Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mammalian ependymin-related protein 1

Gene

EPDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mammalian ependymin-related protein 1
Short name:
MERP-1
Alternative name(s):
Upregulated in colorectal cancer gene 1 protein
Gene namesi
Name:EPDR1
Synonyms:MERP1, UCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17572. EPDR1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • lysosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671908.

Polymorphism and mutation databases

BioMutaiEPDR1.
DMDMi13124620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence analysisAdd
BLAST
Chaini38 – 224187Mammalian ependymin-related protein 1PRO_0000008351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)1 Publication
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UM22.
MaxQBiQ9UM22.
PaxDbiQ9UM22.
PRIDEiQ9UM22.

Expressioni

Gene expression databases

BgeeiQ9UM22.
CleanExiHS_EPDR1.
ExpressionAtlasiQ9UM22. baseline and differential.
GenevisibleiQ9UM22. HS.

Organism-specific databases

HPAiCAB026298.

Interactioni

Protein-protein interaction databases

BioGridi120127. 11 interactions.
IntActiQ9UM22. 3 interactions.
STRINGi9606.ENSP00000453973.

Family & Domainsi

Sequence similaritiesi

Belongs to the ependymin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIY9. Eukaryota.
ENOG4112CW8. LUCA.
GeneTreeiENSGT00530000064036.
HOGENOMiHOG000172504.
HOVERGENiHBG051490.
InParanoidiQ9UM22.
OMAiVMYQQSS.
PhylomeDBiQ9UM22.

Family and domain databases

InterProiIPR001299. Ependymin.
IPR018224. Ependymin_CS.
[Graphical view]
PfamiPF00811. Ependymin. 1 hit.
[Graphical view]
PRINTSiPR00317. EPENDYMIN.
SMARTiSM00026. EPEND. 1 hit.
[Graphical view]
PROSITEiPS00898. EPENDYMIN_1. 1 hit.
PS00899. EPENDYMIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UM22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGRAPLRTV PGALGAWLLG GLWAWTLCGL CSLGAVGAPR PCQAPQQWEG
60 70 80 90 100
RQVMYQQSSG RNSRALLSYD GLNQRVRVLD ERKALIPCKR LFEYILLYKD
110 120 130 140 150
GVMFQIDQAT KQCSKMTLTQ PWDPLDIPQN STFEDQYSIG GPQEQITVQE
160 170 180 190 200
WSDRKSARSY ETWIGIYTVK DCYPVQETFT INYSVILSTR FFDIQLGIKD
210 220
PSVFTPPSTC QMAQLEKMSE DCSW
Length:224
Mass (Da):25,437
Last modified:February 21, 2001 - v2
Checksum:i84ADBA3666261611
GO
Isoform 2 (identifier: Q9UM22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-224: Missing.

Show »
Length:90
Mass (Da):9,861
Checksum:i6466489B5052810C
GO
Isoform 3 (identifier: Q9UM22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPGRAPLRTV...DERKALIPCK → MVRDWEGRCAHRGRPAGGGLSNTQRGGG

Show »
Length:163
Mass (Da):18,672
Checksum:i2DD76E6FCFEDECAF
GO

Sequence cautioni

The sequence AAH00686.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB60269.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071P → S in CAB60269 (Ref. 7) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989MPGRA…LIPCK → MVRDWEGRCAHRGRPAGGGL SNTQRGGG in isoform 3. 1 PublicationVSP_046829Add
BLAST
Alternative sequencei91 – 224134Missing in isoform 2. 1 PublicationVSP_031976Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361252 Genomic DNA. Translation: AAK26441.1.
AY027861 mRNA. Translation: AAK15787.1.
DQ914439 mRNA. Translation: ABI84106.1.
AK290885 mRNA. Translation: BAF83574.1.
AK309180 mRNA. No translation available.
AC018634 Genomic DNA. No translation available.
AC083860 Genomic DNA. No translation available.
AC083865 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW94086.1.
BC000686 mRNA. Translation: AAH00686.2. Different initiation.
BC018299 mRNA. Translation: AAH18299.1.
AJ250475 mRNA. Translation: CAB60269.1. Different initiation.
CCDSiCCDS5454.2. [Q9UM22-1]
CCDS59051.1. [Q9UM22-2]
CCDS59052.1. [Q9UM22-3]
RefSeqiNP_001229875.2. NM_001242946.1. [Q9UM22-2]
NP_001229877.1. NM_001242948.1. [Q9UM22-3]
NP_060019.2. NM_017549.4. [Q9UM22-1]
UniGeneiHs.563491.

