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Protein

Unconventional myosin-VI

Gene

MYO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 1588ATPSequence Analysis

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • ADP binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB
  • minus-end directed microfilament motor activity Source: UniProtKB
  • motor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Endocytosis, Hearing, Protein transport, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_11035. Gap junction degradation.
REACT_18307. Trafficking of AMPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-VI
Alternative name(s):
Unconventional myosin-6
Gene namesi
Name:MYO6
Synonyms:KIAA0389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7605. MYO6.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • axon Source: Ensembl
  • cell cortex Source: UniProtKB
  • clathrin-coated vesicle membrane Source: UniProtKB-SubCell
  • coated pit Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • cytoplasmic membrane-bounded vesicle Source: UniProtKB
  • cytosol Source: Reactome
  • DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
  • endocytic vesicle Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • filamentous actin Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • lysosomal membrane Source: Reactome
  • membrane Source: UniProtKB
  • microvillus Source: Ensembl
  • neuronal cell body Source: Ensembl
  • nuclear membrane Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: Reactome
  • ruffle Source: UniProtKB
  • ruffle membrane Source: UniProtKB-SubCell
  • unconventional myosin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 22 (DFNA22)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA22 is progressive and postlingual, with onset during childhood. By the age of approximately 50 years, affected individuals invariably have profound sensorineural deafness.

See also OMIM:606346
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti442 – 4421C → Y in DFNA22. 1 Publication
VAR_012110
Deafness, autosomal recessive, 37 (DFNB37)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

See also OMIM:607821
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161E → V in DFNB37. 1 Publication
Corresponds to variant rs28936390 [ dbSNP | Ensembl ].
VAR_016209
Deafness, sensorineural, with hypertrophic cardiomyopathy (DFNHCM)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant sensorineural deafness associated with hypertrophic cardiomyopathy.

See also OMIM:606346
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti246 – 2461H → R in DFNHCM. 1 Publication
Corresponds to variant rs28936391 [ dbSNP | Ensembl ].
VAR_029988

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MIMi606346. phenotype.
607821. phenotype.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
228012. Progressive sensorineural hearing loss - hypertrophic cardiomyopathy.
PharmGKBiPA31410.

Polymorphism and mutation databases

BioMutaiMYO6.
DMDMi122065628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12941294Unconventional myosin-VIPRO_0000123464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei405 – 4051Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. Phosphorylated in vitro by p21-activated kinase (PAK) (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UM54.
PaxDbiQ9UM54.
PRIDEiQ9UM54.

PTM databases

PhosphoSiteiQ9UM54.

Expressioni

Tissue specificityi

Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells.1 Publication

Gene expression databases

BgeeiQ9UM54.
CleanExiHS_MYO6.
ExpressionAtlasiQ9UM54. baseline and differential.
GenevisibleiQ9UM54. HS.

Organism-specific databases

HPAiCAB010762.
HPA035483.

Interactioni

Subunit structurei

Homodimer. Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB2P980823EBI-350606,EBI-1171238
Dab2P980784EBI-350606,EBI-1391846From a different organism.

Protein-protein interaction databases

BioGridi110730. 35 interactions.
DIPiDIP-33123N.
IntActiQ9UM54. 15 interactions.
MINTiMINT-239443.
STRINGi9606.ENSP00000358994.

Structurei

3D structure databases

ProteinModelPortaliQ9UM54.
SMRiQ9UM54. Positions 2-922, 1175-1277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 771715Myosin motorAdd
BLAST
Domaini814 – 83421IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni273 – 31745Responsible for slow ATPase activityBy similarityAdd
BLAST
Regioni665 – 6728Actin-bindingSequence Analysis
Regioni782 – 81029Required for binding calmodulinBy similarityAdd
BLAST
Regioni1116 – 11183Interaction with OPTN

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili864 – 1023160Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi920 – 1027108Glu-richAdd
BLAST

Domaini

Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a coiled-coil and a unique globular domain required for interaction with other proteins.

Sequence similaritiesi

Contains 1 IQ domain.Curated
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00790000122950.
HOVERGENiHBG003523.
InParanoidiQ9UM54.
KOiK10358.
OrthoDBiEOG7TQTZZ.
PhylomeDBiQ9UM54.
TreeFamiTF351449.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9UM54-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGKPVWAP HPTDGFQMGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSE AIKSYQGKSL GTRPPHVFAI ADKAFRDMKV LKMSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR EKLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY
310 320 330 340 350
LKAGSMKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSAQ SLEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GTKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEA KLVGILDILD EENRLPQPSD QHFTSAVHQK
560 570 580 590 600
HKDHFRLTIP RKSKLAVHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGYPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNENDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLTC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSVL KDGKPEMNKQ IKNLEISIDT LMAKIKSTMM TQEQIQKEYD
910 920 930 940 950
ALVKSSEELL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEKRRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQKEEESQQQ
1010 1020 1030 1040 1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DLALRRSLDS YPVSKNDGTR
1060 1070 1080 1090 1100
PKMTPEQMAK EMSEFLSRGP AVLATKAAAG TKKYDLSKWK YAELRDTINT
1110 1120 1130 1140 1150
SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP KSVTDYDFAP
1160 1170 1180 1190 1200
FLNNSPQQNP AAQIPARQRE IEMNRQQRFF RIPFIRPADQ YKDPQSKKKG
1210 1220 1230 1240 1250
WWYAHFDGPW IARQMELHPD KPPILLVAGK DDMEMCELNL EETGLTRKRG
1260 1270 1280 1290
AEILPRQFEE IWERCGGIQY LQNAIESRQA RPTYATAMLQ SLLK
Length:1,294
Mass (Da):149,691
Last modified:January 9, 2007 - v4
Checksum:i3A8966E6864B8576
GO
Isoform 1 (identifier: Q9UM54-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1045: Missing.

