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Q9UM63

- PLAL1_HUMAN

UniProt

Q9UM63 - PLAL1_HUMAN

Protein

Zinc finger protein PLAGL1

Gene

PLAGL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri32 – 5625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri62 – 8423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri91 – 11323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri120 – 14223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20724C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell cycle arrest Source: ProtInc
    3. cell differentiation Source: RefGenome
    4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    5. skeletal muscle cell differentiation Source: Ensembl
    6. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein PLAGL1
    Alternative name(s):
    Lost on transformation 1
    Short name:
    LOT-1
    Pleiomorphic adenoma-like protein 1
    Tumor suppressor ZAC
    Gene namesi
    Name:PLAGL1
    Synonyms:LOT1, ZAC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9046. PLAGL1.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti96191. Paternal uniparental disomy of chromosome 6.
    99886. Transient neonatal diabetes mellitus.
    PharmGKBiPA33379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463Zinc finger protein PLAGL1PRO_0000047222Add
    BLAST

    Proteomic databases

    PaxDbiQ9UM63.
    PRIDEiQ9UM63.

    PTM databases

    PhosphoSiteiQ9UM63.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UM63.
    BgeeiQ9UM63.
    CleanExiHS_PLAGL1.
    GenevestigatoriQ9UM63.

    Organism-specific databases

    HPAiHPA055706.

    Interactioni

    Subunit structurei

    Interacts with THRSP.1 Publication

    Protein-protein interaction databases

    BioGridi111341. 10 interactions.
    IntActiQ9UM63. 1 interaction.
    MINTiMINT-1188459.
    STRINGi9606.ENSP00000346810.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UM63.
    SMRiQ9UM63. Positions 4-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri32 – 5625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri62 – 8423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri91 – 11323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri120 – 14223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20724C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG053608.
    InParanoidiQ9UM63.
    OMAiTCGVCAL.
    OrthoDBiEOG71K62Q.
    PhylomeDBiQ9UM63.
    TreeFamiTF332024.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR027770. PLAGL1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF125. PTHR10032:SF125. 1 hit.
    SMARTiSM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UM63-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM    50
    RHMATHSPQK SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY 100
    NTMLGYKRHL ALHAASSGDL TCGVCALELG STEVLLDHLK AHAEEKPPSG 150
    TKEKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT 200
    RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP PFPLGASAQN 250
    GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN 300
    HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD 350
    LAKGNAGKVN LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN 400
    STLALGPGES LPHRLSCLGQ QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT 450
    GSAILPHFHH AFR 463
    Length:463
    Mass (Da):50,819
    Last modified:September 11, 2007 - v2
    Checksum:iB10C74DA409BD4F7
    GO
    Isoform 2 (identifier: Q9UM63-2) [UniParc]FASTAAdd to Basket

    Also known as: ZACdelta2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-52: Missing.

    Show »
    Length:411
    Mass (Da):44,668
    Checksum:i735121F4BF16F7C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811L → F in AAB67041. (PubMed:9150364)Curated
    Sequence conflicti197 – 1971D → V in AAC34250. (PubMed:9722527)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti272 – 2721A → V.
    Corresponds to variant rs35263016 [ dbSNP | Ensembl ].
    VAR_052729

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5252Missing in isoform 2. 4 PublicationsVSP_028123Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72621 mRNA. Translation: AAB67041.1.
    U81992 mRNA. Translation: AAC34250.1.
    AJ006354 mRNA. Translation: CAA06994.1.
    AJ303119 mRNA. Translation: CAC39614.1.
    AJ311395 mRNA. Translation: CAC39615.1.
    AK314570 mRNA. Translation: BAG37151.1.
    AK315184 mRNA. Translation: BAG37625.1.
    BX537397 mRNA. Translation: CAD97639.1.
    AL049844 Genomic DNA. Translation: CAI21447.1.
    AL049844 Genomic DNA. Translation: CAB56564.1.
    CH471051 Genomic DNA. Translation: EAW47852.1.
    CH471051 Genomic DNA. Translation: EAW47853.1.
    CH471051 Genomic DNA. Translation: EAW47854.1.
    CH471051 Genomic DNA. Translation: EAW47855.1.
    CH471051 Genomic DNA. Translation: EAW47856.1.
    BC074814 mRNA. Translation: AAH74814.1.
    BC109085 mRNA. Translation: AAI09086.1.
    BC109086 mRNA. Translation: AAI09087.1.
    CCDSiCCDS5202.1. [Q9UM63-1]
    CCDS5203.1. [Q9UM63-2]
    RefSeqiNP_001074420.1. NM_001080951.1. [Q9UM63-1]
    NP_001074421.1. NM_001080952.1. [Q9UM63-1]
    NP_001074422.1. NM_001080953.1. [Q9UM63-1]
    NP_001074423.1. NM_001080954.1. [Q9UM63-1]
    NP_001074424.1. NM_001080955.1. [Q9UM63-2]
    NP_001074425.1. NM_001080956.1. [Q9UM63-2]
    NP_001275966.1. NM_001289037.1. [Q9UM63-2]
    NP_001275967.1. NM_001289038.1. [Q9UM63-2]
    NP_001275968.1. NM_001289039.1. [Q9UM63-2]
    NP_001275969.1. NM_001289040.1. [Q9UM63-2]
    NP_001275970.1. NM_001289041.1. [Q9UM63-2]
    NP_001275971.1. NM_001289042.1. [Q9UM63-1]
    NP_001275972.1. NM_001289043.1. [Q9UM63-1]
    NP_001275973.1. NM_001289044.1. [Q9UM63-1]
    NP_001275974.1. NM_001289045.1. [Q9UM63-1]
    NP_001275975.1. NM_001289046.1. [Q9UM63-1]
    NP_001275976.1. NM_001289047.1. [Q9UM63-1]
    NP_001275977.1. NM_001289048.1. [Q9UM63-1]
    NP_001275978.1. NM_001289049.1. [Q9UM63-1]
    NP_002647.2. NM_002656.3. [Q9UM63-2]
    NP_006709.2. NM_006718.3. [Q9UM63-1]
    UniGeneiHs.743225.

