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Protein

Synergin gamma

Gene

SYNRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins.

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • intracellular protein transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006114-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Synergin gamma
Alternative name(s):
AP1 subunit gamma-binding protein 1
Gamma-synergin
Gene namesi
Name:SYNRG
Synonyms:AP1GBP1, SYNG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:557. SYNRG.

Subcellular locationi

GO - Cellular componenti

  • AP-1 adaptor complex Source: ProtInc
  • cytoplasm Source: ProtInc
  • Golgi apparatus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000274047.
ENSG00000275066.
PharmGKBiPA24847.

Polymorphism and mutation databases

BioMutaiSYNRG.
DMDMi143811464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723871 – 1314Synergin gammaAdd BLAST1314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei473PhosphoserineCombined sources1
Modified residuei513N6-acetyllysineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei744N6-acetyllysineCombined sources1
Modified residuei752PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei1006PhosphoserineCombined sources1
Modified residuei1073PhosphoserineBy similarity1
Modified residuei1075PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1100PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UMZ2.
PaxDbiQ9UMZ2.
PeptideAtlasiQ9UMZ2.
PRIDEiQ9UMZ2.

PTM databases

iPTMnetiQ9UMZ2.
PhosphoSitePlusiQ9UMZ2.

Expressioni

Gene expression databases

BgeeiENSG00000006114.
CleanExiHS_AP1GBP1.
ExpressionAtlasiQ9UMZ2. baseline and differential.
GenevisibleiQ9UMZ2. HS.

Organism-specific databases

HPAiHPA023554.
HPA023555.

Interactioni

Subunit structurei

Interacts with SCAMP1 via its EH-domain (By similarity). Interacts with GGA1, GGA2 and GGA3. Interacts with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-7240490,EBI-743771

Protein-protein interaction databases

BioGridi116432. 16 interactors.
IntActiQ9UMZ2. 6 interactors.
MINTiMINT-126209.
STRINGi9606.ENSP00000343610.

Structurei

Secondary structure

11314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi284 – 286Combined sources3
Helixi291 – 294Combined sources4
Helixi301 – 309Combined sources9
Helixi318 – 327Combined sources10
Helixi332 – 340Combined sources9
Helixi352 – 366Combined sources15
Helixi374 – 378Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MX7NMR-A279-388[»]
ProteinModelPortaliQ9UMZ2.
SMRiQ9UMZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 388EHPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni518 – 786Interaction with A1P1G1 and A1P1G2Add BLAST269

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 155Sequence analysisAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi457 – 461DFXDF motif 15
Motifi690 – 694DFXDF motif 25
Motifi775 – 779DFXDF motif 35

