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Q9UM63 (PLAL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein PLAGL1
Alternative name(s):
Lost on transformation 1
Short name=LOT-1
Pleiomorphic adenoma-like protein 1
Tumor suppressor ZAC
Gene names
Name:PLAGL1
Synonyms:LOT1, ZAC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Ref.11

Subunit structure

Interacts with THRSP. Ref.11

Subcellular location

Nucleus Ref.4 Ref.11.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UM63-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UM63-2)

Also known as: ZACdelta2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Zinc finger protein PLAGL1
PRO_0000047222

Regions

Zinc finger4 – 2623C2H2-type 1
Zinc finger32 – 5625C2H2-type 2
Zinc finger62 – 8423C2H2-type 3
Zinc finger91 – 11323C2H2-type 4
Zinc finger120 – 14223C2H2-type 5
Zinc finger156 – 17823C2H2-type 6
Zinc finger184 – 20724C2H2-type 7

Natural variations

Alternative sequence1 – 5252Missing in isoform 2.
VSP_028123
Natural variant2721A → V.
Corresponds to variant rs35263016 [ dbSNP | Ensembl ].
VAR_052729

Experimental info

Sequence conflict811L → F in AAB67041. Ref.1
Sequence conflict1971D → V in AAC34250. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: B10C74DA409BD4F7

FASTA46350,819
        10         20         30         40         50         60 
MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM RHMATHSPQK 

        70         80         90        100        110        120 
SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL 

       130        140        150        160        170        180 
TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG 

       190        200        210        220        230        240 
CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP 

       250        260        270        280        290        300 
PFPLGASAQN GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN 

       310        320        330        340        350        360 
HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD LAKGNAGKVN 

       370        380        390        400        410        420 
LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN STLALGPGES LPHRLSCLGQ 

       430        440        450        460 
QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT GSAILPHFHH AFR 

« Hide

Isoform 2 (ZACdelta2) [UniParc].

Checksum: 735121F4BF16F7C8
Show »

FASTA41144,668

References

« Hide 'large scale' references
[1]"Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."
Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R., Hamilton T.C.
Oncogene 14:1973-1979(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."
Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.
J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer."
Varrault A., Ciani E., Apiou F., Bilanges B., Hoffmann A., Pantaloni C., Bockaert J., Spengler D., Journot L.
Proc. Natl. Acad. Sci. U.S.A. 95:8835-8840(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Pituitary.
[4]"Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities."
Bilanges B., Varrault A., Mazumdar A., Pantaloni C., Hoffmann A., Bockaert J., Spengler D., Journot L.
Oncogene 20:1246-1253(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
Tissue: Mammary gland.
[5]"Characterization of the methylation-sensitive promoter of the imprinted ZAC (PLAGL1) gene supports its role in transient neonatal diabetes mellitus."
Varrault A., Bilanges B., Mackay D.J., Basyuk E., Ahr B., Fernandez C., Robinson D.O., Bockaert J., Journot L.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Colon.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal kidney.
[8]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[11]"Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1."
Chou W.Y., Ho C.L., Tseng M.L., Liu S.T., Yen L.C., Huang S.M.
Int. J. Biochem. Cell Biol. 40:1826-1834(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH THRSP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U72621 mRNA. Translation: AAB67041.1.
U81992 mRNA. Translation: AAC34250.1.
AJ006354 mRNA. Translation: CAA06994.1.
AJ303119 mRNA. Translation: CAC39614.1.
AJ311395 mRNA. Translation: CAC39615.1.
AK314570 mRNA. Translation: BAG37151.1.
AK315184 mRNA. Translation: BAG37625.1.
BX537397 mRNA. Translation: CAD97639.1.
AL049844 Genomic DNA. Translation: CAI21447.1.
AL049844 Genomic DNA. Translation: CAB56564.1.
CH471051 Genomic DNA. Translation: EAW47852.1.
CH471051 Genomic DNA. Translation: EAW47853.1.
CH471051 Genomic DNA. Translation: EAW47854.1.
CH471051 Genomic DNA. Translation: EAW47855.1.
CH471051 Genomic DNA. Translation: EAW47856.1.
BC074814 mRNA. Translation: AAH74814.1.
BC109085 mRNA. Translation: AAI09086.1.
BC109086 mRNA. Translation: AAI09087.1.
CCDSCCDS5202.1. [Q9UM63-1]
CCDS5203.1. [Q9UM63-2]
RefSeqNP_001074420.1. NM_001080951.1. [Q9UM63-1]
NP_001074421.1. NM_001080952.1. [Q9UM63-1]
NP_001074422.1. NM_001080953.1. [Q9UM63-1]
NP_001074423.1. NM_001080954.1. [Q9UM63-1]
NP_001074424.1. NM_001080955.1. [Q9UM63-2]
NP_001074425.1. NM_001080956.1. [Q9UM63-2]
NP_001275966.1. NM_001289037.1. [Q9UM63-2]
NP_001275967.1. NM_001289038.1. [Q9UM63-2]
NP_001275968.1. NM_001289039.1. [Q9UM63-2]
NP_001275969.1. NM_001289040.1. [Q9UM63-2]
NP_001275970.1. NM_001289041.1. [Q9UM63-2]
NP_001275971.1. NM_001289042.1. [Q9UM63-1]
NP_001275972.1. NM_001289043.1. [Q9UM63-1]
NP_001275973.1. NM_001289044.1. [Q9UM63-1]
NP_001275974.1. NM_001289045.1. [Q9UM63-1]
NP_001275975.1. NM_001289046.1. [Q9UM63-1]
NP_001275976.1. NM_001289047.1. [Q9UM63-1]
NP_001275977.1. NM_001289048.1. [Q9UM63-1]
NP_001275978.1. NM_001289049.1. [Q9UM63-1]
NP_002647.2. NM_002656.3. [Q9UM63-2]
NP_006709.2. NM_006718.3. [Q9UM63-1]
UniGeneHs.743225.

