Q9UMX3 (BOK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bcl-2-related ovarian killer protein
Short name=hBOK

Alternative name(s):
Bcl-2-like protein 9
Short name=Bcl2-L-9

Gene names

Name:	BOK
Synonyms:	BCL2L9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in apoptosis.
Tissue specificity	Expressed in brain, liver, appendix and lymphoid tissues. Ref.4
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from mutant phenotype. Source: UniProtKB cell proliferation Inferred from expression pattern. Source: UniProtKB signal transduction by p53 class mediator resulting in induction of apoptosis Inferred from mutant phenotype. Source: UniProtKB
Cellular component	mitochondrial membrane Inferred from direct assay. Source: UniProtKB nucleus Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Bcl-2-related ovarian killer protein		PRO_0000143086
Regions
	Motif	32 – 44	13	BH4
	Motif	66 – 82	17	BH3
	Motif	112 – 131	20	BH1
	Motif	164 – 178	15	BH2

Sequences

	Sequence		Length	Mass (Da)
	Q9UMX3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 053ED605FF8EF5B2	FASTA	212	23,280
	10 20 30 40 50 60 MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 70 80 90 100 110 120 GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAGITW 130 140 150 160 170 180 GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV DCLGEFVRKT LATWLRRRGG WTDVLKCVVS 190 200 210 TDPGLRSHWL VAALCSFGRF LKAAFFVLLP ER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionarily conserved Bok proteins in the Bcl-2 family." Zhang H., Holzgreve W., De Geyter C. FEBS Lett. 480:311-313(2000) [PubMed: 11034351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL." Inohara N., Ekhterae D., Garcia I., Carrio R., Merino J., Merry A., Chen S., Nunez G. J. Biol. Chem. 273:8705-8710(1998) [PubMed: 9535847] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF174487 mRNA. Translation: AAD51719.1. BT007272 mRNA. Translation: AAP35936.1. BC006203 mRNA. No translation available.
IPI	IPI00000133.
RefSeq	NP_115904.1. NM_032515.4.
UniGene	Hs.293753.
3D structure databases
ProteinModelPortal	Q9UMX3.
SMR	Q9UMX3. Positions 31-180.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UMX3.
PTM databases
PhosphoSite	Q9UMX3.
Polymorphism databases
DMDM	57012554.
Proteomic databases
PRIDE	Q9UMX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318407; ENSP00000314132; ENSG00000176720.
GeneID	666.
KEGG	hsa:666.
UCSC	uc002wbq.1. human.
Organism-specific databases
CTD	666.
GeneCards	GC02P242517.
H-InvDB	HIX0021003. HIX0030495.
HGNC	HGNC:1087. BOK.
MIM	605404. gene.
neXtProt	NX_Q9UMX3.
PharmGKB	PA25396.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000048498.
HOVERGEN	HBG050709.
InParanoid	Q9UMX3.
OMA	ELEYIRP.
OrthoDB	EOG476K15.
PhylomeDB	Q9UMX3.
Gene expression databases
ArrayExpress	Q9UMX3.
Bgee	Q9UMX3.
CleanEx	HS_BOK.
Genevestigator	Q9UMX3.
GermOnline	ENSG00000176720. Homo sapiens.
Family and domain databases
InterPro	IPR002475. Bcl2-like_apoptosis. IPR000712. Bcl2_BH. [Graphical view]
KO	K02561.
Pfam	PF00452. Bcl-2. 1 hit. [Graphical view]
PRINTS	PR01862. BCL2FAMILY.
SMART	SM00337. BCL. 1 hit. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. False negative. PS01258. BH2. False negative. PS01259. BH3. False negative. PS01260. BH4_1. False negative. PS50063. BH4_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	2716.
SOURCE	Search...

Entry information

Entry name

BOK_HUMAN

Accession

Primary (citable) accession number: Q9UMX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.