Domaini

The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.1 Publication

Sequence similaritiesi

Contains 1 EH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IRB0. Eukaryota.
ENOG410Z4AG. LUCA.
GeneTreeiENSGT00390000010789.
HOGENOMiHOG000293152.
HOVERGENiHBG055053.
InParanoidiQ9UMZ2.
OMAiMFSSVNC.
OrthoDBiEOG091G09OC.
PhylomeDBiQ9UMZ2.
TreeFamiTF316700.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EH_dom.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50031. EH. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UMZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRPGAGSG GGGAAGAGAG SAGGGGFMFP VAGGIRPPQA GLMPMQQQGF
60 70 80 90 100
PMVSVMQPNM QGIMGMNYSS QMSQGPIAMQ AGIPMGPMPA AGMPYLGQAP
110 120 130 140 150
FLGMRPPGPQ YTPDMQKQFA EEQQKRFEQQ QKLLEEERKR RQFEEQKQKL
160 170 180 190 200
RLLSSVKPKT GEKSRDDALE AIKGNLDGFS RDAKMHPTPA SHPKKPGPSL
210 220 230 240 250
EEKFLVSCDI STSGQEQIKL NTSEVGHKAL GPGSSKKYPS LMASNGVAVD
260 270 280 290 300
GCVSGTTTAE AENTSDQNLS IEESGVGVFP SQDPAQPRMP PWIYNESLVP
310 320 330 340 350
DAYKKILETT MTPTGIDTAK LYPILMSSGL PRETLGQIWA LANRTTPGKL
360 370 380 390 400
TKEELYTVLA MIAVTQRGVP AMSPDALNQF PAAPIPTLSG FSMTLPTPVS
410 420 430 440 450
QPTVIPSGPA GSMPLSLGQP VMGINLVGPV GGAAAQASSG FIPTYPANQV
460 470 480 490 500
VKPEEDDFQD FQDASKSGSL DDSFSDFQEL PASSKTSNSQ HGNSAPSLLM
510 520 530 540 550
PLPGTKALPS MDKYAVFKGI AADKSSENTV PPGDPGDKYS AFRELEQTAE
560 570 580 590 600
NKPLGESFAE FRSAGTDDGF TDFKTADSVS PLEPPTKDKT FPPSFPSGTI
610 620 630 640 650
QQKQQTQVKN PLNLADLDMF SSVNCSSEKP LSFSAVFSTS KSVSTPQSTG
660 670 680 690 700
SAATMTALAA TKTSSLADDF GEFSLFGEYS GLAPVGEQDD FADFMAFSNS
710 720 730 740 750
SISSEQKPDD KYDALKEEAS PVPLTSNVGS TVKGGQNSTA ASTKYDVFRQ
760 770 780 790 800
LSLEGSGLGV EDLKDNTPSG KSDDDFADFH SSKFSSINSD KSLGEKAVAF
810 820 830 840 850
RHTKEDSASV KSLDLPSIGG SSVGKEDSED ALSVQFDMKL ADVGGDLKHV
860 870 880 890 900
MSDSSLDLPT VSGQHPPAAD IEDLKYAAFG SYSSNFAVST LTSYDWSDRD
910 920 930 940 950
DATQGRKLSP FVLSAGSGSP SATSILQKKE TSFGSSENIT MTSLSKVTTF
960 970 980 990 1000
VSEDALPETT FPALASFKDT IPQTSEQKEY ENRDYKDFTK QDLPTAERSQ
1010 1020 1030 1040 1050
EATCPSPASS GASQETPNEC SDDFGEFQSE KPKISKFDFL VATSQSKMKS
1060 1070 1080 1090 1100
SEEMIKSELA TFDLSVQGSH KRSLSLGDKE ISRSSPSPAL EQPFRDRSNT
1110 1120 1130 1140 1150
LNEKPALPVI RDKYKDLTGE VEENERYAYE WQRCLGSALN VIKKANDTLN
1160 1170 1180 1190 1200
GISSSSVCTE VIQSAQGMEY LLGVVEVYRV TKRVELGIKA TAVCSEKLQQ
1210 1220 1230 1240 1250
LLKDIDKVWN NLIGFMSLAT LTPDENSLDF SSCMLRPGIK NAQELACGVC
1260 1270 1280 1290 1300
LLNVDSRSRK EEKPAEEHPK KAFNSETDSF KLAYGGHQYH ASCANFWINC
1310
VEPKPPGLVL PDLL
Length:1,314
Mass (Da):140,654
Last modified:April 3, 2007 - v2
Checksum:i70C105203EF0BBBF
GO
Isoform 2 (identifier: Q9UMZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Show »
Length:1,236
Mass (Da):132,654
Checksum:iD22A62B08D8E0B01
GO
Isoform 3 (identifier: Q9UMZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     1260-1271: Missing.

Show »
Length:1,224
Mass (Da):131,222
Checksum:i3D54B7286CED8226
GO
Isoform 4 (identifier: Q9UMZ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1260-1271: Missing.

Note: No experimental confirmation available.
Show »
Length:1,302
Mass (Da):139,223
Checksum:i35E8013E37F73B80
GO
Isoform 5 (identifier: Q9UMZ2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     366-448: Missing.
     870-914: Missing.

Note: No experimental confirmation available.
Show »
Length:1,108
Mass (Da):119,509
Checksum:iF31FEC0F4F4515FC
GO
Isoform 6 (identifier: Q9UMZ2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     1222-1222: T → TCCWEKMTVITKHLSPYHELLEEK

Note: Gene prediction based on EST data.
Show »
Length:1,259
Mass (Da):135,454
Checksum:i00E53A7CC4AC2FC5
GO
Isoform 7 (identifier: Q9UMZ2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.
     198-275: Missing.

Note: No experimental confirmation available.
Show »
Length:1,235
Mass (Da):132,582
Checksum:iC243DC3D72946E67
GO
Isoform 8 (identifier: Q9UMZ2-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     870-914: Missing.
     1260-1271: Missing.

