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Protein

Intercellular adhesion molecule 5

Gene

ICAM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105376-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
Gene namesi
Name:ICAM5
Synonyms:TLCN, TLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:5348. ICAM5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 835ExtracellularSequence analysisAdd BLAST804
Transmembranei836 – 856HelicalSequence analysisAdd BLAST21
Topological domaini857 – 924CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7087.
OpenTargetsiENSG00000105376.
PharmGKBiPA29596.

Polymorphism and mutation databases

BioMutaiICAM5.
DMDMi296439327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001479932 – 924Intercellular adhesion molecule 5Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) (high mannose)1 Publication1
Disulfide bondi55 ↔ 99PROSITE-ProRule annotation1 Publication
Disulfide bondi59 ↔ 103PROSITE-ProRule annotation1 Publication
Glycosylationi74N-linked (GlcNAc...)1 Publication1
Glycosylationi137N-linked (GlcNAc...)1 Publication1
Disulfide bondi142 ↔ 198PROSITE-ProRule annotation1 Publication
Modified residuei182PhosphothreonineCombined sources1
Modified residuei184PhosphothreonineCombined sources1
Glycosylationi195N-linked (GlcNAc...)1 Publication1
Glycosylationi214N-linked (GlcNAc...)1 Publication1
Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
Disulfide bondi498 ↔ 552PROSITE-ProRule annotation
Disulfide bondi580 ↔ 645PROSITE-ProRule annotation
Glycosylationi583N-linked (GlcNAc...)Sequence analysis1
Glycosylationi646N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi673 ↔ 725PROSITE-ProRule annotation
Glycosylationi764N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi769 ↔ 814PROSITE-ProRule annotation
Glycosylationi795N-linked (GlcNAc...)Sequence analysis1
Glycosylationi796N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylation at Asn-54 is critical for functional folding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UMF0.
PaxDbiQ9UMF0.
PeptideAtlasiQ9UMF0.
PRIDEiQ9UMF0.

PTM databases

iPTMnetiQ9UMF0.
PhosphoSitePlusiQ9UMF0.

Expressioni

Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Gene expression databases

BgeeiENSG00000105376.
CleanExiHS_ICAM5.
ExpressionAtlasiQ9UMF0. baseline and differential.
GenevisibleiQ9UMF0. HS.

Organism-specific databases

HPAiCAB025178.
HPA008943.
HPA009083.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P050943EBI-6398041,EBI-5847257From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112942. 20 interactors.
IntActiQ9UMF0. 18 interactors.
STRINGi9606.ENSP00000221980.

Structurei

Secondary structure

1924
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 46Combined sources11
Beta strandi49 – 57Combined sources9
Beta strandi63 – 68Combined sources6
Beta strandi70 – 79Combined sources10
Beta strandi82 – 90Combined sources9
Beta strandi92 – 95Combined sources4
Beta strandi98 – 103Combined sources6
Beta strandi106 – 111Combined sources6
Beta strandi113 – 118Combined sources6
Beta strandi130 – 133Combined sources4
Beta strandi136 – 144Combined sources9
Helixi150 – 152Combined sources3
Beta strandi153 – 159Combined sources7
Beta strandi162 – 168Combined sources7
Beta strandi179 – 186Combined sources8
Helixi189 – 191Combined sources3
Beta strandi195 – 203Combined sources9
Helixi205 – 207Combined sources3
Beta strandi211 – 215Combined sources5
Beta strandi223 – 226Combined sources4
Beta strandi232 – 234Combined sources3
Beta strandi237 – 241Combined sources5
Beta strandi245 – 251Combined sources7
Beta strandi253 – 256Combined sources4
Helixi257 – 259Combined sources3
Beta strandi261 – 271Combined sources11
Beta strandi274 – 278Combined sources5
Beta strandi281 – 288Combined sources8
Beta strandi295 – 306Combined sources12
Beta strandi309 – 320Combined sources12
Beta strandi326 – 330Combined sources5
Beta strandi332 – 335Combined sources4
Beta strandi339 – 345Combined sources7
Beta strandi348 – 354Combined sources7
Beta strandi366 – 371Combined sources6
Helixi374 – 376Combined sources3
Beta strandi379 – 389Combined sources11
Beta strandi392 – 405Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BN3X-ray2.10B32-227[»]
4OI9X-ray2.50A32-409[»]
4OIAX-ray3.70A/B32-409[»]
4OIBX-ray3.50A32-409[»]
ProteinModelPortaliQ9UMF0.
SMRiQ9UMF0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UMF0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 130Ig-like C2-type 1Add BLAST83
Domaini135 – 235Ig-like C2-type 2Add BLAST101
Domaini242 – 329Ig-like C2-type 3Add BLAST88
Domaini337 – 402Ig-like C2-type 4Add BLAST66
Domaini408 – 486Ig-like C2-type 5Add BLAST79
Domaini491 – 568Ig-like C2-type 6Add BLAST78
Domaini573 – 662Ig-like C2-type 7Add BLAST90
Domaini666 – 739Ig-like C2-type 8Add BLAST74
Domaini746 – 830Ig-like C2-type 9Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM. Eukaryota.
ENOG410YQ1Q. LUCA.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000168514.
HOVERGENiHBG052077.
InParanoidiQ9UMF0.
KOiK06769.
OMAiFEEPSCP.
OrthoDBiEOG091G022Y.
PhylomeDBiQ9UMF0.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 9 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UMF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELMPLPP WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG AQELIRRSFA GEPPRARGAV LTATVLARRE DHGANFSCRA
210 220 230 240 250
ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE VGSERPVSCT
260 270 280 290 300
LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL
310 320 330 340 350
VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA
360 370 380 390 400
LVTLEGVPAA VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA
410 420 430 440 450
ELRVLYAPRL DDSDCPRSWT WPEGPEQTLR CEARGNPEPS VHCARSDGGA
460 470 480 490 500
VLALGLLGPV TRALSGTYRC KAANDQGEAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL RVAREHAGTY
560 570 580 590 600
RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG
610 620 630 640 650
KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR
660 670 680 690 700
HGSVAKTVVV SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV
710 720 730 740 750
RCSREGIPWP EQQRVSREDA GTYHCVATNA HGTDSRTVTV GVEYRPVVAE
760 770 780 790 800
LAASPPGGVR PGGNFTLTCR AEAWPPAQIS WRAPPGALNI GLSSNNSTLS
810 820 830 840 850
VAGAMGSHGG EYECAATNAH GRHARRITVR VAGPWLWVAV GGAAGGAALL
860 870 880 890 900
AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG
910 920
PEAAGGAAES PAEGEVFAIQ LTSA
Length:924
Mass (Da):97,116
Last modified:May 18, 2010 - v3
Checksum:i97D0A9467BD16D30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti614A → T in AAC50959 (PubMed:8995416).Curated1
Sequence conflicti786G → R in AAC97931 (PubMed:9828136).Curated1
Sequence conflicti816A → R in AAC50959 (PubMed:8995416).Curated1
Sequence conflicti816A → R in AAC97931 (PubMed:9828136).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035515140L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035516188R → W in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_056046301V → I.1 PublicationCorresponds to variant rs1056538dbSNPEnsembl.1
Natural variantiVAR_056047348A → T.1 PublicationCorresponds to variant rs2228615dbSNPEnsembl.1
Natural variantiVAR_035517488E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72671 mRNA. Translation: AAC50959.1.
AF082802 Genomic DNA. Translation: AAC97931.1.
AC011511 Genomic DNA. No translation available.
CCDSiCCDS12233.1.
RefSeqiNP_003250.3. NM_003259.3.
XP_011526531.1. XM_011528229.1.
UniGeneiHs.465862.

