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Protein

Calpain-11

Gene

CAPN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139By similarity1
Active sitei296By similarity1
Active sitei320By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi623 – 6341PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi653 – 6642PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: ProtInc
  • calcium ion binding Source: InterPro
  • peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137225-MONOMER.
BRENDAi3.4.22.B31. 2681.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiC02.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-11 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 11
Short name:
CANP 11
Gene namesi
Name:CAPN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1478. CAPN11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137225.
PharmGKBiPA26059.

Polymorphism and mutation databases

BioMutaiCAPN11.
DMDMi218511961.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077291 – 739Calpain-11Add BLAST739

Proteomic databases

PaxDbiQ9UMQ6.
PeptideAtlasiQ9UMQ6.
PRIDEiQ9UMQ6.

PTM databases

iPTMnetiQ9UMQ6.
PhosphoSitePlusiQ9UMQ6.

Expressioni

Tissue specificityi

Highest expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000137225.
CleanExiHS_CAPN11.
ExpressionAtlasiQ9UMQ6. baseline and differential.
GenevisibleiQ9UMQ6. HS.

Organism-specific databases

HPAiCAB018070.
HPA030955.

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.

Protein-protein interaction databases

BioGridi116304. 6 interactors.
IntActiQ9UMQ6. 4 interactors.
STRINGi9606.ENSP00000381758.

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ6.
SMRiQ9UMQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 378Calpain catalyticPROSITE-ProRule annotationAdd BLAST300
Domaini610 – 643EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini640 – 675EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni379 – 551Domain IIIAdd BLAST173
Regioni552 – 567LinkerAdd BLAST16
Regioni568 – 738Domain IVAdd BLAST171

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ9UMQ6.
KOiK08580.
OMAiEKHSESW.
OrthoDBiEOG091G049E.
PhylomeDBiQ9UMQ6.
TreeFamiTF314748.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UMQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSPGPSLP ESAESLDGSQ EDKPRGSCAE PTFTDTGMVA HINNSRLKAK
60 70 80 90 100
GVGQHDNAQN FGNQSFEELR AACLRKGELF EDPLFPAEPS SLGFKDLGPN
110 120 130 140 150
SKNVQNISWQ RPKDIINNPL FIMDGISPTD ICQGILGDCW LLAAIGSLTT
160 170 180 190 200
CPKLLYRVVP RGQSFKKNYA GIFHFQIWQF GQWVNVVVDD RLPTKNDKLV
210 220 230 240 250
FVHSTERSEF WSALLEKAYA KLSGSYEALS GGSTMEGLED FTGGVAQSFQ
260 270 280 290 300
LQRPPQNLLR LLRKAVERSS LMGCSIEVTS DSELESMTDK MLVRGHAYSV
310 320 330 340 350
TGLQDVHYRG KMETLIRVRN PWGRIEWNGA WSDSAREWEE VASDIQMQLL
360 370 380 390 400
HKTEDGEFWM SYQDFLNNFT LLEICNLTPD TLSGDYKSYW HTTFYEGSWR
410 420 430 440 450
RGSSAGGCRN HPGTFWTNPQ FKISLPEGDD PEDDAEGNVV VCTCLVALMQ
460 470 480 490 500
KNWRHARQQG AQLQTIGFVL YAVPKEFQNI QDVHLKKEFF TKYQDHGFSE
510 520 530 540 550
IFTNSREVSS QLRLPPGEYI IIPSTFEPHR DADFLLRVFT EKHSESWELD
560 570 580 590 600
EVNYAEQLQE EKVSEDDMDQ DFLHLFKIVA GEGKEIGVYE LQRLLNRMAI
610 620 630 640 650
KFKSFKTKGF GLDACRCMIN LMDKDGSGKL GLLEFKILWK KLKKWMDIFR
660 670 680 690 700
ECDQDHSGTL NSYEMRLVIE KAGIKLNNKV MQVLVARYAD DDLIIDFDSF
710 720 730
ISCFLRLKTM FTFFLTMDPK NTGHICLSLE QWLQMTMWG
Length:739
Mass (Da):84,423
Last modified:December 16, 2008 - v2
Checksum:i8B102AF286259EFB
GO

Sequence cautioni

The sequence AAH33733 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG36761 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB52137 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033713266V → M.Corresponds to variant rs6938938dbSNPEnsembl.1
Natural variantiVAR_033714441V → A.1 PublicationCorresponds to variant rs16871612dbSNPEnsembl.1
Natural variantiVAR_033715521I → V.Corresponds to variant rs34710081dbSNPEnsembl.1
Natural variantiVAR_033716544S → R.Corresponds to variant rs35527493dbSNPEnsembl.1
Natural variantiVAR_024587728S → N.Corresponds to variant rs7761137dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314054 mRNA. Translation: BAG36761.1. Different initiation.
AL365192 Genomic DNA. Translation: CAI20532.2.
CH471081 Genomic DNA. Translation: EAX04250.1.
BC033733 mRNA. Translation: AAH33733.1. Different initiation.
AJ242832 mRNA. Translation: CAB52137.1. Different initiation.
CCDSiCCDS47436.1.
RefSeqiNP_008989.2. NM_007058.3.
UniGeneiHs.225953.

Genome annotation databases

EnsembliENST00000398776; ENSP00000381758; ENSG00000137225.
GeneIDi11131.
KEGGihsa:11131.
UCSCiuc003owt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314054 mRNA. Translation: BAG36761.1. Different initiation.
AL365192 Genomic DNA. Translation: CAI20532.2.
CH471081 Genomic DNA. Translation: EAX04250.1.
BC033733 mRNA. Translation: AAH33733.1. Different initiation.
AJ242832 mRNA. Translation: CAB52137.1. Different initiation.
CCDSiCCDS47436.1.
RefSeqiNP_008989.2. NM_007058.3.
UniGeneiHs.225953.

3D structure databases

ProteinModelPortaliQ9UMQ6.
SMRiQ9UMQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116304. 6 interactors.
IntActiQ9UMQ6. 4 interactors.
STRINGi9606.ENSP00000381758.

Protein family/group databases

MEROPSiC02.013.

PTM databases

iPTMnetiQ9UMQ6.
PhosphoSitePlusiQ9UMQ6.

Polymorphism and mutation databases

BioMutaiCAPN11.
DMDMi218511961.

Proteomic databases

PaxDbiQ9UMQ6.
PeptideAtlasiQ9UMQ6.
PRIDEiQ9UMQ6.

Protocols and materials databases

DNASUi11131.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398776; ENSP00000381758; ENSG00000137225.
GeneIDi11131.
KEGGihsa:11131.
UCSCiuc003owt.1. human.

Organism-specific databases

CTDi11131.
GeneCardsiCAPN11.
H-InvDBHIX0200891.
HGNCiHGNC:1478. CAPN11.
HPAiCAB018070.
HPA030955.
MIMi604822. gene.
neXtProtiNX_Q9UMQ6.
OpenTargetsiENSG00000137225.
PharmGKBiPA26059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ9UMQ6.
KOiK08580.
OMAiEKHSESW.
OrthoDBiEOG091G049E.
PhylomeDBiQ9UMQ6.
TreeFamiTF314748.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137225-MONOMER.
BRENDAi3.4.22.B31. 2681.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Miscellaneous databases

GenomeRNAii11131.
PROiQ9UMQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137225.
CleanExiHS_CAPN11.
ExpressionAtlasiQ9UMQ6. baseline and differential.
GenevisibleiQ9UMQ6. HS.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN11_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ6
Secondary accession number(s): B2RA64, Q5T3G1, Q8N4R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.