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Q9UMF0

- ICAM5_HUMAN

UniProt

Q9UMF0 - ICAM5_HUMAN

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Protein

Intercellular adhesion molecule 5

Gene

ICAM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

GO - Biological processi

  1. phagocytosis Source: Ensembl
  2. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
Gene namesi
Name:ICAM5
Synonyms:TLCN, TLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:5348. ICAM5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 924893Intercellular adhesion molecule 5PRO_0000014799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) (high mannose)1 Publication
Disulfide bondi55 ↔ 991 PublicationPROSITE-ProRule annotation
Disulfide bondi59 ↔ 1031 PublicationPROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)1 Publication
Glycosylationi137 – 1371N-linked (GlcNAc...)1 Publication
Disulfide bondi142 ↔ 1981 PublicationPROSITE-ProRule annotation
Modified residuei182 – 1821Phosphothreonine1 Publication
Modified residuei184 – 1841Phosphothreonine1 Publication
Glycosylationi195 – 1951N-linked (GlcNAc...)1 Publication
Glycosylationi214 – 2141N-linked (GlcNAc...)1 Publication
Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
Disulfide bondi498 ↔ 552PROSITE-ProRule annotation
Disulfide bondi580 ↔ 645PROSITE-ProRule annotation
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi646 – 6461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi673 ↔ 725PROSITE-ProRule annotation
Glycosylationi764 – 7641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi769 ↔ 814PROSITE-ProRule annotation
Glycosylationi795 – 7951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi796 – 7961N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylation at Asn-54 is critical for functional folding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UMF0.
PaxDbiQ9UMF0.
PRIDEiQ9UMF0.

PTM databases

PhosphoSiteiQ9UMF0.

Expressioni

Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Gene expression databases

BgeeiQ9UMF0.
CleanExiHS_ICAM5.
ExpressionAtlasiQ9UMF0. baseline and differential.
GenevestigatoriQ9UMF0.

Organism-specific databases

HPAiCAB025178.
HPA008943.
HPA009083.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P050943EBI-6398041,EBI-5847257From a different organism.

Protein-protein interaction databases

BioGridi112942. 3 interactions.
IntActiQ9UMF0. 1 interaction.
STRINGi9606.ENSP00000221980.

Structurei

Secondary structure

1
924
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 4611Combined sources
Beta strandi49 – 579Combined sources
Beta strandi63 – 686Combined sources
Beta strandi70 – 7910Combined sources
Beta strandi82 – 909Combined sources
Beta strandi92 – 954Combined sources
Beta strandi98 – 1036Combined sources
Beta strandi106 – 1116Combined sources
Beta strandi113 – 1186Combined sources
Beta strandi130 – 1334Combined sources
Beta strandi136 – 1449Combined sources
Helixi150 – 1523Combined sources
Beta strandi153 – 1597Combined sources
Beta strandi162 – 1687Combined sources
Beta strandi179 – 1868Combined sources
Helixi189 – 1913Combined sources
Beta strandi195 – 2039Combined sources
Helixi205 – 2073Combined sources
Beta strandi211 – 2155Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BN3X-ray2.10B32-227[»]
4OI9X-ray2.50A32-409[»]
4OIAX-ray3.70A/B32-409[»]
4OIBX-ray3.50A32-409[»]
ProteinModelPortaliQ9UMF0.
SMRiQ9UMF0. Positions 32-823.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UMF0.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 835804ExtracellularSequence AnalysisAdd
BLAST
Topological domaini857 – 92468CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei836 – 85621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 13083Ig-like C2-type 1Add
BLAST
Domaini135 – 235101Ig-like C2-type 2Add
BLAST
Domaini242 – 32988Ig-like C2-type 3Add
BLAST
Domaini337 – 40266Ig-like C2-type 4Add
BLAST
Domaini408 – 48679Ig-like C2-type 5Add
BLAST
Domaini491 – 56878Ig-like C2-type 6Add
BLAST
Domaini573 – 66290Ig-like C2-type 7Add
BLAST
Domaini666 – 73974Ig-like C2-type 8Add
BLAST
Domaini746 – 83085Ig-like C2-type 9Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000168514.
HOVERGENiHBG052077.
InParanoidiQ9UMF0.
KOiK06769.
OMAiVCNATNR.
OrthoDBiEOG7MD4PS.
PhylomeDBiQ9UMF0.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UMF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELMPLPP WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG AQELIRRSFA GEPPRARGAV LTATVLARRE DHGANFSCRA
210 220 230 240 250
ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE VGSERPVSCT
260 270 280 290 300
LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL
310 320 330 340 350
VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA
360 370 380 390 400
LVTLEGVPAA VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA
410 420 430 440 450
ELRVLYAPRL DDSDCPRSWT WPEGPEQTLR CEARGNPEPS VHCARSDGGA
460 470 480 490 500
VLALGLLGPV TRALSGTYRC KAANDQGEAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL RVAREHAGTY
560 570 580 590 600
RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG
610 620 630 640 650
KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR
660 670 680 690 700
HGSVAKTVVV SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV
710 720 730 740 750
RCSREGIPWP EQQRVSREDA GTYHCVATNA HGTDSRTVTV GVEYRPVVAE
760 770 780 790 800
LAASPPGGVR PGGNFTLTCR AEAWPPAQIS WRAPPGALNI GLSSNNSTLS
810 820 830 840 850
VAGAMGSHGG EYECAATNAH GRHARRITVR VAGPWLWVAV GGAAGGAALL
860 870 880 890 900
AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG
910 920
PEAAGGAAES PAEGEVFAIQ LTSA
Length:924
Mass (Da):97,116
Last modified:May 18, 2010 - v3
Checksum:i97D0A9467BD16D30
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti614 – 6141A → T in AAC50959. (PubMed:8995416)Curated
Sequence conflicti786 – 7861G → R in AAC97931. (PubMed:9828136)Curated
Sequence conflicti816 – 8161A → R in AAC50959. (PubMed:8995416)Curated
Sequence conflicti816 – 8161A → R in AAC97931. (PubMed:9828136)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_035515
Natural varianti188 – 1881R → W in a breast cancer sample; somatic mutation. 1 Publication
VAR_035516
Natural varianti301 – 3011V → I.1 Publication
Corresponds to variant rs1056538 [ dbSNP | Ensembl ].
VAR_056046
Natural varianti348 – 3481A → T.1 Publication
Corresponds to variant rs2228615 [ dbSNP | Ensembl ].
VAR_056047
Natural varianti488 – 4881E → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_035517

