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Q9UMZ3

- PTPRQ_HUMAN

UniProt

Q9UMZ3 - PTPRQ_HUMAN

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Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

PTPRQ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2233 – 22331Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of fat cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
Alternative name(s):
Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
Short name:
PTP-RQ
Short name:
R-PTP-Q
Gene namesi
Name:PTPRQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:9679. PTPRQ.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 19471912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1948 – 196821HelicalSequence AnalysisAdd
BLAST
Topological domaini1969 – 2332364CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 84A (DFNB84A) [MIM:613391]: A form of non-syndromic deafness characterized by progressive, sensorineural hearing loss and vestibular dysfunction.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811R → G in DFNB84A. 1 Publication
VAR_063526

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MIMi613391. phenotype.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 23322297Phosphatidylinositol phosphatase PTPRQPRO_0000302850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi944 – 9441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1038 – 10381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1080 – 10801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1101 – 11011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1290 – 12901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1295 – 12951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1844 – 18441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UMZ3.
PRIDEiQ9UMZ3.

PTM databases

PhosphoSiteiQ9UMZ3.

Expressioni

Tissue specificityi

In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.2 Publications

Developmental stagei

Expressed at highest levels in fetal kidney, followed by fetal lung and fetal cochlea.1 Publication

Inductioni

Down-regulated during adipogenesis of mesenchymal stem cells.1 Publication

Gene expression databases

BgeeiQ9UMZ3.
CleanExiHS_PTPRQ.
GenevestigatoriQ9UMZ3.

Organism-specific databases

HPAiHPA053245.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393751.

Structurei

Secondary structure

1
2332
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2018 – 20203Combined sources
Helixi2021 – 204222Combined sources
Helixi2053 – 20564Combined sources
Helixi2058 – 20636Combined sources
Turni2073 – 20753Combined sources
Turni2086 – 20894Combined sources
Beta strandi2092 – 20965Combined sources
Beta strandi2099 – 21013Combined sources
Beta strandi2105 – 21095Combined sources
Helixi2113 – 21153Combined sources
Helixi2116 – 212611Combined sources
Beta strandi2130 – 21334Combined sources
Beta strandi2156 – 21594Combined sources
Beta strandi2162 – 217110Combined sources
Beta strandi2173 – 218412Combined sources
Beta strandi2187 – 219610Combined sources
Beta strandi2201 – 22044Combined sources
Helixi2209 – 222113Combined sources
Beta strandi2224 – 22263Combined sources
Beta strandi2229 – 223810Combined sources
Helixi2239 – 225517Combined sources
Beta strandi2257 – 22593Combined sources
Helixi2261 – 227111Combined sources
Helixi2279 – 229214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKCX-ray1.56A2015-2293[»]
ProteinModelPortaliQ9UMZ3.
SMRiQ9UMZ3. Positions 11-232, 310-335, 347-429, 572-1271, 1288-1406, 1432-1458, 1472-1576, 1701-1776, 1988-2328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 9964Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 19596Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini199 – 29496Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini350 – 43889Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 53999Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini514 – 60693Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini610 – 70596Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 79990Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini804 – 89491Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini899 – 98890Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini993 – 1093101Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Domaini1098 – 119093Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini1192 – 128291Fibronectin type-III 13PROSITE-ProRule annotationAdd
BLAST
Domaini1287 – 138094Fibronectin type-III 14PROSITE-ProRule annotationAdd
BLAST
Domaini1384 – 147087Fibronectin type-III 15PROSITE-ProRule annotationAdd
BLAST
Domaini1474 – 1578105Fibronectin type-III 16PROSITE-ProRule annotationAdd
BLAST
Domaini1583 – 168199Fibronectin type-III 17PROSITE-ProRule annotationAdd
BLAST
Domaini1686 – 1787102Fibronectin type-III 18PROSITE-ProRule annotationAdd
BLAST
Domaini2036 – 2292257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000115793.
HOVERGENiHBG108308.
InParanoidiQ9UMZ3.
PhylomeDBiQ9UMZ3.
TreeFamiTF351926.

