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Q9UMQ6

- CAN11_HUMAN

UniProt

Q9UMQ6 - CAN11_HUMAN

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Protein

Calpain-11

Gene

CAPN11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391By similarity
Active sitei296 – 2961By similarity
Active sitei320 – 3201By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi623 – 634121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi653 – 664122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
  2. calcium ion binding Source: InterPro
  3. peptidase activity Source: ProtInc

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiC02.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-11 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 11
Short name:
CANP 11
Gene namesi
Name:CAPN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1478. CAPN11.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. cytoplasm Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Calpain-11PRO_0000207729Add
BLAST

Proteomic databases

PaxDbiQ9UMQ6.
PRIDEiQ9UMQ6.

PTM databases

PhosphoSiteiQ9UMQ6.

Expressioni

Tissue specificityi

Highest expression in testis.1 Publication

Gene expression databases

BgeeiQ9UMQ6.
CleanExiHS_CAPN11.
ExpressionAtlasiQ9UMQ6. baseline.
GenevestigatoriQ9UMQ6.

Organism-specific databases

HPAiCAB018070.
HPA030955.

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.

Protein-protein interaction databases

BioGridi116304. 4 interactions.
IntActiQ9UMQ6. 4 interactions.
STRINGi9606.ENSP00000381758.

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ6.
SMRiQ9UMQ6. Positions 37-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 378300Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini610 – 64334EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini640 – 67536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 551173Domain IIIAdd
BLAST
Regioni552 – 56716LinkerAdd
BLAST
Regioni568 – 738171Domain IVAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG327523.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ9UMQ6.
KOiK08580.
OMAiEKHSESW.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ9UMQ6.
TreeFamiTF314748.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UMQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYSPGPSLP ESAESLDGSQ EDKPRGSCAE PTFTDTGMVA HINNSRLKAK
60 70 80 90 100
GVGQHDNAQN FGNQSFEELR AACLRKGELF EDPLFPAEPS SLGFKDLGPN
110 120 130 140 150
SKNVQNISWQ RPKDIINNPL FIMDGISPTD ICQGILGDCW LLAAIGSLTT
160 170 180 190 200
CPKLLYRVVP RGQSFKKNYA GIFHFQIWQF GQWVNVVVDD RLPTKNDKLV
210 220 230 240 250
FVHSTERSEF WSALLEKAYA KLSGSYEALS GGSTMEGLED FTGGVAQSFQ
260 270 280 290 300
LQRPPQNLLR LLRKAVERSS LMGCSIEVTS DSELESMTDK MLVRGHAYSV
310 320 330 340 350
TGLQDVHYRG KMETLIRVRN PWGRIEWNGA WSDSAREWEE VASDIQMQLL
360 370 380 390 400
HKTEDGEFWM SYQDFLNNFT LLEICNLTPD TLSGDYKSYW HTTFYEGSWR
410 420 430 440 450
RGSSAGGCRN HPGTFWTNPQ FKISLPEGDD PEDDAEGNVV VCTCLVALMQ
460 470 480 490 500
KNWRHARQQG AQLQTIGFVL YAVPKEFQNI QDVHLKKEFF TKYQDHGFSE
510 520 530 540 550
IFTNSREVSS QLRLPPGEYI IIPSTFEPHR DADFLLRVFT EKHSESWELD
560 570 580 590 600
EVNYAEQLQE EKVSEDDMDQ DFLHLFKIVA GEGKEIGVYE LQRLLNRMAI
610 620 630 640 650
KFKSFKTKGF GLDACRCMIN LMDKDGSGKL GLLEFKILWK KLKKWMDIFR
660 670 680 690 700
ECDQDHSGTL NSYEMRLVIE KAGIKLNNKV MQVLVARYAD DDLIIDFDSF
710 720 730
ISCFLRLKTM FTFFLTMDPK NTGHICLSLE QWLQMTMWG
Length:739
Mass (Da):84,423
Last modified:December 16, 2008 - v2
Checksum:i8B102AF286259EFB
GO