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72671 mRNA. Translation: AAC50959.1.
AF082802 Genomic DNA. Translation: AAC97931.1.
AC011511 Genomic DNA. No translation available.
CCDSiCCDS12233.1.
RefSeqiNP_003250.3. NM_003259.3.
UniGeneiHs.465862.

Genome annotation databases

EnsembliENST00000221980; ENSP00000221980; ENSG00000105376.
GeneIDi7087.
KEGGihsa:7087.
UCSCiuc002mnu.4. human.

Polymorphism databases

DMDMi296439327.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72671 mRNA. Translation: AAC50959.1 .
AF082802 Genomic DNA. Translation: AAC97931.1 .
AC011511 Genomic DNA. No translation available.
CCDSi CCDS12233.1.
RefSeqi NP_003250.3. NM_003259.3.
UniGenei Hs.465862.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BN3 X-ray 2.10 B 32-227 [» ]
4OI9 X-ray 2.50 A 32-409 [» ]
4OIA X-ray 3.70 A/B 32-409 [» ]
4OIB X-ray 3.50 A 32-409 [» ]
ProteinModelPortali Q9UMF0.
SMRi Q9UMF0. Positions 32-823.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112942. 3 interactions.
IntActi Q9UMF0. 1 interaction.
STRINGi 9606.ENSP00000221980.

PTM databases

PhosphoSitei Q9UMF0.

Polymorphism databases

DMDMi 296439327.

Proteomic databases

MaxQBi Q9UMF0.
PaxDbi Q9UMF0.
PRIDEi Q9UMF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221980 ; ENSP00000221980 ; ENSG00000105376 .
GeneIDi 7087.
KEGGi hsa:7087.
UCSCi uc002mnu.4. human.

Organism-specific databases

CTDi 7087.
GeneCardsi GC19P010400.
H-InvDB HIX0014740.
HGNCi HGNC:5348. ICAM5.
HPAi CAB025178.
HPA008943.
HPA009083.
MIMi 601852. gene.
neXtProti NX_Q9UMF0.
PharmGKBi PA29596.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146347.
GeneTreei ENSGT00530000063246.
HOGENOMi HOG000168514.
HOVERGENi HBG052077.
InParanoidi Q9UMF0.
KOi K06769.
OMAi VCNATNR.
OrthoDBi EOG7MD4PS.
PhylomeDBi Q9UMF0.
TreeFami TF333745.

Miscellaneous databases

EvolutionaryTracei Q9UMF0.
GeneWikii ICAM5.
GenomeRNAii 7087.
NextBioi 27719.
PROi Q9UMF0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UMF0.
CleanExi HS_ICAM5.
ExpressionAtlasi Q9UMF0. baseline and differential.
Genevestigatori Q9UMF0.

Family and domain databases

Gene3Di 2.60.40.10. 12 hits.
InterProi IPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF03921. ICAM_N. 1 hit.
[Graphical view ]
PRINTSi PR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTi SM00409. IG. 4 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1."
    Mizuno T., Yoshihara Y., Inazawa J., Kagamiyama H., Mori K.
    J. Biol. Chem. 272:1156-1163(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-301 AND THR-348.
    Tissue: Brain.
  2. "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2."
    Kilgannon P., Turner T., Meyer J., Wisdom W., Gallatin W.M.
    Genomics 54:328-330(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182 AND THR-184, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. "An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5."
    Zhang H., Casasnovas J.M., Jin M., Liu J.H., Gahmberg C.G., Springer T.A., Wang J.H.
    Mol. Cell 31:432-437(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 32-227 IN COMPLEX WITH ITGAL, GLYCOSYLATION AT ASN-54; ASN-74; ASN-137; ASN-195 AND ASN-214, DISULFIDE BONDS.
  6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-140; TRP-188 AND GLN-488.

Entry informationi

Entry nameiICAM5_HUMAN
AccessioniPrimary (citable) accession number: Q9UMF0
Secondary accession number(s): Q9Y6F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3