##gff-version 3 Q9UMX1 UniProtKB Chain 1 484 . . . ID=PRO_0000072302;Note=Suppressor of fused homolog Q9UMX1 UniProtKB Region 1 24 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UMX1 UniProtKB Region 279 360 . . . Note=Disordered;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24311597;Dbxref=PMID:24311597 Q9UMX1 UniProtKB Compositional bias 9 24 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UMX1 UniProtKB Modified residue 301 301 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UMX1 UniProtKB Modified residue 303 303 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Q9UMX1 UniProtKB Modified residue 342 342 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27234298,ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163,PMID:27234298 Q9UMX1 UniProtKB Modified residue 346 346 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27234298,ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163,PMID:27234298 Q9UMX1 UniProtKB Modified residue 352 352 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234298;Dbxref=PMID:27234298 Q9UMX1 UniProtKB Modified residue 353 353 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234298;Dbxref=PMID:27234298 Q9UMX1 UniProtKB Modified residue 481 481 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9UMX1 UniProtKB Cross-link 257 257 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234298;Dbxref=PMID:27234298 Q9UMX1 UniProtKB Cross-link 321 321 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UMX1 UniProtKB Alternative sequence 433 484 . . . ID=VSP_013280;Note=In isoform 3. ILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH->VRRPFFFSLLPFIDFLAHPSSSPLAALDGTPSWGAGHECLMDSGPGACV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10564661;Dbxref=PMID:10564661 Q9UMX1 UniProtKB Alternative sequence 433 433 . . . ID=VSP_013278;Note=In isoform 2. I->L;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10564661,ECO:0000303|PubMed:12975309;Dbxref=PMID:10564661,PMID:12975309 Q9UMX1 UniProtKB Alternative sequence 434 484 . . . ID=VSP_013279;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10564661,ECO:0000303|PubMed:12975309;Dbxref=PMID:10564661,PMID:12975309 Q9UMX1 UniProtKB Natural variant 15 15 . . . ID=VAR_021566;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12068298;Dbxref=dbSNP:rs28942088,PMID:12068298 Q9UMX1 UniProtKB Natural variant 19 19 . . . ID=VAR_080418;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=PMID:28965847 Q9UMX1 UniProtKB Natural variant 37 37 . . . ID=VAR_080419;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs745793517,PMID:28965847 Q9UMX1 UniProtKB Natural variant 77 77 . . . ID=VAR_080420;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=PMID:28965847 Q9UMX1 UniProtKB Natural variant 176 176 . . . ID=VAR_080421;Note=In JBTS32%3B decreased stability%3B no effect on nuclear and cytoplasmic localization%3B decreased interaction with GLI3%3B no effect on interaction with GLI1%3B decreased repression of the hedgehog/smoothened signaling pathway. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs1554852272,PMID:28965847 Q9UMX1 UniProtKB Natural variant 289 289 . . . ID=VAR_080422;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs149016373,PMID:28965847 Q9UMX1 UniProtKB Natural variant 293 293 . . . ID=VAR_080423;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs574002050,PMID:28965847 Q9UMX1 UniProtKB Natural variant 299 484 . . . ID=VAR_080424;Note=Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=PMID:28965847 Q9UMX1 UniProtKB Natural variant 340 340 . . . ID=VAR_021567;Note=A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12068298;Dbxref=dbSNP:rs34135067,PMID:12068298 Q9UMX1 UniProtKB Natural variant 382 382 . . . ID=VAR_080425;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs1401882800,PMID:28965847 Q9UMX1 UniProtKB Natural variant 406 406 . . . ID=VAR_080426;Note=In JBTS32%3B decreased stability%3B forms cytoplasmic aggregates%3B decreased interaction with GLI3%3B no effect on interaction with GLI1%3B decreased repression of the hedgehog/smoothened signaling pathway. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs1554854758,PMID:28965847 Q9UMX1 UniProtKB Natural variant 442 442 . . . ID=VAR_080427;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=dbSNP:rs772598739,PMID:28965847 Q9UMX1 UniProtKB Natural variant 481 481 . . . ID=VAR_080428;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28965847;Dbxref=PMID:28965847 Q9UMX1 UniProtKB Mutagenesis 106 106 . . . Note=No effect on down-regulation of GLI1 activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 111 111 . . . Note=No effect on down-regulation of GLI1 activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 128 128 . . . Note=No effect on down-regulation of GLI1 activity. T->A%2CD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 147 147 . . . Note=Impairs interaction with GLI1 and GLI2. Abolishes interaction with GLI1 and GLI2%3B when associated with R-159 and R-380. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24217340;Dbxref=PMID:24217340 Q9UMX1 UniProtKB Mutagenesis 152 152 . . . Note=No effect on down-regulation of GLI1 activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 159 159 . . . Note=Abolishes down-regulation of GLI1 activity. Has only slight effect on GLI1 binding. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 159 159 . . . Note=Impairs interaction with GLI1 and GLI2. Abolishes interaction with GLI1 and GLI2%3B when associated with R-147 and R-380. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24217340;Dbxref=PMID:24217340 Q9UMX1 UniProtKB Mutagenesis 181 181 . . . Note=No effect on down-regulation of GLI1 activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 221 221 . . . Note=No effect on down-regulation of GLI1 activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 257 257 . . . Note=Abolishes ubiquitination by the SCF(FBXL17) complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234298;Dbxref=PMID:27234298 Q9UMX1 UniProtKB Mutagenesis 262 262 . . . Note=No effect on down-regulation of GLI1 activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15367681;Dbxref=PMID:15367681 Q9UMX1 UniProtKB Mutagenesis 342 346 . . . Note=Increased interaction with FBXL17 and ubiquitination by the SCF(FBXL17) complex. SRKDS->ARKDA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234298;Dbxref=PMID:27234298 Q9UMX1 UniProtKB Mutagenesis 342 346 . . . Note=Phosphomimetic mutant%3B decreased interaction with FBXL17 and ubiquitination by the SCF(FBXL17) complex. SRKDS->DRKDD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27234298;Dbxref=PMID:27234298 Q9UMX1 UniProtKB Mutagenesis 380 380 . . . Note=Impairs interaction with GLI1 and GLI2. Abolishes interaction with GLI1 and GLI2%3B when associated with R-147 and R-159. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24217340;Dbxref=PMID:24217340 Q9UMX1 UniProtKB Sequence conflict 336 336 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9UMX1 UniProtKB Helix 27 29 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KM8 Q9UMX1 UniProtKB Helix 32 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 52 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 60 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 69 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 80 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 87 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 101 105 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 110 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 136 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 160 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BLB Q9UMX1 UniProtKB Beta strand 169 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 176 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 188 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 193 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 205 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 216 224 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 227 229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Turn 230 234 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 244 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 250 262 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 266 276 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 363 367 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4BL9 Q9UMX1 UniProtKB Beta strand 369 373 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 375 378 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 381 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 389 391 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 395 403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 405 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 420 422 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 424 427 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 430 434 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 437 446 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Turn 447 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 460 464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 465 467 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Beta strand 469 473 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD Q9UMX1 UniProtKB Helix 476 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4KMD