Reviewed, UniProtKB/Swiss-Prot Q9UMZ2 (SYNRG_HUMAN)

Names and origin

Protein names

Recommended name:
    Synergin gamma
Alternative name(s):
    AP1 subunit gamma-binding protein 1
    Gamma-synergin

Gene names

Name:	SYNRG
Synonyms:	AP1GBP1, SYNG

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins.
Subunit structure	Interacts with SCAMP1 via its EH-domain By similarity. Interacts with GGA1, GGA2 and GGA3. Interacts with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1.
Subcellular location	Cytoplasm By similarity. Golgi apparatus › trans-Golgi network membrane; Peripheral membrane protein By similarity. Note: Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1 By similarity.
Domain	The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2. Ref.5
Sequence similarities	Contains 1 EH domain.
Sequence caution	The sequence AK126988 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Biological process	Endocytosis Protein transport Transport
Cellular component	Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW intracellular protein transport Ref.1 Traceable author statement. Source: ProtInc
Cellular component	AP-1 adaptor complex Ref.1 Traceable author statement. Source: ProtInc extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UMZ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UMZ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Isoform 3 (identifier: Q9UMZ2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     1260-1271: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1314	1314	Synergin gamma		PRO_0000072387
Regions
	Domain	295 – 388	94	EH
	Region	518 – 786	269	Interaction with A1P1G1 and A1P1G2
	Coiled coil	115 – 155	41	Potential
	Motif	457 – 461	5	DFXDF motif 1
	Motif	690 – 694	5	DFXDF motif 2
	Motif	775 – 779	5	DFXDF motif 3
Amino acid modifications
	Modified residue	473	1	Phosphoserine Ref.9
	Modified residue	513	1	N6-acetyllysine Ref.12
	Modified residue	744	1	N6-acetyllysine Ref.12
	Modified residue	752	1	Phosphoserine Ref.9 Ref.6 Ref.8
	Modified residue	756	1	Phosphoserine Ref.6
	Modified residue	852	1	Phosphoserine
	Modified residue	855	1	Phosphoserine
	Modified residue	909	1	Phosphoserine Ref.9
	Modified residue	919	1	Phosphoserine Ref.9
	Modified residue	935	1	Phosphoserine Ref.9
	Modified residue	936	1	Phosphoserine
	Modified residue	1075	1	Phosphoserine Ref.9 Ref.7
Natural variations
	Alternative sequence	198 – 275	78	Missing in isoform 2 and isoform 3.		VSP_023015
	Alternative sequence	1260 – 1271	12	Missing in isoform 3.		VSP_023016
	Natural variant	40	1	A → G: dbSNP rs12944821.		VAR_051395
	Natural variant	222	1	T → A: dbSNP rs12602536.		VAR_051396
Experimental info
	Sequence conflict	40	1	Missing in AAI17314. Ref.2
	Sequence conflict	213	1	S → P in AK126988. Ref.3
	Sequence conflict	349	1	K → R in AK126988. Ref.3
	Sequence conflict	1123	1	E → K in AAD49732. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 70C105203EF0BBBF	FASTA	1,314	140,654