Show »
Length:1,285
Mass (Da):148,714
Checksum:iBCB4FDFE920712CD
GO
Isoform 2 (identifier: Q9UM54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1068: Missing.

Show »
Length:1,262
Mass (Da):146,048
Checksum:iCF1FA35796FC1C60
GO
Isoform 4 (identifier: Q9UM54-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1155: Missing.

Show »
Length:1,285
Mass (Da):148,685
Checksum:iF68A79F74AB9170C
GO
Isoform 5 (identifier: Q9UM54-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1068: Missing.
     1147-1155: Missing.

Show »
Length:1,253
Mass (Da):145,042
Checksum:iDD739BA2DD557EEF
GO
Isoform 6 (identifier: Q9UM54-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1156: DFAPFLNNSP → A

Show »
Length:1,285
Mass (Da):148,659
Checksum:iEAE6008E2FAC170C
GO

Sequence cautioni

The sequence BAA20843.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1156 – 11561P → A in CAI42826 (PubMed:14574404).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161E → V in DFNB37. 1 Publication
Corresponds to variant rs28936390 [ dbSNP | Ensembl ].
VAR_016209
Natural varianti246 – 2461H → R in DFNHCM. 1 Publication
Corresponds to variant rs28936391 [ dbSNP | Ensembl ].
VAR_029988
Natural varianti442 – 4421C → Y in DFNA22. 1 Publication
VAR_012110

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1037 – 106832Missing in isoform 2 and isoform 5. 1 PublicationVSP_007985Add
BLAST
Alternative sequencei1037 – 10459Missing in isoform 1. 2 PublicationsVSP_022332
Alternative sequencei1147 – 115610DFAPFLNNSP → A in isoform 6. 1 PublicationVSP_042208
Alternative sequencei1147 – 11559Missing in isoform 4 and isoform 5. CuratedVSP_022333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90236 mRNA. Translation: AAC51654.2.
AF229111
, AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA. Translation: AAK00229.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19520.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19521.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19522.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42824.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42825.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42826.1.
AB002387 mRNA. Translation: BAA20843.2. Different initiation.
CH471051 Genomic DNA. Translation: EAW48730.1.
CH471051 Genomic DNA. Translation: EAW48731.1.
BC146764 mRNA. Translation: AAI46765.1.
BP333853 mRNA. No translation available.
CCDSiCCDS34487.1. [Q9UM54-1]
CCDS75481.1. [Q9UM54-2]
RefSeqiNP_001287828.1. NM_001300899.1. [Q9UM54-2]
NP_004990.3. NM_004999.3. [Q9UM54-1]
UniGeneiHs.149387.

Genome annotation databases

EnsembliENST00000369977; ENSP00000358994; ENSG00000196586. [Q9UM54-1]
ENST00000369985; ENSP00000359002; ENSG00000196586. [Q9UM54-2]
ENST00000615563; ENSP00000478013; ENSG00000196586. [Q9UM54-2]
GeneIDi4646.
KEGGihsa:4646.
UCSCiuc003pig.1. human. [Q9UM54-5]
uc003pih.1. human. [Q9UM54-1]
uc003pii.1. human. [Q9UM54-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90236 mRNA. Translation: AAC51654.2.
AF229111
, AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA. Translation: AAK00229.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19520.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19521.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19522.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42824.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42825.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42826.1.
AB002387 mRNA. Translation: BAA20843.2. Different initiation.
CH471051 Genomic DNA. Translation: EAW48730.1.
CH471051 Genomic DNA. Translation: EAW48731.1.
BC146764 mRNA. Translation: AAI46765.1.
BP333853 mRNA. No translation available.
CCDSiCCDS34487.1. [Q9UM54-1]
CCDS75481.1. [Q9UM54-2]
RefSeqiNP_001287828.1. NM_001300899.1. [Q9UM54-2]
NP_004990.3. NM_004999.3. [Q9UM54-1]
UniGeneiHs.149387.

