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Protein

Calpain-11

Gene

CAPN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139By similarity1
Active sitei296By similarity1
Active sitei320By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi623 – 6341PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi653 – 6642PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • calcium ion binding Source: InterPro
  • peptidase activity Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.22.B31 2681
ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.013

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-11 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 11
Short name:
CANP 11
Gene namesi
Name:CAPN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137225.12
HGNCiHGNC:1478 CAPN11
MIMi604822 gene
neXtProtiNX_Q9UMQ6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137225
PharmGKBiPA26059

Polymorphism and mutation databases

BioMutaiCAPN11
DMDMi218511961

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077291 – 739Calpain-11Add BLAST739

Proteomic databases

PaxDbiQ9UMQ6
PeptideAtlasiQ9UMQ6
PRIDEiQ9UMQ6

PTM databases

iPTMnetiQ9UMQ6
PhosphoSitePlusiQ9UMQ6

Expressioni

Tissue specificityi

Highest expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000137225
CleanExiHS_CAPN11
ExpressionAtlasiQ9UMQ6 baseline and differential
GenevisibleiQ9UMQ6 HS

Organism-specific databases

HPAiCAB018070
HPA030955

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.

Protein-protein interaction databases

BioGridi116304, 6 interactors
IntActiQ9UMQ6, 4 interactors
STRINGi9606.ENSP00000381758

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 378Calpain catalyticPROSITE-ProRule annotationAdd BLAST300
Domaini610 – 643EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini640 – 675EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni379 – 551Domain IIIAdd BLAST173
Regioni552 – 567LinkerAdd BLAST16
Regioni568 – 738Domain IVAdd BLAST171

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232035
HOVERGENiHBG012645
InParanoidiQ9UMQ6
KOiK08580
OMAiEKHSESW
OrthoDBiEOG091G049E
PhylomeDBiQ9UMQ6
TreeFamiTF314748

Family and domain databases

CDDicd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF13833 EF-hand_8, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49758 SSF49758, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UMQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSPGPSLP ESAESLDGSQ EDKPRGSCAE PTFTDTGMVA HINNSRLKAK
60 70 80 90 100
GVGQHDNAQN FGNQSFEELR AACLRKGELF EDPLFPAEPS SLGFKDLGPN
110 120 130 140 150
SKNVQNISWQ RPKDIINNPL FIMDGISPTD ICQGILGDCW LLAAIGSLTT
160 170 180 190 200
CPKLLYRVVP RGQSFKKNYA GIFHFQIWQF GQWVNVVVDD RLPTKNDKLV
210 220 230 240 250
FVHSTERSEF WSALLEKAYA KLSGSYEALS GGSTMEGLED FTGGVAQSFQ
260 270 280 290 300
LQRPPQNLLR LLRKAVERSS LMGCSIEVTS DSELESMTDK MLVRGHAYSV
310 320 330 340 350
TGLQDVHYRG KMETLIRVRN PWGRIEWNGA WSDSAREWEE VASDIQMQLL
360 370 380 390 400
HKTEDGEFWM SYQDFLNNFT LLEICNLTPD TLSGDYKSYW HTTFYEGSWR
410 420 430 440 450
RGSSAGGCRN HPGTFWTNPQ FKISLPEGDD PEDDAEGNVV VCTCLVALMQ
460 470 480 490 500
KNWRHARQQG AQLQTIGFVL YAVPKEFQNI QDVHLKKEFF TKYQDHGFSE
510 520 530 540 550
IFTNSREVSS QLRLPPGEYI IIPSTFEPHR DADFLLRVFT EKHSESWELD
560 570 580 590 600
EVNYAEQLQE EKVSEDDMDQ DFLHLFKIVA GEGKEIGVYE LQRLLNRMAI
610 620 630 640 650
KFKSFKTKGF GLDACRCMIN LMDKDGSGKL GLLEFKILWK KLKKWMDIFR
660 670 680 690 700
ECDQDHSGTL NSYEMRLVIE KAGIKLNNKV MQVLVARYAD DDLIIDFDSF
710 720 730
ISCFLRLKTM FTFFLTMDPK NTGHICLSLE QWLQMTMWG
Length:739
Mass (Da):84,423
Last modified:December 16, 2008 - v2
Checksum:i8B102AF286259EFB
GO

Sequence cautioni

The sequence AAH33733 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG36761 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB52137 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033713266V → M. Corresponds to variant dbSNP:rs6938938Ensembl.1
Natural variantiVAR_033714441V → A1 PublicationCorresponds to variant dbSNP:rs16871612Ensembl.1
Natural variantiVAR_033715521I → V. Corresponds to variant dbSNP:rs34710081Ensembl.1
Natural variantiVAR_033716544S → R. Corresponds to variant dbSNP:rs35527493Ensembl.1
Natural variantiVAR_024587728S → N. Corresponds to variant dbSNP:rs7761137Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314054 mRNA Translation: BAG36761.1 Different initiation.
AL365192 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04250.1
BC033733 mRNA Translation: AAH33733.1 Different initiation.
AJ242832 mRNA Translation: CAB52137.1 Different initiation.
CCDSiCCDS47436.1
RefSeqiNP_008989.2, NM_007058.3
UniGeneiHs.225953

Genome annotation databases

EnsembliENST00000398776; ENSP00000381758; ENSG00000137225
GeneIDi11131
KEGGihsa:11131
UCSCiuc003owt.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAN11_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ6
Secondary accession number(s): B2RA64, Q5T3G1, Q8N4R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: April 25, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health