ID   Q9UN28_HUMAN            Unreviewed;       339 AA.
AC   Q9UN28;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   RecName: Full=C-C chemokine receptor type 5 {ECO:0000256|ARBA:ARBA00019124};
DE   Flags: Fragment;
GN   Name=CCR5 {ECO:0000313|EMBL:AAD47670.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAD47670.1};
RN   [1] {ECO:0000313|EMBL:AAD47670.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kunstman K., Chen Z., Korber B., Oprondek J., Stanton J., Agy M.,
RA   Shibata R., Yoder A., Pillai S., Kuiken C., Marx P., Wolinksy S.;
RT   "Sequences of the CCR5 genes from diverse simian and prosimian species.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAD47670.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14581567; DOI=10.1128/JVI.77.22.12310-12318.2003;
RA   Kunstman K.J., Puffer B., Korber B.T., Kuiken C., Smith U.R., Kunstman J.,
RA   Stanton J., Agy M., Shibata R., Yoder A.D., Pillai S., Doms R.W., Marx P.,
RA   Wolinsky S.M.;
RT   "Structure and function of CC-chemokine receptor 5 homologues derived from
RT   representative primate species and subspecies of the taxonomic suborders
RT   Prosimii and Anthropoidea.";
RL   J. Virol. 77:12310-12318(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; AF161913; AAD47670.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9UN28; -.
DR   PeptideAtlas; Q9UN28; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   CDD; cd15184; 7tmA_CCR5_CCR2; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR002240; Chemokine_CCR5.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF686; C-C CHEMOKINE RECEPTOR TYPE 5; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01110; CHEMOKINER5.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AAD47670.1};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        61..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..290
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAD47670.1"
FT   NON_TER         339
FT                   /evidence="ECO:0000313|EMBL:AAD47670.1"
SQ   SEQUENCE   339 AA;  39184 MW;  56C819F92D6DB1A6 CRC64;
     PIYDINYYTS EPCQKINVKQ IAARLLPPLY SLVFIFGFVG NMLVILILIN CKRLKSMTDI
     YLLNLAISDL FFLLTVPFWA HYAAAQWDFG NTMCQLLTGL YFIGFFSGIF FIILLTIDRY
     LAVVHAVFAL KARTVTFGVV TSVITWVVAV FASLPGIIFT RSQKEGLHYT CSSHFPYSQY
     QFWKNFQTLK IVILGLVLPL LVMVICYSGI LKTLLRCRNE KKRHRAVRLI FTIMIVYFLF
     WAPYNIVLLL NTFQEFFGLN NCRSSNRLDQ AMQVTETLGM THCCINPIIY AFVGEKFRNY
     LLVFFQKHIA KRFCKCCSIF QQEAPERASS VYTRSTGEQ
//