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Protein

Unconventional myosin-VI

Gene

MYO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 158ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • ADP binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calmodulin binding Source: UniProtKB
  • minus-end directed microfilament motor activity Source: UniProtKB
  • motor activity Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  • endocytosis Source: UniProtKB
  • intracellular protein transport Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of secretion Source: UniProtKB
  • response to drug Source: Ensembl
  • sensory perception of sound Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Endocytosis, Hearing, Protein transport, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32559-MONOMER.
ReactomeiR-HSA-190873. Gap junction degradation.
R-HSA-399719. Trafficking of AMPA receptors.
SIGNORiQ9UM54.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-VI
Alternative name(s):
Unconventional myosin-6
Gene namesi
Name:MYO6
Synonyms:KIAA0389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7605. MYO6.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • cell-cell adherens junction Source: BHF-UCL
  • cell cortex Source: UniProtKB
  • clathrin-coated pit Source: UniProtKB-SubCell
  • clathrin-coated vesicle membrane Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB
  • cytosol Source: Reactome
  • DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
  • endocytic vesicle Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • filamentous actin Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • lysosomal membrane Source: Reactome
  • membrane Source: UniProtKB
  • microvillus Source: Ensembl
  • nuclear membrane Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: Reactome
  • ruffle Source: UniProtKB
  • ruffle membrane Source: UniProtKB-SubCell
  • unconventional myosin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 22 (DFNA22)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA22 is progressive and postlingual, with onset during childhood. By the age of approximately 50 years, affected individuals invariably have profound sensorineural deafness.
See also OMIM:606346
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012110442C → Y in DFNA22. 1 Publication1
Deafness, autosomal recessive, 37 (DFNB37)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:607821
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016209216E → V in DFNB37. 1 PublicationCorresponds to variant rs28936390dbSNPEnsembl.1
Deafness, sensorineural, with hypertrophic cardiomyopathy (DFNHCM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant sensorineural deafness associated with hypertrophic cardiomyopathy.
See also OMIM:606346
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029988246H → R in DFNHCM. 1 PublicationCorresponds to variant rs28936391dbSNPEnsembl.1

Keywords - Diseasei

Cardiomyopathy, Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi4646.
MalaCardsiMYO6.
MIMi606346. phenotype.
607821. phenotype.
OpenTargetsiENSG00000196586.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
228012. Progressive sensorineural hearing loss - hypertrophic cardiomyopathy.
PharmGKBiPA31410.

Polymorphism and mutation databases

BioMutaiMYO6.
DMDMi122065628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234641 – 1294Unconventional myosin-VIAdd BLAST1294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphoserineCombined sources1
Modified residuei405PhosphothreonineCombined sources1
Modified residuei604PhosphoserineBy similarity1
Modified residuei1025PhosphoserineBy similarity1
Modified residuei1155PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. Phosphorylated in vitro by p21-activated kinase (PAK) (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UM54.
MaxQBiQ9UM54.
PaxDbiQ9UM54.
PeptideAtlasiQ9UM54.
PRIDEiQ9UM54.

PTM databases

iPTMnetiQ9UM54.
PhosphoSitePlusiQ9UM54.
SwissPalmiQ9UM54.

Expressioni

Tissue specificityi

Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000196586.
CleanExiHS_MYO6.
ExpressionAtlasiQ9UM54. baseline and differential.
GenevisibleiQ9UM54. HS.

Organism-specific databases

HPAiCAB010762.
HPA035483.

Interactioni

Subunit structurei

Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB2P980823EBI-350606,EBI-1171238
Dab2P980784EBI-350606,EBI-1391846From a different organism.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110730. 82 interactors.
DIPiDIP-33123N.
IntActiQ9UM54. 42 interactors.
MINTiMINT-239443.
STRINGi9606.ENSP00000358994.

Structurei

Secondary structure

11294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi999 – 1022Combined sources24
Helixi1026 – 1036Combined sources11
Helixi1038 – 1040Combined sources3
Helixi1055 – 1066Combined sources12
Beta strandi1077 – 1079Combined sources3
Helixi1091 – 1100Combined sources10
Helixi1106 – 1119Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N0ZNMR-A1080-1122[»]
2N10NMR-A1080-1131[»]
2N11NMR-A998-1071[»]
2N12NMR-A1050-1131[»]
2N13NMR-A/D1080-1122[»]
ProteinModelPortaliQ9UM54.
SMRiQ9UM54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 771Myosin motorAdd BLAST715
Domaini814 – 834IQAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni273 – 317Responsible for slow ATPase activityBy similarityAdd BLAST45
Regioni665 – 672Actin-bindingSequence analysis8
Regioni782 – 810Required for binding calmodulinBy similarityAdd BLAST29
Regioni835 – 916Three-helix bundleAdd BLAST82
Regioni917 – 984SAH1 PublicationAdd BLAST68
Regioni1116 – 1118Interaction with OPTN3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi920 – 1027Glu-richAdd BLAST108