Sequence cautioni

The sequence AAH33733.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG36761.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB52137.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti266 – 2661V → M.
Corresponds to variant rs6938938 [ dbSNP | Ensembl ].
VAR_033713
Natural varianti441 – 4411V → A.1 Publication
Corresponds to variant rs16871612 [ dbSNP | Ensembl ].
VAR_033714
Natural varianti521 – 5211I → V.
Corresponds to variant rs34710081 [ dbSNP | Ensembl ].
VAR_033715
Natural varianti544 – 5441S → R.
Corresponds to variant rs35527493 [ dbSNP | Ensembl ].
VAR_033716
Natural varianti728 – 7281S → N.
Corresponds to variant rs7761137 [ dbSNP | Ensembl ].
VAR_024587

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314054 mRNA. Translation: BAG36761.1. Different initiation.
AL365192 Genomic DNA. Translation: CAI20532.2.
CH471081 Genomic DNA. Translation: EAX04250.1.
BC033733 mRNA. Translation: AAH33733.1. Different initiation.
AJ242832 mRNA. Translation: CAB52137.1. Different initiation.
CCDSiCCDS47436.1.
RefSeqiNP_008989.2. NM_007058.3.
UniGeneiHs.225953.

Genome annotation databases

EnsembliENST00000398776; ENSP00000381758; ENSG00000137225.
GeneIDi11131.
KEGGihsa:11131.
UCSCiuc003owt.1. human.

Polymorphism databases

DMDMi218511961.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314054 mRNA. Translation: BAG36761.1 . Different initiation.
AL365192 Genomic DNA. Translation: CAI20532.2 .
CH471081 Genomic DNA. Translation: EAX04250.1 .
BC033733 mRNA. Translation: AAH33733.1 . Different initiation.
AJ242832 mRNA. Translation: CAB52137.1 . Different initiation.
CCDSi CCDS47436.1.
RefSeqi NP_008989.2. NM_007058.3.
UniGenei Hs.225953.

3D structure databases

ProteinModelPortali Q9UMQ6.
SMRi Q9UMQ6. Positions 37-733.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116304. 4 interactions.
IntActi Q9UMQ6. 4 interactions.
STRINGi 9606.ENSP00000381758.

Protein family/group databases

MEROPSi C02.013.

PTM databases

PhosphoSitei Q9UMQ6.

Polymorphism databases

DMDMi 218511961.

Proteomic databases

PaxDbi Q9UMQ6.
PRIDEi Q9UMQ6.

Protocols and materials databases

DNASUi 11131.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398776 ; ENSP00000381758 ; ENSG00000137225 .
GeneIDi 11131.
KEGGi hsa:11131.
UCSCi uc003owt.1. human.

Organism-specific databases

CTDi 11131.
GeneCardsi GC06P044126.
H-InvDB HIX0200891.
HGNCi HGNC:1478. CAPN11.
HPAi CAB018070.
HPA030955.
MIMi 604822. gene.
neXtProti NX_Q9UMQ6.
PharmGKBi PA26059.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327523.
GeneTreei ENSGT00760000118971.
HOGENOMi HOG000232035.
HOVERGENi HBG012645.
InParanoidi Q9UMQ6.
KOi K08580.
OMAi EKHSESW.
OrthoDBi EOG7RV9FM.
PhylomeDBi Q9UMQ6.
TreeFami TF314748.

Miscellaneous databases

GenomeRNAii 11131.
NextBioi 42308.
PROi Q9UMQ6.
SOURCEi Search...

Gene expression databases

Bgeei Q9UMQ6.
CleanExi HS_CAPN11.
ExpressionAtlasi Q9UMQ6. baseline.
Genevestigatori Q9UMQ6.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-441.
    Tissue: Brain.
  5. "CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6."
    Dear T.N., Moller A., Boehm T.
    Genomics 59:243-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-739, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAN11_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ6
Secondary accession number(s): B2RA64, Q5T3G1, Q8N4R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3