Q9UN28 (Q9UN28_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
C-C chemokine receptor 5 EMBL AAD47670.1

Gene names

Name:

CCR5 EMBL AAD47670.1

Organism

Homo sapiens (Human) EMBL AAD47670.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	339 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS000355
Molecular function	G-protein coupled receptor RuleBase RU000688 SAAS SAAS000355 Receptor Transducer
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAD47670.1
	Non-terminal residue	339	1	EMBL AAD47670.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UN28 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 56C819F92D6DB1A6	FASTA	339	39,184
	10 20 30 40 50 60 PIYDINYYTS EPCQKINVKQ IAARLLPPLY SLVFIFGFVG NMLVILILIN CKRLKSMTDI 70 80 90 100 110 120 YLLNLAISDL FFLLTVPFWA HYAAAQWDFG NTMCQLLTGL YFIGFFSGIF FIILLTIDRY 130 140 150 160 170 180 LAVVHAVFAL KARTVTFGVV TSVITWVVAV FASLPGIIFT RSQKEGLHYT CSSHFPYSQY 190 200 210 220 230 240 QFWKNFQTLK IVILGLVLPL LVMVICYSGI LKTLLRCRNE KKRHRAVRLI FTIMIVYFLF 250 260 270 280 290 300 WAPYNIVLLL NTFQEFFGLN NCRSSNRLDQ AMQVTETLGM THCCINPIIY AFVGEKFRNY 310 320 330 LLVFFQKHIA KRFCKCCSIF QQEAPERASS VYTRSTGEQ

References

[1]	"Sequences of the CCR5 genes from diverse simian and prosimian species." Kunstman K., Chen Z., Korber B., Oprondek J., Stanton J., Agy M., Shibata R., Yoder A., Pillai S., Kuiken C., Marx P., Wolinksy S. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea." Kunstman K.J., Puffer B., Korber B.T., Kuiken C., Smith U.R., Kunstman J., Stanton J., Agy M., Shibata R., Yoder A.D., Pillai S., Doms R.W., Marx P., Wolinsky S.M. J. Virol. 77:12310-12318(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF161913 Genomic DNA. Translation: AAD47670.1.
IPI	IPI00743929.
UniGene	Hs.450802.
3D structure databases
ProteinModelPortal	Q9UN28.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106917.
Family and domain databases
InterPro	IPR002240. Chemokine_CCR5. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01110. CHEMOKINER5. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UN28_HUMAN

Accession

Primary (citable) accession number: Q9UN28

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.