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Q9UN28

- Q9UN28_HUMAN

UniProt

Q9UN28 - Q9UN28_HUMAN

Protein
Submitted name:

C-C chemokine receptor 5

Gene

CCR5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. immune response Source: InterPro
    3. inflammatory response Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    C-C chemokine receptor 5Imported
    Gene namesi
    Name:CCR5Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UN28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG106917.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002240. Chemokine_CCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01110. CHEMOKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9UN28-1 [UniParc]FASTAAdd to Basket

    « Hide

    PIYDINYYTS EPCQKINVKQ IAARLLPPLY SLVFIFGFVG NMLVILILIN    50
    CKRLKSMTDI YLLNLAISDL FFLLTVPFWA HYAAAQWDFG NTMCQLLTGL 100
    YFIGFFSGIF FIILLTIDRY LAVVHAVFAL KARTVTFGVV TSVITWVVAV 150
    FASLPGIIFT RSQKEGLHYT CSSHFPYSQY QFWKNFQTLK IVILGLVLPL 200
    LVMVICYSGI LKTLLRCRNE KKRHRAVRLI FTIMIVYFLF WAPYNIVLLL 250
    NTFQEFFGLN NCRSSNRLDQ AMQVTETLGM THCCINPIIY AFVGEKFRNY 300
    LLVFFQKHIA KRFCKCCSIF QQEAPERASS VYTRSTGEQ 339
    Length:339
    Mass (Da):39,184
    Last modified:May 1, 2000 - v1
    Checksum:i56C819F92D6DB1A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei339 – 3391Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161913 Genomic DNA. Translation: AAD47670.1.
    UniGeneiHs.450802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161913 Genomic DNA. Translation: AAD47670.1 .
    UniGenei Hs.450802.

    3D structure databases

    ProteinModelPortali Q9UN28.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106917.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002240. Chemokine_CCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01110. CHEMOKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of the CCR5 genes from diverse simian and prosimian species."
      Kunstman K., Chen Z., Korber B., Oprondek J., Stanton J., Agy M., Shibata R., Yoder A., Pillai S., Kuiken C., Marx P., Wolinksy S.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea."
      Kunstman K.J., Puffer B., Korber B.T., Kuiken C., Smith U.R., Kunstman J., Stanton J., Agy M., Shibata R., Yoder A.D., Pillai S., Doms R.W., Marx P., Wolinsky S.M.
      J. Virol. 77:12310-12318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UN28_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN28
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.