Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neudesin

Gene

NENF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).By similarity1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neudesin
Alternative name(s):
Cell immortalization-related protein 2
Neuron-derived neurotrophic factor
Protein GIG471 Publication
Secreted protein of unknown function
Short name:
SPUF protein
Gene namesi
Name:NENFImported
Synonyms:CIR2, SPUF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117691.9
HGNCiHGNC:30384 NENF
MIMi611874 gene
neXtProtiNX_Q9UMX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi29937
OpenTargetsiENSG00000117691
PharmGKBiPA142671266

Polymorphism and mutation databases

BioMutaiNENF
DMDMi46577571

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001859832 – 172NeudesinAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UMX5
MaxQBiQ9UMX5
PaxDbiQ9UMX5
PeptideAtlasiQ9UMX5
PRIDEiQ9UMX5
TopDownProteomicsiQ9UMX5

PTM databases

iPTMnetiQ9UMX5
PhosphoSitePlusiQ9UMX5

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.1 Publication

Inductioni

Up-regulated in immortal cells. Induced in estrogen receptor positive breast cancer expressing progesterone receptor.2 Publications

Gene expression databases

BgeeiENSG00000117691
CleanExiHS_NENF
GenevisibleiQ9UMX5 HS

Organism-specific databases

HPAiHPA026763
HPA028488

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118976, 35 interactors
IntActiQ9UMX5, 1 interactor
STRINGi9606.ENSP00000355955

Structurei

3D structure databases

ProteinModelPortaliQ9UMX5
SMRiQ9UMX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 129Cytochrome b5 heme-bindingAdd BLAST86

Domaini

The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1110 Eukaryota
ENOG4111UG0 LUCA
GeneTreeiENSGT00730000110948
HOGENOMiHOG000187840
HOVERGENiHBG059971
InParanoidiQ9UMX5
OMAiGKGAPYN
OrthoDBiEOG091G0QKM
PhylomeDBiQ9UMX5
TreeFamiTF332131

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UMX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGPAPRRRL RPLAALALVL ALAPGLPTAR AGQTPRPAER GPPVRLFTEE
60 70 80 90 100
ELARYGGEEE DQPIYLAVKG VVFDVTSGKE FYGRGAPYNA LTGKDSTRGV
110 120 130 140 150
AKMSLDPADL THDTTGLTAK ELEALDEVFT KVYKAKYPIV GYTARRILNE
160 170
DGSPNLDFKP EDQPHFDIKD EF
Length:172
Mass (Da):18,856
Last modified:May 1, 2000 - v1
Checksum:i24527D540B000F2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74D → E in BAD96855 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126219 mRNA Translation: BAD72063.1
AF173937 mRNA Translation: AAD51419.1
AY762102 mRNA Translation: AAX07829.1
AK223135 mRNA Translation: BAD96855.1
CH471100 Genomic DNA Translation: EAW93389.1
BC008823 mRNA Translation: AAH08823.1
CCDSiCCDS1505.1
RefSeqiNP_037481.1, NM_013349.4
UniGeneiHs.461787

Genome annotation databases

EnsembliENST00000366988; ENSP00000355955; ENSG00000117691
GeneIDi29937
KEGGihsa:29937
UCSCiuc001hjd.3 human

Similar proteinsi

Entry informationi

Entry nameiNENF_HUMAN
AccessioniPrimary (citable) accession number: Q9UMX5
Secondary accession number(s): A1KYQ8, Q53FZ6, Q5TM90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health