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Q9UMQ3

- BARX2_HUMAN

UniProt

Q9UMQ3 - BARX2_HUMAN

Protein

Homeobox protein BarH-like 2

Gene

BARX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi133 – 19260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: MGI
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. cartilage condensation Source: Ensembl
    2. catagen Source: Ensembl
    3. myotube differentiation Source: Ensembl
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein BarH-like 2
    Gene namesi
    Name:BARX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:956. BARX2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: HPA
    2. nucleus Source: HPA
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Homeobox protein BarH-like 2PRO_0000048838Add
    BLAST

    Proteomic databases

    PaxDbiQ9UMQ3.
    PRIDEiQ9UMQ3.

    PTM databases

    PhosphoSiteiQ9UMQ3.

    Expressioni

    Tissue specificityi

    Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

    Gene expression databases

    ArrayExpressiQ9UMQ3.
    BgeeiQ9UMQ3.
    CleanExiHS_BARX2.
    GenevestigatoriQ9UMQ3.

    Organism-specific databases

    HPAiCAB033311.
    HPA047657.

    Interactioni

    Protein-protein interaction databases

    BioGridi114108. 1 interaction.
    STRINGi9606.ENSP00000281437.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UMQ3.
    SMRiQ9UMQ3. Positions 125-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BAR homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG324720.
    HOGENOMiHOG000231924.
    HOVERGENiHBG050665.
    InParanoidiQ9UMQ3.
    KOiK09361.
    OMAiVCPSLIV.
    OrthoDBiEOG71G9VZ.
    PhylomeDBiQ9UMQ3.
    TreeFamiTF350735.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UMQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS    50
    LVVRPKPLHS CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH 100
    QVTEAVSAEA PGGEALASSE SETEQPTPRQ KKPRRSRTIF TELQLMGLEK 150
    KFQKQKYLST PDRLDLAQSL GLTQLQVKTW YQNRRMKWKK MVLKGGQEAP 200
    TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ EELCEAQEPK 250
    ARDVPLEMAE PPDPPQELPI PSSEPPPLS 279
    Length:279
    Mass (Da):31,188
    Last modified:July 28, 2009 - v3
    Checksum:i8C2537E524528467
    GO

    Sequence cautioni

    The sequence AAC04705.1 differs from that shown. Reason: Frameshift at position 11.
    The sequence AAF09453.1 differs from that shown. Reason: Frameshift at position 11.
    The sequence AAC04705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAF09453.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031924 mRNA. Translation: AAC04705.1. Sequence problems.
    AF171222
    , AF171219, AF171220, AF171221 Genomic DNA. Translation: AAF09453.1. Sequence problems.
    AJ243512 mRNA. Translation: CAB50736.1.
    AP003775 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67743.1.
    BC069378 mRNA. Translation: AAH69378.1.
    BC111432 mRNA. Translation: AAI11433.1.
    BC111572 mRNA. Translation: AAI11573.1.
    CCDSiCCDS8481.1.
    RefSeqiNP_003649.2. NM_003658.4.
    UniGeneiHs.591944.

    Genome annotation databases

    EnsembliENST00000281437; ENSP00000281437; ENSG00000043039.
    GeneIDi8538.
    KEGGihsa:8538.
    UCSCiuc001qfc.4. human.

    Polymorphism databases

    DMDMi254763427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031924 mRNA. Translation: AAC04705.1 . Sequence problems.
    AF171222
    , AF171219 , AF171220 , AF171221 Genomic DNA. Translation: AAF09453.1 . Sequence problems.
    AJ243512 mRNA. Translation: CAB50736.1 .
    AP003775 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67743.1 .
    BC069378 mRNA. Translation: AAH69378.1 .
    BC111432 mRNA. Translation: AAI11433.1 .
    BC111572 mRNA. Translation: AAI11573.1 .
    CCDSi CCDS8481.1.
    RefSeqi NP_003649.2. NM_003658.4.
    UniGenei Hs.591944.

    3D structure databases

    ProteinModelPortali Q9UMQ3.
    SMRi Q9UMQ3. Positions 125-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114108. 1 interaction.
    STRINGi 9606.ENSP00000281437.

    PTM databases

    PhosphoSitei Q9UMQ3.

    Polymorphism databases

    DMDMi 254763427.

    Proteomic databases

    PaxDbi Q9UMQ3.
    PRIDEi Q9UMQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281437 ; ENSP00000281437 ; ENSG00000043039 .
    GeneIDi 8538.
    KEGGi hsa:8538.
    UCSCi uc001qfc.4. human.

    Organism-specific databases

    CTDi 8538.
    GeneCardsi GC11P129279.
    H-InvDB HIX0171307.
    HGNCi HGNC:956. BARX2.
    HPAi CAB033311.
    HPA047657.
    MIMi 604823. gene.
    neXtProti NX_Q9UMQ3.
    PharmGKBi PA25260.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324720.
    HOGENOMi HOG000231924.
    HOVERGENi HBG050665.
    InParanoidi Q9UMQ3.
    KOi K09361.
    OMAi VCPSLIV.
    OrthoDBi EOG71G9VZ.
    PhylomeDBi Q9UMQ3.
    TreeFami TF350735.

    Miscellaneous databases

    GenomeRNAii 8538.
    NextBioi 31980.
    PROi Q9UMQ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UMQ3.
    Bgeei Q9UMQ3.
    CleanExi HS_BARX2.
    Genevestigatori Q9UMQ3.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms."
      Hjalt T.A., Murray J.C.
      Genomics 62:456-459(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Expression cloning of the human version of Barx2 as a cAMP response element binding protein- (CREB)- interacting factor."
      Lindon C., Goodbourn S.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiBARX2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UMQ3
    Secondary accession number(s): O43518, Q6NT51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3