    Genome annotation databases

    EnsembliENST00000354765; ENSP00000346810; ENSG00000118495. [Q9UM63-1]
    ENST00000360537; ENSP00000353734; ENSG00000118495. [Q9UM63-1]
    ENST00000367571; ENSP00000356543; ENSG00000118495. [Q9UM63-1]
    ENST00000367572; ENSP00000356544; ENSG00000118495. [Q9UM63-2]
    ENST00000392307; ENSP00000376124; ENSG00000118495. [Q9UM63-2]
    ENST00000416623; ENSP00000400060; ENSG00000118495. [Q9UM63-1]
    ENST00000417959; ENSP00000395960; ENSG00000118495. [Q9UM63-2]
    ENST00000437412; ENSP00000392418; ENSG00000118495. [Q9UM63-2]
    ENST00000444202; ENSP00000400929; ENSG00000118495. [Q9UM63-1]
    GeneIDi5325.
    KEGGihsa:5325.
    UCSCiuc003qjv.3. human. [Q9UM63-1]

    Polymorphism databases

    DMDMi158523334.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72621 mRNA. Translation: AAB67041.1 .
    U81992 mRNA. Translation: AAC34250.1 .
    AJ006354 mRNA. Translation: CAA06994.1 .
    AJ303119 mRNA. Translation: CAC39614.1 .
    AJ311395 mRNA. Translation: CAC39615.1 .
    AK314570 mRNA. Translation: BAG37151.1 .
    AK315184 mRNA. Translation: BAG37625.1 .
    BX537397 mRNA. Translation: CAD97639.1 .
    AL049844 Genomic DNA. Translation: CAI21447.1 .
    AL049844 Genomic DNA. Translation: CAB56564.1 .
    CH471051 Genomic DNA. Translation: EAW47852.1 .
    CH471051 Genomic DNA. Translation: EAW47853.1 .
    CH471051 Genomic DNA. Translation: EAW47854.1 .
    CH471051 Genomic DNA. Translation: EAW47855.1 .
    CH471051 Genomic DNA. Translation: EAW47856.1 .
    BC074814 mRNA. Translation: AAH74814.1 .
    BC109085 mRNA. Translation: AAI09086.1 .
    BC109086 mRNA. Translation: AAI09087.1 .
    CCDSi CCDS5202.1. [Q9UM63-1 ]
    CCDS5203.1. [Q9UM63-2 ]
    RefSeqi NP_001074420.1. NM_001080951.1. [Q9UM63-1 ]
    NP_001074421.1. NM_001080952.1. [Q9UM63-1 ]
    NP_001074422.1. NM_001080953.1. [Q9UM63-1 ]
    NP_001074423.1. NM_001080954.1. [Q9UM63-1 ]
    NP_001074424.1. NM_001080955.1. [Q9UM63-2 ]
    NP_001074425.1. NM_001080956.1. [Q9UM63-2 ]
    NP_001275966.1. NM_001289037.1. [Q9UM63-2 ]
    NP_001275967.1. NM_001289038.1. [Q9UM63-2 ]
    NP_001275968.1. NM_001289039.1. [Q9UM63-2 ]
    NP_001275969.1. NM_001289040.1. [Q9UM63-2 ]
    NP_001275970.1. NM_001289041.1. [Q9UM63-2 ]
    NP_001275971.1. NM_001289042.1. [Q9UM63-1 ]
    NP_001275972.1. NM_001289043.1. [Q9UM63-1 ]
    NP_001275973.1. NM_001289044.1. [Q9UM63-1 ]
    NP_001275974.1. NM_001289045.1. [Q9UM63-1 ]
    NP_001275975.1. NM_001289046.1. [Q9UM63-1 ]
    NP_001275976.1. NM_001289047.1. [Q9UM63-1 ]
    NP_001275977.1. NM_001289048.1. [Q9UM63-1 ]
    NP_001275978.1. NM_001289049.1. [Q9UM63-1 ]
    NP_002647.2. NM_002656.3. [Q9UM63-2 ]
    NP_006709.2. NM_006718.3. [Q9UM63-1 ]
    UniGenei Hs.743225.

