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Q9UMZ3

- PTPRQ_HUMAN

UniProt

Q9UMZ3 - PTPRQ_HUMAN

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Protein

Phosphatidylinositol phosphatase PTPRQ

Gene
PTPRQ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2233 – 22331Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inner ear morphogenesis Source: Ensembl
  2. regulation of fat cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
Gene namesi
Name:PTPRQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9679. PTPRQ.

Subcellular locationi

Membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 19471912Extracellular Reviewed predictionAdd
BLAST
Transmembranei1948 – 196821Helical; Reviewed predictionAdd
BLAST
Topological domaini1969 – 2332364Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 84A (DFNB84A) [MIM:613391]: A form of non-syndromic deafness characterized by progressive, sensorineural hearing loss and vestibular dysfunction.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811R → G in DFNB84A. 1 Publication
VAR_063526

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MIMi613391. phenotype.
Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Chaini36 – 23322297Phosphatidylinositol phosphatase PTPRQPRO_0000302850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi944 – 9441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1038 – 10381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1080 – 10801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1101 – 11011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1290 – 12901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1295 – 12951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1844 – 18441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UMZ3.
PRIDEiQ9UMZ3.

PTM databases

PhosphoSiteiQ9UMZ3.

Expressioni

Tissue specificityi

In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.2 Publications

Developmental stagei

Expressed at highest levels in fetal kidney, followed by fetal lung and fetal cochlea.1 Publication

Inductioni

Down-regulated during adipogenesis of mesenchymal stem cells.1 Publication

Gene expression databases

BgeeiQ9UMZ3.
CleanExiHS_PTPRQ.
GenevestigatoriQ9UMZ3.

Organism-specific databases

HPAiHPA053245.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393751.

Structurei

Secondary structure

1
2332
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2018 – 20203
Helixi2021 – 204222
Helixi2053 – 20564
Helixi2058 – 20636
Turni2073 – 20753
Turni2086 – 20894
Beta strandi2092 – 20965
Beta strandi2099 – 21013
Beta strandi2105 – 21095
Helixi2113 – 21153
Helixi2116 – 212611
Beta strandi2130 – 21334
Beta strandi2156 – 21594
Beta strandi2162 – 217110
Beta strandi2173 – 218412
Beta strandi2187 – 219610
Beta strandi2201 – 22044
Helixi2209 – 222113
Beta strandi2224 – 22263
Beta strandi2229 – 223810
Helixi2239 – 225517
Beta strandi2257 – 22593
Helixi2261 – 227111
Helixi2279 – 229214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKCX-ray1.56A2015-2293[»]
ProteinModelPortaliQ9UMZ3.
SMRiQ9UMZ3. Positions 11-232, 309-474, 572-1460, 1472-1576, 1583-1659, 1701-1776, 1988-2328.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 9964Fibronectin type-III 1Add
BLAST
Domaini100 – 19596Fibronectin type-III 2Add
BLAST
Domaini199 – 29496Fibronectin type-III 3Add
BLAST
Domaini350 – 43889Fibronectin type-III 4Add
BLAST
Domaini441 – 53999Fibronectin type-III 5Add
BLAST
Domaini514 – 60693Fibronectin type-III 6Add
BLAST
Domaini610 – 70596Fibronectin type-III 7Add
BLAST
Domaini710 – 79990Fibronectin type-III 8Add
BLAST
Domaini804 – 89491Fibronectin type-III 9Add
BLAST
Domaini899 – 98890Fibronectin type-III 10Add
BLAST
Domaini993 – 1093101Fibronectin type-III 11Add
BLAST
Domaini1098 – 119093Fibronectin type-III 12Add
BLAST
Domaini1192 – 128291Fibronectin type-III 13Add
BLAST
Domaini1287 – 138094Fibronectin type-III 14Add
BLAST
Domaini1384 – 147087Fibronectin type-III 15Add
BLAST
Domaini1474 – 1578105Fibronectin type-III 16Add
BLAST
Domaini1583 – 168199Fibronectin type-III 17Add
BLAST
Domaini1686 – 1787102Fibronectin type-III 18Add
BLAST
Domaini2036 – 2292257Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000115793.
HOVERGENiHBG108308.
InParanoidiQ9UMZ3.
PhylomeDBiQ9UMZ3.
TreeFamiTF351926.