	10 20 30 40 50 60 MALRPGAGSG GGGAAGAGAG SAGGGGFMFP VAGGIRPPQA GLMPMQQQGF PMVSVMQPNM 70 80 90 100 110 120 QGIMGMNYSS QMSQGPIAMQ AGIPMGPMPA AGMPYLGQAP FLGMRPPGPQ YTPDMQKQFA 130 140 150 160 170 180 EEQQKRFEQQ QKLLEEERKR RQFEEQKQKL RLLSSVKPKT GEKSRDDALE AIKGNLDGFS 190 200 210 220 230 240 RDAKMHPTPA SHPKKPGPSL EEKFLVSCDI STSGQEQIKL NTSEVGHKAL GPGSSKKYPS 250 260 270 280 290 300 LMASNGVAVD GCVSGTTTAE AENTSDQNLS IEESGVGVFP SQDPAQPRMP PWIYNESLVP 310 320 330 340 350 360 DAYKKILETT MTPTGIDTAK LYPILMSSGL PRETLGQIWA LANRTTPGKL TKEELYTVLA 370 380 390 400 410 420 MIAVTQRGVP AMSPDALNQF PAAPIPTLSG FSMTLPTPVS QPTVIPSGPA GSMPLSLGQP 430 440 450 460 470 480 VMGINLVGPV GGAAAQASSG FIPTYPANQV VKPEEDDFQD FQDASKSGSL DDSFSDFQEL 490 500 510 520 530 540 PASSKTSNSQ HGNSAPSLLM PLPGTKALPS MDKYAVFKGI AADKSSENTV PPGDPGDKYS 550 560 570 580 590 600 AFRELEQTAE NKPLGESFAE FRSAGTDDGF TDFKTADSVS PLEPPTKDKT FPPSFPSGTI 610 620 630 640 650 660 QQKQQTQVKN PLNLADLDMF SSVNCSSEKP LSFSAVFSTS KSVSTPQSTG SAATMTALAA 670 680 690 700 710 720 TKTSSLADDF GEFSLFGEYS GLAPVGEQDD FADFMAFSNS SISSEQKPDD KYDALKEEAS 730 740 750 760 770 780 PVPLTSNVGS TVKGGQNSTA ASTKYDVFRQ LSLEGSGLGV EDLKDNTPSG KSDDDFADFH 790 800 810 820 830 840 SSKFSSINSD KSLGEKAVAF RHTKEDSASV KSLDLPSIGG SSVGKEDSED ALSVQFDMKL 850 860 870 880 890 900 ADVGGDLKHV MSDSSLDLPT VSGQHPPAAD IEDLKYAAFG SYSSNFAVST LTSYDWSDRD 910 920 930 940 950 960 DATQGRKLSP FVLSAGSGSP SATSILQKKE TSFGSSENIT MTSLSKVTTF VSEDALPETT 970 980 990 1000 1010 1020 FPALASFKDT IPQTSEQKEY ENRDYKDFTK QDLPTAERSQ EATCPSPASS GASQETPNEC 1030 1040 1050 1060 1070 1080 SDDFGEFQSE KPKISKFDFL VATSQSKMKS SEEMIKSELA TFDLSVQGSH KRSLSLGDKE 1090 1100 1110 1120 1130 1140 ISRSSPSPAL EQPFRDRSNT LNEKPALPVI RDKYKDLTGE VEENERYAYE WQRCLGSALN 1150 1160 1170 1180 1190 1200 VIKKANDTLN GISSSSVCTE VIQSAQGMEY LLGVVEVYRV TKRVELGIKA TAVCSEKLQQ 1210 1220 1230 1240 1250 1260 LLKDIDKVWN NLIGFMSLAT LTPDENSLDF SSCMLRPGIK NAQELACGVC LLNVDSRSRK 1270 1280 1290 1300 1310 EEKPAEEHPK KAFNSETDSF KLAYGGHQYH ASCANFWINC VEPKPPGLVL PDLL
	Isoform 2. Checksum: D22A62B08D8E0B01	FASTA	1,236	132,654
	10 20 30 40 50 60 MALRPGAGSG GGGAAGAGAG SAGGGGFMFP VAGGIRPPQA GLMPMQQQGF PMVSVMQPNM 70 80 90 100 110 120 QGIMGMNYSS QMSQGPIAMQ AGIPMGPMPA AGMPYLGQAP FLGMRPPGPQ YTPDMQKQFA 130 140 150 160 170 180 EEQQKRFEQQ QKLLEEERKR RQFEEQKQKL RLLSSVKPKT GEKSRDDALE AIKGNLDGFS 190 200 210 220 230 240 RDAKMHPTPA SHPKKPGVGV FPSQDPAQPR MPPWIYNESL VPDAYKKILE TTMTPTGIDT 250 260 270 280 290 300 AKLYPILMSS GLPRETLGQI WALANRTTPG KLTKEELYTV LAMIAVTQRG VPAMSPDALN 310 320 330 340 350 360 QFPAAPIPTL SGFSMTLPTP VSQPTVIPSG PAGSMPLSLG QPVMGINLVG PVGGAAAQAS 370 380 390 400 410 420 SGFIPTYPAN QVVKPEEDDF QDFQDASKSG SLDDSFSDFQ ELPASSKTSN SQHGNSAPSL 430 440 450 460 470 480 LMPLPGTKAL PSMDKYAVFK GIAADKSSEN TVPPGDPGDK YSAFRELEQT AENKPLGESF 490 500 510 520 530 540 AEFRSAGTDD GFTDFKTADS VSPLEPPTKD KTFPPSFPSG TIQQKQQTQV KNPLNLADLD 550 560 570 580 590 600 MFSSVNCSSE KPLSFSAVFS TSKSVSTPQS TGSAATMTAL AATKTSSLAD DFGEFSLFGE 610 620 630 640 650 660 YSGLAPVGEQ DDFADFMAFS NSSISSEQKP DDKYDALKEE ASPVPLTSNV GSTVKGGQNS 670 680 690 