    3D structure databases

    ProteinModelPortali Q9UM63.
    SMRi Q9UM63. Positions 4-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111341. 10 interactions.
    IntActi Q9UM63. 1 interaction.
    MINTi MINT-1188459.
    STRINGi 9606.ENSP00000346810.

    PTM databases

    PhosphoSitei Q9UM63.

    Polymorphism databases

    DMDMi 158523334.

    Proteomic databases

    PaxDbi Q9UM63.
    PRIDEi Q9UM63.

    Protocols and materials databases

    DNASUi 5325.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354765 ; ENSP00000346810 ; ENSG00000118495 . [Q9UM63-1 ]
    ENST00000360537 ; ENSP00000353734 ; ENSG00000118495 . [Q9UM63-1 ]
    ENST00000367571 ; ENSP00000356543 ; ENSG00000118495 . [Q9UM63-1 ]
    ENST00000367572 ; ENSP00000356544 ; ENSG00000118495 . [Q9UM63-2 ]
    ENST00000392307 ; ENSP00000376124 ; ENSG00000118495 . [Q9UM63-2 ]
    ENST00000416623 ; ENSP00000400060 ; ENSG00000118495 . [Q9UM63-1 ]
    ENST00000417959 ; ENSP00000395960 ; ENSG00000118495 . [Q9UM63-2 ]
    ENST00000437412 ; ENSP00000392418 ; ENSG00000118495 . [Q9UM63-2 ]
    ENST00000444202 ; ENSP00000400929 ; ENSG00000118495 . [Q9UM63-1 ]
    GeneIDi 5325.
    KEGGi hsa:5325.
    UCSCi uc003qjv.3. human. [Q9UM63-1 ]

    Organism-specific databases

    CTDi 5325.
    GeneCardsi GC06M144261.
    GeneReviewsi PLAGL1.
    HGNCi HGNC:9046. PLAGL1.
    HPAi HPA055706.
    MIMi 603044. gene.
    neXtProti NX_Q9UM63.
    Orphaneti 96191. Paternal uniparental disomy of chromosome 6.
    99886. Transient neonatal diabetes mellitus.
    PharmGKBi PA33379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG053608.
    InParanoidi Q9UM63.
    OMAi TCGVCAL.
    OrthoDBi EOG71K62Q.
    PhylomeDBi Q9UM63.
    TreeFami TF332024.

    Miscellaneous databases

    ChiTaRSi PLAGL1. human.
    GeneWikii PLAGL1.
    GenomeRNAii 5325.
    NextBioi 20600.
    PROi Q9UM63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UM63.
    Bgeei Q9UM63.
    CleanExi HS_PLAGL1.
    Genevestigatori Q9UM63.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR027770. PLAGL1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF125. PTHR10032:SF125. 1 hit.
    SMARTi SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."
      Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R., Hamilton T.C.
      Oncogene 14:1973-1979(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."
      Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.
      J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer."
      Varrault A., Ciani E., Apiou F., Bilanges B., Hoffmann A., Pantaloni C., Bockaert J., Spengler D., Journot L.
      Proc. Natl. Acad. Sci. U.S.A. 95:8835-8840(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    4. "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities."
      Bilanges B., Varrault A., Mazumdar A., Pantaloni C., Hoffmann A., Bockaert J., Spengler D., Journot L.
      Oncogene 20:1246-1253(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
      Tissue: Mammary gland.
    5. "Characterization of the methylation-sensitive promoter of the imprinted ZAC (PLAGL1) gene supports its role in transient neonatal diabetes mellitus."
      Varrault A., Bilanges B., Mackay D.J., Basyuk E., Ahr B., Fernandez C., Robinson D.O., Bockaert J., Journot L.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal kidney.
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    11. "Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1."
      Chou W.Y., Ho C.L., Tseng M.L., Liu S.T., Yen L.C., Huang S.M.
      Int. J. Biochem. Cell Biol. 40:1826-1834(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH THRSP.

    Entry informationi

    Entry nameiPLAL1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UM63
    Secondary accession number(s): B2RBA4
    , B2RCM8, E1P595, E1P597, O76019, Q7Z3V8, Q92981, Q96JR9, Q9UIZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3