Family and domain databases

Gene3Di2.60.40.10. 19 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 17 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 17 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UMZ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVPIKPEQ PEKLRAFNIS THSFSLHWSL PSGHVERYQV DLVPDSGFVT
60 70 80 90 100
IRDLGGGEYQ VDVSNVVPGT RYDITISSIS TTYTSPVTRI VTTNVTKPGP
110 120 130 140 150
PVFLAGERVG SAGILLSWNT PPNPNGRIIS YIVKYKEVCP WMQTVYTQVR
160 170 180 190 200
SKPDSLEVLL TNLNPGTTYE IKVAAENSAG IGVFSDPFLF QTAESAPGKV
210 220 230 240 250
VNLTVEAYNA SAVKLIWYLP RQPNGKITSF KISVKHARSG IVVKDVSIRV
260 270 280 290 300
EDILTGKLPE CNENSESFLW STASPSPTLG RVTPPSRTTH SSSTLTQNEI
310 320 330 340 350
SSVWKEPISF VVTHLRPYTT YLFEVSAVTT EAGYIDSTIV RTPESVPEGP
360 370 380 390 400
PQNCVTGNIT GKSFSILWDP PTIVTGKFSY RVELYGPSGR ILDNSTKDLK
410 420 430 440 450
FAFTNLTPFT MYDVYIAAET SAGTGPKSNI SVFTPPDVPG AVFDLQLAEV
460 470 480 490 500
ESTQVRITWK KPRQPNGIIN QYRVKVLVPE TGIILENTLL TGNNEYINDP
510 520 530 540 550
MAPEIVNIVE PMVGLYEGSA EMSSDLHSLA TFIYNSHPDK NFPARNRAED
560 570 580 590 600
QTSPVVTTRN QYITDIAAEQ LSYVIRRLVP FTEHMISVSA FTIMGEGPPT
610 620 630 640 650
VLSVRTRQQV PSSIKIINYK NISSSSILLY WDPPEYPNGK ITHYTIYAME
660 670 680 690 700
LDTNRAFQIT TIDNSFLITG LKKYTKYKMR VAASTHVGES SLSEENDIFV
710 720 730 740 750
RTSEDEPESS PQDVEVIDVT ADEIRLKWSP PEKPNGIIIA YEVLYKNIDT
760 770 780 790 800
LYMKNTSTTD IILRNLRPHT LYNISVRSYT RFGHGNQVSS LLSVRTSETV
810 820 830 840 850
PDSAPENITY KNISSGEIEL SFLPPSSPNG IIKKYTIYLK RSNGNEERTI
860 870 880 890 900
NTTSLTQNIK VLKKYTQYII EVSASTLKGE GVRSAPISIL TEEDAPDSPP
910 920 930 940 950
QDFSVKQLSG VTVKLSWQPP LEPNGIILYY TVYVWNRSSL KTINVTETSL
960 970 980 990 1000
ELSDLDYNVE YSAYVTASTR FGDGKTRSNI ISFQTPEGAP SDPPKDVYYA
1010 1020 1030 1040 1050
NLSSSSIILF WTPPSKPNGI IQYYSVYYRN TSGTFMQNFT LHEVTNDFDN
1060 1070 1080 1090 1100
MTVSTIIDKL TIFSYYTFWL TASTSVGNGN KSSDIIEVYT DQDIPEGFVG
1110 1120 1130 1140 1150
NLTYESISST AINVSWVPPA QPNGLVFYYV SLILQQTPRH VRPPLVTYER
1160 1170 1180 1190 1200
SIYFDNLEKY TDYILKITPS TEKGFSDTYT AQLYIKTEED VPETSPIINT
1210 1220 1230 1240 1250
FKNLSSTSVL LSWDPPVKPN GAIISYDLTL QGPNENYSFI TSDNYIILEE
1260 1270 1280 1290 1300
LSPFTLYSFF AAARTRKGLG PSSILFFYTD ESVPLAPPQN LTLINCTSDF
1310 1320 1330 1340 1350
VWLKWSPSPL PGGIVKVYSF KIHEHETDTI YYKNISGFKT EAKLVGLEPV
1360 1370 1380 1390 1400
STYSIRVSAF TKVGNGNQFS NVVKFTTQES VPDVVQNMQC MATSWQSVLV
1410 1420 1430 1440 1450
KWDPPKKANG IITQYMVTVE RNSTKVSPQD HMYTFIKLLA NTSYVFKVRA
1460 1470 1480 1490 1500
