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Protein

Mammalian ependymin-related protein 1

Gene

EPDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mammalian ependymin-related protein 1
Short name:
MERP-1
Alternative name(s):
Upregulated in colorectal cancer gene 1 protein
Gene namesi
Name:EPDR1
Synonyms:MERP1, UCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17572. EPDR1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: Ensembl
  • lysosome Source: Ensembl

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54749.
OpenTargetsiENSG00000086289.
PharmGKBiPA142671908.

Polymorphism and mutation databases

BioMutaiEPDR1.
DMDMi13124620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000835138 – 224Mammalian ependymin-related protein 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UM22.
PaxDbiQ9UM22.
PeptideAtlasiQ9UM22.
PRIDEiQ9UM22.

Expressioni

Gene expression databases

BgeeiENSG00000086289.
CleanExiHS_EPDR1.
ExpressionAtlasiQ9UM22. baseline and differential.
GenevisibleiQ9UM22. HS.

Organism-specific databases

HPAiCAB026298.

Interactioni

Protein-protein interaction databases

BioGridi120127. 13 interactors.
IntActiQ9UM22. 15 interactors.

Family & Domainsi

Sequence similaritiesi

Belongs to the ependymin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIY9. Eukaryota.
ENOG4112CW8. LUCA.
GeneTreeiENSGT00530000064036.
HOGENOMiHOG000172504.
HOVERGENiHBG051490.
InParanoidiQ9UM22.
OMAiAPLQWEG.
OrthoDBiEOG091G0RC0.
PhylomeDBiQ9UM22.

Family and domain databases

InterProiView protein in InterPro
IPR001299. Ependymin.
IPR018224. Ependymin_CS.
PANTHERiPTHR10697. PTHR10697. 1 hit.
PfamiView protein in Pfam
PF00811. Ependymin. 1 hit.
PRINTSiPR00317. EPENDYMIN.
SMARTiView protein in SMART
SM00026. EPEND. 1 hit.
PROSITEiView protein in PROSITE
PS00898. EPENDYMIN_1. 1 hit.
PS00899. EPENDYMIN_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UM22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGRAPLRTV PGALGAWLLG GLWAWTLCGL CSLGAVGAPR PCQAPQQWEG
60 70 80 90 100
RQVMYQQSSG RNSRALLSYD GLNQRVRVLD ERKALIPCKR LFEYILLYKD
110 120 130 140 150
GVMFQIDQAT KQCSKMTLTQ PWDPLDIPQN STFEDQYSIG GPQEQITVQE
160 170 180 190 200
WSDRKSARSY ETWIGIYTVK DCYPVQETFT INYSVILSTR FFDIQLGIKD
210 220
PSVFTPPSTC QMAQLEKMSE DCSW
Length:224
Mass (Da):25,437
Last modified:February 21, 2001 - v2
Checksum:i84ADBA3666261611
GO
Isoform 2 (identifier: Q9UM22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-224: Missing.

Show »
Length:90
Mass (Da):9,861
Checksum:i6466489B5052810C
GO
Isoform 3 (identifier: Q9UM22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPGRAPLRTV...DERKALIPCK → MVRDWEGRCAHRGRPAGGGLSNTQRGGG

Show »
Length:163
Mass (Da):18,672
Checksum:i2DD76E6FCFEDECAF
GO

Sequence cautioni

The sequence AAH00686 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB60269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207P → S in CAB60269 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468291 – 89MPGRA…LIPCK → MVRDWEGRCAHRGRPAGGGL SNTQRGGG in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_03197691 – 224Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361252 Genomic DNA. Translation: AAK26441.1.
AY027861 mRNA. Translation: AAK15787.1.
DQ914439 mRNA. Translation: ABI84106.1.
AK290885 mRNA. Translation: BAF83574.1.
AK309180 mRNA. No translation available.
AC018634 Genomic DNA. No translation available.
AC083860 Genomic DNA. No translation available.
AC083865 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW94086.1.
BC000686 mRNA. Translation: AAH00686.2. Different initiation.
BC018299 mRNA. Translation: AAH18299.1.
AJ250475 mRNA. Translation: CAB60269.1. Different initiation.
CCDSiCCDS5454.2. [Q9UM22-1]
CCDS59051.1. [Q9UM22-2]
CCDS59052.1. [Q9UM22-3]
RefSeqiNP_001229875.2. NM_001242946.1. [Q9UM22-2]
NP_001229877.1. NM_001242948.1. [Q9UM22-3]
NP_060019.2. NM_017549.4. [Q9UM22-1]
UniGeneiHs.563491.

Genome annotation databases

EnsembliENST00000199448; ENSP00000199448; ENSG00000086289. [Q9UM22-1]
ENST00000423717; ENSP00000409211; ENSG00000086289. [Q9UM22-2]
ENST00000425345; ENSP00000413359; ENSG00000086289. [Q9UM22-3]
GeneIDi54749.
KEGGihsa:54749.
UCSCiuc003tfp.5. human. [Q9UM22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEPDR1_HUMAN
AccessioniPrimary (citable) accession number: Q9UM22
Secondary accession number(s): A8K4C0
, C9JYS3, Q06BL0, Q99M77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: July 5, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families