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Protein

Sex comb on midleg-like protein 1

Gene

SCML1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000047634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sex comb on midleg-like protein 1
Gene namesi
Name:SCML1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10580. SCML1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047634.
PharmGKBiPA34998.

Polymorphism and mutation databases

BioMutaiSCML1.
DMDMi254763330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976271 – 329Sex comb on midleg-like protein 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UN30.
PeptideAtlasiQ9UN30.
PRIDEiQ9UN30.

PTM databases

iPTMnetiQ9UN30.
PhosphoSitePlusiQ9UN30.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in fetal and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000047634.
CleanExiHS_SCML1.
ExpressionAtlasiQ9UN30. baseline and differential.
GenevisibleiQ9UN30. HS.

Organism-specific databases

HPAiHPA035270.
HPA035271.
HPA061397.

Interactioni

Protein-protein interaction databases

BioGridi112227. 13 interactors.
IntActiQ9UN30. 14 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9UN30.
SMRiQ9UN30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 325SAMPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the SCM family.Curated
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00840000130035.
HOGENOMiHOG000036073.
HOVERGENiHBG094812.
InParanoidiQ9UN30.
KOiK11464.
OMAiYSPTLPV.
OrthoDBiEOG091G0FBX.
PhylomeDBiQ9UN30.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9UN30-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSNSSSEID VIKTRIPTYD EDDNTILYAY ETKPEFVNKE PNIVSDASCN
60 70 80 90 100
TEEQLKTVDD VLIHCQVIYD ALQNLDKKID VIRRKVSKIQ RFHARSLWTN
110 120 130 140 150
HKRYGYKKHS YRLVKKLKLQ KMKKNEVYET FSYPESYSPT LPVSRRENNS
160 170 180 190 200
PSNLPRPSFC MEEYQRAELE EDPILSRTPS PVHPSDFSEH NCQPYYASDG
210 220 230 240 250
ATYGSSSGLC LGNPRADSIH NTYSTDHASA APPSVTRSPV ENDGYIEEGS
260 270 280 290 300
ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL
310 320
LKHLGVKLGT AVKLCYYIDR LKQGKCFEN
Length:329
Mass (Da):37,447
Last modified:July 28, 2009 - v2
Checksum:i7B9D3679509DE56E
GO
Isoform 1 (identifier: Q9UN30-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Show »
Length:208
Mass (Da):23,131
Checksum:i372BAB0770E2204B
GO
Isoform 2 (identifier: Q9UN30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-39: IKTRIPTYDEDDNTILYAYETKPEFVNK → Q

Show »
Length:302
Mass (Da):34,216
Checksum:i3D0B96B0865ABF96
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378001 – 121Missing in isoform 1. 3 PublicationsAdd BLAST121
Alternative sequenceiVSP_03780112 – 39IKTRI…EFVNK → Q in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160728 mRNA. Translation: AAD47635.1.
EU370780 Genomic DNA. Translation: ABY68575.1.
AK313993 mRNA. Translation: BAG36705.1.
Z93242 Genomic DNA. Translation: CAI42727.1.
Z93242 Genomic DNA. Translation: CAI42728.1.
CH471074 Genomic DNA. Translation: EAW98929.1.
BC105028 mRNA. Translation: AAI05029.1.
BC026159 mRNA. Translation: AAH26159.2.
CCDSiCCDS14182.2. [Q9UN30-2]
CCDS35210.1. [Q9UN30-3]
CCDS35211.1. [Q9UN30-1]
RefSeqiNP_001032624.1. NM_001037535.2. [Q9UN30-1]
NP_001032625.1. NM_001037536.2. [Q9UN30-1]
NP_001032629.1. NM_001037540.2. [Q9UN30-3]
NP_006737.2. NM_006746.5. [Q9UN30-2]
XP_006724571.1. XM_006724508.3. [Q9UN30-3]
XP_016885212.1. XM_017029723.1. [Q9UN30-2]
UniGeneiHs.109655.
Hs.658510.

Genome annotation databases

EnsembliENST00000380041; ENSP00000369380; ENSG00000047634. [Q9UN30-3]
ENST00000380043; ENSP00000369382; ENSG00000047634. [Q9UN30-2]
ENST00000380045; ENSP00000369384; ENSG00000047634. [Q9UN30-1]
ENST00000398080; ENSP00000381154; ENSG00000047634. [Q9UN30-1]
GeneIDi6322.
KEGGihsa:6322.
UCSCiuc004cyb.5. human. [Q9UN30-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF160728 mRNA. Translation: AAD47635.1.
EU370780 Genomic DNA. Translation: ABY68575.1.
AK313993 mRNA. Translation: BAG36705.1.
Z93242 Genomic DNA. Translation: CAI42727.1.
Z93242 Genomic DNA. Translation: CAI42728.1.
CH471074 Genomic DNA. Translation: EAW98929.1.
BC105028 mRNA. Translation: AAI05029.1.
BC026159 mRNA. Translation: AAH26159.2.
CCDSiCCDS14182.2. [Q9UN30-2]
CCDS35210.1. [Q9UN30-3]
CCDS35211.1. [Q9UN30-1]
RefSeqiNP_001032624.1. NM_001037535.2. [Q9UN30-1]
NP_001032625.1. NM_001037536.2. [Q9UN30-1]
NP_001032629.1. NM_001037540.2. [Q9UN30-3]
NP_006737.2. NM_006746.5. [Q9UN30-2]
XP_006724571.1. XM_006724508.3. [Q9UN30-3]
XP_016885212.1. XM_017029723.1. [Q9UN30-2]
UniGeneiHs.109655.
Hs.658510.

3D structure databases

ProteinModelPortaliQ9UN30.
SMRiQ9UN30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112227. 13 interactors.
IntActiQ9UN30. 14 interactors.

PTM databases

iPTMnetiQ9UN30.
PhosphoSitePlusiQ9UN30.

Polymorphism and mutation databases

BioMutaiSCML1.
DMDMi254763330.

Proteomic databases

PaxDbiQ9UN30.
PeptideAtlasiQ9UN30.
PRIDEiQ9UN30.

Protocols and materials databases

DNASUi6322.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380041; ENSP00000369380; ENSG00000047634. [Q9UN30-3]
ENST00000380043; ENSP00000369382; ENSG00000047634. [Q9UN30-2]
ENST00000380045; ENSP00000369384; ENSG00000047634. [Q9UN30-1]
ENST00000398080; ENSP00000381154; ENSG00000047634. [Q9UN30-1]
GeneIDi6322.
KEGGihsa:6322.
UCSCiuc004cyb.5. human. [Q9UN30-3]

Organism-specific databases

CTDi6322.
GeneCardsiSCML1.
HGNCiHGNC:10580. SCML1.
HPAiHPA035270.
HPA035271.
HPA061397.
MIMi300227. gene.
neXtProtiNX_Q9UN30.
OpenTargetsiENSG00000047634.
PharmGKBiPA34998.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00840000130035.
HOGENOMiHOG000036073.
HOVERGENiHBG094812.
InParanoidiQ9UN30.
KOiK11464.
OMAiYSPTLPV.
OrthoDBiEOG091G0FBX.
PhylomeDBiQ9UN30.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000047634-MONOMER.

Miscellaneous databases

GenomeRNAii6322.
PROiQ9UN30.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000047634.
CleanExiHS_SCML1.
ExpressionAtlasiQ9UN30. baseline and differential.
GenevisibleiQ9UN30. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCML1_HUMAN
AccessioniPrimary (citable) accession number: Q9UN30
Secondary accession number(s): B0FZN6
, B2RA08, Q5H968, Q5H969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.