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Protein

Homeobox protein BarH-like 2

Gene

BARX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi133 – 192HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000043039-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 2
Gene namesi
Name:BARX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:956. BARX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8538.
OpenTargetsiENSG00000043039.
PharmGKBiPA25260.

Polymorphism and mutation databases

BioMutaiBARX2.
DMDMi254763427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488381 – 279Homeobox protein BarH-like 2Add BLAST279

Proteomic databases

EPDiQ9UMQ3.
PaxDbiQ9UMQ3.
PeptideAtlasiQ9UMQ3.
PRIDEiQ9UMQ3.

PTM databases

iPTMnetiQ9UMQ3.
PhosphoSitePlusiQ9UMQ3.

Expressioni

Tissue specificityi

Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

Gene expression databases

BgeeiENSG00000043039.
CleanExiHS_BARX2.
GenevisibleiQ9UMQ3. HS.

Organism-specific databases

HPAiCAB033311.

Interactioni

Protein-protein interaction databases

BioGridi114108. 1 interactor.
IntActiQ9UMQ3. 2 interactors.
STRINGi9606.ENSP00000281437.

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ3.
SMRiQ9UMQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231924.
HOVERGENiHBG050665.
InParanoidiQ9UMQ3.
KOiK09361.
OMAiLHSCTGP.
OrthoDBiEOG091G10IN.
PhylomeDBiQ9UMQ3.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UMQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS
60 70 80 90 100
LVVRPKPLHS CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH
110 120 130 140 150
QVTEAVSAEA PGGEALASSE SETEQPTPRQ KKPRRSRTIF TELQLMGLEK
160 170 180 190 200
KFQKQKYLST PDRLDLAQSL GLTQLQVKTW YQNRRMKWKK MVLKGGQEAP
210 220 230 240 250
TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ EELCEAQEPK
260 270
ARDVPLEMAE PPDPPQELPI PSSEPPPLS
Length:279
Mass (Da):31,188
Last modified:July 28, 2009 - v3
Checksum:i8C2537E524528467
GO

Sequence cautioni

The sequence AAC04705 differs from that shown. Reason: Frameshift at position 11.Curated
The sequence AAC04705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF09453 differs from that shown. Reason: Frameshift at position 11.Curated
The sequence AAF09453 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031924 mRNA. Translation: AAC04705.1. Sequence problems.
AF171222
, AF171219, AF171220, AF171221 Genomic DNA. Translation: AAF09453.1. Sequence problems.
AJ243512 mRNA. Translation: CAB50736.1.
AP003775 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67743.1.
BC069378 mRNA. Translation: AAH69378.1.
BC111432 mRNA. Translation: AAI11433.1.
BC111572 mRNA. Translation: AAI11573.1.
CCDSiCCDS8481.1.
RefSeqiNP_003649.2. NM_003658.4.
UniGeneiHs.591944.

Genome annotation databases

EnsembliENST00000281437; ENSP00000281437; ENSG00000043039.
GeneIDi8538.
KEGGihsa:8538.
UCSCiuc001qfc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031924 mRNA. Translation: AAC04705.1. Sequence problems.
AF171222
, AF171219, AF171220, AF171221 Genomic DNA. Translation: AAF09453.1. Sequence problems.
AJ243512 mRNA. Translation: CAB50736.1.
AP003775 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67743.1.
BC069378 mRNA. Translation: AAH69378.1.
BC111432 mRNA. Translation: AAI11433.1.
BC111572 mRNA. Translation: AAI11573.1.
CCDSiCCDS8481.1.
RefSeqiNP_003649.2. NM_003658.4.
UniGeneiHs.591944.

3D structure databases

ProteinModelPortaliQ9UMQ3.
SMRiQ9UMQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114108. 1 interactor.
IntActiQ9UMQ3. 2 interactors.
STRINGi9606.ENSP00000281437.

PTM databases

iPTMnetiQ9UMQ3.
PhosphoSitePlusiQ9UMQ3.

Polymorphism and mutation databases

BioMutaiBARX2.
DMDMi254763427.

Proteomic databases

EPDiQ9UMQ3.
PaxDbiQ9UMQ3.
PeptideAtlasiQ9UMQ3.
PRIDEiQ9UMQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281437; ENSP00000281437; ENSG00000043039.
GeneIDi8538.
KEGGihsa:8538.
UCSCiuc001qfc.5. human.

Organism-specific databases

CTDi8538.
DisGeNETi8538.
GeneCardsiBARX2.
H-InvDBHIX0171307.
HGNCiHGNC:956. BARX2.
HPAiCAB033311.
MIMi604823. gene.
neXtProtiNX_Q9UMQ3.
OpenTargetsiENSG00000043039.
PharmGKBiPA25260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231924.
HOVERGENiHBG050665.
InParanoidiQ9UMQ3.
KOiK09361.
OMAiLHSCTGP.
OrthoDBiEOG091G10IN.
PhylomeDBiQ9UMQ3.
TreeFamiTF350735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000043039-MONOMER.

Miscellaneous databases

GenomeRNAii8538.
PROiQ9UMQ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000043039.
CleanExiHS_BARX2.
GenevisibleiQ9UMQ3. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBARX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ3
Secondary accession number(s): O43518, Q6NT51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.