Show »
Length:1,179
Mass (Da):126,214
Checksum:iBAEC72332586ED58
GO

Sequence cautioni

The sequence AK126988 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213S → P in AK126988 (PubMed:14702039).Curated1
Sequence conflicti349K → R in AK126988 (PubMed:14702039).Curated1
Sequence conflicti1123E → K in AAD49732 (PubMed:10477754).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05139540A → G.Corresponds to variant rs12944821dbSNPEnsembl.1
Natural variantiVAR_051396222T → A.Corresponds to variant rs12602536dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05473240Missing in isoform 7. 1 Publication1
Alternative sequenceiVSP_023015198 – 275Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_043281366 – 448Missing in isoform 5. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_043282870 – 914Missing in isoform 5 and isoform 8. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0547331222T → TCCWEKMTVITKHLSPYHEL LEEK in isoform 6. Curated1
Alternative sequenceiVSP_0230161260 – 1271Missing in isoform 3, isoform 4 and isoform 8. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169548 mRNA. Translation: AAD49732.1.
AC004099 Genomic DNA. No translation available.
AC091199 Genomic DNA. No translation available.
BC090930 mRNA. Translation: AAH90930.1.
BC117313 mRNA. Translation: AAI17314.1.
BC143476 mRNA. Translation: AAI43477.1.
BC143478 mRNA. Translation: AAI43479.1.
AK126988 mRNA. No translation available.
CCDSiCCDS11321.1. [Q9UMZ2-1]
CCDS11322.2. [Q9UMZ2-4]
CCDS54113.1. [Q9UMZ2-6]
CCDS54114.1. [Q9UMZ2-7]
CCDS59284.1. [Q9UMZ2-8]
CCDS59285.1. [Q9UMZ2-9]
RefSeqiNP_001157016.1. NM_001163544.2. [Q9UMZ2-3]
NP_001157017.1. NM_001163545.2. [Q9UMZ2-8]
NP_001157018.1. NM_001163546.2. [Q9UMZ2-9]
NP_001157019.1. NM_001163547.2. [Q9UMZ2-6]
NP_009178.3. NM_007247.5. [Q9UMZ2-1]
NP_542117.3. NM_080550.4. [Q9UMZ2-4]
NP_942583.1. NM_198882.2. [Q9UMZ2-7]
XP_016879582.1. XM_017024093.1. [Q9UMZ2-5]
UniGeneiHs.594647.

Genome annotation databases

EnsembliENST00000610513; ENSP00000478707; ENSG00000274047. [Q9UMZ2-6]
ENST00000612223; ENSP00000483453; ENSG00000275066. [Q9UMZ2-1]
ENST00000613407; ENSP00000483152; ENSG00000274047. [Q9UMZ2-7]
ENST00000614941; ENSP00000481151; ENSG00000275066. [Q9UMZ2-6]
ENST00000616179; ENSP00000482962; ENSG00000275066. [Q9UMZ2-9]
ENST00000618176; ENSP00000482597; ENSG00000274047. [Q9UMZ2-4]
ENST00000618402; ENSP00000480288; ENSG00000274047. [Q9UMZ2-1]
ENST00000619541; ENSP00000477885; ENSG00000275066. [Q9UMZ2-8]
ENST00000621136; ENSP00000484529; ENSG00000275066. [Q9UMZ2-4]
ENST00000622045; ENSP00000483063; ENSG00000275066. [Q9UMZ2-7]
ENST00000632841; ENSP00000487672; ENSG00000274047. [Q9UMZ2-9]
ENST00000633429; ENSP00000488473; ENSG00000274047. [Q9UMZ2-8]
GeneIDi11276.
KEGGihsa:11276.
UCSCiuc002hoa.4. human. [Q9UMZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169548 mRNA. Translation: AAD49732.1.
AC004099 Genomic DNA. No translation available.
AC091199 Genomic DNA. No translation available.
BC090930 mRNA. Translation: AAH90930.1.
BC117313 mRNA. Translation: AAI17314.1.
BC143476 mRNA. Translation: AAI43477.1.
BC143478 mRNA. Translation: AAI43479.1.
AK126988 mRNA. No translation available.
CCDSiCCDS11321.1. [Q9UMZ2-1]
CCDS11322.2. [Q9UMZ2-4]
CCDS54113.1. [Q9UMZ2-6]
CCDS54114.1. [Q9UMZ2-7]
CCDS59284.1. [Q9UMZ2-8]
CCDS59285.1. [Q9UMZ2-9]
RefSeqiNP_001157016.1. NM_001163544.2. [Q9UMZ2-3]
NP_001157017.1. NM_001163545.2. [Q9UMZ2-8]
NP_001157018.1. NM_001163546.2. [Q9UMZ2-9]
NP_001157019.1. NM_001163547.2. [Q9UMZ2-6]
NP_009178.3. NM_007247.5. [Q9UMZ2-1]
NP_542117.3. NM_080550.4. [Q9UMZ2-4]
NP_942583.1. NM_198882.2. [Q9UMZ2-7]
XP_016879582.1. XM_017024093.1. [Q9UMZ2-5]
UniGeneiHs.594647.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MX7NMR-A279-388[»]
ProteinModelPortaliQ9UMZ2.
SMRiQ9UMZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116432. 16 interactors.
IntActiQ9UMZ2. 6 interactors.
MINTiMINT-126209.
STRINGi9606.ENSP00000343610.

