Q9UMX2 (OAZ3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase antizyme 3
Short name=AZ3
Short name=ODC-Az 3

Gene names

Name:

OAZ3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
Subunit structure	Interacts with GGN By similarity.
Subcellular location	Nucleus. Cytoplasm By similarity.
Tissue specificity	Testis specific.
Developmental stage	Expression starts early in spermiogenesis and finishes in the late spermatid phase.
Miscellaneous	A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Sequence similarities	Belongs to the ODC antizyme family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Ribosomal frameshifting
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular nitrogen compound metabolic process Traceable author statement. Source: Reactome regulation of cellular amino acid metabolic process Traceable author statement. Source: Reactome spermatogenesis Traceable author statement. Source: ProtInc
Cellular component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ornithine decarboxylase inhibitor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by ribosomal frameshifting. [Select]

Note: A ribosomal frameshift occurs between the codons for Ser-28 and Glu-29. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

Isoform 1 (identifier: Q9UMX2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Ornithine decarboxylase antizyme 3		PRO_0000220859

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0D0988A29A9BC6E7	FASTA	187	21,375
	10 20 30 40 50 60 MLPRCYKSIT YKEEEDLTLQ PRSCLQCSES LVGLQEGKST EQGNHDQLKE LYSAGNLTVL 70 80 90 100 110 120 ATDPLLHQDP VQLDFHFRLT SQTSAHWHGL LCDRRLFLDI PYQALDQGNR ESLTATLEYV 130 140 150 160 170 180 EEKTNVDSVF VNFQNDRNDR GALLRAFSYM GFEVVRPDHP ALPPLDNVIF MVYPLERDVG HLPSEPP

References

[1]	"Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3." Ivanov I.P., Rohrwasser A., Terreros D.A., Gesteland R.F., Atkins J.F. Proc. Natl. Acad. Sci. U.S.A. 97:4808-4813(2000) [PubMed: 10781085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF175296 mRNA. Translation: AAD51734.1.
IPI	IPI00009040.
RefSeq	NP_001128411.1. NM_001134939.1. NP_057262.2. NM_016178.2.
UniGene	Hs.713789.
3D structure databases
ProteinModelPortal	Q9UMX2.
SMR	Q9UMX2. Positions 50-176.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UMX2.
Polymorphism databases
DMDM	13431750.
Proteomic databases
PRIDE	Q9UMX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321531; ENSP00000313922; ENSG00000143450.
GeneID	51686.
KEGG	hsa:51686.
Organism-specific databases
CTD	51686.
GeneCards	GC01P151735.
HGNC	HGNC:8097. OAZ3.
MIM	605138. gene.
neXtProt	NX_Q9UMX2.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000009476.
HOGENOM	HBG506093.
HOVERGEN	HBG101008.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9UMX2.
Bgee	Q9UMX2.
CleanEx	HS_OAZ3.
Genevestigator	Q9UMX2.
GermOnline	ENSG00000143450. Homo sapiens.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR002993. ODC_AZ. [Graphical view]
PANTHER	PTHR10279. ODC_AZ. 1 hit.
Pfam	PF02100. ODC_AZ. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS01337. ODC_AZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00129. L-Ornithine.
NextBio	55690.
SOURCE	Search...

Entry information

Entry name

OAZ3_HUMAN

Accession

Primary (citable) accession number: Q9UMX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.