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Protein

Sorting nexin-12

Gene

SNX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei73Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei96Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei119Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • negative regulation of early endosome to late endosome transport Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of protein catabolic process Source: UniProtKB
  • negative regulation of protein processing Source: UniProtKB
  • negative regulation of protein transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: UniProtKB
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-12
Gene namesi
Name:SNX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14976. SNX12.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extrinsic component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29934.
OpenTargetsiENSG00000147164.
PharmGKBiPA37952.

Polymorphism and mutation databases

BioMutaiSNX12.
DMDMi50403807.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002138582 – 172Sorting nexin-12Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei23PhosphotyrosineCombined sources1
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UMY4.
PaxDbiQ9UMY4.
PeptideAtlasiQ9UMY4.
PRIDEiQ9UMY4.
TopDownProteomicsiQ9UMY4-2. [Q9UMY4-2]

2D gel databases

UCD-2DPAGEQ9UMY4.

PTM databases

iPTMnetiQ9UMY4.
PhosphoSitePlusiQ9UMY4.

Miscellaneous databases

PMAP-CutDBQ9UMY4.

Expressioni

Gene expression databases

BgeeiENSG00000147164.
CleanExiHS_SNX12.
ExpressionAtlasiQ9UMY4. baseline and differential.
GenevisibleiQ9UMY4. HS.

Organism-specific databases

HPAiCAB070423.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150415EBI-1752602,EBI-714543
NCK1P163333EBI-1752602,EBI-389883

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118974. 25 interactors.
IntActiQ9UMY4. 6 interactors.
MINTiMINT-3082546.
STRINGi9606.ENSP00000363392.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 45Combined sources15
Beta strandi47 – 55Combined sources9
Beta strandi59 – 62Combined sources4
Beta strandi64 – 70Combined sources7
Helixi72 – 82Combined sources11
Beta strandi83 – 87Combined sources5
Helixi113 – 132Combined sources20
Helixi134 – 138Combined sources5
Helixi140 – 145Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSKNMR-A27-159[»]
ProteinModelPortaliQ9UMY4.
SMRiQ9UMY4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UMY4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 152PXPROSITE-ProRule annotationAdd BLAST125

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
HOVERGENiHBG055338.
InParanoidiQ9UMY4.
KOiK17918.
PhylomeDBiQ9UMY4.
TreeFamiTF314980.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UMY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY
60 70 80 90 100
EVRMRTNLPI FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR
110 120 130 140 150
QLPFRGDEGI FEESFIEERR QGLEQFINKI AGHPLAQNER CLHMFLQEEA
160 170
IDRNYVPGKS LAVSCPGWSA VA
Length:172
Mass (Da):19,730
Last modified:July 19, 2004 - v3
Checksum:iA9221EB7A4CD5A29
GO
Isoform 2 (identifier: Q9UMY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-172: SLAVSCPGWSAVA → VRQ

Show »
Length:162
Mass (Da):18,885
Checksum:i48CBC16A86AFDB08
GO
Isoform 3 (identifier: Q9UMY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-55: Missing.
     160-172: SLAVSCPGWSAVA → VRQ

Note: Gene prediction based on EST data.
Show »
Length:158
Mass (Da):18,342
Checksum:i281C74C856723BFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101Q → K in AAD48491 (PubMed:11485546).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04683052 – 55Missing in isoform 3. Curated4
Alternative sequenceiVSP_011038160 – 172SLAVS…WSAVA → VRQ in isoform 2 and isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171229 mRNA. Translation: AAD48491.1.
BT007203 mRNA. Translation: AAP35867.1.
AL590764 Genomic DNA. No translation available.
BC020559 mRNA. No translation available.
CCDSiCCDS14405.1. [Q9UMY4-2]
CCDS59169.1. [Q9UMY4-3]
RefSeqiNP_001243117.1. NM_001256188.1. [Q9UMY4-3]
UniGeneiHs.260750.

Genome annotation databases

EnsembliENST00000276105; ENSP00000276105; ENSG00000147164. [Q9UMY4-3]
ENST00000374274; ENSP00000363392; ENSG00000147164. [Q9UMY4-2]
ENST00000622277; ENSP00000481314; ENSG00000147164. [Q9UMY4-2]
GeneIDi29934.
KEGGihsa:29934.
UCSCiuc004dyq.5. human. [Q9UMY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171229 mRNA. Translation: AAD48491.1.
BT007203 mRNA. Translation: AAP35867.1.
AL590764 Genomic DNA. No translation available.
BC020559 mRNA. No translation available.
CCDSiCCDS14405.1. [Q9UMY4-2]
CCDS59169.1. [Q9UMY4-3]
RefSeqiNP_001243117.1. NM_001256188.1. [Q9UMY4-3]
UniGeneiHs.260750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSKNMR-A27-159[»]
ProteinModelPortaliQ9UMY4.
SMRiQ9UMY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118974. 25 interactors.
IntActiQ9UMY4. 6 interactors.
MINTiMINT-3082546.
STRINGi9606.ENSP00000363392.

PTM databases

iPTMnetiQ9UMY4.
PhosphoSitePlusiQ9UMY4.

Polymorphism and mutation databases

BioMutaiSNX12.
DMDMi50403807.

2D gel databases

UCD-2DPAGEQ9UMY4.

Proteomic databases

EPDiQ9UMY4.
PaxDbiQ9UMY4.
PeptideAtlasiQ9UMY4.
PRIDEiQ9UMY4.
TopDownProteomicsiQ9UMY4-2. [Q9UMY4-2]

Protocols and materials databases

DNASUi29934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276105; ENSP00000276105; ENSG00000147164. [Q9UMY4-3]
ENST00000374274; ENSP00000363392; ENSG00000147164. [Q9UMY4-2]
ENST00000622277; ENSP00000481314; ENSG00000147164. [Q9UMY4-2]
GeneIDi29934.
KEGGihsa:29934.
UCSCiuc004dyq.5. human. [Q9UMY4-1]

Organism-specific databases

CTDi29934.
DisGeNETi29934.
GeneCardsiSNX12.
H-InvDBHIX0022439.
HGNCiHGNC:14976. SNX12.
HPAiCAB070423.
MIMi300883. gene.
neXtProtiNX_Q9UMY4.
OpenTargetsiENSG00000147164.
PharmGKBiPA37952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
HOVERGENiHBG055338.
InParanoidiQ9UMY4.
KOiK17918.
PhylomeDBiQ9UMY4.
TreeFamiTF314980.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147164-MONOMER.

Miscellaneous databases

ChiTaRSiSNX12. human.
EvolutionaryTraceiQ9UMY4.
GenomeRNAii29934.
PMAP-CutDBQ9UMY4.
PROiQ9UMY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147164.
CleanExiHS_SNX12.
ExpressionAtlasiQ9UMY4. baseline and differential.
GenevisibleiQ9UMY4. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX12_HUMAN
AccessioniPrimary (citable) accession number: Q9UMY4
Secondary accession number(s): F8W8K5, Q8WUG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.