STSAGEGDES TCHVSTLPET VPSVPTNIAF SDVQSTSATL TWIRPDTILG
1510 1520 1530 1540 1550
YFQNYKITTQ LRAQKCKEWE SEECVEYQKI QYLYEAHLTE ETVYGLKKFR
1560 1570 1580 1590 1600
WYRFQVAAST NAGYGNASNW ISTKTLPGPP DGPPENVHVV ATSPFSISIS
1610 1620 1630 1640 1650
WSEPAVITGP TCYLIDVKSV DNDEFNISFI KSNEENKTIE IKDLEIFTRY
1660 1670 1680 1690 1700
SVVITAFTGN ISAAYVEGKS SAEMIVTTLE SAPKDPPNNM TFQKIPDEVT
1710 1720 1730 1740 1750
KFQLTFLPPS QPNGNIQVYQ ALVYREDDPT AVQIHNLSII QKTNTFVIAM
1760 1770 1780 1790 1800
LEGLKGGHTY NISVYAVNSA GAGPKVPMRI TMDIKAPARP KTKPTPIYDA
1810 1820 1830 1840 1850
TGKLLVTSTT ITIRMPICYY SDDHGPIKNV QVLVTETGAQ HDGNVTKWYD
1860 1870 1880 1890 1900
AYFNKARPYF TNEGFPNPPC TEGKTKFSGN EEIYIIGADN ACMIPGNEDK
1910 1920 1930 1940 1950
ICNGPLKPKK QYLFKFRATN IMGQFTDSDY SDPVKTLGEG LSERTVEIIL
1960 1970 1980 1990 2000
SVTLCILSII LLGTAIFAFA RIRQKQKEGG TYSPQDAEII DTKLKLDQLI
2010 2020 2030 2040 2050
TVADLELKDE RLTRPISKKS FLQHVEELCT NNNLKFQEEF SELPKFLQDL
2060 2070 2080 2090 2100
SSTDADLPWN RAKNRFPNIK PYNNNRVKLI ADASVPGSDY INASYISGYL
2110 2120 2130 2140 2150
CPNEFIATQG PLPGTVGDFW RMVWETRAKT LVMLTQCFEK GRIRCHQYWP
2160 2170 2180 2190 2200
EDNKPVTVFG DIVITKLMED VQIDWTIRDL KIERHGDCMT VRQCNFTAWP
2210 2220 2230 2240 2250
EHGVPENSAP LIHFVKLVRA SRAHDTTPMI VHCSAGVGRT GVFIALDHLT
2260 2270 2280 2290 2300
QHINDHDFVD IYGLVAELRS ERMCMVQNLA QYIFLHQCIL DLLSNKGSNQ
2310 2320 2330
PICFVNYSAL QKMDSLDAME GDVELEWEET TM
Length:2,332
Mass (Da):260,924
Last modified:September 11, 2007 - v2
Checksum:i999D87AA00BA04C2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811R → G in DFNB84A. 1 Publication
VAR_063526
Natural varianti471 – 4711Q → E.1 Publication
Corresponds to variant rs61729287 [ dbSNP | Ensembl ].
VAR_069041
Natural varianti1040 – 10401T → I.
Corresponds to variant rs12316867 [ dbSNP | Ensembl ].
VAR_034970
Natural varianti1098 – 10981F → L.
Corresponds to variant rs6539524 [ dbSNP | Ensembl ].
VAR_034971
Natural varianti1120 – 11201A → P.
Corresponds to variant rs7975340 [ dbSNP | Ensembl ].
VAR_034972
Natural varianti1244 – 12441N → D.
Corresponds to variant rs17713202 [ dbSNP | Ensembl ].
VAR_034973
Natural varianti1734 – 17341I → T.
Corresponds to variant rs7963963 [ dbSNP | Ensembl ].
VAR_034974
Natural varianti2121 – 21211R → K.
Corresponds to variant rs1163042 [ dbSNP | Ensembl ].
VAR_034975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083812 Genomic DNA. No translation available.
AC074031 Genomic DNA. No translation available.
AF169351 mRNA. Translation: AAD50277.1.
UniGeneiHs.539284.