3D structure databases

ProteinModelPortalQ9UM63.
SMRQ9UM63. Positions 4-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111341. 10 interactions.
IntActQ9UM63. 1 interaction.
MINTMINT-1188459.
STRING9606.ENSP00000346810.

PTM databases

PhosphoSiteQ9UM63.

Polymorphism databases

DMDM158523334.

Proteomic databases

PaxDbQ9UM63.
PRIDEQ9UM63.

Protocols and materials databases

DNASU5325.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354765; ENSP00000346810; ENSG00000118495. [Q9UM63-1]
ENST00000360537; ENSP00000353734; ENSG00000118495. [Q9UM63-1]
ENST00000367571; ENSP00000356543; ENSG00000118495. [Q9UM63-1]
ENST00000367572; ENSP00000356544; ENSG00000118495. [Q9UM63-2]
ENST00000392307; ENSP00000376124; ENSG00000118495. [Q9UM63-2]
ENST00000392309; ENSP00000376125; ENSG00000118495. [Q9UM63-1]
ENST00000416623; ENSP00000400060; ENSG00000118495. [Q9UM63-1]
ENST00000417959; ENSP00000395960; ENSG00000118495. [Q9UM63-2]
ENST00000429150; ENSP00000398409; ENSG00000118495. [Q9UM63-1]
ENST00000437412; ENSP00000392418; ENSG00000118495. [Q9UM63-2]
ENST00000444202; ENSP00000400929; ENSG00000118495. [Q9UM63-1]
GeneID5325.
KEGGhsa:5325.
UCSCuc003qjv.3. human. [Q9UM63-1]

Organism-specific databases

CTD5325.
GeneCardsGC06M144261.
GeneReviewsPLAGL1.
HGNCHGNC:9046. PLAGL1.
HPAHPA055706.
MIM603044. gene.
neXtProtNX_Q9UM63.
Orphanet96191. Paternal uniparental disomy of chromosome 6.
99886. Transient neonatal diabetes mellitus.
PharmGKBPA33379.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG053608.
InParanoidQ9UM63.
OMATCGVCAL.
OrthoDBEOG71K62Q.
PhylomeDBQ9UM63.
TreeFamTF332024.

Gene expression databases

ArrayExpressQ9UM63.
BgeeQ9UM63.
CleanExHS_PLAGL1.
GenevestigatorQ9UM63.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF125. PTHR10032:SF125. 1 hit.
SMARTSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPLAGL1. human.
GeneWikiPLAGL1.
GenomeRNAi5325.
NextBio20600.
PROQ9UM63.
SOURCESearch...

Entry information

Entry namePLAL1_HUMAN
AccessionPrimary (citable) accession number: Q9UM63
Secondary accession number(s): B2RBA4 expand/collapse secondary AC list , B2RCM8, E1P595, E1P597, O76019, Q7Z3V8, Q92981, Q96JR9, Q9UIZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM