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Protein

Nucleolar protein 7

Gene

NOL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137420-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 7
Alternative name(s):
Nucleolar protein of 27 kDa
Gene namesi
Name:NOL7
Synonyms:C6orf90, NOP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21040. NOL7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51406.
OpenTargetsiENSG00000225921.
PharmGKBiPA134881915.

Polymorphism and mutation databases

BioMutaiNOL7.
DMDMi71152014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969371 – 257Nucleolar protein 7Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UMY1.
PaxDbiQ9UMY1.
PeptideAtlasiQ9UMY1.
PRIDEiQ9UMY1.
TopDownProteomicsiQ9UMY1-1. [Q9UMY1-1]
Q9UMY1-2. [Q9UMY1-2]

2D gel databases

SWISS-2DPAGEQ9UMY1.

PTM databases

iPTMnetiQ9UMY1.
PhosphoSitePlusiQ9UMY1.

Expressioni

Tissue specificityi

Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000225921.
CleanExiHS_NOL7.
ExpressionAtlasiQ9UMY1. baseline and differential.
GenevisibleiQ9UMY1. HS.

Organism-specific databases

HPAiHPA029185.
HPA049693.

Interactioni

Protein-protein interaction databases

BioGridi119526. 16 interactors.
IntActiQ9UMY1. 6 interactors.
MINTiMINT-4541814.
STRINGi9606.ENSP00000405674.

Structurei

3D structure databases

ProteinModelPortaliQ9UMY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 104Sequence analysisAdd BLAST40

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0GQ. Eukaryota.
ENOG410YNFM. LUCA.
GeneTreeiENSGT00390000004118.
HOGENOMiHOG000220870.
HOVERGENiHBG079866.
InParanoidiQ9UMY1.
OMAiAQFLNNA.
OrthoDBiEOG091G0WWD.
PhylomeDBiQ9UMY1.
TreeFamiTF336320.

Family and domain databases

InterProiIPR012579. NOL7_C.
[Graphical view]
PfamiPF08157. NUC129. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UMY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLRPRASR APASAEAMVD EGQLASEEEE AEHGLLLGQP SSGAAAEPLE
60 70 80 90 100
EDEEGDDEFD DEAPEELTFA SAQAEAREEE RRVRETVRRD KTLLKEKRKR
110 120 130 140 150
REELFIEQKK RKLLPDTILE KLTTASQTNI KKSPGKVKEV NLQKKNEDCE
160 170 180 190 200
KGNDSKKVKV QKVQSVSQNK SYLAVRLKDQ DLRDSRQQAA QAFIHNSLYG
210 220 230 240 250
PGTNRTTVNK FLSLANKRLP VKRAAVQFLN NAWGIQKKQN AKRFKRRWMV

RKMKTKK
Length:257
Mass (Da):29,426
Last modified:June 1, 2001 - v2
Checksum:i84DB1906362263AF
GO
Isoform 2 (identifier: Q9UMY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-145: VNLQKK → GMTILI
     146-257: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:145
Mass (Da):16,329
Checksum:iBD0EA7ECEAC773C6
GO

Sequence cautioni

The sequence CAB43398 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAI19840 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200G → A in CAB43398 (PubMed:17974005).Curated1
Sequence conflicti209N → D in CAB43398 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014791140 – 145VNLQKK → GMTILI in isoform 2. Curated6
Alternative sequenceiVSP_014792146 – 257Missing in isoform 2. CuratedAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172066 mRNA. Translation: AAD49745.2.
AK075301 mRNA. Translation: BAC11534.1.
AL441883 Genomic DNA. Translation: CAI19839.1.
AL441883 Genomic DNA. Translation: CAI19840.1. Sequence problems.
BC023517 mRNA. Translation: AAH23517.1.
BC062683 mRNA. Translation: AAH62683.1.
AL050299 mRNA. Translation: CAB43398.1. Sequence problems.
CCDSiCCDS4528.1. [Q9UMY1-1]
PIRiT08718.
RefSeqiNP_001304653.1. NM_001317724.1. [Q9UMY1-1]
NP_057251.2. NM_016167.4. [Q9UMY1-1]
UniGeneiHs.306242.
Hs.708182.

Genome annotation databases

EnsembliENST00000451315; ENSP00000405674; ENSG00000225921. [Q9UMY1-1]
GeneIDi51406.
KEGGihsa:51406.
UCSCiuc003naz.4. human. [Q9UMY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172066 mRNA. Translation: AAD49745.2.
AK075301 mRNA. Translation: BAC11534.1.
AL441883 Genomic DNA. Translation: CAI19839.1.
AL441883 Genomic DNA. Translation: CAI19840.1. Sequence problems.
BC023517 mRNA. Translation: AAH23517.1.
BC062683 mRNA. Translation: AAH62683.1.
AL050299 mRNA. Translation: CAB43398.1. Sequence problems.
CCDSiCCDS4528.1. [Q9UMY1-1]
PIRiT08718.
RefSeqiNP_001304653.1. NM_001317724.1. [Q9UMY1-1]
NP_057251.2. NM_016167.4. [Q9UMY1-1]
UniGeneiHs.306242.
Hs.708182.

3D structure databases

ProteinModelPortaliQ9UMY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119526. 16 interactors.
IntActiQ9UMY1. 6 interactors.
MINTiMINT-4541814.
STRINGi9606.ENSP00000405674.

PTM databases

iPTMnetiQ9UMY1.
PhosphoSitePlusiQ9UMY1.

Polymorphism and mutation databases

BioMutaiNOL7.
DMDMi71152014.

2D gel databases

SWISS-2DPAGEQ9UMY1.

Proteomic databases

EPDiQ9UMY1.
PaxDbiQ9UMY1.
PeptideAtlasiQ9UMY1.
PRIDEiQ9UMY1.
TopDownProteomicsiQ9UMY1-1. [Q9UMY1-1]
Q9UMY1-2. [Q9UMY1-2]

Protocols and materials databases

DNASUi51406.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451315; ENSP00000405674; ENSG00000225921. [Q9UMY1-1]
GeneIDi51406.
KEGGihsa:51406.
UCSCiuc003naz.4. human. [Q9UMY1-1]

Organism-specific databases

CTDi51406.
DisGeNETi51406.
GeneCardsiNOL7.
HGNCiHGNC:21040. NOL7.
HPAiHPA029185.
HPA049693.
MIMi611533. gene.
neXtProtiNX_Q9UMY1.
OpenTargetsiENSG00000225921.
PharmGKBiPA134881915.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0GQ. Eukaryota.
ENOG410YNFM. LUCA.
GeneTreeiENSGT00390000004118.
HOGENOMiHOG000220870.
HOVERGENiHBG079866.
InParanoidiQ9UMY1.
OMAiAQFLNNA.
OrthoDBiEOG091G0WWD.
PhylomeDBiQ9UMY1.
TreeFamiTF336320.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137420-MONOMER.

Miscellaneous databases

ChiTaRSiNOL7. human.
GeneWikiiNOL7.
GenomeRNAii51406.
PROiQ9UMY1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000225921.
CleanExiHS_NOL7.
ExpressionAtlasiQ9UMY1. baseline and differential.
GenevisibleiQ9UMY1. HS.

Family and domain databases

InterProiIPR012579. NOL7_C.
[Graphical view]
PfamiPF08157. NUC129. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UMY1
Secondary accession number(s): Q5T297, Q9Y3U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.