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Q9UMQ3

- BARX2_HUMAN

UniProt

Q9UMQ3 - BARX2_HUMAN

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Protein

Homeobox protein BarH-like 2

Gene

BARX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi133 – 19260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: MGI
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. cartilage condensation Source: Ensembl
  2. catagen Source: Ensembl
  3. myotube differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 2
Gene namesi
Name:BARX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:956. BARX2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: HPA
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Homeobox protein BarH-like 2PRO_0000048838Add
BLAST

Proteomic databases

PaxDbiQ9UMQ3.
PRIDEiQ9UMQ3.

PTM databases

PhosphoSiteiQ9UMQ3.

Expressioni

Tissue specificityi

Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

Gene expression databases

BgeeiQ9UMQ3.
CleanExiHS_BARX2.
ExpressionAtlasiQ9UMQ3. baseline and differential.
GenevestigatoriQ9UMQ3.

Organism-specific databases

HPAiCAB033311.
HPA047657.

Interactioni

Protein-protein interaction databases

BioGridi114108. 1 interaction.
STRINGi9606.ENSP00000281437.

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ3.
SMRiQ9UMQ3. Positions 125-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG324720.
GeneTreeiENSGT00760000118844.
HOGENOMiHOG000231924.
HOVERGENiHBG050665.
InParanoidiQ9UMQ3.
KOiK09361.
OMAiVCPSLIV.
OrthoDBiEOG71G9VZ.
PhylomeDBiQ9UMQ3.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UMQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS
60 70 80 90 100
LVVRPKPLHS CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH
110 120 130 140 150
QVTEAVSAEA PGGEALASSE SETEQPTPRQ KKPRRSRTIF TELQLMGLEK
160 170 180 190 200
KFQKQKYLST PDRLDLAQSL GLTQLQVKTW YQNRRMKWKK MVLKGGQEAP
210 220 230 240 250
TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ EELCEAQEPK
260 270
ARDVPLEMAE PPDPPQELPI PSSEPPPLS
Length:279
Mass (Da):31,188
Last modified:July 28, 2009 - v3
Checksum:i8C2537E524528467
GO

Sequence cautioni

The sequence AAC04705.1 differs from that shown. Reason: Frameshift at position 11.
The sequence AAF09453.1 differs from that shown. Reason: Frameshift at position 11.
The sequence AAC04705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAF09453.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031924 mRNA. Translation: AAC04705.1. Sequence problems.
AF171222
, AF171219, AF171220, AF171221 Genomic DNA. Translation: AAF09453.1. Sequence problems.
AJ243512 mRNA. Translation: CAB50736.1.
AP003775 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67743.1.
BC069378 mRNA. Translation: AAH69378.1.
BC111432 mRNA. Translation: AAI11433.1.
BC111572 mRNA. Translation: AAI11573.1.
CCDSiCCDS8481.1.
RefSeqiNP_003649.2. NM_003658.4.
UniGeneiHs.591944.

Genome annotation databases

EnsembliENST00000281437; ENSP00000281437; ENSG00000043039.
GeneIDi8538.
KEGGihsa:8538.
UCSCiuc001qfc.4. human.

Polymorphism databases

DMDMi254763427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031924 mRNA. Translation: AAC04705.1 . Sequence problems.
AF171222
, AF171219 , AF171220 , AF171221 Genomic DNA. Translation: AAF09453.1 . Sequence problems.
AJ243512 mRNA. Translation: CAB50736.1 .
AP003775 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67743.1 .
BC069378 mRNA. Translation: AAH69378.1 .
BC111432 mRNA. Translation: AAI11433.1 .
BC111572 mRNA. Translation: AAI11573.1 .
CCDSi CCDS8481.1.
RefSeqi NP_003649.2. NM_003658.4.
UniGenei Hs.591944.

3D structure databases

ProteinModelPortali Q9UMQ3.
SMRi Q9UMQ3. Positions 125-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114108. 1 interaction.
STRINGi 9606.ENSP00000281437.

PTM databases

PhosphoSitei Q9UMQ3.

Polymorphism databases

DMDMi 254763427.

Proteomic databases

PaxDbi Q9UMQ3.
PRIDEi Q9UMQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281437 ; ENSP00000281437 ; ENSG00000043039 .
GeneIDi 8538.
KEGGi hsa:8538.
UCSCi uc001qfc.4. human.

Organism-specific databases

CTDi 8538.
GeneCardsi GC11P129279.
H-InvDB HIX0171307.
HGNCi HGNC:956. BARX2.
HPAi CAB033311.
HPA047657.
MIMi 604823. gene.
neXtProti NX_Q9UMQ3.
PharmGKBi PA25260.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324720.
GeneTreei ENSGT00760000118844.
HOGENOMi HOG000231924.
HOVERGENi HBG050665.
InParanoidi Q9UMQ3.
KOi K09361.
OMAi VCPSLIV.
OrthoDBi EOG71G9VZ.
PhylomeDBi Q9UMQ3.
TreeFami TF350735.

Miscellaneous databases

GenomeRNAii 8538.
NextBioi 31980.
PROi Q9UMQ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UMQ3.
CleanExi HS_BARX2.
ExpressionAtlasi Q9UMQ3. baseline and differential.
Genevestigatori Q9UMQ3.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms."
    Hjalt T.A., Murray J.C.
    Genomics 62:456-459(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Expression cloning of the human version of Barx2 as a cAMP response element binding protein- (CREB)- interacting factor."
    Lindon C., Goodbourn S.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBARX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ3
Secondary accession number(s): O43518, Q6NT51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3