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Q9UMB0

- Q9UMB0_HUMAN

UniProt

Q9UMB0 - Q9UMB0_HUMAN

Protein
Submitted name:

Fibroblast growth factor receptor-related protein

Gene

K-SAM

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. fibroblast growth factor-activated receptor activity Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. axonogenesis Source: Ensembl
    3. bone mineralization Source: Ensembl
    4. branch elongation involved in salivary gland morphogenesis Source: Ensembl
    5. branching involved in labyrinthine layer morphogenesis Source: Ensembl
    6. branching morphogenesis of a nerve Source: Ensembl
    7. bud elongation involved in lung branching Source: Ensembl
    8. cell fate commitment Source: Ensembl
    9. coronal suture morphogenesis Source: Ensembl
    10. embryonic cranial skeleton morphogenesis Source: InterPro
    11. embryonic digestive tract morphogenesis Source: Ensembl
    12. embryonic pattern specification Source: Ensembl
    13. endodermal digestive tract morphogenesis Source: Ensembl
    14. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    15. epithelial to mesenchymal transition Source: Ensembl
    16. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: Ensembl
    17. hair follicle morphogenesis Source: Ensembl
    18. lacrimal gland development Source: Ensembl
    19. lateral sprouting from an epithelium Source: Ensembl
    20. lens fiber cell development Source: Ensembl
    21. limb bud formation Source: Ensembl
    22. lung alveolus development Source: Ensembl
    23. lung-associated mesenchyme development Source: Ensembl
    24. lung lobe morphogenesis Source: Ensembl
    25. mammary gland bud formation Source: Ensembl
    26. membranous septum morphogenesis Source: Ensembl
    27. mesenchymal cell differentiation involved in lung development Source: Ensembl
    28. mesenchymal cell proliferation involved in lung development Source: Ensembl
    29. mesodermal cell differentiation Source: Ensembl
    30. midbrain development Source: Ensembl
    31. multicellular organism growth Source: Ensembl
    32. negative regulation of epithelial cell proliferation Source: Ensembl
    33. negative regulation of mitosis Source: Ensembl
    34. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    35. neuromuscular junction development Source: Ensembl
    36. odontogenesis Source: Ensembl
    37. organ growth Source: Ensembl
    38. otic vesicle formation Source: Ensembl
    39. outflow tract septum morphogenesis Source: Ensembl
    40. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    41. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    42. positive regulation of cell division Source: Ensembl
    43. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    44. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    45. positive regulation of mesenchymal cell proliferation Source: Ensembl
    46. positive regulation of smooth muscle cell proliferation Source: Ensembl
    47. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    48. post-embryonic development Source: Ensembl
    49. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    50. prostate epithelial cord elongation Source: Ensembl
    51. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    52. regulation of cell fate commitment Source: Ensembl
    53. regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    54. regulation of multicellular organism growth Source: Ensembl
    55. regulation of smoothened signaling pathway Source: Ensembl
    56. regulation of smooth muscle cell differentiation Source: Ensembl
    57. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: Ensembl
    58. synaptic vesicle transport Source: Ensembl
    59. ureteric bud development Source: Ensembl
    60. ventricular cardiac muscle tissue morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fibroblast growth factor receptor-related proteinImported
    Gene namesi
    Name:K-SAMImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UMB0.
    BgeeiQ9UMB0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UMB0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000263410.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR028175. FGF_rcpt_2.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    [Graphical view]
    PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9UMB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    PANASTVVGG DVEFVCKVYS DAQPHIQWIK HVEKNGSKYG PDGLPYLKVL    50
    KHSGINSSNA EVLALFNVTE ADAGEYICKV SNYIGQANQS AWLTVLPKQQ 100
    Length:100
    Mass (Da):10,847
    Last modified:May 1, 2000 - v1
    Checksum:iE92E028C34733E34
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei100 – 1001Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S40853, S40851 Genomic DNA. Translation: AAB19319.1.
    PIRiA41794.
    UniGeneiHs.533683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S40853 , S40851 Genomic DNA. Translation: AAB19319.1 .
    PIRi A41794.
    UniGenei Hs.533683.

    3D structure databases

    ProteinModelPortali Q9UMB0.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000263410.

    Gene expression databases

    ArrayExpressi Q9UMB0.
    Bgeei Q9UMB0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR028175. FGF_rcpt_2.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    [Graphical view ]
    PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor."
      Champion-Arnaud P., Ronsin C., Gilbert E., Gesnel M.C., Houssaint E., Breathnach R.
      Oncogene 6:979-987(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UMB0_HUMAN
    AccessioniPrimary (citable) accession number: Q9UMB0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.