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Protein

Bcl-2-related ovarian killer protein

Gene

BOK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces apoptosis in a manner dependent on BAX and BAK.1 Publication

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: UniProtKB
  • brain development Source: Ensembl
  • cell proliferation Source: UniProtKB
  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • male gonad development Source: Ensembl
  • neuron apoptotic process Source: Ensembl
  • oligodendrocyte differentiation Source: Ensembl
  • positive regulation of execution phase of apoptosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related ovarian killer protein
Short name:
hBOK
Alternative name(s):
Bcl-2-like protein 9
Short name:
Bcl2-L-9
Gene namesi
Name:BOK
Synonyms:BCL2L9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1087. BOK.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB
  • mitochondrial outer membrane Source: GO_Central
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25396.

Polymorphism and mutation databases

BioMutaiBOK.
DMDMi57012554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Bcl-2-related ovarian killer proteinPRO_0000143086Add
BLAST

Proteomic databases

PaxDbiQ9UMX3.
PRIDEiQ9UMX3.

PTM databases

PhosphoSiteiQ9UMX3.

Expressioni

Tissue specificityi

Expressed in brain, liver, appendix and lymphoid tissues.1 Publication

Gene expression databases

BgeeiQ9UMX3.
CleanExiHS_BOK.
ExpressionAtlasiQ9UMX3. baseline and differential.
GenevisibleiQ9UMX3. HS.

Interactioni

Protein-protein interaction databases

BioGridi107134. 6 interactions.
IntActiQ9UMX3. 1 interaction.
STRINGi9606.ENSP00000314132.

Structurei

3D structure databases

ProteinModelPortaliQ9UMX3.
SMRiQ9UMX3. Positions 45-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 4413BH4Add
BLAST
Motifi66 – 8217BH3Add
BLAST
Motifi112 – 13120BH1Add
BLAST
Motifi164 – 17815BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241746.
GeneTreeiENSGT00510000048498.
HOVERGENiHBG050709.
InParanoidiQ9UMX3.
KOiK02561.
OMAiCRDYIHS.
OrthoDBiEOG7FZ00G.
PhylomeDBiQ9UMX3.
TreeFamiTF315834.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF39. PTHR11256:SF39. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UMX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW
60 70 80 90 100
SAPERAAPVP GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP
110 120 130 140 150
VVTDAFLAVA GHIFSAGITW GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV
160 170 180 190 200
DCLGEFVRKT LATWLRRRGG WTDVLKCVVS TDPGLRSHWL VAALCSFGRF
210
LKAAFFVLLP ER
Length:212
Mass (Da):23,280
Last modified:May 1, 2000 - v1
Checksum:i053ED605FF8EF5B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174487 mRNA. Translation: AAD51719.1.
BT007272 mRNA. Translation: AAP35936.1.
BC006203 mRNA. No translation available.
CCDSiCCDS2550.1.
RefSeqiNP_115904.1. NM_032515.4.
XP_005247094.1. XM_005247037.3.
UniGeneiHs.293753.
Hs.734656.

Genome annotation databases

EnsembliENST00000318407; ENSP00000314132; ENSG00000176720.
GeneIDi666.
KEGGihsa:666.
UCSCiuc002wbq.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174487 mRNA. Translation: AAD51719.1.
BT007272 mRNA. Translation: AAP35936.1.
BC006203 mRNA. No translation available.
CCDSiCCDS2550.1.
RefSeqiNP_115904.1. NM_032515.4.
XP_005247094.1. XM_005247037.3.
UniGeneiHs.293753.
Hs.734656.

3D structure databases

ProteinModelPortaliQ9UMX3.
SMRiQ9UMX3. Positions 45-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107134. 6 interactions.
IntActiQ9UMX3. 1 interaction.
STRINGi9606.ENSP00000314132.

PTM databases

PhosphoSiteiQ9UMX3.

Polymorphism and mutation databases

BioMutaiBOK.
DMDMi57012554.

Proteomic databases

PaxDbiQ9UMX3.
PRIDEiQ9UMX3.

Protocols and materials databases

DNASUi666.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318407; ENSP00000314132; ENSG00000176720.
GeneIDi666.
KEGGihsa:666.
UCSCiuc002wbq.3. human.

Organism-specific databases

CTDi666.
GeneCardsiGC02P242498.
H-InvDBHIX0030495.
HGNCiHGNC:1087. BOK.
MIMi605404. gene.
neXtProtiNX_Q9UMX3.
PharmGKBiPA25396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241746.
GeneTreeiENSGT00510000048498.
HOVERGENiHBG050709.
InParanoidiQ9UMX3.
KOiK02561.
OMAiCRDYIHS.
OrthoDBiEOG7FZ00G.
PhylomeDBiQ9UMX3.
TreeFamiTF315834.

Miscellaneous databases

ChiTaRSiBOK. human.
GeneWikiiBOK_(gene).
GenomeRNAii666.
NextBioi2716.
PROiQ9UMX3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UMX3.
CleanExiHS_BOK.
ExpressionAtlasiQ9UMX3. baseline and differential.
GenevisibleiQ9UMX3. HS.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF39. PTHR11256:SF39. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionarily conserved Bok proteins in the Bcl-2 family."
    Zhang H., Holzgreve W., De Geyter C.
    FEBS Lett. 480:311-313(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL."
    Inohara N., Ekhterae D., Garcia I., Carrio R., Merino J., Merry A., Chen S., Nunez G.
    J. Biol. Chem. 273:8705-8710(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Intracellular localization of the BCL-2 family member BOK and functional implications."
    Echeverry N., Bachmann D., Ke F., Strasser A., Simon H.U., Kaufmann T.
    Cell Death Differ. 20:785-799(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiBOK_HUMAN
AccessioniPrimary (citable) accession number: Q9UMX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.