Genome annotation databases

EnsembliENST00000199448; ENSP00000199448; ENSG00000086289. [Q9UM22-1]
ENST00000423717; ENSP00000409211; ENSG00000086289. [Q9UM22-2]
ENST00000425345; ENSP00000413359; ENSG00000086289. [Q9UM22-3]
GeneIDi54749.
KEGGihsa:54749.
UCSCiuc003tfp.5. human. [Q9UM22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361252 Genomic DNA. Translation: AAK26441.1.
AY027861 mRNA. Translation: AAK15787.1.
DQ914439 mRNA. Translation: ABI84106.1.
AK290885 mRNA. Translation: BAF83574.1.
AK309180 mRNA. No translation available.
AC018634 Genomic DNA. No translation available.
AC083860 Genomic DNA. No translation available.
AC083865 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW94086.1.
BC000686 mRNA. Translation: AAH00686.2. Different initiation.
BC018299 mRNA. Translation: AAH18299.1.
AJ250475 mRNA. Translation: CAB60269.1. Different initiation.
CCDSiCCDS5454.2. [Q9UM22-1]
CCDS59051.1. [Q9UM22-2]
CCDS59052.1. [Q9UM22-3]
RefSeqiNP_001229875.2. NM_001242946.1. [Q9UM22-2]
NP_001229877.1. NM_001242948.1. [Q9UM22-3]
NP_060019.2. NM_017549.4. [Q9UM22-1]
UniGeneiHs.563491.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120127. 11 interactions.
IntActiQ9UM22. 3 interactions.
STRINGi9606.ENSP00000453973.

Polymorphism and mutation databases

BioMutaiEPDR1.
DMDMi13124620.

Proteomic databases

EPDiQ9UM22.
MaxQBiQ9UM22.
PaxDbiQ9UM22.
PRIDEiQ9UM22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199448; ENSP00000199448; ENSG00000086289. [Q9UM22-1]
ENST00000423717; ENSP00000409211; ENSG00000086289. [Q9UM22-2]
ENST00000425345; ENSP00000413359; ENSG00000086289. [Q9UM22-3]
GeneIDi54749.
KEGGihsa:54749.
UCSCiuc003tfp.5. human. [Q9UM22-1]

Organism-specific databases

CTDi54749.
GeneCardsiEPDR1.
H-InvDBHIX0006607.
HGNCiHGNC:17572. EPDR1.
HPAiCAB026298.
neXtProtiNX_Q9UM22.
PharmGKBiPA142671908.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIY9. Eukaryota.
ENOG4112CW8. LUCA.
GeneTreeiENSGT00530000064036.
HOGENOMiHOG000172504.
HOVERGENiHBG051490.
InParanoidiQ9UM22.
OMAiVMYQQSS.
PhylomeDBiQ9UM22.

Miscellaneous databases

GenomeRNAii54749.
NextBioi57351.
PROiQ9UM22.

Gene expression databases

BgeeiQ9UM22.
CleanExiHS_EPDR1.
ExpressionAtlasiQ9UM22. baseline and differential.
GenevisibleiQ9UM22. HS.

Family and domain databases

InterProiIPR001299. Ependymin.
IPR018224. Ependymin_CS.
[Graphical view]
PfamiPF00811. Ependymin. 1 hit.
[Graphical view]
PRINTSiPR00317. EPENDYMIN.
SMARTiSM00026. EPEND. 1 hit.
[Graphical view]
PROSITEiPS00898. EPENDYMIN_1. 1 hit.
PS00899. EPENDYMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel family of mammalian ependymin-related proteins (MERPs) in hematopoietic, nonhematopoietic, and malignant tissues."
    Apostolopoulos J., Sparrow R.L., McLeod J.L., Collier F.M., Darcy P.K., Slater H.R., Ngu C., Gregorio-King C.C., Kirkland M.A.
    DNA Cell Biol. 20:625-635(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "Characterization of mammalian ependymin proteins."
    Gregorio-King C.C., Collier F.M., Elliott K.L., Kirkland M.A.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  7. "Genes that are differentially expressed in colon cancer."
    Nimmrich I., Erdmann S., Melchers U.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-224 (ISOFORM 1).
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130.
    Tissue: Liver.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEPDR1_HUMAN
AccessioniPrimary (citable) accession number: Q9UM22
Secondary accession number(s): A8K4C0
, C9JYS3, Q06BL0, Q99M77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.