700 710 720 TAASTKYDVF RQLSLEGSGL GVEDLKDNTP SGKSDDDFAD FHSSKFSSIN SDKSLGEKAV 730 740 750 760 770 780 AFRHTKEDSA SVKSLDLPSI GGSSVGKEDS EDALSVQFDM KLADVGGDLK HVMSDSSLDL 790 800 810 820 830 840 PTVSGQHPPA ADIEDLKYAA FGSYSSNFAV STLTSYDWSD RDDATQGRKL SPFVLSAGSG 850 860 870 880 890 900 SPSATSILQK KETSFGSSEN ITMTSLSKVT TFVSEDALPE TTFPALASFK DTIPQTSEQK 910 920 930 940 950 960 EYENRDYKDF TKQDLPTAER SQEATCPSPA SSGASQETPN ECSDDFGEFQ SEKPKISKFD 970 980 990 1000 1010 1020 FLVATSQSKM KSSEEMIKSE LATFDLSVQG SHKRSLSLGD KEISRSSPSP ALEQPFRDRS 1030 1040 1050 1060 1070 1080 NTLNEKPALP VIRDKYKDLT GEVEENERYA YEWQRCLGSA LNVIKKANDT LNGISSSSVC 1090 1100 1110 1120 1130 1140 TEVIQSAQGM EYLLGVVEVY RVTKRVELGI KATAVCSEKL QQLLKDIDKV WNNLIGFMSL 1150 1160 1170 1180 1190 1200 ATLTPDENSL DFSSCMLRPG IKNAQELACG VCLLNVDSRS RKEEKPAEEH PKKAFNSETD 1210 1220 1230 SFKLAYGGHQ YHASCANFWI NCVEPKPPGL VLPDLL
	Isoform 3. Checksum: 3D54B7286CED8226	FASTA	1,224	131,222
	10 20 30 40 50 60 MALRPGAGSG GGGAAGAGAG SAGGGGFMFP VAGGIRPPQA GLMPMQQQGF PMVSVMQPNM 70 80 90 100 110 120 QGIMGMNYSS QMSQGPIAMQ AGIPMGPMPA AGMPYLGQAP FLGMRPPGPQ YTPDMQKQFA 130 140 150 160 170 180 EEQQKRFEQQ QKLLEEERKR RQFEEQKQKL RLLSSVKPKT GEKSRDDALE AIKGNLDGFS 190 200 210 220 230 240 RDAKMHPTPA SHPKKPGVGV FPSQDPAQPR MPPWIYNESL VPDAYKKILE TTMTPTGIDT 250 260 270 280 290 300 AKLYPILMSS GLPRETLGQI WALANRTTPG KLTKEELYTV LAMIAVTQRG VPAMSPDALN 310 320 330 340 350 360 QFPAAPIPTL SGFSMTLPTP VSQPTVIPSG PAGSMPLSLG QPVMGINLVG PVGGAAAQAS 370 380 390 400 410 420 SGFIPTYPAN QVVKPEEDDF QDFQDASKSG SLDDSFSDFQ ELPASSKTSN SQHGNSAPSL 430 440 450 460 470 480 LMPLPGTKAL PSMDKYAVFK GIAADKSSEN TVPPGDPGDK YSAFRELEQT AENKPLGESF 490 500 510 520 530 540 AEFRSAGTDD GFTDFKTADS VSPLEPPTKD KTFPPSFPSG TIQQKQQTQV KNPLNLADLD 550 560 570 580 590 600 MFSSVNCSSE KPLSFSAVFS TSKSVSTPQS TGSAATMTAL AATKTSSLAD DFGEFSLFGE 610 620 630 640 650 660 YSGLAPVGEQ DDFADFMAFS NSSISSEQKP DDKYDALKEE ASPVPLTSNV GSTVKGGQNS 670 680 690 700 710 720 TAASTKYDVF RQLSLEGSGL GVEDLKDNTP SGKSDDDFAD FHSSKFSSIN SDKSLGEKAV 730 740 750 760 770 780 AFRHTKEDSA SVKSLDLPSI GGSSVGKEDS EDALSVQFDM KLADVGGDLK HVMSDSSLDL 790 800 810 820 830 840 PTVSGQHPPA ADIEDLKYAA FGSYSSNFAV STLTSYDWSD RDDATQGRKL SPFVLSAGSG 850 860 870 880 890 900 SPSATSILQK KETSFGSSEN ITMTSLSKVT TFVSEDALPE TTFPALASFK DTIPQTSEQK 910 920 930 940 950 960 EYENRDYKDF TKQDLPTAER SQEATCPSPA SSGASQETPN ECSDDFGEFQ SEKPKISKFD 970 980 990 1000 1010 1020 FLVATSQSKM KSSEEMIKSE LATFDLSVQG SHKRSLSLGD KEISRSSPSP ALEQPFRDRS 1030 1040 1050 1060 1070 1080 NTLNEKPALP VIRDKYKDLT GEVEENERYA YEWQRCLGSA LNVIKKANDT LNGISSSSVC 1090 1100 1110 1120 1130 1140 TEVIQSAQGM EYLLGVVEVY RVTKRVELGI KATAVCSEKL QQLLKDIDKV WNNLIGFMSL 1150 1160 1170 1180 1190 1200 ATLTPDENSL DFSSCMLRPG IKNAQELACG VCLLNVDSRS RAFNSETDSF KLAYGGHQYH 1210 1220 ASCANFWINC VEPKPPGLVL PDLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin." Page L.J., Sowerby P.J., Lui W.W.Y., Robinson M.S. J. Cell Biol. 146:993-1004(1999) [PubMed: 10477754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Lymph.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-493 (ISOFORM 1). Tissue: Brain.
