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Q9UMQ6

- CAN11_HUMAN

UniProt

Q9UMQ6 - CAN11_HUMAN

Protein

Calpain-11

Gene

CAPN11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei139 – 1391By similarity
    Active sitei296 – 2961By similarity
    Active sitei320 – 3201By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi623 – 634121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi653 – 664122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
    2. calcium ion binding Source: InterPro
    3. peptidase activity Source: ProtInc

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiC02.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-11 (EC:3.4.22.-)
    Alternative name(s):
    Calcium-activated neutral proteinase 11
    Short name:
    CANP 11
    Gene namesi
    Name:CAPN11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1478. CAPN11.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: UniProtKB-SubCell
    2. cytoplasm Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26059.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Calpain-11PRO_0000207729Add
    BLAST

    Proteomic databases

    PaxDbiQ9UMQ6.
    PRIDEiQ9UMQ6.

    PTM databases

    PhosphoSiteiQ9UMQ6.

    Expressioni

    Tissue specificityi

    Highest expression in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9UMQ6.
    BgeeiQ9UMQ6.
    CleanExiHS_CAPN11.
    GenevestigatoriQ9UMQ6.

    Organism-specific databases

    HPAiCAB018070.
    HPA030955.

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) and a small (regulatory) subunit.

    Protein-protein interaction databases

    BioGridi116304. 4 interactions.
    IntActiQ9UMQ6. 4 interactions.
    STRINGi9606.ENSP00000381758.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UMQ6.
    SMRiQ9UMQ6. Positions 37-733.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 378300Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST
    Domaini610 – 64334EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini640 – 67536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni379 – 551173Domain IIIAdd
    BLAST
    Regioni552 – 56716LinkerAdd
    BLAST
    Regioni568 – 738171Domain IVAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG327523.
    HOGENOMiHOG000232035.
    HOVERGENiHBG012645.
    InParanoidiQ9UMQ6.
    KOiK08580.
    OMAiEKHSESW.
    OrthoDBiEOG7RV9FM.
    PhylomeDBiQ9UMQ6.
    TreeFamiTF314748.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PfamiPF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UMQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYSPGPSLP ESAESLDGSQ EDKPRGSCAE PTFTDTGMVA HINNSRLKAK    50
    GVGQHDNAQN FGNQSFEELR AACLRKGELF EDPLFPAEPS SLGFKDLGPN 100
    SKNVQNISWQ RPKDIINNPL FIMDGISPTD ICQGILGDCW LLAAIGSLTT 150
    CPKLLYRVVP RGQSFKKNYA GIFHFQIWQF GQWVNVVVDD RLPTKNDKLV 200
    FVHSTERSEF WSALLEKAYA KLSGSYEALS GGSTMEGLED FTGGVAQSFQ 250
    LQRPPQNLLR LLRKAVERSS LMGCSIEVTS DSELESMTDK MLVRGHAYSV 300
    TGLQDVHYRG KMETLIRVRN PWGRIEWNGA WSDSAREWEE VASDIQMQLL 350
    HKTEDGEFWM SYQDFLNNFT LLEICNLTPD TLSGDYKSYW HTTFYEGSWR 400
    RGSSAGGCRN HPGTFWTNPQ FKISLPEGDD PEDDAEGNVV VCTCLVALMQ 450
    KNWRHARQQG AQLQTIGFVL YAVPKEFQNI QDVHLKKEFF TKYQDHGFSE 500
    IFTNSREVSS QLRLPPGEYI IIPSTFEPHR DADFLLRVFT EKHSESWELD 550
    EVNYAEQLQE EKVSEDDMDQ DFLHLFKIVA GEGKEIGVYE LQRLLNRMAI 600
    KFKSFKTKGF GLDACRCMIN LMDKDGSGKL GLLEFKILWK KLKKWMDIFR 650
    ECDQDHSGTL NSYEMRLVIE KAGIKLNNKV MQVLVARYAD DDLIIDFDSF 700
    ISCFLRLKTM FTFFLTMDPK NTGHICLSLE QWLQMTMWG 739
    Length:739
    Mass (Da):84,423
    Last modified:December 16, 2008 - v2
    Checksum:i8B102AF286259EFB
    GO

