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Q9UMX3 (BOK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bcl-2-related ovarian killer protein

Short name=hBOK
Alternative name(s):
Bcl-2-like protein 9
Short name=Bcl2-L-9
Gene names
Name:BOK
Synonyms:BCL2L9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in apoptosis.

Tissue specificity

Expressed in brain, liver, appendix and lymphoid tissues. Ref.4

Sequence similarities

Belongs to the Bcl-2 family.

Ontologies

Keywords
   Biological processApoptosis
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from mutant phenotype PubMed 20673843. Source: UniProtKB

apoptotic process

Inferred from direct assay PubMed 15102863. Source: UniProtKB

brain development

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Inferred from expression pattern PubMed 19095301. Source: UniProtKB

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from Biological aspect of Ancestor. Source: RefGenome

intrinsic apoptotic signaling pathway by p53 class mediator

Inferred from mutant phenotype PubMed 15102863. Source: UniProtKB

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from Biological aspect of Ancestor. Source: RefGenome

male gonad development

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of execution phase of apoptosis

Inferred from mutant phenotype PubMed 20673843. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15868100PubMed 20673843. Source: UniProtKB

mitochondrial membrane

Inferred from direct assay PubMed 15868100. Source: UniProtKB

mitochondrial outer membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

mitochondrion

Inferred from direct assay PubMed 19095301. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 19095301PubMed 20673843. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15868100. Source: UniProtKB

protein heterodimerization activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein homodimerization activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Bcl-2-related ovarian killer protein
PRO_0000143086

Regions

Motif32 – 4413BH4
Motif66 – 8217BH3
Motif112 – 13120BH1
Motif164 – 17815BH2

Sequences

Sequence LengthMass (Da)Tools
Q9UMX3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 053ED605FF8EF5B2

FASTA21223,280
        10         20         30         40         50         60 
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 

        70         80         90        100        110        120 
GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAGITW 

       130        140        150        160        170        180 
GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV DCLGEFVRKT LATWLRRRGG WTDVLKCVVS 

       190        200        210 
TDPGLRSHWL VAALCSFGRF LKAAFFVLLP ER 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionarily conserved Bok proteins in the Bcl-2 family."
Zhang H., Holzgreve W., De Geyter C.
FEBS Lett. 480:311-313(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]"Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL."
Inohara N., Ekhterae D., Garcia I., Carrio R., Merino J., Merry A., Chen S., Nunez G.
J. Biol. Chem. 273:8705-8710(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF174487 mRNA. Translation: AAD51719.1.
BT007272 mRNA. Translation: AAP35936.1.
BC006203 mRNA. No translation available.
CCDSCCDS2550.1.
RefSeqNP_115904.1. NM_032515.4.
XP_005247094.1. XM_005247037.2.
UniGeneHs.293753.
Hs.734656.

3D structure databases

ProteinModelPortalQ9UMX3.
SMRQ9UMX3. Positions 45-175.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107134. 5 interactions.
IntActQ9UMX3. 1 interaction.
STRING9606.ENSP00000314132.

PTM databases

PhosphoSiteQ9UMX3.

Polymorphism databases

DMDM57012554.

Proteomic databases

PaxDbQ9UMX3.
PRIDEQ9UMX3.

Protocols and materials databases

DNASU666.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318407; ENSP00000314132; ENSG00000176720.
GeneID666.
KEGGhsa:666.
UCSCuc002wbq.3. human.

Organism-specific databases

CTD666.
GeneCardsGC02P242517.
H-InvDBHIX0030495.
HGNCHGNC:1087. BOK.
MIM605404. gene.
neXtProtNX_Q9UMX3.
PharmGKBPA25396.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241746.
HOVERGENHBG050709.
InParanoidQ9UMX3.
KOK02561.
OMAEFVHARL.
OrthoDBEOG7FZ00G.
PhylomeDBQ9UMX3.
TreeFamTF315834.

Gene expression databases

ArrayExpressQ9UMX3.
BgeeQ9UMX3.
CleanExHS_BOK.
GenevestigatorQ9UMX3.

Family and domain databases

InterProIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF39. PTHR11256:SF39. 1 hit.
PfamPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSPR01862. BCL2FAMILY.
PROSITEPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBOK_(gene).
GenomeRNAi666.
NextBio2716.
PROQ9UMX3.
SOURCESearch...

Entry information

Entry nameBOK_HUMAN
AccessionPrimary (citable) accession number: Q9UMX3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM