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Q9UMZ3

- PTPRQ_HUMAN

UniProt

Q9UMZ3 - PTPRQ_HUMAN

Protein

Phosphatidylinositol phosphatase PTPRQ

Gene

PTPRQ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2233 – 22331Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inner ear morphogenesis Source: Ensembl
    2. regulation of fat cell differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol phosphatase PTPRQ (EC:3.1.3.-)
    Alternative name(s):
    Receptor-type tyrosine-protein phosphatase Q (EC:3.1.3.48)
    Short name:
    PTP-RQ
    Short name:
    R-PTP-Q
    Gene namesi
    Name:PTPRQ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9679. PTPRQ.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal recessive, 84A (DFNB84A) [MIM:613391]: A form of non-syndromic deafness characterized by progressive, sensorineural hearing loss and vestibular dysfunction.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti281 – 2811R → G in DFNB84A. 1 Publication
    VAR_063526

    Keywords - Diseasei

    Deafness, Disease mutation, Non-syndromic deafness

    Organism-specific databases

    MIMi613391. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 23322297Phosphatidylinositol phosphatase PTPRQPRO_0000302850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi944 – 9441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1038 – 10381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1080 – 10801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1101 – 11011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1290 – 12901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1295 – 12951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1844 – 18441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9UMZ3.
    PRIDEiQ9UMZ3.

    PTM databases

    PhosphoSiteiQ9UMZ3.

    Expressioni

    Tissue specificityi

    In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.2 Publications

    Developmental stagei

    Expressed at highest levels in fetal kidney, followed by fetal lung and fetal cochlea.1 Publication

    Inductioni

    Down-regulated during adipogenesis of mesenchymal stem cells.1 Publication

    Gene expression databases

    BgeeiQ9UMZ3.
    CleanExiHS_PTPRQ.
    GenevestigatoriQ9UMZ3.

    Organism-specific databases

    HPAiHPA053245.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000393751.

    Structurei

    Secondary structure

    1
    2332
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni2018 – 20203
    Helixi2021 – 204222
    Helixi2053 – 20564
    Helixi2058 – 20636
    Turni2073 – 20753
    Turni2086 – 20894
    Beta strandi2092 – 20965
    Beta strandi2099 – 21013
    Beta strandi2105 – 21095
    Helixi2113 – 21153
    Helixi2116 – 212611
    Beta strandi2130 – 21334
    Beta strandi2156 – 21594
    Beta strandi2162 – 217110
    Beta strandi2173 – 218412
    Beta strandi2187 – 219610
    Beta strandi2201 – 22044
    Helixi2209 – 222113
    Beta strandi2224 – 22263
    Beta strandi2229 – 223810
    Helixi2239 – 225517
    Beta strandi2257 – 22593
    Helixi2261 – 227111
    Helixi2279 – 229214

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IKCX-ray1.56A2015-2293[»]
    ProteinModelPortaliQ9UMZ3.
    SMRiQ9UMZ3. Positions 11-232, 309-474, 572-1460, 1472-1576, 1583-1659, 1701-1776, 1988-2328.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 19471912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1969 – 2332364CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1948 – 196821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 9964Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini100 – 19596Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini199 – 29496Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini350 – 43889Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini441 – 53999Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini514 – 60693Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini610 – 70596Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini710 – 79990Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini804 – 89491Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini899 – 98890Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini993 – 1093101Fibronectin type-III 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1098 – 119093Fibronectin type-III 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1192 – 128291Fibronectin type-III 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1287 – 138094Fibronectin type-III 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1384 – 147087Fibronectin type-III 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1474 – 1578105Fibronectin type-III 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1583 – 168199Fibronectin type-III 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1686 – 1787102Fibronectin type-III 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini2036 – 2292257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 18 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000115793.
    HOVERGENiHBG108308.
    InParanoidiQ9UMZ3.
    PhylomeDBiQ9UMZ3.
    TreeFamiTF351926.

    Family and domain databases

    Gene3Di2.60.40.10. 19 hits.
    3.90.190.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 14 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 17 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 11 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50853. FN3. 17 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UMZ3-1 [UniParc]FASTAAdd to Basket

