Q9UMQ3 (BARX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein BarH-like 2

Gene names

Name:

BARX2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia By similarity.
Subcellular location	Nucleus.
Tissue specificity	Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.
Sequence similarities	Belongs to the BAR homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAC04705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAC04705.1 differs from that shown. Reason: Frameshift at position 11. The sequence AAF09453.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAF09453.1 differs from that shown. Reason: Frameshift at position 11.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage condensation Inferred from electronic annotation. Source: Compara catagen Inferred from electronic annotation. Source: Compara myotube differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from direct assay Ref.1. Source: MGI chromatin binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Homeobox protein BarH-like 2		PRO_0000048838
Regions
	DNA binding	133 – 192	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	Q9UMQ3 [UniParc]. Last modified July 28, 2009. Version 3. Checksum: 8C2537E524528467	FASTA	279	31,188
	10 20 30 40 50 60 MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS LVVRPKPLHS 70 80 90 100 110 120 CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH QVTEAVSAEA PGGEALASSE 130 140 150 160 170 180 SETEQPTPRQ KKPRRSRTIF TELQLMGLEK KFQKQKYLST PDRLDLAQSL GLTQLQVKTW 190 200 210 220 230 240 YQNRRMKWKK MVLKGGQEAP TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ 250 260 270 EELCEAQEPK ARDVPLEMAE PPDPPQELPI PSSEPPPLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosomal localization of the human BARX2 homeobox protein gene." Krasner A., Wallace L., Thiagalingam A., Jones C., Lengauer C., Minahan L., Ma Y., Kalikin L., Feinberg A.P., Jabs E.W., Tunnacliffe A., Baylin S.B., Ball D.W., Nelkin B.D. Gene 250:171-180(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms." Hjalt T.A., Murray J.C. Genomics 62:456-459(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Expression cloning of the human version of Barx2 as a cAMP response element binding protein- (CREB)- interacting factor." Lindon C., Goodbourn S. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF031924 mRNA. Translation: AAC04705.1. Sequence problems. AF171222 , AF171219, AF171220, AF171221 Genomic DNA. Translation: AAF09453.1. Sequence problems. AJ243512 mRNA. Translation: CAB50736.1. AP003775 Genomic DNA. No translation available. CH471065 Genomic DNA. Translation: EAW67743.1. BC069378 mRNA. Translation: AAH69378.1. BC111432 mRNA. Translation: AAI11433.1. BC111572 mRNA. Translation: AAI11573.1.
IPI	IPI00216572.
RefSeq	NP_003649.2. NM_003658.4.
UniGene	Hs.591944.
3D structure databases
ProteinModelPortal	Q9UMQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000281437.
PTM databases
PhosphoSite	Q9UMQ3.
Polymorphism databases
DMDM	254763427.
Proteomic databases
PaxDb	Q9UMQ3.
PRIDE	Q9UMQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281437; ENSP00000281437; ENSG00000043039.
GeneID	8538.
KEGG	hsa:8538.
UCSC	uc001qfc.4. human.
Organism-specific databases
CTD	8538.
GeneCards	GC11P129279.
H-InvDB	HIX0171307.
HGNC	HGNC:956. BARX2.
HPA	CAB033311.
MIM	604823. gene.
neXtProt	NX_Q9UMQ3.
PharmGKB	PA25260.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG324720.
HOGENOM	HOG000231924.
HOVERGEN	HBG050665.
InParanoid	Q9UMQ3.
KO	K09361.
OMA	VITRQPP.
OrthoDB	EOG45TCP8.
PhylomeDB	Q9UMQ3.
Gene expression databases
ArrayExpress	Q9UMQ3.
Bgee	Q9UMQ3.
CleanEx	HS_BARX2.
Genevestigator	Q9UMQ3.
GermOnline	ENSG00000043039. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8538.
NextBio	31980.
SOURCE	Search...

Entry information

Entry name

BARX2_HUMAN

Accession

Primary (citable) accession number: Q9UMQ3
Secondary accession number(s): O43518, Q6NT51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	July 28, 2009
Last modified:	May 29, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.