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Protein

Sorting nexin-12

Gene

SNX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711Phosphatidylinositol 3-phosphateBy similarity
Binding sitei73 – 731Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei96 – 961Phosphatidylinositol 3-phosphateBy similarity
Binding sitei119 – 1191Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • negative regulation of early endosome to late endosome transport Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of protein catabolic process Source: UniProtKB
  • negative regulation of protein processing Source: UniProtKB
  • negative regulation of protein transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: UniProtKB
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-12
Gene namesi
Name:SNX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14976. SNX12.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extrinsic component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37952.

Polymorphism and mutation databases

BioMutaiSNX12.
DMDMi50403807.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 172171Sorting nexin-12PRO_0000213858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei23 – 231PhosphotyrosineCombined sources
Modified residuei73 – 731PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UMY4.
MaxQBiQ9UMY4.
PaxDbiQ9UMY4.
PeptideAtlasiQ9UMY4.
PRIDEiQ9UMY4.
TopDownProteomicsiQ9UMY4-2. [Q9UMY4-2]

2D gel databases

UCD-2DPAGEQ9UMY4.

PTM databases

iPTMnetiQ9UMY4.
PhosphoSiteiQ9UMY4.

Miscellaneous databases

PMAP-CutDBQ9UMY4.

Expressioni

Gene expression databases

BgeeiENSG00000147164.
CleanExiHS_SNX12.
ExpressionAtlasiQ9UMY4. baseline and differential.
GenevisibleiQ9UMY4. HS.

Organism-specific databases

HPAiCAB070423.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-1752602,EBI-714543
NCK1P163333EBI-1752602,EBI-389883

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118974. 25 interactions.
IntActiQ9UMY4. 6 interactions.
MINTiMINT-3082546.
STRINGi9606.ENSP00000363392.

Structurei

Secondary structure

1
172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 4515Combined sources
Beta strandi47 – 559Combined sources
Beta strandi59 – 624Combined sources
Beta strandi64 – 707Combined sources
Helixi72 – 8211Combined sources
Beta strandi83 – 875Combined sources
Helixi113 – 13220Combined sources
Helixi134 – 1385Combined sources
Helixi140 – 1456Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSKNMR-A27-159[»]
ProteinModelPortaliQ9UMY4.
SMRiQ9UMY4. Positions 28-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UMY4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 152125PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
HOVERGENiHBG055338.
InParanoidiQ9UMY4.
KOiK17918.
PhylomeDBiQ9UMY4.
TreeFamiTF314980.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UMY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY
60 70 80 90 100
EVRMRTNLPI FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR
110 120 130 140 150
QLPFRGDEGI FEESFIEERR QGLEQFINKI AGHPLAQNER CLHMFLQEEA
160 170
IDRNYVPGKS LAVSCPGWSA VA
Length:172
Mass (Da):19,730
Last modified:July 19, 2004 - v3
Checksum:iA9221EB7A4CD5A29
GO
Isoform 2 (identifier: Q9UMY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-172: SLAVSCPGWSAVA → VRQ

Show »
Length:162
Mass (Da):18,885
Checksum:i48CBC16A86AFDB08
GO
Isoform 3 (identifier: Q9UMY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-55: Missing.
     160-172: SLAVSCPGWSAVA → VRQ

Note: Gene prediction based on EST data.
Show »
Length:158
Mass (Da):18,342
Checksum:i281C74C856723BFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011Q → K in AAD48491 (PubMed:11485546).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 554Missing in isoform 3. CuratedVSP_046830
Alternative sequencei160 – 17213SLAVS…WSAVA → VRQ in isoform 2 and isoform 3. 1 PublicationVSP_011038Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171229 mRNA. Translation: AAD48491.1.
BT007203 mRNA. Translation: AAP35867.1.
AL590764 Genomic DNA. No translation available.
BC020559 mRNA. No translation available.
CCDSiCCDS14405.1. [Q9UMY4-2]
CCDS59169.1. [Q9UMY4-3]
RefSeqiNP_001243117.1. NM_001256188.1. [Q9UMY4-3]
UniGeneiHs.260750.

Genome annotation databases

EnsembliENST00000276105; ENSP00000276105; ENSG00000147164. [Q9UMY4-3]
ENST00000374274; ENSP00000363392; ENSG00000147164. [Q9UMY4-2]
ENST00000622277; ENSP00000481314; ENSG00000147164. [Q9UMY4-2]
GeneIDi29934.
KEGGihsa:29934.
UCSCiuc004dyq.5. human. [Q9UMY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171229 mRNA. Translation: AAD48491.1.
BT007203 mRNA. Translation: AAP35867.1.
AL590764 Genomic DNA. No translation available.
BC020559 mRNA. No translation available.
CCDSiCCDS14405.1. [Q9UMY4-2]
CCDS59169.1. [Q9UMY4-3]
RefSeqiNP_001243117.1. NM_001256188.1. [Q9UMY4-3]
UniGeneiHs.260750.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSKNMR-A27-159[»]
ProteinModelPortaliQ9UMY4.
SMRiQ9UMY4. Positions 28-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118974. 25 interactions.
IntActiQ9UMY4. 6 interactions.
MINTiMINT-3082546.
STRINGi9606.ENSP00000363392.

PTM databases

iPTMnetiQ9UMY4.
PhosphoSiteiQ9UMY4.

Polymorphism and mutation databases

BioMutaiSNX12.
DMDMi50403807.

2D gel databases

UCD-2DPAGEQ9UMY4.

Proteomic databases

EPDiQ9UMY4.
MaxQBiQ9UMY4.
PaxDbiQ9UMY4.
PeptideAtlasiQ9UMY4.
PRIDEiQ9UMY4.
TopDownProteomicsiQ9UMY4-2. [Q9UMY4-2]

Protocols and materials databases

DNASUi29934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276105; ENSP00000276105; ENSG00000147164. [Q9UMY4-3]
ENST00000374274; ENSP00000363392; ENSG00000147164. [Q9UMY4-2]
ENST00000622277; ENSP00000481314; ENSG00000147164. [Q9UMY4-2]
GeneIDi29934.
KEGGihsa:29934.
UCSCiuc004dyq.5. human. [Q9UMY4-1]

Organism-specific databases

CTDi29934.
GeneCardsiSNX12.
H-InvDBHIX0022439.
HGNCiHGNC:14976. SNX12.
HPAiCAB070423.
MIMi300883. gene.
neXtProtiNX_Q9UMY4.
PharmGKBiPA37952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000234882.
HOVERGENiHBG055338.
InParanoidiQ9UMY4.
KOiK17918.
PhylomeDBiQ9UMY4.
TreeFamiTF314980.

Miscellaneous databases

ChiTaRSiSNX12. human.
EvolutionaryTraceiQ9UMY4.
GenomeRNAii29934.
PMAP-CutDBQ9UMY4.
PROiQ9UMY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147164.
CleanExiHS_SNX12.
ExpressionAtlasiQ9UMY4. baseline and differential.
GenevisibleiQ9UMY4. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX12_HUMAN
AccessioniPrimary (citable) accession number: Q9UMY4
Secondary accession number(s): F8W8K5, Q8WUG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.