Genome annotation databases

EnsembliENST00000266688; ENSP00000266688; ENSG00000139304.
UCSCiuc001sze.2. human.

Polymorphism databases

DMDMi158563998.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083812 Genomic DNA. No translation available.
AC074031 Genomic DNA. No translation available.
AF169351 mRNA. Translation: AAD50277.1 .
UniGenei Hs.539284.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IKC X-ray 1.56 A 2015-2293 [» ]
ProteinModelPortali Q9UMZ3.
SMRi Q9UMZ3. Positions 11-232, 310-335, 347-429, 572-1271, 1288-1406, 1432-1458, 1472-1576, 1701-1776, 1988-2328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000393751.

PTM databases

PhosphoSitei Q9UMZ3.

Polymorphism databases

DMDMi 158563998.

Proteomic databases

PaxDbi Q9UMZ3.
PRIDEi Q9UMZ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266688 ; ENSP00000266688 ; ENSG00000139304 .
UCSCi uc001sze.2. human.

Organism-specific databases

GeneCardsi GC12P080837.
H-InvDB HIX0201920.
HGNCi HGNC:9679. PTPRQ.
HPAi HPA053245.
MIMi 603317. gene.
613391. phenotype.
neXtProti NX_Q9UMZ3.
Orphaneti 90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000115793.
HOVERGENi HBG108308.
InParanoidi Q9UMZ3.
PhylomeDBi Q9UMZ3.
TreeFami TF351926.

Miscellaneous databases

ChiTaRSi PTPRQ. human.
PROi Q9UMZ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UMZ3.
CleanExi HS_PTPRQ.
Genevestigatori Q9UMZ3.

Family and domain databases

Gene3Di 2.60.40.10. 19 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 14 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 17 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 17 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Differential expression of PTPase RNAs resulting from K562 differentiation induced by PMA."
    Dayton M.A., Blanchard K.L.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2133-2266.
  3. "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
    Seifert R.A., Coats S.A., Oganesian A., Wright M.B., Dishmon M., Booth C.J., Johnson R.J., Alpers C.E., Bowen-Pope D.F.
    Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells."
    Jung H., Kim W.K., Kim do H., Cho Y.S., Kim S.J., Park S.G., Park B.C., Lim H.M., Bae K.H., Lee S.C.
    Biochem. Biophys. Res. Commun. 383:252-257(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  5. "Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction."
    Schraders M., Oostrik J., Huygen P.L., Strom T.M., van Wijk E., Kunst H.P., Hoefsloot L.H., Cremers C.W., Admiraal R.J., Kremer H.
    Am. J. Hum. Genet. 86:604-610(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT DFNB84A GLY-281.
  6. "Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84."
    Shahin H., Rahil M., Abu Rayan A., Avraham K.B., King M.C., Kanaan M., Walsh T.
    J. Med. Genet. 47:643-645(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN DFNB84A, VARIANT GLU-471.

Entry informationi

Entry nameiPTPRQ_HUMAN
AccessioniPrimary (citable) accession number: Q9UMZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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