Domaini

Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a three-helix bundle region, a SAH domain and a unique globular domain required for interaction with other proteins such as cargo-binding.Curated
The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. Its contribution to the mechanism confering the myosin movement on actin filaments is debated.By similarity1 Publication

Sequence similaritiesi

Contains 1 IQ domain.Curated
Contains 1 myosin motor domain.Curated

Phylogenomic databases

eggNOGiKOG0163. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00860000133764.
HOVERGENiHBG003523.
InParanoidiQ9UM54.
KOiK10358.
PhylomeDBiQ9UM54.
TreeFamiTF351449.

Family and domain databases

InterProiIPR032412. Myosin-VI_CBD.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF16521. Myosin-VI_CBD. 1 hit.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9UM54-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGKPVWAP HPTDGFQMGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSE AIKSYQGKSL GTRPPHVFAI ADKAFRDMKV LKMSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR EKLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY
310 320 330 340 350
LKAGSMKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSAQ SLEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GTKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEA KLVGILDILD EENRLPQPSD QHFTSAVHQK
560 570 580 590 600
HKDHFRLTIP RKSKLAVHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGYPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNENDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLTC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSVL KDGKPEMNKQ IKNLEISIDT LMAKIKSTMM TQEQIQKEYD
910 920 930 940 950
ALVKSSEELL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEKRRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQKEEESQQQ
1010 1020 1030 1040 1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DLALRRSLDS YPVSKNDGTR
1060 1070 1080 1090 1100
PKMTPEQMAK EMSEFLSRGP AVLATKAAAG TKKYDLSKWK YAELRDTINT
1110 1120 1130 1140 1150
SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP KSVTDYDFAP
1160 1170 1180 1190 1200
FLNNSPQQNP AAQIPARQRE IEMNRQQRFF RIPFIRPADQ YKDPQSKKKG
1210 1220 1230 1240 1250
WWYAHFDGPW IARQMELHPD KPPILLVAGK DDMEMCELNL EETGLTRKRG
1260 1270 1280 1290
AEILPRQFEE IWERCGGIQY LQNAIESRQA RPTYATAMLQ SLLK
Length:1,294
Mass (Da):149,691
Last modified:January 9, 2007 - v4
Checksum:i3A8966E6864B8576
GO
Isoform 1 (identifier: Q9UM54-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1045: Missing.

Show »
Length:1,285
Mass (Da):148,714
Checksum:iBCB4FDFE920712CD
GO
Isoform 2 (identifier: Q9UM54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1068: Missing.

Show »
Length:1,262
Mass (Da):146,048
Checksum:iCF1FA35796FC1C60
GO
Isoform 4 (identifier: Q9UM54-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1155: Missing.

Show »
Length:1,285
Mass (Da):148,685
Checksum:iF68A79F74AB9170C
GO
Isoform 5 (identifier: Q9UM54-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1068: Missing.
     1147-1155: Missing.

Show »
Length:1,253
Mass (Da):145,042
Checksum:iDD739BA2DD557EEF
GO
Isoform 6 (identifier: Q9UM54-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1156: DFAPFLNNSP → A

Show »
Length:1,285
Mass (Da):148,659
Checksum:iEAE6008E2FAC170C
GO

Sequence cautioni

The sequence BAA20843 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1156P → A in CAI42826 (PubMed:14574404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016209216E → V in DFNB37. 1 PublicationCorresponds to variant rs28936390dbSNPEnsembl.1
Natural variantiVAR_029988246H → R in DFNHCM. 1 PublicationCorresponds to variant rs28936391dbSNPEnsembl.1
Natural variantiVAR_012110442C → Y in DFNA22. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0079851037 – 1068Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_0223321037 – 1045Missing in isoform 1. 2 Publications9
Alternative sequenceiVSP_0422081147 – 1156DFAPFLNNSP → A in isoform 6. 1 Publication10
Alternative sequenceiVSP_0223331147 – 1155Missing in isoform 4 and isoform 5. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90236 mRNA. Translation: AAC51654.2.
AF229111
, AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA. Translation: AAK00229.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19520.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19521.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19522.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42824.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42825.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42826.1.
AB002387 mRNA. Translation: BAA20843.2. Different initiation.
CH471051 Genomic DNA. Translation: EAW48730.1.
CH471051 Genomic DNA. Translation: EAW48731.1.
BC146764 mRNA. Translation: AAI46765.1.
BP333853 mRNA. No translation available.
CCDSiCCDS34487.1. [Q9UM54-1]
CCDS75481.1. [Q9UM54-2]
RefSeqiNP_001287828.1. NM_001300899.1. [Q9UM54-2]
NP_004990.3. NM_004999.3. [Q9UM54-1]
UniGeneiHs.149387.