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    MKKVPIKPEQ PEKLRAFNIS THSFSLHWSL PSGHVERYQV DLVPDSGFVT     50
    IRDLGGGEYQ VDVSNVVPGT RYDITISSIS TTYTSPVTRI VTTNVTKPGP 100
    PVFLAGERVG SAGILLSWNT PPNPNGRIIS YIVKYKEVCP WMQTVYTQVR 150
    SKPDSLEVLL TNLNPGTTYE IKVAAENSAG IGVFSDPFLF QTAESAPGKV 200
    VNLTVEAYNA SAVKLIWYLP RQPNGKITSF KISVKHARSG IVVKDVSIRV 250
    EDILTGKLPE CNENSESFLW STASPSPTLG RVTPPSRTTH SSSTLTQNEI 300
    SSVWKEPISF VVTHLRPYTT YLFEVSAVTT EAGYIDSTIV RTPESVPEGP 350
    PQNCVTGNIT GKSFSILWDP PTIVTGKFSY RVELYGPSGR ILDNSTKDLK 400
    FAFTNLTPFT MYDVYIAAET SAGTGPKSNI SVFTPPDVPG AVFDLQLAEV 450
    ESTQVRITWK KPRQPNGIIN QYRVKVLVPE TGIILENTLL TGNNEYINDP 500
    MAPEIVNIVE PMVGLYEGSA EMSSDLHSLA TFIYNSHPDK NFPARNRAED 550
    QTSPVVTTRN QYITDIAAEQ LSYVIRRLVP FTEHMISVSA FTIMGEGPPT 600
    VLSVRTRQQV PSSIKIINYK NISSSSILLY WDPPEYPNGK ITHYTIYAME 650
    LDTNRAFQIT TIDNSFLITG LKKYTKYKMR VAASTHVGES SLSEENDIFV 700
    RTSEDEPESS PQDVEVIDVT ADEIRLKWSP PEKPNGIIIA YEVLYKNIDT 750
    LYMKNTSTTD IILRNLRPHT LYNISVRSYT RFGHGNQVSS LLSVRTSETV 800
    PDSAPENITY KNISSGEIEL SFLPPSSPNG IIKKYTIYLK RSNGNEERTI 850
    NTTSLTQNIK VLKKYTQYII EVSASTLKGE GVRSAPISIL TEEDAPDSPP 900
    QDFSVKQLSG VTVKLSWQPP LEPNGIILYY TVYVWNRSSL KTINVTETSL 950
    ELSDLDYNVE YSAYVTASTR FGDGKTRSNI ISFQTPEGAP SDPPKDVYYA 1000
    NLSSSSIILF WTPPSKPNGI IQYYSVYYRN TSGTFMQNFT LHEVTNDFDN 1050
    MTVSTIIDKL TIFSYYTFWL TASTSVGNGN KSSDIIEVYT DQDIPEGFVG 1100
    NLTYESISST AINVSWVPPA QPNGLVFYYV SLILQQTPRH VRPPLVTYER 1150
    SIYFDNLEKY TDYILKITPS TEKGFSDTYT AQLYIKTEED VPETSPIINT 1200
    FKNLSSTSVL LSWDPPVKPN GAIISYDLTL QGPNENYSFI TSDNYIILEE 1250
    LSPFTLYSFF AAARTRKGLG PSSILFFYTD ESVPLAPPQN LTLINCTSDF 1300
    VWLKWSPSPL PGGIVKVYSF KIHEHETDTI YYKNISGFKT EAKLVGLEPV 1350
    STYSIRVSAF TKVGNGNQFS NVVKFTTQES VPDVVQNMQC MATSWQSVLV 1400
    KWDPPKKANG IITQYMVTVE RNSTKVSPQD HMYTFIKLLA NTSYVFKVRA 1450
    STSAGEGDES TCHVSTLPET VPSVPTNIAF SDVQSTSATL TWIRPDTILG 1500
    YFQNYKITTQ LRAQKCKEWE SEECVEYQKI QYLYEAHLTE ETVYGLKKFR 1550
    WYRFQVAAST NAGYGNASNW ISTKTLPGPP DGPPENVHVV ATSPFSISIS 1600
    WSEPAVITGP TCYLIDVKSV DNDEFNISFI KSNEENKTIE IKDLEIFTRY 1650
    SVVITAFTGN ISAAYVEGKS SAEMIVTTLE SAPKDPPNNM TFQKIPDEVT 1700
    KFQLTFLPPS QPNGNIQVYQ ALVYREDDPT AVQIHNLSII QKTNTFVIAM 1750
    LEGLKGGHTY NISVYAVNSA GAGPKVPMRI TMDIKAPARP KTKPTPIYDA 1800
    TGKLLVTSTT ITIRMPICYY SDDHGPIKNV QVLVTETGAQ HDGNVTKWYD 1850
    AYFNKARPYF TNEGFPNPPC TEGKTKFSGN EEIYIIGADN ACMIPGNEDK 1900
    ICNGPLKPKK QYLFKFRATN IMGQFTDSDY SDPVKTLGEG LSERTVEIIL 1950
    SVTLCILSII LLGTAIFAFA RIRQKQKEGG TYSPQDAEII DTKLKLDQLI 2000
    TVADLELKDE RLTRPISKKS FLQHVEELCT NNNLKFQEEF SELPKFLQDL 2050
    SSTDADLPWN RAKNRFPNIK PYNNNRVKLI ADASVPGSDY INASYISGYL 2100
    CPNEFIATQG PLPGTVGDFW RMVWETRAKT LVMLTQCFEK GRIRCHQYWP 2150
    EDNKPVTVFG DIVITKLMED VQIDWTIRDL KIERHGDCMT VRQCNFTAWP 2200
    EHGVPENSAP LIHFVKLVRA SRAHDTTPMI VHCSAGVGRT GVFIALDHLT 2250
    QHINDHDFVD IYGLVAELRS ERMCMVQNLA QYIFLHQCIL DLLSNKGSNQ 2300
    PICFVNYSAL QKMDSLDAME GDVELEWEET TM 2332
    Length:2,332
    Mass (Da):260,924
    Last modified:September 11, 2007 - v2
    Checksum:i999D87AA00BA04C2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti281 – 2811R → G in DFNB84A. 1 Publication
    VAR_063526
    Natural varianti471 – 4711Q → E.1 Publication
    Corresponds to variant rs61729287 [ dbSNP | Ensembl ].
    VAR_069041
    Natural varianti1040 – 10401T → I.
    Corresponds to variant rs12316867 [ dbSNP | Ensembl ].
    VAR_034970
    Natural varianti1098 – 10981F → L.
    Corresponds to variant rs6539524 [ dbSNP | Ensembl ].
    VAR_034971
    Natural varianti1120 – 11201A → P.
    Corresponds to variant rs7975340 [ dbSNP | Ensembl ].
    VAR_034972
    Natural varianti1244 – 12441N → D.
    Corresponds to variant rs17713202 [ dbSNP | Ensembl ].
    VAR_034973
    Natural varianti1734 – 17341I → T.
    Corresponds to variant rs7963963 [ dbSNP | Ensembl ].
    VAR_034974
    Natural varianti2121 – 21211R → K.
    Corresponds to variant rs1163042 [ dbSNP | Ensembl ].
    VAR_034975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC083812 Genomic DNA. No translation available.
    AC074031 Genomic DNA. No translation available.
    AF169351 mRNA. Translation: AAD50277.1.
    UniGeneiHs.539284.