Genome annotation databases

EnsembliENST00000221980; ENSP00000221980; ENSG00000105376.
GeneIDi7087.
KEGGihsa:7087.
UCSCiuc002mnu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72671 mRNA. Translation: AAC50959.1.
AF082802 Genomic DNA. Translation: AAC97931.1.
AC011511 Genomic DNA. No translation available.
CCDSiCCDS12233.1.
RefSeqiNP_003250.3. NM_003259.3.
XP_011526531.1. XM_011528229.1.
UniGeneiHs.465862.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BN3X-ray2.10B32-227[»]
4OI9X-ray2.50A32-409[»]
4OIAX-ray3.70A/B32-409[»]
4OIBX-ray3.50A32-409[»]
ProteinModelPortaliQ9UMF0.
SMRiQ9UMF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112942. 20 interactors.
IntActiQ9UMF0. 18 interactors.
STRINGi9606.ENSP00000221980.

PTM databases

iPTMnetiQ9UMF0.
PhosphoSitePlusiQ9UMF0.

Polymorphism and mutation databases

BioMutaiICAM5.
DMDMi296439327.

Proteomic databases

MaxQBiQ9UMF0.
PaxDbiQ9UMF0.
PeptideAtlasiQ9UMF0.
PRIDEiQ9UMF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221980; ENSP00000221980; ENSG00000105376.
GeneIDi7087.
KEGGihsa:7087.
UCSCiuc002mnu.5. human.

Organism-specific databases

CTDi7087.
DisGeNETi7087.
GeneCardsiICAM5.
H-InvDBHIX0014740.
HGNCiHGNC:5348. ICAM5.
HPAiCAB025178.
HPA008943.
HPA009083.
MIMi601852. gene.
neXtProtiNX_Q9UMF0.
OpenTargetsiENSG00000105376.
PharmGKBiPA29596.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPHM. Eukaryota.
ENOG410YQ1Q. LUCA.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000168514.
HOVERGENiHBG052077.
InParanoidiQ9UMF0.
KOiK06769.
OMAiFEEPSCP.
OrthoDBiEOG091G022Y.
PhylomeDBiQ9UMF0.
TreeFamiTF333745.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105376-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-216083. Integrin cell surface interactions.

Miscellaneous databases

EvolutionaryTraceiQ9UMF0.
GeneWikiiICAM5.
GenomeRNAii7087.
PROiQ9UMF0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105376.
CleanExiHS_ICAM5.
ExpressionAtlasiQ9UMF0. baseline and differential.
GenevisibleiQ9UMF0. HS.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 9 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICAM5_HUMAN
AccessioniPrimary (citable) accession number: Q9UMF0
Secondary accession number(s): Q9Y6F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.