3D structure databases

ProteinModelPortaliQ9UM54.
SMRiQ9UM54. Positions 2-922, 1175-1277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110730. 35 interactions.
DIPiDIP-33123N.
IntActiQ9UM54. 15 interactions.
MINTiMINT-239443.
STRINGi9606.ENSP00000358994.

PTM databases

PhosphoSiteiQ9UM54.

Polymorphism and mutation databases

BioMutaiMYO6.
DMDMi122065628.

Proteomic databases

MaxQBiQ9UM54.
PaxDbiQ9UM54.
PRIDEiQ9UM54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369977; ENSP00000358994; ENSG00000196586. [Q9UM54-1]
ENST00000369985; ENSP00000359002; ENSG00000196586. [Q9UM54-2]
ENST00000615563; ENSP00000478013; ENSG00000196586. [Q9UM54-2]
GeneIDi4646.
KEGGihsa:4646.
UCSCiuc003pig.1. human. [Q9UM54-5]
uc003pih.1. human. [Q9UM54-1]
uc003pii.1. human. [Q9UM54-2]

Organism-specific databases

CTDi4646.
GeneCardsiGC06P076515.
GeneReviewsiMYO6.
HGNCiHGNC:7605. MYO6.
HPAiCAB010762.
HPA035483.
MIMi600970. gene.
606346. phenotype.
607821. phenotype.
neXtProtiNX_Q9UM54.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
228012. Progressive sensorineural hearing loss - hypertrophic cardiomyopathy.
PharmGKBiPA31410.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00790000122950.
HOVERGENiHBG003523.
InParanoidiQ9UM54.
KOiK10358.
OrthoDBiEOG7TQTZZ.
PhylomeDBiQ9UM54.
TreeFamiTF351449.

Enzyme and pathway databases

ReactomeiREACT_11035. Gap junction degradation.
REACT_18307. Trafficking of AMPA receptors.

Miscellaneous databases

ChiTaRSiMYO6. human.
GeneWikiiMYO6.
GenomeRNAii4646.
NextBioi17908.
PROiQ9UM54.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UM54.
CleanExiHS_MYO6.
ExpressionAtlasiQ9UM54. baseline and differential.
GenevisibleiQ9UM54. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice."
    Avraham K.B., Hasson T., Sobe T., Balsara B., Testa J.R., Skvorak A.B., Morton C.C., Copeland N.G., Jenkins N.A.
    Hum. Mol. Genet. 6:1225-1231(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. Avraham K.B.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Genomic organization of the human myosin VI gene (MYO6), a candidate gene for neurosensory and storage disorders."
    Kuehn M.H., Hageman G.S.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 5).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1102-1294 (ISOFORM 6).
    Tissue: Salivary gland.
  9. Cited for: FUNCTION.
  10. "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis."
    Buss F., Arden S.D., Lindsay M., Luzio J.P., Kendrick-Jones J.
    EMBO J. 20:3676-3684(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ENDOCYTOSIS, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
  11. "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton."
    Morris S.M., Arden S.D., Roberts R.C., Kendrick-Jones J., Cooper J.A., Luzio J.P., Buss F.
    Traffic 3:331-341(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAB2.
  12. "Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator."
    Swiatecka-Urban A., Boyd C., Coutermarsh B., Karlson K.H., Barnaby R., Aschenbrenner L., Langford G.M., Hasson T., Stanton B.A.
    J. Biol. Chem. 279:38025-38031(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CFTR.
  13. Cited for: SUBUNIT.
  14. "Nuclear myosin VI enhances RNA polymerase II-dependent transcription."
    Vreugde S., Ferrai C., Miluzio A., Hauben E., Marchisio P.C., Crippa M.P., Bussi M., Biffo S.
    Mol. Cell 23:749-755(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Myosin VI is a mediator of the p53-dependent cell survival pathway."
    Jung E.J., Liu G., Zhou W., Chen X.
    Mol. Cell. Biol. 26:2175-2186(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-405, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  18. "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss."
    Melchionda S., Ahituv N., Bisceglia L., Sobe T., Glaser F., Rabionet R., Arbones M.L., Notarangelo A., Di Iorio E., Carella M., Zelante L., Estivill X., Avraham K.B., Gasparini P.
    Am. J. Hum. Genet. 69:635-640(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DFNA22 TYR-442.
  19. Cited for: VARIANT DFNB37 VAL-216.
  20. "Novel association of hypertrophic cardiomyopathy, sensorineural deafness, and a mutation in unconventional myosin VI (MYO6)."
    Mohiddin S.A., Ahmed Z.M., Griffith A.J., Tripodi D., Friedman T.B., Fananapazir L., Morell R.J.
    J. Med. Genet. 41:309-314(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DFNHCM ARG-246.

Entry informationi

Entry nameiMYO6_HUMAN
AccessioniPrimary (citable) accession number: Q9UM54
Secondary accession number(s): A6H8V4
, E1P540, Q5TEM5, Q5TEM6, Q5TEM7, Q9BZZ7, Q9UEG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 9, 2007
Last modified: June 24, 2015
This is version 156 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.