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Q9UMQ6

- CAN11_HUMAN

UniProt

Q9UMQ6 - CAN11_HUMAN

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Protein
Calpain-11
Gene
CAPN11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391 By similarity
Active sitei296 – 2961 By similarity
Active sitei320 – 3201 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi623 – 634121 Reviewed prediction
Add
BLAST
Calcium bindingi653 – 664122 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
  3. peptidase activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiC02.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-11 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 11
Short name:
CANP 11
Gene namesi
Name:CAPN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1478. CAPN11.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: UniProtKB-SubCell
  2. cytoplasm Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Calpain-11
PRO_0000207729Add
BLAST

Proteomic databases

PaxDbiQ9UMQ6.
PRIDEiQ9UMQ6.

PTM databases

PhosphoSiteiQ9UMQ6.

Expressioni

Tissue specificityi

Highest expression in testis.1 Publication

Gene expression databases

ArrayExpressiQ9UMQ6.
BgeeiQ9UMQ6.
CleanExiHS_CAPN11.
GenevestigatoriQ9UMQ6.

Organism-specific databases

HPAiCAB018070.
HPA030955.

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.

Protein-protein interaction databases

BioGridi116304. 4 interactions.
IntActiQ9UMQ6. 4 interactions.
STRINGi9606.ENSP00000381758.

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ6.
SMRiQ9UMQ6. Positions 37-733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 378300Calpain catalytic
Add
BLAST
Domaini610 – 64334EF-hand 1
Add
BLAST
Domaini640 – 67536EF-hand 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 551173Domain III
Add
BLAST
Regioni552 – 56716Linker
Add
BLAST
Regioni568 – 738171Domain IV
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG327523.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ9UMQ6.
KOiK08580.
OMAiEKHSESW.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ9UMQ6.
TreeFamiTF314748.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UMQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MLYSPGPSLP ESAESLDGSQ EDKPRGSCAE PTFTDTGMVA HINNSRLKAK    50
GVGQHDNAQN FGNQSFEELR AACLRKGELF EDPLFPAEPS SLGFKDLGPN 100
SKNVQNISWQ RPKDIINNPL FIMDGISPTD ICQGILGDCW LLAAIGSLTT 150
CPKLLYRVVP RGQSFKKNYA GIFHFQIWQF GQWVNVVVDD RLPTKNDKLV 200
FVHSTERSEF WSALLEKAYA KLSGSYEALS GGSTMEGLED FTGGVAQSFQ 250
LQRPPQNLLR LLRKAVERSS LMGCSIEVTS DSELESMTDK MLVRGHAYSV 300
TGLQDVHYRG KMETLIRVRN PWGRIEWNGA WSDSAREWEE VASDIQMQLL 350
HKTEDGEFWM SYQDFLNNFT LLEICNLTPD TLSGDYKSYW HTTFYEGSWR 400
RGSSAGGCRN HPGTFWTNPQ FKISLPEGDD PEDDAEGNVV VCTCLVALMQ 450
KNWRHARQQG AQLQTIGFVL YAVPKEFQNI QDVHLKKEFF TKYQDHGFSE 500
IFTNSREVSS QLRLPPGEYI IIPSTFEPHR DADFLLRVFT EKHSESWELD 550
EVNYAEQLQE EKVSEDDMDQ DFLHLFKIVA GEGKEIGVYE LQRLLNRMAI 600
KFKSFKTKGF GLDACRCMIN LMDKDGSGKL GLLEFKILWK KLKKWMDIFR 650
ECDQDHSGTL NSYEMRLVIE KAGIKLNNKV MQVLVARYAD DDLIIDFDSF 700
ISCFLRLKTM FTFFLTMDPK NTGHICLSLE QWLQMTMWG 739
Length:739
Mass (Da):84,423
Last modified:December 16, 2008 - v2
Checksum:i8B102AF286259EFB
GO

Sequence cautioni

The sequence AAH33733.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG36761.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB52137.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti266 – 2661V → M.
Corresponds to variant rs6938938 [ dbSNP | Ensembl ].
VAR_033713
Natural varianti441 – 4411V → A.1 Publication
Corresponds to variant rs16871612 [ dbSNP | Ensembl ].
VAR_033714
Natural varianti521 – 5211I → V.
Corresponds to variant rs34710081 [ dbSNP | Ensembl ].
VAR_033715
Natural varianti544 – 5441S → R.
Corresponds to variant rs35527493 [ dbSNP | Ensembl ].
VAR_033716
Natural varianti728 – 7281S → N.
Corresponds to variant rs7761137 [ dbSNP | Ensembl ].
VAR_024587

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314054 mRNA. Translation: BAG36761.1. Different initiation.
AL365192 Genomic DNA. Translation: CAI20532.2.
CH471081 Genomic DNA. Translation: EAX04250.1.
BC033733 mRNA. Translation: AAH33733.1. Different initiation.
AJ242832 mRNA. Translation: CAB52137.1. Different initiation.
CCDSiCCDS47436.1.
RefSeqiNP_008989.2. NM_007058.3.
UniGeneiHs.225953.

Genome annotation databases

EnsembliENST00000398776; ENSP00000381758; ENSG00000137225.
GeneIDi11131.
KEGGihsa:11131.
UCSCiuc003owt.1. human.

Polymorphism databases

DMDMi218511961.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314054 mRNA. Translation: BAG36761.1 . Different initiation.
AL365192 Genomic DNA. Translation: CAI20532.2 .
CH471081 Genomic DNA. Translation: EAX04250.1 .
BC033733 mRNA. Translation: AAH33733.1 . Different initiation.
AJ242832 mRNA. Translation: CAB52137.1 . Different initiation.
CCDSi CCDS47436.1.
RefSeqi NP_008989.2. NM_007058.3.
UniGenei Hs.225953.

3D structure databases

ProteinModelPortali Q9UMQ6.
SMRi Q9UMQ6. Positions 37-733.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116304. 4 interactions.
IntActi Q9UMQ6. 4 interactions.
STRINGi 9606.ENSP00000381758.

Protein family/group databases

MEROPSi C02.013.

PTM databases

PhosphoSitei Q9UMQ6.

Polymorphism databases

DMDMi 218511961.

Proteomic databases

PaxDbi Q9UMQ6.
PRIDEi Q9UMQ6.

Protocols and materials databases

DNASUi 11131.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398776 ; ENSP00000381758 ; ENSG00000137225 .
GeneIDi 11131.
KEGGi hsa:11131.
UCSCi uc003owt.1. human.

Organism-specific databases

CTDi 11131.
GeneCardsi GC06P044126.
H-InvDB HIX0200891.
HGNCi HGNC:1478. CAPN11.
HPAi CAB018070.
HPA030955.
MIMi 604822. gene.
neXtProti NX_Q9UMQ6.
PharmGKBi PA26059.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327523.
HOGENOMi HOG000232035.
HOVERGENi HBG012645.
InParanoidi Q9UMQ6.
KOi K08580.
OMAi EKHSESW.
OrthoDBi EOG7RV9FM.
PhylomeDBi Q9UMQ6.
TreeFami TF314748.

Miscellaneous databases

GenomeRNAii 11131.
NextBioi 42308.
PROi Q9UMQ6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UMQ6.
Bgeei Q9UMQ6.
CleanExi HS_CAPN11.
Genevestigatori Q9UMQ6.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-441.
    Tissue: Brain.
  5. "CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6."
    Dear T.N., Moller A., Boehm T.
    Genomics 59:243-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-739, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAN11_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ6
Secondary accession number(s): B2RA64, Q5T3G1, Q8N4R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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