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Protein

Spermatogenesis-associated protein 2

Gene

SPATA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in the regulation of spermatogenesis.

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 2
Alternative name(s):
Spermatogenesis-associated protein PD1
Gene namesi
Name:SPATA2
Synonyms:KIAA0757, PD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000158480.10
HGNCiHGNC:14681 SPATA2
MIMi607662 gene
neXtProtiNX_Q9UM82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9825
OpenTargetsiENSG00000158480
PharmGKBiPA37909

Polymorphism and mutation databases

BioMutaiSPATA2
DMDMi13633942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721001 – 520Spermatogenesis-associated protein 2Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UM82
MaxQBiQ9UM82
PaxDbiQ9UM82
PeptideAtlasiQ9UM82
PRIDEiQ9UM82

PTM databases

iPTMnetiQ9UM82
PhosphoSitePlusiQ9UM82

Expressioni

Tissue specificityi

Highly expressed in Sertoli cells, but not detected in spermatogenic cells. Low expression in spleen, thymus and prostate.

Gene expression databases

BgeeiENSG00000158480
CleanExiHS_SPATA2
GenevisibleiQ9UM82 HS

Organism-specific databases

HPAiHPA048581
HPA052224

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11516335 interactors.
CORUMiQ9UM82
IntActiQ9UM82 23 interactors.
STRINGi9606.ENSP00000289431

Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 24Combined sources16
Helixi40 – 51Combined sources12
Helixi52 – 54Combined sources3
Helixi57 – 59Combined sources3
Beta strandi62 – 64Combined sources3
Helixi66 – 76Combined sources11
Helixi82 – 101Combined sources20
Helixi106 – 109Combined sources4
Beta strandi114 – 116Combined sources3
Helixi117 – 121Combined sources5
Turni122 – 125Combined sources4
Helixi128 – 137Combined sources10
Beta strandi140 – 143Combined sources4
Beta strandi146 – 150Combined sources5
Helixi156 – 182Combined sources27
Turni183 – 185Combined sources3
Helixi190 – 199Combined sources10
Helixi204 – 216Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LJMX-ray1.45A7-219[»]
5LJNX-ray2.70C/D334-341[»]
ProteinModelPortaliQ9UM82
SMRiQ9UM82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 81Poly-Ser6

Sequence similaritiesi

Belongs to the SPATA2 family.Curated

Phylogenomic databases

eggNOGiENOG410IGAI Eukaryota
ENOG410XZJ4 LUCA
GeneTreeiENSGT00530000063956
HOGENOMiHOG000133025
HOVERGENiHBG057357
InParanoidiQ9UM82
KOiK17595
OMAiCSKVSCD
OrthoDBiEOG091G05ZD
PhylomeDBiQ9UM82
TreeFamiTF328840

Family and domain databases

InterProiView protein in InterPro
IPR029744 SPATA2
PANTHERiPTHR15326:SF8 PTHR15326:SF8, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UM82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPSSMDTK FKDDLFRKYV QFHESKVDTT TSRQRPGSDE CLRVAASTLL
60 70 80 90 100
SLHKVDPFYR FRLIQFYEVV ESSLRSLSSS SLRALHGAFS MLETVGINLF
110 120 130 140 150
LYPWKKEFRS IKTYTGPFVY YVKSTLLEED IRAILSCMGY TPELGTAYKL
160 170 180 190 200
RELVETLQVK MVSFELFLAK VECEQMLEIH SQVKDKGYSE LDIVSERKSS
210 220 230 240 250
AEDVRGCSDA LRRRAEGREH LTASMSRVAL QKSASERAAK DYYKPRVTKP
260 270 280 290 300
SRSVDAYDSY WESRKPPLKA SLSLRKEPVA TDVGDDLKDE IIRPSPSLLT
310 320 330 340 350
MASSPHGSPD VLPPASPSNG PALLRGTYFS TQDDVDLYTD SEPRATYRRQ
360 370 380 390 400
DALRPDVWLL RNDAHSLYHK RSPPAKESAL SKCQSCGLSC SSSLCQRCDS
410 420 430 440 450
LLTCPPASKP SAFPSKASTH DSLAHGASLR EKYPGQTQGL DRLPHLHSKS
460 470 480 490 500
KPSTTPTSRC GFCNRPGATN TCTQCSKVSC DACLSAYHYD PCYKKSELHK
510 520
FMPNNQLNYK STQLSHLVYR
Length:520
Mass (Da):58,427
Last modified:April 27, 2001 - v2
Checksum:iD29869B601166C89
GO

Sequence cautioni

The sequence BAA34477 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172E → D in AAD28324 (PubMed:10222154).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051368443L → F. Corresponds to variant dbSNP:rs2072985Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28164 mRNA Translation: AAD28324.1
AB018300 mRNA Translation: BAA34477.2 Different initiation.
AL031685 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75645.1
CH471077 Genomic DNA Translation: EAW75646.1
BC009481 mRNA Translation: AAH09481.1
CCDSiCCDS13422.1
RefSeqiNP_001129245.1, NM_001135773.1
NP_006029.1, NM_006038.3
XP_006723957.1, XM_006723894.1
XP_011527418.1, XM_011529116.1
UniGeneiHs.48513

Genome annotation databases

EnsembliENST00000289431; ENSP00000289431; ENSG00000158480
ENST00000422556; ENSP00000416799; ENSG00000158480
GeneIDi9825
KEGGihsa:9825
UCSCiuc002xuw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPAT2_HUMAN
AccessioniPrimary (citable) accession number: Q9UM82
Secondary accession number(s): E1P626, O94857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: February 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome