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Q9UMX3

- BOK_HUMAN

UniProt

Q9UMX3 - BOK_HUMAN

Protein

Bcl-2-related ovarian killer protein

Gene

BOK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May play a role in apoptosis.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein heterodimerization activity Source: RefGenome
    3. protein homodimerization activity Source: RefGenome

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. apoptotic process Source: UniProtKB
    3. brain development Source: Ensembl
    4. cell proliferation Source: UniProtKB
    5. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
    6. intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
    7. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
    8. male gonad development Source: Ensembl
    9. neuron apoptotic process Source: Ensembl
    10. oligodendrocyte differentiation Source: Ensembl
    11. positive regulation of apoptotic process Source: Ensembl
    12. positive regulation of execution phase of apoptosis Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-related ovarian killer protein
    Short name:
    hBOK
    Alternative name(s):
    Bcl-2-like protein 9
    Short name:
    Bcl2-L-9
    Gene namesi
    Name:BOK
    Synonyms:BCL2L9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:1087. BOK.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrial membrane Source: UniProtKB
    3. mitochondrial outer membrane Source: RefGenome
    4. mitochondrion Source: UniProtKB
    5. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25396.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Bcl-2-related ovarian killer proteinPRO_0000143086Add
    BLAST

    Proteomic databases

    PaxDbiQ9UMX3.
    PRIDEiQ9UMX3.

    PTM databases

    PhosphoSiteiQ9UMX3.

    Expressioni

    Tissue specificityi

    Expressed in brain, liver, appendix and lymphoid tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9UMX3.
    BgeeiQ9UMX3.
    CleanExiHS_BOK.
    GenevestigatoriQ9UMX3.

    Interactioni

    Protein-protein interaction databases

    BioGridi107134. 5 interactions.
    IntActiQ9UMX3. 1 interaction.
    STRINGi9606.ENSP00000314132.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UMX3.
    SMRiQ9UMX3. Positions 45-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi32 – 4413BH4Add
    BLAST
    Motifi66 – 8217BH3Add
    BLAST
    Motifi112 – 13120BH1Add
    BLAST
    Motifi164 – 17815BH2Add
    BLAST

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG241746.
    HOVERGENiHBG050709.
    InParanoidiQ9UMX3.
    KOiK02561.
    OMAiEFVHARL.
    OrthoDBiEOG7FZ00G.
    PhylomeDBiQ9UMX3.
    TreeFamiTF315834.

    Family and domain databases

    InterProiIPR002475. Bcl2-like.
    IPR026298. Blc2_fam.
    IPR026309. BOK.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF39. PTHR11256:SF39. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PRINTSiPR01862. BCL2FAMILY.
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UMX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW    50
    SAPERAAPVP GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP 100
    VVTDAFLAVA GHIFSAGITW GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV 150
    DCLGEFVRKT LATWLRRRGG WTDVLKCVVS TDPGLRSHWL VAALCSFGRF 200
    LKAAFFVLLP ER 212
    Length:212
    Mass (Da):23,280
    Last modified:May 1, 2000 - v1
    Checksum:i053ED605FF8EF5B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174487 mRNA. Translation: AAD51719.1.
    BT007272 mRNA. Translation: AAP35936.1.
    BC006203 mRNA. No translation available.
    CCDSiCCDS2550.1.
    RefSeqiNP_115904.1. NM_032515.4.
    XP_005247094.1. XM_005247037.2.
    UniGeneiHs.293753.
    Hs.734656.

    Genome annotation databases

    EnsembliENST00000318407; ENSP00000314132; ENSG00000176720.
    GeneIDi666.
    KEGGihsa:666.
    UCSCiuc002wbq.3. human.

    Polymorphism databases

    DMDMi57012554.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174487 mRNA. Translation: AAD51719.1 .
    BT007272 mRNA. Translation: AAP35936.1 .
    BC006203 mRNA. No translation available.
    CCDSi CCDS2550.1.
    RefSeqi NP_115904.1. NM_032515.4.
    XP_005247094.1. XM_005247037.2.
    UniGenei Hs.293753.
    Hs.734656.

    3D structure databases

    ProteinModelPortali Q9UMX3.
    SMRi Q9UMX3. Positions 45-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107134. 5 interactions.
    IntActi Q9UMX3. 1 interaction.
    STRINGi 9606.ENSP00000314132.

    PTM databases

    PhosphoSitei Q9UMX3.

    Polymorphism databases

    DMDMi 57012554.

    Proteomic databases

    PaxDbi Q9UMX3.
    PRIDEi Q9UMX3.

    Protocols and materials databases

    DNASUi 666.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318407 ; ENSP00000314132 ; ENSG00000176720 .
    GeneIDi 666.
    KEGGi hsa:666.
    UCSCi uc002wbq.3. human.

    Organism-specific databases

    CTDi 666.
    GeneCardsi GC02P242517.
    H-InvDB HIX0030495.
    HGNCi HGNC:1087. BOK.
    MIMi 605404. gene.
    neXtProti NX_Q9UMX3.
    PharmGKBi PA25396.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241746.
    HOVERGENi HBG050709.
    InParanoidi Q9UMX3.
    KOi K02561.
    OMAi EFVHARL.
    OrthoDBi EOG7FZ00G.
    PhylomeDBi Q9UMX3.
    TreeFami TF315834.

    Miscellaneous databases

    GeneWikii BOK_(gene).
    GenomeRNAii 666.
    NextBioi 2716.
    PROi Q9UMX3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UMX3.
    Bgeei Q9UMX3.
    CleanExi HS_BOK.
    Genevestigatori Q9UMX3.

    Family and domain databases

    InterProi IPR002475. Bcl2-like.
    IPR026298. Blc2_fam.
    IPR026309. BOK.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF39. PTHR11256:SF39. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01862. BCL2FAMILY.
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionarily conserved Bok proteins in the Bcl-2 family."
      Zhang H., Holzgreve W., De Geyter C.
      FEBS Lett. 480:311-313(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. "Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL."
      Inohara N., Ekhterae D., Garcia I., Carrio R., Merino J., Merry A., Chen S., Nunez G.
      J. Biol. Chem. 273:8705-8710(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiBOK_HUMAN
    AccessioniPrimary (citable) accession number: Q9UMX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3