[4]	"Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin." Takatsu H., Yoshino K., Nakayama K. Biochem. Biophys. Res. Commun. 271:719-725(2000) [PubMed: 10814529] [Abstract] Cited for: INTERACTION WITH GGA1; GGA2; GGA3; AP1G1 AND AP1G2.
[5]	"EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking." Mills I.G., Praefcke G.J.K., Vallis Y., Peter B.J., Olesen L.E., Gallop J.L., Butler P.J.G., Evans P.R., McMahon H.T. J. Cell Biol. 160:213-222(2003) [PubMed: 12538641] [Abstract] Cited for: DOMAIN, INTERACTION WITH AP1G1.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752 AND SER-756, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1075, MASS SPECTROMETRY. Tissue: Platelet.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752, MASS SPECTROMETRY.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-752; SER-909; SER-919; SER-935 AND SER-1075, MASS SPECTROMETRY.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-919; SER-935 AND SER-936, MASS SPECTROMETRY.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-752; SER-852 AND SER-855, MASS SPECTROMETRY. Tissue: T-cell.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-513 AND LYS-744, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF169548 mRNA. Translation: AAD49732.1. BC090930 mRNA. Translation: AAH90930.1. BC117313 mRNA. Translation: AAI17314.1. BC143478 mRNA. Translation: AAI43479.1. AK126988 mRNA. No translation available.
IPI	IPI00297931. IPI00798416. IPI00827622.
RefSeq	NP_001157016.1. NP_001157017.1. NP_001157018.1. NP_001157019.1. NP_009178.3. NP_542117.3. NP_942583.1.
UniGene	Hs.655178
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UMZ2.
PTM databases
PhosphoSite	Q9UMZ2.
Proteomic databases
PRIDE	Q9UMZ2.
Genome annotation databases
Ensembl	ENST00000339208; ENSP00000343610; ENSG00000006114; Homo sapiens. [Genome view] ENST00000346661; ENSP00000005279; ENSG00000006114; Homo sapiens. [Genome view]
GeneID	11276.
KEGG	hsa:11276.
UCSC	uc002hoa.1. human. uc002hoc.1. human. uc002hod.1. human.
Organism-specific databases
CTD	11276.
GeneCards	GC17M032952.
H-InvDB	HIX0013748.
HGNC	HGNC:557. SYNRG.
HPA	HPA023554. HPA023555.
MIM	607291. gene.
PharmGKB	PA24847.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UMZ2.
HOVERGEN	Q9UMZ2.
Gene expression databases
ArrayExpress	Q9UMZ2.
Bgee	Q9UMZ2.
CleanEx	HS_AP1GBP1.
Genevestigator	Q9UMZ2.
GermOnline	ENSG00000006114. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR000261. EPS15_homology. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PROSITE	PS50031. EH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	42921.
SOURCE	Search...

Entry information

Entry name

SYNRG_HUMAN

Accession

Primary (citable) accession number: Q9UMZ2
Secondary accession number(s): B7ZKZ3 , Q17RI2, Q5BKU5, Q6ZT17

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	April 3, 2007
Last modified:	November 24, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.