q9UN36-2]
    NP_963293.1. NM_201535.1. [Q9UN36-1]
    NP_963294.1. NM_201536.1. [Q9UN36-2]
    NP_963831.1. NM_201537.1. [Q9UN36-1]
    NP_963832.1. NM_201538.1. [Q9UN36-2]
    NP_963833.1. NM_201539.1. [Q9UN36-1]
    NP_963834.1. NM_201540.1. [Q9UN36-1]
    NP_963835.1. NM_201541.1. [Q9UN36-2]
    UniGeneiHs.525205.

    Genome annotation databases

    EnsembliENST00000298684; ENSP00000298684; ENSG00000165795. [Q9UN36-4]
    ENST00000298687; ENSP00000298687; ENSG00000165795. [Q9UN36-1]
    ENST00000350792; ENSP00000344620; ENSG00000165795. [Q9UN36-2]
    ENST00000360463; ENSP00000353649; ENSG00000165795. [Q9UN36-2]
    ENST00000397844; ENSP00000380943; ENSG00000165795. [Q9UN36-5]
    ENST00000397847; ENSP00000380945; ENSG00000165795. [Q9UN36-3]
    ENST00000397851; ENSP00000380949; ENSG00000165795. [Q9UN36-1]
    ENST00000397853; ENSP00000380951; ENSG00000165795. [Q9UN36-1]
    ENST00000397856; ENSP00000380954; ENSG00000165795. [Q9UN36-5]
    ENST00000397858; ENSP00000380956; ENSG00000165795. [Q9UN36-1]
    ENST00000403829; ENSP00000385889; ENSG00000165795. [Q9UN36-6]
    ENST00000553503; ENSP00000452306; ENSG00000165795. [Q9UN36-2]
    ENST00000554143; ENSP00000452006; ENSG00000165795. [Q9UN36-2]
    ENST00000555158; ENSP00000452038; ENSG00000165795. [Q9UN36-2]
    ENST00000556147; ENSP00000451712; ENSG00000165795. [Q9UN36-1]
    GeneIDi57447.
    KEGGihsa:57447.
    UCSCiuc001vyt.3. human. [Q9UN36-1]
    uc001vyu.3. human. [Q9UN36-4]
    uc001vyv.3. human. [Q9UN36-2]
    uc001vzc.3. human. [Q9UN36-5]
    uc010aig.3. human. [Q9UN36-3]

    Polymorphism databases

    DMDMi20141615.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF304051 mRNA. Translation: AAL08624.1 .
    AF159092 mRNA. Translation: AAD43131.2 .
    AY028430 Genomic DNA. Translation: AAK50340.1 .
    AB033074 mRNA. Translation: BAA86562.1 . Different initiation.
    AL136574 mRNA. Translation: CAB66509.1 .
    BX247987 mRNA. Translation: CAD62321.1 .
    BX248031 mRNA. Translation: CAD62350.1 . Different initiation.
    AK096999 mRNA. Translation: BAG53405.1 .
    AK293514 mRNA. Translation: BAG56997.1 .
    CR749252 mRNA. Translation: CAH18108.1 .
    AL161668 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66423.1 .
    CH471078 Genomic DNA. Translation: EAW66422.1 .
    CH471078 Genomic DNA. Translation: EAW66424.1 .
    CH471078 Genomic DNA. Translation: EAW66425.1 .
    CH471078 Genomic DNA. Translation: EAW66426.1 .
    CH471078 Genomic DNA. Translation: EAW66427.1 .
    CH471078 Genomic DNA. Translation: EAW66428.1 .
    CH471078 Genomic DNA. Translation: EAW66429.1 .
    CH471078 Genomic DNA. Translation: EAW66430.1 .
    BC010458 mRNA. Translation: AAH10458.1 .
    BC011240 mRNA. Translation: AAH11240.1 .
    BC093038 mRNA. Translation: AAH93038.1 .
    CCDSi CCDS61384.1. [Q9UN36-3 ]
    CCDS61386.1. [Q9UN36-6 ]
    CCDS9564.1. [Q9UN36-2 ]
    CCDS9565.1. [Q9UN36-1 ]
    RefSeqi NP_001269140.1. NM_001282211.1. [Q9UN36-6 ]
    NP_001269141.1. NM_001282212.1. [Q9UN36-5 ]
    NP_001269142.1. NM_001282213.1. [Q9UN36-2 ]
    NP_001269143.1. NM_001282214.1. [Q9UN36-2 ]
    NP_001269144.1. NM_001282215.1. [Q9UN36-3 ]
    NP_001269145.1. NM_001282216.1.
    NP_057334.1. NM_016250.2. [Q9UN36-2 ]
    NP_963293.1. NM_201535.1. [Q9UN36-1 ]
    NP_963294.1. NM_201536.1. [Q9UN36-2 ]
    NP_963831.1. NM_201537.1. [Q9UN36-1 ]
    NP_963832.1. NM_201538.1. [Q9UN36-2 ]
    NP_963833.1. NM_201539.1. [Q9UN36-1 ]
    NP_963834.1. NM_201540.1. [Q9UN36-1 ]
    NP_963835.1. NM_201541.1. [Q9UN36-2 ]
    UniGenei Hs.525205.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XMQ X-ray 2.81 A/B/C 40-318 [» ]
    2XMR X-ray 2.00 A/B/C 40-318 [» ]
    2XMS X-ray 2.15 A 40-318 [» ]
    ProteinModelPortali Q9UN36.
    SMRi Q9UN36. Positions 38-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121520. 2 interactions.
    IntActi Q9UN36. 3 interactions.
    MINTi MINT-3082604.

    PTM databases

    PhosphoSitei Q9UN36.

