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Protein
Submitted name:

Fibroblast growth factor receptor-related protein

Gene

K-SAM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. fibroblast growth factor-activated receptor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. axonogenesis Source: Ensembl
  3. bone mineralization Source: Ensembl
  4. branch elongation involved in salivary gland morphogenesis Source: Ensembl
  5. branching involved in labyrinthine layer morphogenesis Source: Ensembl
  6. branching morphogenesis of a nerve Source: Ensembl
  7. bud elongation involved in lung branching Source: Ensembl
  8. cell fate commitment Source: Ensembl
  9. coronal suture morphogenesis Source: Ensembl
  10. embryonic cranial skeleton morphogenesis Source: InterPro
  11. embryonic digestive tract morphogenesis Source: Ensembl
  12. embryonic pattern specification Source: Ensembl
  13. endodermal digestive tract morphogenesis Source: Ensembl
  14. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  15. epithelial to mesenchymal transition Source: Ensembl
  16. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: Ensembl
  17. hair follicle morphogenesis Source: Ensembl
  18. lacrimal gland development Source: Ensembl
  19. lateral sprouting from an epithelium Source: Ensembl
  20. lens fiber cell development Source: Ensembl
  21. limb bud formation Source: Ensembl
  22. lung alveolus development Source: Ensembl
  23. lung-associated mesenchyme development Source: Ensembl
  24. lung lobe morphogenesis Source: Ensembl
  25. mammary gland bud formation Source: Ensembl
  26. membranous septum morphogenesis Source: Ensembl
  27. mesenchymal cell differentiation involved in lung development Source: Ensembl
  28. mesenchymal cell proliferation involved in lung development Source: Ensembl
  29. mesodermal cell differentiation Source: Ensembl
  30. midbrain development Source: Ensembl
  31. multicellular organism growth Source: Ensembl
  32. negative regulation of epithelial cell proliferation Source: Ensembl
  33. negative regulation of mitotic nuclear division Source: Ensembl
  34. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  35. neuromuscular junction development Source: Ensembl
  36. odontogenesis Source: Ensembl
  37. otic vesicle formation Source: Ensembl
  38. outflow tract septum morphogenesis Source: Ensembl
  39. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  40. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  41. positive regulation of cell division Source: Ensembl
  42. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  43. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  44. positive regulation of mesenchymal cell proliferation Source: Ensembl
  45. positive regulation of smooth muscle cell proliferation Source: Ensembl
  46. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  47. post-embryonic development Source: Ensembl
  48. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  49. prostate epithelial cord elongation Source: Ensembl
  50. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  51. regulation of cell fate commitment Source: Ensembl
  52. regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  53. regulation of multicellular organism growth Source: Ensembl
  54. regulation of smoothened signaling pathway Source: Ensembl
  55. regulation of smooth muscle cell differentiation Source: Ensembl
  56. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: Ensembl
  57. synaptic vesicle transport Source: Ensembl
  58. ureteric bud development Source: Ensembl
  59. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor-related proteinImported
Gene namesi
Name:K-SAMImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9UMB0.
ExpressionAtlasiQ9UMB0. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9UMB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000263410.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028175. FGF_rcpt_2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UMB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PANASTVVGG DVEFVCKVYS DAQPHIQWIK HVEKNGSKYG PDGLPYLKVL
60 70 80 90 100
KHSGINSSNA EVLALFNVTE ADAGEYICKV SNYIGQANQS AWLTVLPKQQ
Length:100
Mass (Da):10,847
Last modified:May 1, 2000 - v1
Checksum:iE92E028C34733E34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei100 – 1001Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40853, S40851 Genomic DNA. Translation: AAB19319.1.
PIRiA41794.
UniGeneiHs.533683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40853, S40851 Genomic DNA. Translation: AAB19319.1.
PIRiA41794.
UniGeneiHs.533683.

3D structure databases

ProteinModelPortaliQ9UMB0.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9UMB0.

Protein family/group databases

MEROPSiI43.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000263410.

Miscellaneous databases

ChiTaRSiFGFR2. human.

Gene expression databases

BgeeiQ9UMB0.
ExpressionAtlasiQ9UMB0. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028175. FGF_rcpt_2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor."
    Champion-Arnaud P., Ronsin C., Gilbert E., Gesnel M.C., Houssaint E., Breathnach R.
    Oncogene 6:979-987(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UMB0_HUMAN
AccessioniPrimary (citable) accession number: Q9UMB0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.