    Sequence cautioni

    The sequence AAH33733.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG36761.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB52137.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti266 – 2661V → M.
    Corresponds to variant rs6938938 [ dbSNP | Ensembl ].
    VAR_033713
    Natural varianti441 – 4411V → A.1 Publication
    Corresponds to variant rs16871612 [ dbSNP | Ensembl ].
    VAR_033714
    Natural varianti521 – 5211I → V.
    Corresponds to variant rs34710081 [ dbSNP | Ensembl ].
    VAR_033715
    Natural varianti544 – 5441S → R.
    Corresponds to variant rs35527493 [ dbSNP | Ensembl ].
    VAR_033716
    Natural varianti728 – 7281S → N.
    Corresponds to variant rs7761137 [ dbSNP | Ensembl ].
    VAR_024587

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK314054 mRNA. Translation: BAG36761.1. Different initiation.
    AL365192 Genomic DNA. Translation: CAI20532.2.
    CH471081 Genomic DNA. Translation: EAX04250.1.
    BC033733 mRNA. Translation: AAH33733.1. Different initiation.
    AJ242832 mRNA. Translation: CAB52137.1. Different initiation.
    CCDSiCCDS47436.1.
    RefSeqiNP_008989.2. NM_007058.3.
    UniGeneiHs.225953.

    Genome annotation databases

    EnsembliENST00000398776; ENSP00000381758; ENSG00000137225.
    GeneIDi11131.
    KEGGihsa:11131.
    UCSCiuc003owt.1. human.

    Polymorphism databases

    DMDMi218511961.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK314054 mRNA. Translation: BAG36761.1 . Different initiation.
    AL365192 Genomic DNA. Translation: CAI20532.2 .
    CH471081 Genomic DNA. Translation: EAX04250.1 .
    BC033733 mRNA. Translation: AAH33733.1 . Different initiation.
    AJ242832 mRNA. Translation: CAB52137.1 . Different initiation.
    CCDSi CCDS47436.1.
    RefSeqi NP_008989.2. NM_007058.3.
    UniGenei Hs.225953.

    3D structure databases

    ProteinModelPortali Q9UMQ6.
    SMRi Q9UMQ6. Positions 37-733.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116304. 4 interactions.
    IntActi Q9UMQ6. 4 interactions.
    STRINGi 9606.ENSP00000381758.

    Protein family/group databases

    MEROPSi C02.013.

    PTM databases

    PhosphoSitei Q9UMQ6.

    Polymorphism databases

    DMDMi 218511961.

    Proteomic databases

    PaxDbi Q9UMQ6.
    PRIDEi Q9UMQ6.

    Protocols and materials databases

    DNASUi 11131.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398776 ; ENSP00000381758 ; ENSG00000137225 .
    GeneIDi 11131.
    KEGGi hsa:11131.
    UCSCi uc003owt.1. human.

    Organism-specific databases

    CTDi 11131.
    GeneCardsi GC06P044126.
    H-InvDB HIX0200891.
    HGNCi HGNC:1478. CAPN11.
    HPAi CAB018070.
    HPA030955.
    MIMi 604822. gene.
    neXtProti NX_Q9UMQ6.
    PharmGKBi PA26059.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327523.
    HOGENOMi HOG000232035.
    HOVERGENi HBG012645.
    InParanoidi Q9UMQ6.
    KOi K08580.
    OMAi EKHSESW.
    OrthoDBi EOG7RV9FM.
    PhylomeDBi Q9UMQ6.
    TreeFami TF314748.

    Miscellaneous databases

    GenomeRNAii 11131.
    NextBioi 42308.
    PROi Q9UMQ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UMQ6.
    Bgeei Q9UMQ6.
    CleanExi HS_CAPN11.
    Genevestigatori Q9UMQ6.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    Pfami PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-441.
      Tissue: Brain.
    5. "CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6."
      Dear T.N., Moller A., Boehm T.
      Genomics 59:243-247(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-739, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCAN11_HUMAN
    AccessioniPrimary (citable) accession number: Q9UMQ6
    Secondary accession number(s): B2RA64, Q5T3G1, Q8N4R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3