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Protein

Ornithine decarboxylase antizyme 3

Gene

OAZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPolyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 3
Short name:
AZ3
Short name:
ODC-Az 3
Gene namesi
Name:OAZ3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8097. OAZ3.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143450.
PharmGKBiPA31886.

Chemistry databases

DrugBankiDB00129. L-Ornithine.

Polymorphism and mutation databases

DMDMi13431750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208591 – 235Ornithine decarboxylase antizyme 3Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UMX2.
PeptideAtlasiQ9UMX2.
PRIDEiQ9UMX2.

PTM databases

iPTMnetiQ9UMX2.
PhosphoSitePlusiQ9UMX2.

Expressioni

Tissue specificityi

Testis specific.

Developmental stagei

Expression starts early in spermiogenesis and finishes in the late spermatid phase.

Gene expression databases

BgeeiENSG00000143450.
CleanExiHS_OAZ3.
ExpressionAtlasiQ9UMX2. baseline and differential.
GenevisibleiQ9UMX2. HS.

Organism-specific databases

HPAiHPA030136.

Interactioni

Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240). Interacts with GGN (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119677. 34 interactors.
IntActiQ9UMX2. 13 interactors.
STRINGi9606.ENSP00000415904.

Structurei

3D structure databases

ProteinModelPortaliQ9UMX2.
SMRiQ9UMX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
GeneTreeiENSGT00390000009476.
HOGENOMiHOG000115254.
HOVERGENiHBG101008.
InParanoidiQ9UMX2.
KOiK16614.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR029913. ODC-AZ_3.
IPR002993. ODC_AZ.
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF13. PTHR10279:SF13. 1 hit.
PfamiView protein in Pfam
PF02100. ODC_AZ. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS01337. ODC_AZ. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing and ribosomal frameshifting. AlignAdd to basket

Note: A ribosomal frameshift occurs between the codons for Ser-76 and Glu-77. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Isoform 1 (identifier: Q9UMX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCKRCRPSV YSLSYIKRGK TRNYLYPIWS PYAYYLYCYK YRITLREKML
60 70 80 90 100
PRCYKSITYK EEEDLTLQPR SCLQCSESLV GLQEGKSTEQ GNHDQLKELY
110 120 130 140 150
SAGNLTVLAT DPLLHQDPVQ LDFHFRLTSQ TSAHWHGLLC DRRLFLDIPY
160 170 180 190 200
QALDQGNRES LTATLEYVEE KTNVDSVFVN FQNDRNDRGA LLRAFSYMGF
210 220 230
EVVRPDHPAL PPLDNVIFMV YPLERDVGHL PSEPP
Length:235
Mass (Da):27,413
Last modified:October 29, 2014 - v2
Checksum:iD9DA9CD9CAEED311
GO
Isoform 2 (identifier: Q9UMX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-56: MLPRCYKS → MTVPWRPGKRR
     71-76: SCLQCS → PASSAP

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,650
Checksum:iD416886E1902962B
GO

Sequence cautioni

The sequence AAD51734 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence AAD51734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0567891 – 48Missing in isoform 2. Add BLAST48
Alternative sequenceiVSP_05679049 – 56MLPRCYKS → MTVPWRPGKRR in isoform 2. 1 Publication8
Alternative sequenceiVSP_05679171 – 76SCLQCS → PASSAP in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175296 mRNA. Translation: AAD51734.1. Sequence problems.
AL589765 Genomic DNA. No translation available.
BC073949 mRNA. Translation: AAH73949.1.
CCDSiCCDS58028.1. [Q9UMX2-2]
CCDS81378.1. [Q9UMX2-1]
RefSeqiNP_001128411.1. NM_001134939.1.
NP_001288300.1. NM_001301371.1.
NP_057262.2. NM_016178.2. [Q9UMX2-1]
UniGeneiHs.713789.

Genome annotation databases

EnsembliENST00000627780; ENSP00000486158; ENSG00000143450. [Q9UMX2-2]
ENST00000639906; ENSP00000492131; ENSG00000143450. [Q9UMX2-1]
GeneIDi51686.
KEGGihsa:51686.
UCSCiuc010pdl.3. human. [Q9UMX2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Ribosomal frameshifting

Similar proteinsi

Entry informationi

Entry nameiOAZ3_HUMAN
AccessioniPrimary (citable) accession number: Q9UMX2
Secondary accession number(s): E7EUE7, Q6GMR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 29, 2014
Last modified: August 30, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families