PTM databases

iPTMnetiQ9UMZ2.
PhosphoSitePlusiQ9UMZ2.

Polymorphism and mutation databases

BioMutaiSYNRG.
DMDMi143811464.

Proteomic databases

EPDiQ9UMZ2.
PaxDbiQ9UMZ2.
PeptideAtlasiQ9UMZ2.
PRIDEiQ9UMZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610513; ENSP00000478707; ENSG00000274047. [Q9UMZ2-6]
ENST00000612223; ENSP00000483453; ENSG00000275066. [Q9UMZ2-1]
ENST00000613407; ENSP00000483152; ENSG00000274047. [Q9UMZ2-7]
ENST00000614941; ENSP00000481151; ENSG00000275066. [Q9UMZ2-6]
ENST00000616179; ENSP00000482962; ENSG00000275066. [Q9UMZ2-9]
ENST00000618176; ENSP00000482597; ENSG00000274047. [Q9UMZ2-4]
ENST00000618402; ENSP00000480288; ENSG00000274047. [Q9UMZ2-1]
ENST00000619541; ENSP00000477885; ENSG00000275066. [Q9UMZ2-8]
ENST00000621136; ENSP00000484529; ENSG00000275066. [Q9UMZ2-4]
ENST00000622045; ENSP00000483063; ENSG00000275066. [Q9UMZ2-7]
ENST00000632841; ENSP00000487672; ENSG00000274047. [Q9UMZ2-9]
ENST00000633429; ENSP00000488473; ENSG00000274047. [Q9UMZ2-8]
GeneIDi11276.
KEGGihsa:11276.
UCSCiuc002hoa.4. human. [Q9UMZ2-1]

Organism-specific databases

CTDi11276.
GeneCardsiSYNRG.
HGNCiHGNC:557. SYNRG.
HPAiHPA023554.
HPA023555.
MIMi607291. gene.
neXtProtiNX_Q9UMZ2.
OpenTargetsiENSG00000274047.
ENSG00000275066.
PharmGKBiPA24847.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRB0. Eukaryota.
ENOG410Z4AG. LUCA.
GeneTreeiENSGT00390000010789.
HOGENOMiHOG000293152.
HOVERGENiHBG055053.
InParanoidiQ9UMZ2.
OMAiMFSSVNC.
OrthoDBiEOG091G09OC.
PhylomeDBiQ9UMZ2.
TreeFamiTF316700.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006114-MONOMER.

Miscellaneous databases

ChiTaRSiSYNRG. human.
GeneWikiiSynergin_gamma.
GenomeRNAii11276.
PROiQ9UMZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006114.
CleanExiHS_AP1GBP1.
ExpressionAtlasiQ9UMZ2. baseline and differential.
GenevisibleiQ9UMZ2. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EH_dom.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50031. EH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYNRG_HUMAN
AccessioniPrimary (citable) accession number: Q9UMZ2
Secondary accession number(s): A8MWU4
, B7ZKZ2, B7ZKZ3, Q17RI2, Q5BKU5, Q6ZT17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.