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Protein

Sorting nexin-12

Gene

SNX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei73Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei96Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei119Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • negative regulation of early endosome to late endosome transport Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of protein catabolic process Source: UniProtKB
  • negative regulation of protein processing Source: UniProtKB
  • negative regulation of protein transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: UniProtKB
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-12
Gene namesi
Name:SNX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147164.11
HGNCiHGNC:14976 SNX12
MIMi300883 gene
neXtProtiNX_Q9UMY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29934
OpenTargetsiENSG00000147164
PharmGKBiPA37952

Polymorphism and mutation databases

BioMutaiSNX12
DMDMi50403807

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002138582 – 172Sorting nexin-12Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei23PhosphotyrosineCombined sources1
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UMY4
PaxDbiQ9UMY4
PeptideAtlasiQ9UMY4
PRIDEiQ9UMY4
TopDownProteomicsiQ9UMY4-2 [Q9UMY4-2]

2D gel databases

UCD-2DPAGEiQ9UMY4

PTM databases

iPTMnetiQ9UMY4
PhosphoSitePlusiQ9UMY4

Miscellaneous databases

PMAP-CutDBiQ9UMY4

Expressioni

Gene expression databases

BgeeiENSG00000147164
CleanExiHS_SNX12
ExpressionAtlasiQ9UMY4 baseline and differential
GenevisibleiQ9UMY4 HS

Organism-specific databases

HPAiCAB070423

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118974, 27 interactors
IntActiQ9UMY4, 7 interactors
MINTiQ9UMY4
STRINGi9606.ENSP00000363392

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 45Combined sources15
Beta strandi47 – 55Combined sources9
Beta strandi59 – 62Combined sources4
Beta strandi64 – 70Combined sources7
Helixi72 – 82Combined sources11
Beta strandi83 – 87Combined sources5
Helixi113 – 132Combined sources20
Helixi134 – 138Combined sources5
Helixi140 – 145Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSKNMR-A27-159[»]
ProteinModelPortaliQ9UMY4
SMRiQ9UMY4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UMY4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 152PXPROSITE-ProRule annotationAdd BLAST125

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2527 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00650000093174
HOGENOMiHOG000234882
HOVERGENiHBG055338
InParanoidiQ9UMY4
KOiK17918
PhylomeDBiQ9UMY4
TreeFamiTF314980

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UMY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY
60 70 80 90 100
EVRMRTNLPI FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR
110 120 130 140 150
QLPFRGDEGI FEESFIEERR QGLEQFINKI AGHPLAQNER CLHMFLQEEA
160 170
IDRNYVPGKS LAVSCPGWSA VA
Length:172
Mass (Da):19,730
Last modified:July 19, 2004 - v3
Checksum:iA9221EB7A4CD5A29
GO
Isoform 2 (identifier: Q9UMY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-172: SLAVSCPGWSAVA → VRQ

Show »
Length:162
Mass (Da):18,885
Checksum:i48CBC16A86AFDB08
GO
Isoform 3 (identifier: Q9UMY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-55: Missing.
     160-172: SLAVSCPGWSAVA → VRQ

Note: Gene prediction based on EST data.
Show »
Length:158
Mass (Da):18,342
Checksum:i281C74C856723BFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101Q → K in AAD48491 (PubMed:11485546).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04683052 – 55Missing in isoform 3. Curated4
Alternative sequenceiVSP_011038160 – 172SLAVS…WSAVA → VRQ in isoform 2 and isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171229 mRNA Translation: AAD48491.1
BT007203 mRNA Translation: AAP35867.1
AL590764 Genomic DNA No translation available.
BC020559 mRNA No translation available.
CCDSiCCDS14405.1 [Q9UMY4-2]
CCDS59169.1 [Q9UMY4-3]
RefSeqiNP_001243117.1, NM_001256188.1 [Q9UMY4-3]
UniGeneiHs.260750

Genome annotation databases

EnsembliENST00000276105; ENSP00000276105; ENSG00000147164 [Q9UMY4-3]
ENST00000374274; ENSP00000363392; ENSG00000147164 [Q9UMY4-2]
ENST00000622277; ENSP00000481314; ENSG00000147164 [Q9UMY4-2]
GeneIDi29934
KEGGihsa:29934
UCSCiuc004dyq.5 human [Q9UMY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNX12_HUMAN
AccessioniPrimary (citable) accession number: Q9UMY4
Secondary accession number(s): F8W8K5, Q8WUG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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