    Polymorphism databases

    DMDMi 20141615.

    Proteomic databases

    MaxQBi Q9UN36.
    PaxDbi Q9UN36.
    PRIDEi Q9UN36.

    Protocols and materials databases

    DNASUi 57447.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298684 ; ENSP00000298684 ; ENSG00000165795 . [Q9UN36-4 ]
    ENST00000298687 ; ENSP00000298687 ; ENSG00000165795 . [Q9UN36-1 ]
    ENST00000350792 ; ENSP00000344620 ; ENSG00000165795 . [Q9UN36-2 ]
    ENST00000360463 ; ENSP00000353649 ; ENSG00000165795 . [Q9UN36-2 ]
    ENST00000397844 ; ENSP00000380943 ; ENSG00000165795 . [Q9UN36-5 ]
    ENST00000397847 ; ENSP00000380945 ; ENSG00000165795 . [Q9UN36-3 ]
    ENST00000397851 ; ENSP00000380949 ; ENSG00000165795 . [Q9UN36-1 ]
    ENST00000397853 ; ENSP00000380951 ; ENSG00000165795 . [Q9UN36-1 ]
    ENST00000397856 ; ENSP00000380954 ; ENSG00000165795 . [Q9UN36-5 ]
    ENST00000397858 ; ENSP00000380956 ; ENSG00000165795 . [Q9UN36-1 ]
    ENST00000403829 ; ENSP00000385889 ; ENSG00000165795 . [Q9UN36-6 ]
    ENST00000553503 ; ENSP00000452306 ; ENSG00000165795 . [Q9UN36-2 ]
    ENST00000554143 ; ENSP00000452006 ; ENSG00000165795 . [Q9UN36-2 ]
    ENST00000555158 ; ENSP00000452038 ; ENSG00000165795 . [Q9UN36-2 ]
    ENST00000556147 ; ENSP00000451712 ; ENSG00000165795 . [Q9UN36-1 ]
    GeneIDi 57447.
    KEGGi hsa:57447.
    UCSCi uc001vyt.3. human. [Q9UN36-1 ]
    uc001vyu.3. human. [Q9UN36-4 ]
    uc001vyv.3. human. [Q9UN36-2 ]
    uc001vzc.3. human. [Q9UN36-5 ]
    uc010aig.3. human. [Q9UN36-3 ]

    Organism-specific databases

    CTDi 57447.
    GeneCardsi GC14M021484.
    HGNCi HGNC:14460. NDRG2.
    HPAi CAB017491.
    HPA002896.
    HPA003590.
    MIMi 605272. gene.
    neXtProti NX_Q9UN36.
    PharmGKBi PA31483.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310435.
    HOVERGENi HBG052591.
    InParanoidi Q9UN36.
    OMAi FQFGDMQ.
    OrthoDBi EOG7KH9JS.
    PhylomeDBi Q9UN36.
    TreeFami TF313168.

    Miscellaneous databases

    ChiTaRSi NDRG2. human.
    EvolutionaryTracei Q9UN36.
    GeneWikii NDRG2.
    GenomeRNAii 57447.
    NextBioi 35471146.
    PROi Q9UN36.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UN36.
    Bgeei Q9UN36.
    Genevestigatori Q9UN36.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR004142. NDRG.
    [Graphical view ]
    PANTHERi PTHR11034. PTHR11034. 1 hit.
    Pfami PF03096. Ndr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart."
      Zhou R.-H., Kokame K., Tsukamoto Y., Yutani C., Kato H., Miyata T.
      Genomics 73:86-97(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family."
      Qu X., Zhai Y., Wei H., Zhang C., Xing G., Yu Y., He F.
      Mol. Cell. Biochem. 229:35-44(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation."
      Deng Y., Yao L., Chau L., Ng S.S.-M., Peng Y., Liu X., Au W.-S., Wang J., Li F., Ji S., Han H., Nie X., Li Q., Kung H.-F., Leung S.-Y., Lin M.C.-M.
      Int. J. Cancer 106:342-347(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), TISSUE SPECIFICITY, FUNCTION.
      Tissue: Brain.
    4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    6. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
      Tissue: Neuroblastoma.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
      Tissue: Cerebellum and Small intestine.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hippocampus.
    9. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT VAL-48.
      Tissue: Brain.
    12. "Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells."
      Choi S.-C., Kim K.D., Kim J.-T., Kim J.-W., Yoon D.-Y., Choe Y.-K., Chang Y.-S., Paik S.-G., Lim J.-S.
      FEBS Lett. 553:413-418(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    13. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    14. "NDRG2 expression and mutation in human liver and pancreatic cancers."
      Hu X.-L., Liu X.-P., Lin S.-X., Deng Y.-C., Liu N., Li X., Yao L.-B.
      World J. Gastroenterol. 10:3518-3521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    15. "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma."
      Lusis E.A., Watson M.A., Chicoine M.R., Lyman M., Roerig P., Reifenberger G., Gutmann D.H., Perry A.
      Cancer Res. 65:7121-7126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328; SER-332; SER-338 AND THR-348, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor."
      Hwang J., Kim Y., Kang H.B., Jaroszewski L., Deacon A.M., Lee H., Choi W.C., Kim K.J., Kim C.H., Kang B.S., Lee J.O., Oh T.K., Kim J.W., Wilson I.A., Kim M.H.
      J. Biol. Chem. 286:12450-12460(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 40-318, FUNCTION, INTERACTION WITH CTNNB1, MUTAGENESIS OF LEU-186, ABSENCE OF HYDROLASE ACTIVITY.

    Entry informationi

    Entry nameiNDRG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN36
    Secondary accession number(s): B3KUE3
    , B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3