Family and domain databases

Gene3Di2.60.40.10. 19 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 17 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 17 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UMZ3-1 [UniParc]FASTAAdd to Basket

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MKKVPIKPEQ PEKLRAFNIS THSFSLHWSL PSGHVERYQV DLVPDSGFVT     50
IRDLGGGEYQ VDVSNVVPGT RYDITISSIS TTYTSPVTRI VTTNVTKPGP 100
PVFLAGERVG SAGILLSWNT PPNPNGRIIS YIVKYKEVCP WMQTVYTQVR 150
SKPDSLEVLL TNLNPGTTYE IKVAAENSAG IGVFSDPFLF QTAESAPGKV 200
VNLTVEAYNA SAVKLIWYLP RQPNGKITSF KISVKHARSG IVVKDVSIRV 250
EDILTGKLPE CNENSESFLW STASPSPTLG RVTPPSRTTH SSSTLTQNEI 300
SSVWKEPISF VVTHLRPYTT YLFEVSAVTT EAGYIDSTIV RTPESVPEGP 350
PQNCVTGNIT GKSFSILWDP PTIVTGKFSY RVELYGPSGR ILDNSTKDLK 400
FAFTNLTPFT MYDVYIAAET SAGTGPKSNI SVFTPPDVPG AVFDLQLAEV 450
ESTQVRITWK KPRQPNGIIN QYRVKVLVPE TGIILENTLL TGNNEYINDP 500
MAPEIVNIVE PMVGLYEGSA EMSSDLHSLA TFIYNSHPDK NFPARNRAED 550
QTSPVVTTRN QYITDIAAEQ LSYVIRRLVP FTEHMISVSA FTIMGEGPPT 600
VLSVRTRQQV PSSIKIINYK NISSSSILLY WDPPEYPNGK ITHYTIYAME 650
LDTNRAFQIT TIDNSFLITG LKKYTKYKMR VAASTHVGES SLSEENDIFV 700
RTSEDEPESS PQDVEVIDVT ADEIRLKWSP PEKPNGIIIA YEVLYKNIDT 750
LYMKNTSTTD IILRNLRPHT LYNISVRSYT RFGHGNQVSS LLSVRTSETV 800
PDSAPENITY KNISSGEIEL SFLPPSSPNG IIKKYTIYLK RSNGNEERTI 850
NTTSLTQNIK VLKKYTQYII EVSASTLKGE GVRSAPISIL TEEDAPDSPP 900
QDFSVKQLSG VTVKLSWQPP LEPNGIILYY TVYVWNRSSL KTINVTETSL 950
ELSDLDYNVE YSAYVTASTR FGDGKTRSNI ISFQTPEGAP SDPPKDVYYA 1000
NLSSSSIILF WTPPSKPNGI IQYYSVYYRN TSGTFMQNFT LHEVTNDFDN 1050
MTVSTIIDKL TIFSYYTFWL TASTSVGNGN KSSDIIEVYT DQDIPEGFVG 1100
NLTYESISST AINVSWVPPA QPNGLVFYYV SLILQQTPRH VRPPLVTYER 1150
SIYFDNLEKY TDYILKITPS TEKGFSDTYT AQLYIKTEED VPETSPIINT 1200
FKNLSSTSVL LSWDPPVKPN GAIISYDLTL QGPNENYSFI TSDNYIILEE 1250
LSPFTLYSFF AAARTRKGLG PSSILFFYTD ESVPLAPPQN LTLINCTSDF 1300
VWLKWSPSPL PGGIVKVYSF KIHEHETDTI YYKNISGFKT EAKLVGLEPV 1350
STYSIRVSAF TKVGNGNQFS NVVKFTTQES VPDVVQNMQC MATSWQSVLV 1400
KWDPPKKANG IITQYMVTVE RNSTKVSPQD HMYTFIKLLA NTSYVFKVRA 1450
STSAGEGDES TCHVSTLPET VPSVPTNIAF SDVQSTSATL TWIRPDTILG 1500
YFQNYKITTQ LRAQKCKEWE SEECVEYQKI QYLYEAHLTE ETVYGLKKFR 1550
WYRFQVAAST NAGYGNASNW ISTKTLPGPP DGPPENVHVV ATSPFSISIS 1600
WSEPAVITGP TCYLIDVKSV DNDEFNISFI KSNEENKTIE IKDLEIFTRY 1650
SVVITAFTGN ISAAYVEGKS SAEMIVTTLE SAPKDPPNNM TFQKIPDEVT 1700
KFQLTFLPPS QPNGNIQVYQ ALVYREDDPT AVQIHNLSII QKTNTFVIAM 1750
LEGLKGGHTY NISVYAVNSA GAGPKVPMRI TMDIKAPARP KTKPTPIYDA 1800
TGKLLVTSTT ITIRMPICYY SDDHGPIKNV QVLVTETGAQ HDGNVTKWYD 1850
AYFNKARPYF TNEGFPNPPC TEGKTKFSGN EEIYIIGADN ACMIPGNEDK 1900
ICNGPLKPKK QYLFKFRATN IMGQFTDSDY SDPVKTLGEG LSERTVEIIL 1950
SVTLCILSII LLGTAIFAFA RIRQKQKEGG TYSPQDAEII DTKLKLDQLI 2000
TVADLELKDE RLTRPISKKS FLQHVEELCT NNNLKFQEEF SELPKFLQDL 2050
SSTDADLPWN RAKNRFPNIK PYNNNRVKLI ADASVPGSDY INASYISGYL 2100
CPNEFIATQG PLPGTVGDFW RMVWETRAKT LVMLTQCFEK GRIRCHQYWP 2150
EDNKPVTVFG DIVITKLMED VQIDWTIRDL KIERHGDCMT VRQCNFTAWP 2200
EHGVPENSAP LIHFVKLVRA SRAHDTTPMI VHCSAGVGRT GVFIALDHLT 2250
QHINDHDFVD IYGLVAELRS ERMCMVQNLA QYIFLHQCIL DLLSNKGSNQ 2300
PICFVNYSAL QKMDSLDAME GDVELEWEET TM 2332
Length:2,332
Mass (Da):260,924
Last modified:September 11, 2007 - v2
Checksum:i999D87AA00BA04C2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811R → G in DFNB84A. 1 Publication
VAR_063526
Natural varianti471 – 4711Q → E.1 Publication
Corresponds to variant rs61729287 [ dbSNP | Ensembl ].
VAR_069041
Natural varianti1040 – 10401T → I.
Corresponds to variant rs12316867 [ dbSNP | Ensembl ].
VAR_034970
Natural varianti1098 – 10981F → L.
Corresponds to variant rs6539524 [ dbSNP | Ensembl ].
VAR_034971
Natural varianti1120 – 11201A → P.
Corresponds to variant rs7975340 [ dbSNP | Ensembl ].
VAR_034972
Natural varianti1244 – 12441N → D.
Corresponds to variant rs17713202 [ dbSNP | Ensembl ].
VAR_034973
Natural varianti1734 – 17341I → T.
Corresponds to variant rs7963963 [ dbSNP | Ensembl ].
VAR_034974
Natural varianti2121 – 21211R → K.
Corresponds to variant rs1163042 [ dbSNP | Ensembl ].
VAR_034975