    Genome annotation databases

    EnsembliENST00000266688; ENSP00000266688; ENSG00000139304.
    UCSCiuc001sze.2. human.

    Polymorphism databases

    DMDMi158563998.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC083812 Genomic DNA. No translation available.
    AC074031 Genomic DNA. No translation available.
    AF169351 mRNA. Translation: AAD50277.1 .
    UniGenei Hs.539284.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IKC X-ray 1.56 A 2015-2293 [» ]
    ProteinModelPortali Q9UMZ3.
    SMRi Q9UMZ3. Positions 11-232, 309-474, 572-1460, 1472-1576, 1583-1659, 1701-1776, 1988-2328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000393751.

    PTM databases

    PhosphoSitei Q9UMZ3.

    Polymorphism databases

    DMDMi 158563998.

    Proteomic databases

    PaxDbi Q9UMZ3.
    PRIDEi Q9UMZ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266688 ; ENSP00000266688 ; ENSG00000139304 .
    UCSCi uc001sze.2. human.

    Organism-specific databases

    GeneCardsi GC12P080837.
    H-InvDB HIX0201920.
    HGNCi HGNC:9679. PTPRQ.
    HPAi HPA053245.
    MIMi 603317. gene.
    613391. phenotype.
    neXtProti NX_Q9UMZ3.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000115793.
    HOVERGENi HBG108308.
    InParanoidi Q9UMZ3.
    PhylomeDBi Q9UMZ3.
    TreeFami TF351926.

    Miscellaneous databases

    PROi Q9UMZ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UMZ3.
    CleanExi HS_PTPRQ.
    Genevestigatori Q9UMZ3.

    Family and domain databases

    Gene3Di 2.60.40.10. 19 hits.
    3.90.190.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 14 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 17 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 11 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50853. FN3. 17 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Differential expression of PTPase RNAs resulting from K562 differentiation induced by PMA."
      Dayton M.A., Blanchard K.L.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2133-2266.
    3. "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
      Seifert R.A., Coats S.A., Oganesian A., Wright M.B., Dishmon M., Booth C.J., Johnson R.J., Alpers C.E., Bowen-Pope D.F.
      Exp. Cell Res. 287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells."
      Jung H., Kim W.K., Kim do H., Cho Y.S., Kim S.J., Park S.G., Park B.C., Lim H.M., Bae K.H., Lee S.C.
      Biochem. Biophys. Res. Commun. 383:252-257(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    5. "Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction."
      Schraders M., Oostrik J., Huygen P.L., Strom T.M., van Wijk E., Kunst H.P., Hoefsloot L.H., Cremers C.W., Admiraal R.J., Kremer H.
      Am. J. Hum. Genet. 86:604-610(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT DFNB84A GLY-281.
    6. "Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84."
      Shahin H., Rahil M., Abu Rayan A., Avraham K.B., King M.C., Kanaan M., Walsh T.
      J. Med. Genet. 47:643-645(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN DFNB84A, VARIANT GLU-471.

    Entry informationi

    Entry nameiPTPRQ_HUMAN
    AccessioniPrimary (citable) accession number: Q9UMZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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