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Protein

Spermatogenesis-associated protein 2

Gene

SPATA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in the regulation of spermatogenesis.

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 2
Alternative name(s):
Spermatogenesis-associated protein PD1
Gene namesi
Name:SPATA2
Synonyms:KIAA0757, PD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:14681. SPATA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9825.
OpenTargetsiENSG00000158480.
PharmGKBiPA37909.

Polymorphism and mutation databases

BioMutaiSPATA2.
DMDMi13633942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721001 – 520Spermatogenesis-associated protein 2Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UM82.
MaxQBiQ9UM82.
PaxDbiQ9UM82.
PeptideAtlasiQ9UM82.
PRIDEiQ9UM82.

PTM databases

iPTMnetiQ9UM82.
PhosphoSitePlusiQ9UM82.

Expressioni

Tissue specificityi

Highly expressed in Sertoli cells, but not detected in spermatogenic cells. Low expression in spleen, thymus and prostate.

Gene expression databases

BgeeiENSG00000158480.
CleanExiHS_SPATA2.
GenevisibleiQ9UM82. HS.

Organism-specific databases

HPAiHPA048581.
HPA052224.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-744066,EBI-618309
LZTS2Q9BRK43EBI-744066,EBI-741037
MAD1L1Q9Y6D93EBI-744066,EBI-742610
TRIM27P143733EBI-744066,EBI-719493

Protein-protein interaction databases

BioGridi115163. 27 interactors.
IntActiQ9UM82. 23 interactors.
MINTiMINT-1457833.
STRINGi9606.ENSP00000289431.

Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 24Combined sources16
Helixi40 – 51Combined sources12
Helixi52 – 54Combined sources3
Helixi57 – 59Combined sources3
Beta strandi62 – 64Combined sources3
Helixi66 – 76Combined sources11
Helixi82 – 101Combined sources20
Helixi106 – 109Combined sources4
Beta strandi114 – 116Combined sources3
Helixi117 – 121Combined sources5
Turni122 – 125Combined sources4
Helixi128 – 137Combined sources10
Beta strandi140 – 143Combined sources4
Beta strandi146 – 150Combined sources5
Helixi156 – 182Combined sources27
Turni183 – 185Combined sources3
Helixi190 – 199Combined sources10
Helixi204 – 216Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LJMX-ray1.45A7-219[»]
5LJNX-ray2.70C/D334-341[»]
ProteinModelPortaliQ9UM82.
SMRiQ9UM82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 81Poly-Ser6

Sequence similaritiesi

Belongs to the SPATA2 family.Curated

Phylogenomic databases

eggNOGiENOG410IGAI. Eukaryota.
ENOG410XZJ4. LUCA.
GeneTreeiENSGT00530000063956.
HOGENOMiHOG000133025.
HOVERGENiHBG057357.
InParanoidiQ9UM82.
KOiK17595.
OMAiCSKVSCD.
OrthoDBiEOG091G05ZD.
PhylomeDBiQ9UM82.
TreeFamiTF328840.

Family and domain databases

InterProiIPR029744. SPATA2.
[Graphical view]
PANTHERiPTHR15326:SF8. PTHR15326:SF8. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UM82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPSSMDTK FKDDLFRKYV QFHESKVDTT TSRQRPGSDE CLRVAASTLL
60 70 80 90 100
SLHKVDPFYR FRLIQFYEVV ESSLRSLSSS SLRALHGAFS MLETVGINLF
110 120 130 140 150
LYPWKKEFRS IKTYTGPFVY YVKSTLLEED IRAILSCMGY TPELGTAYKL
160 170 180 190 200
RELVETLQVK MVSFELFLAK VECEQMLEIH SQVKDKGYSE LDIVSERKSS
210 220 230 240 250
AEDVRGCSDA LRRRAEGREH LTASMSRVAL QKSASERAAK DYYKPRVTKP
260 270 280 290 300
SRSVDAYDSY WESRKPPLKA SLSLRKEPVA TDVGDDLKDE IIRPSPSLLT
310 320 330 340 350
MASSPHGSPD VLPPASPSNG PALLRGTYFS TQDDVDLYTD SEPRATYRRQ
360 370 380 390 400
DALRPDVWLL RNDAHSLYHK RSPPAKESAL SKCQSCGLSC SSSLCQRCDS
410 420 430 440 450
LLTCPPASKP SAFPSKASTH DSLAHGASLR EKYPGQTQGL DRLPHLHSKS
460 470 480 490 500
KPSTTPTSRC GFCNRPGATN TCTQCSKVSC DACLSAYHYD PCYKKSELHK
510 520
FMPNNQLNYK STQLSHLVYR
Length:520
Mass (Da):58,427
Last modified:April 27, 2001 - v2
Checksum:iD29869B601166C89
GO

