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Q9UMB0

- Q9UMB0_HUMAN

UniProt

Q9UMB0 - Q9UMB0_HUMAN

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Protein
Submitted name:

Fibroblast growth factor receptor-related protein

Gene

K-SAM

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. fibroblast growth factor-activated receptor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. axonogenesis Source: Ensembl
  3. bone mineralization Source: Ensembl
  4. branch elongation involved in salivary gland morphogenesis Source: Ensembl
  5. branching involved in labyrinthine layer morphogenesis Source: Ensembl
  6. branching morphogenesis of a nerve Source: Ensembl
  7. bud elongation involved in lung branching Source: Ensembl
  8. cell fate commitment Source: Ensembl
  9. coronal suture morphogenesis Source: Ensembl
  10. embryonic cranial skeleton morphogenesis Source: InterPro
  11. embryonic digestive tract morphogenesis Source: Ensembl
  12. embryonic pattern specification Source: Ensembl
  13. endodermal digestive tract morphogenesis Source: Ensembl
  14. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  15. epithelial to mesenchymal transition Source: Ensembl
  16. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: Ensembl
  17. hair follicle morphogenesis Source: Ensembl
  18. lacrimal gland development Source: Ensembl
  19. lateral sprouting from an epithelium Source: Ensembl
  20. lens fiber cell development Source: Ensembl
  21. limb bud formation Source: Ensembl
  22. lung alveolus development Source: Ensembl
  23. lung-associated mesenchyme development Source: Ensembl
  24. lung lobe morphogenesis Source: Ensembl
  25. mammary gland bud formation Source: Ensembl
  26. membranous septum morphogenesis Source: Ensembl
  27. mesenchymal cell differentiation involved in lung development Source: Ensembl
  28. mesenchymal cell proliferation involved in lung development Source: Ensembl
  29. mesodermal cell differentiation Source: Ensembl
  30. midbrain development Source: Ensembl
  31. multicellular organism growth Source: Ensembl
  32. negative regulation of epithelial cell proliferation Source: Ensembl
  33. negative regulation of mitosis Source: Ensembl
  34. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  35. neuromuscular junction development Source: Ensembl
  36. odontogenesis Source: Ensembl
  37. organ growth Source: Ensembl
  38. otic vesicle formation Source: Ensembl
  39. outflow tract septum morphogenesis Source: Ensembl
  40. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  41. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  42. positive regulation of cell division Source: Ensembl
  43. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  44. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  45. positive regulation of mesenchymal cell proliferation Source: Ensembl
  46. positive regulation of smooth muscle cell proliferation Source: Ensembl
  47. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  48. post-embryonic development Source: Ensembl
  49. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  50. prostate epithelial cord elongation Source: Ensembl
  51. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  52. regulation of cell fate commitment Source: Ensembl
  53. regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  54. regulation of multicellular organism growth Source: Ensembl
  55. regulation of smoothened signaling pathway Source: Ensembl
  56. regulation of smooth muscle cell differentiation Source: Ensembl
  57. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: Ensembl
  58. synaptic vesicle transport Source: Ensembl
  59. ureteric bud development Source: Ensembl
  60. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor-related proteinImported
Gene namesi
Name:K-SAMImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9UMB0.
ExpressionAtlasiQ9UMB0. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9UMB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000263410.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028175. FGF_rcpt_2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UMB0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PANASTVVGG DVEFVCKVYS DAQPHIQWIK HVEKNGSKYG PDGLPYLKVL
60 70 80 90 100
KHSGINSSNA EVLALFNVTE ADAGEYICKV SNYIGQANQS AWLTVLPKQQ
Length:100
Mass (Da):10,847
Last modified:May 1, 2000 - v1
Checksum:iE92E028C34733E34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei100 – 1001Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40853, S40851 Genomic DNA. Translation: AAB19319.1.
PIRiA41794.
UniGeneiHs.533683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40853 , S40851 Genomic DNA. Translation: AAB19319.1 .
PIRi A41794.
UniGenei Hs.533683.

3D structure databases

ProteinModelPortali Q9UMB0.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9UMB0.

Protein family/group databases

MEROPSi I43.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000263410.

Miscellaneous databases

ChiTaRSi FGFR2. human.

Gene expression databases

Bgeei Q9UMB0.
ExpressionAtlasi Q9UMB0. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR028175. FGF_rcpt_2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view ]
PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
Pfami PF07679. I-set. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor."
    Champion-Arnaud P., Ronsin C., Gilbert E., Gesnel M.C., Houssaint E., Breathnach R.
    Oncogene 6:979-987(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UMB0_HUMAN
AccessioniPrimary (citable) accession number: Q9UMB0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.