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC083812 Genomic DNA. No translation available.
AC074031 Genomic DNA. No translation available.
AF169351 mRNA. Translation: AAD50277.1.
UniGeneiHs.539284.

Genome annotation databases

EnsembliENST00000266688; ENSP00000266688; ENSG00000139304.
UCSCiuc001sze.2. human.

Polymorphism databases

DMDMi158563998.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC083812 Genomic DNA. No translation available.
AC074031 Genomic DNA. No translation available.
AF169351 mRNA. Translation: AAD50277.1 .
UniGenei Hs.539284.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IKC X-ray 1.56 A 2015-2293 [» ]
ProteinModelPortali Q9UMZ3.
SMRi Q9UMZ3. Positions 11-232, 309-474, 572-1460, 1472-1576, 1583-1659, 1701-1776, 1988-2328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000393751.

PTM databases

PhosphoSitei Q9UMZ3.

Polymorphism databases

DMDMi 158563998.

Proteomic databases

PaxDbi Q9UMZ3.
PRIDEi Q9UMZ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266688 ; ENSP00000266688 ; ENSG00000139304 .
UCSCi uc001sze.2. human.

Organism-specific databases

GeneCardsi GC12P080837.
H-InvDB HIX0201920.
HGNCi HGNC:9679. PTPRQ.
HPAi HPA053245.
MIMi 603317. gene.
613391. phenotype.
neXtProti NX_Q9UMZ3.
Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000115793.
HOVERGENi HBG108308.
InParanoidi Q9UMZ3.
PhylomeDBi Q9UMZ3.
TreeFami TF351926.

Miscellaneous databases

PROi Q9UMZ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UMZ3.
CleanExi HS_PTPRQ.
Genevestigatori Q9UMZ3.

Family and domain databases

Gene3Di 2.60.40.10. 19 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 17 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 17 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Differential expression of PTPase RNAs resulting from K562 differentiation induced by PMA."
    Dayton M.A., Blanchard K.L.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2133-2266.
  3. "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
    Seifert R.A., Coats S.A., Oganesian A., Wright M.B., Dishmon M., Booth C.J., Johnson R.J., Alpers C.E., Bowen-Pope D.F.
    Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells."
    Jung H., Kim W.K., Kim do H., Cho Y.S., Kim S.J., Park S.G., Park B.C., Lim H.M., Bae K.H., Lee S.C.
    Biochem. Biophys. Res. Commun. 383:252-257(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  5. "Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction."
    Schraders M., Oostrik J., Huygen P.L., Strom T.M., van Wijk E., Kunst H.P., Hoefsloot L.H., Cremers C.W., Admiraal R.J., Kremer H.
    Am. J. Hum. Genet. 86:604-610(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT DFNB84A GLY-281.
  6. "Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84."
    Shahin H., Rahil M., Abu Rayan A., Avraham K.B., King M.C., Kanaan M., Walsh T.
    J. Med. Genet. 47:643-645(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN DFNB84A, VARIANT GLU-471.

Entry informationi

Entry nameiPTPRQ_HUMAN
AccessioniPrimary (citable) accession number: Q9UMZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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