Sequence cautioni

The sequence BAA34477 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172E → D in AAD28324 (PubMed:10222154).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051368443L → F.Corresponds to variant rs2072985dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28164 mRNA. Translation: AAD28324.1.
AB018300 mRNA. Translation: BAA34477.2. Different initiation.
AL031685 Genomic DNA. Translation: CAB46029.1.
CH471077 Genomic DNA. Translation: EAW75645.1.
CH471077 Genomic DNA. Translation: EAW75646.1.
BC009481 mRNA. Translation: AAH09481.1.
CCDSiCCDS13422.1.
RefSeqiNP_001129245.1. NM_001135773.1.
NP_006029.1. NM_006038.3.
XP_006723957.1. XM_006723894.1.
XP_011527418.1. XM_011529116.1.
UniGeneiHs.48513.

Genome annotation databases

EnsembliENST00000289431; ENSP00000289431; ENSG00000158480.
ENST00000422556; ENSP00000416799; ENSG00000158480.
GeneIDi9825.
KEGGihsa:9825.
UCSCiuc002xuw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28164 mRNA. Translation: AAD28324.1.
AB018300 mRNA. Translation: BAA34477.2. Different initiation.
AL031685 Genomic DNA. Translation: CAB46029.1.
CH471077 Genomic DNA. Translation: EAW75645.1.
CH471077 Genomic DNA. Translation: EAW75646.1.
BC009481 mRNA. Translation: AAH09481.1.
CCDSiCCDS13422.1.
RefSeqiNP_001129245.1. NM_001135773.1.
NP_006029.1. NM_006038.3.
XP_006723957.1. XM_006723894.1.
XP_011527418.1. XM_011529116.1.
UniGeneiHs.48513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LJMX-ray1.45A7-219[»]
5LJNX-ray2.70C/D334-341[»]
ProteinModelPortaliQ9UM82.
SMRiQ9UM82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115163. 27 interactors.
IntActiQ9UM82. 23 interactors.
MINTiMINT-1457833.
STRINGi9606.ENSP00000289431.

PTM databases

iPTMnetiQ9UM82.
PhosphoSitePlusiQ9UM82.

Polymorphism and mutation databases

BioMutaiSPATA2.
DMDMi13633942.

Proteomic databases

EPDiQ9UM82.
MaxQBiQ9UM82.
PaxDbiQ9UM82.
PeptideAtlasiQ9UM82.
PRIDEiQ9UM82.

Protocols and materials databases

DNASUi9825.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289431; ENSP00000289431; ENSG00000158480.
ENST00000422556; ENSP00000416799; ENSG00000158480.
GeneIDi9825.
KEGGihsa:9825.
UCSCiuc002xuw.5. human.

Organism-specific databases

CTDi9825.
DisGeNETi9825.
GeneCardsiSPATA2.
HGNCiHGNC:14681. SPATA2.
HPAiHPA048581.
HPA052224.
MIMi607662. gene.
neXtProtiNX_Q9UM82.
OpenTargetsiENSG00000158480.
PharmGKBiPA37909.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGAI. Eukaryota.
ENOG410XZJ4. LUCA.
GeneTreeiENSGT00530000063956.
HOGENOMiHOG000133025.
HOVERGENiHBG057357.
InParanoidiQ9UM82.
KOiK17595.
OMAiCSKVSCD.
OrthoDBiEOG091G05ZD.
PhylomeDBiQ9UM82.
TreeFamiTF328840.

Miscellaneous databases

GeneWikiiSPATA2.
GenomeRNAii9825.
PROiQ9UM82.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158480.
CleanExiHS_SPATA2.
GenevisibleiQ9UM82. HS.

Family and domain databases

InterProiIPR029744. SPATA2.
[Graphical view]
PANTHERiPTHR15326:SF8. PTHR15326:SF8. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPAT2_HUMAN
AccessioniPrimary (citable) accession number: Q9UM82
Secondary accession number(s): E1P626, O94857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.