Genome annotation databases

EnsembliENST00000369977; ENSP00000358994; ENSG00000196586. [Q9UM54-1]
ENST00000369985; ENSP00000359002; ENSG00000196586. [Q9UM54-2]
ENST00000615563; ENSP00000478013; ENSG00000196586. [Q9UM54-2]
GeneIDi4646.
KEGGihsa:4646.
UCSCiuc003pih.2. human. [Q9UM54-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90236 mRNA. Translation: AAC51654.2.
AF229111
, AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA. Translation: AAK00229.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19520.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19521.1.
AL109897, AL136093 Genomic DNA. Translation: CAI19522.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42824.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42825.1.
AL136093, AL109897 Genomic DNA. Translation: CAI42826.1.
AB002387 mRNA. Translation: BAA20843.2. Different initiation.
CH471051 Genomic DNA. Translation: EAW48730.1.
CH471051 Genomic DNA. Translation: EAW48731.1.
BC146764 mRNA. Translation: AAI46765.1.
BP333853 mRNA. No translation available.
CCDSiCCDS34487.1. [Q9UM54-1]
CCDS75481.1. [Q9UM54-2]
RefSeqiNP_001287828.1. NM_001300899.1. [Q9UM54-2]
NP_004990.3. NM_004999.3. [Q9UM54-1]
UniGeneiHs.149387.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N0ZNMR-A1080-1122[»]
2N10NMR-A1080-1131[»]
2N11NMR-A998-1071[»]
2N12NMR-A1050-1131[»]
2N13NMR-A/D1080-1122[»]
ProteinModelPortaliQ9UM54.
SMRiQ9UM54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110730. 82 interactors.
DIPiDIP-33123N.
IntActiQ9UM54. 42 interactors.
MINTiMINT-239443.
STRINGi9606.ENSP00000358994.

PTM databases

iPTMnetiQ9UM54.
PhosphoSitePlusiQ9UM54.
SwissPalmiQ9UM54.

Polymorphism and mutation databases

BioMutaiMYO6.
DMDMi122065628.

Proteomic databases

EPDiQ9UM54.
MaxQBiQ9UM54.
PaxDbiQ9UM54.
PeptideAtlasiQ9UM54.
PRIDEiQ9UM54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369977; ENSP00000358994; ENSG00000196586. [Q9UM54-1]
ENST00000369985; ENSP00000359002; ENSG00000196586. [Q9UM54-2]
ENST00000615563; ENSP00000478013; ENSG00000196586. [Q9UM54-2]
GeneIDi4646.
KEGGihsa:4646.
UCSCiuc003pih.2. human. [Q9UM54-3]

Organism-specific databases

CTDi4646.
DisGeNETi4646.
GeneCardsiMYO6.
GeneReviewsiMYO6.
HGNCiHGNC:7605. MYO6.
HPAiCAB010762.
HPA035483.
MalaCardsiMYO6.
MIMi600970. gene.
606346. phenotype.
607821. phenotype.
neXtProtiNX_Q9UM54.
OpenTargetsiENSG00000196586.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
228012. Progressive sensorineural hearing loss - hypertrophic cardiomyopathy.
PharmGKBiPA31410.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0163. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00860000133764.
HOVERGENiHBG003523.
InParanoidiQ9UM54.
KOiK10358.
PhylomeDBiQ9UM54.
TreeFamiTF351449.

Enzyme and pathway databases

BioCyciZFISH:G66-32559-MONOMER.
ReactomeiR-HSA-190873. Gap junction degradation.
R-HSA-399719. Trafficking of AMPA receptors.
SIGNORiQ9UM54.

Miscellaneous databases

ChiTaRSiMYO6. human.
GeneWikiiMYO6.
GenomeRNAii4646.
PROiQ9UM54.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196586.
CleanExiHS_MYO6.
ExpressionAtlasiQ9UM54. baseline and differential.
GenevisibleiQ9UM54. HS.

Family and domain databases

InterProiIPR032412. Myosin-VI_CBD.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF16521. Myosin-VI_CBD. 1 hit.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO6_HUMAN
AccessioniPrimary (citable) accession number: Q9UM54
Secondary accession number(s): A6H8V4
, E1P540, Q5TEM5, Q5TEM6, Q5TEM7, Q9BZZ7, Q9UEG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 172 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6).Curated
Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.