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Q9UMQ3 (BARX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein BarH-like 2
Gene names
Name:BARX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia By similarity.

Subcellular location

Nucleus.

Tissue specificity

Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

Sequence similarities

Belongs to the BAR homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAC04705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAC04705.1 differs from that shown. Reason: Frameshift at position 11.

The sequence AAF09453.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAF09453.1 differs from that shown. Reason: Frameshift at position 11.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Homeobox protein BarH-like 2
PRO_0000048838

Regions

DNA binding133 – 19260Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q9UMQ3 [UniParc].

Last modified July 28, 2009. Version 3.
Checksum: 8C2537E524528467

FASTA27931,188
        10         20         30         40         50         60 
MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS LVVRPKPLHS 

        70         80         90        100        110        120 
CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH QVTEAVSAEA PGGEALASSE 

       130        140        150        160        170        180 
SETEQPTPRQ KKPRRSRTIF TELQLMGLEK KFQKQKYLST PDRLDLAQSL GLTQLQVKTW 

       190        200        210        220        230        240 
YQNRRMKWKK MVLKGGQEAP TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ 

       250        260        270 
EELCEAQEPK ARDVPLEMAE PPDPPQELPI PSSEPPPLS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal localization of the human BARX2 homeobox protein gene."
Krasner A., Wallace L., Thiagalingam A., Jones C., Lengauer C., Minahan L., Ma Y., Kalikin L., Feinberg A.P., Jabs E.W., Tunnacliffe A., Baylin S.B., Ball D.W., Nelkin B.D.
Gene 250:171-180(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms."
Hjalt T.A., Murray J.C.
Genomics 62:456-459(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Expression cloning of the human version of Barx2 as a cAMP response element binding protein- (CREB)- interacting factor."
Lindon C., Goodbourn S.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF031924 mRNA. Translation: AAC04705.1. Sequence problems.
AF171222 expand/collapse EMBL AC list , AF171219, AF171220, AF171221 Genomic DNA. Translation: AAF09453.1. Sequence problems.
AJ243512 mRNA. Translation: CAB50736.1.
AP003775 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67743.1.
BC069378 mRNA. Translation: AAH69378.1.
BC111432 mRNA. Translation: AAI11433.1.
BC111572 mRNA. Translation: AAI11573.1.
RefSeqNP_003649.2. NM_003658.4.
UniGeneHs.591944.

3D structure databases

ProteinModelPortalQ9UMQ3.
SMRQ9UMQ3. Positions 125-190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114108. 1 interaction.
STRING9606.ENSP00000281437.

PTM databases

PhosphoSiteQ9UMQ3.

Polymorphism databases

DMDM254763427.

Proteomic databases

PaxDbQ9UMQ3.
PRIDEQ9UMQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281437; ENSP00000281437; ENSG00000043039.
GeneID8538.
KEGGhsa:8538.
UCSCuc001qfc.4. human.

Organism-specific databases

CTD8538.
GeneCardsGC11P129279.
H-InvDBHIX0171307.
HGNCHGNC:956. BARX2.
HPACAB033311.
HPA047657.
MIM604823. gene.
neXtProtNX_Q9UMQ3.
PharmGKBPA25260.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG324720.
HOGENOMHOG000231924.
HOVERGENHBG050665.
InParanoidQ9UMQ3.
KOK09361.
OMAVITRQPP.
OrthoDBEOG71G9VZ.
PhylomeDBQ9UMQ3.
TreeFamTF350735.

Gene expression databases

ArrayExpressQ9UMQ3.
BgeeQ9UMQ3.
CleanExHS_BARX2.
GenevestigatorQ9UMQ3.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8538.
NextBio31980.
PROQ9UMQ3.
SOURCESearch...

Entry information

Entry nameBARX2_HUMAN
AccessionPrimary (citable) accession number: Q9UMQ3
Secondary accession number(s): O43518, Q6NT51
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM