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Protein

Hippocalcin-like protein 4

Gene

HPCAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi159 – 170123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium channel regulator activity Source: Ensembl
  • calcium ion binding Source: ProtInc

GO - Biological processi

  • central nervous system development Source: ProtInc
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 4
Short name:
HLP4
Gene namesi
Name:HPCAL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18212. HPCAL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924885.

Polymorphism and mutation databases

DMDMi51316542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 191190Hippocalcin-like protein 4PRO_0000073777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ9UM19.
MaxQBiQ9UM19.
PaxDbiQ9UM19.
PRIDEiQ9UM19.

PTM databases

iPTMnetiQ9UM19.
PhosphoSiteiQ9UM19.

Expressioni

Gene expression databases

BgeeiQ9UM19.
CleanExiHS_HPCAL4.
ExpressionAtlasiQ9UM19. baseline and differential.
GenevisibleiQ9UM19. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q4ZH493EBI-744820,EBI-10192429
FAM131CQ96AQ93EBI-744820,EBI-741921
tirQ7DB773EBI-744820,EBI-6480811From a different organism.
TTC12Q9H892-23EBI-744820,EBI-10274410

Protein-protein interaction databases

BioGridi119542. 11 interactions.
IntActiQ9UM19. 7 interactions.
MINTiMINT-1436248.
STRINGi9606.ENSP00000361935.

Structurei

3D structure databases

ProteinModelPortaliQ9UM19.
SMRiQ9UM19. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 18136EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiQ9UM19.
OMAiFAKMDKD.
OrthoDBiEOG7GJ6F3.
PhylomeDBiQ9UM19.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029534. VILIP-2.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF84. PTHR23055:SF84. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UM19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTNSKLAP EVLEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ
60 70 80 90 100
LYIKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS VTSRGSFEQK
110 120 130 140 150
LNWAFEMYDL DGDGRITRLE MLEIIEAIYK MVGTVIMMRM NQDGLTPQQR
160 170 180 190
VDKIFKKMDQ DKDDQITLEE FKEAAKSDPS IVLLLQCDMQ K
Length:191
Mass (Da):22,202
Last modified:January 23, 2007 - v3
Checksum:iF705065604A8A38D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791P → A in AAH30827 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001105 mRNA. Translation: BAA86892.1.
AL136591 mRNA. Translation: CAB66526.1.
AK312314 mRNA. Translation: BAG35239.1.
AL035404 Genomic DNA. Translation: CAI19574.1.
CH471059 Genomic DNA. Translation: EAX07257.1.
CH471059 Genomic DNA. Translation: EAX07258.1.
BC030827 mRNA. Translation: AAH30827.1.
CCDSiCCDS441.1.
RefSeqiNP_001269325.1. NM_001282396.1.
NP_057341.1. NM_016257.3.
UniGeneiHs.743975.

Genome annotation databases

EnsembliENST00000372844; ENSP00000361935; ENSG00000116983.
ENST00000617690; ENSP00000481834; ENSG00000116983.
GeneIDi51440.
KEGGihsa:51440.
UCSCiuc001cdr.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001105 mRNA. Translation: BAA86892.1.
AL136591 mRNA. Translation: CAB66526.1.
AK312314 mRNA. Translation: BAG35239.1.
AL035404 Genomic DNA. Translation: CAI19574.1.
CH471059 Genomic DNA. Translation: EAX07257.1.
CH471059 Genomic DNA. Translation: EAX07258.1.
BC030827 mRNA. Translation: AAH30827.1.
CCDSiCCDS441.1.
RefSeqiNP_001269325.1. NM_001282396.1.
NP_057341.1. NM_016257.3.
UniGeneiHs.743975.

3D structure databases

ProteinModelPortaliQ9UM19.
SMRiQ9UM19. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119542. 11 interactions.
IntActiQ9UM19. 7 interactions.
MINTiMINT-1436248.
STRINGi9606.ENSP00000361935.

PTM databases

iPTMnetiQ9UM19.
PhosphoSiteiQ9UM19.

Polymorphism and mutation databases

DMDMi51316542.

Proteomic databases

EPDiQ9UM19.
MaxQBiQ9UM19.
PaxDbiQ9UM19.
PRIDEiQ9UM19.

Protocols and materials databases

DNASUi51440.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372844; ENSP00000361935; ENSG00000116983.
ENST00000617690; ENSP00000481834; ENSG00000116983.
GeneIDi51440.
KEGGihsa:51440.
UCSCiuc001cdr.5. human.

Organism-specific databases

CTDi51440.
GeneCardsiHPCAL4.
HGNCiHGNC:18212. HPCAL4.
neXtProtiNX_Q9UM19.
PharmGKBiPA134924885.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiQ9UM19.
OMAiFAKMDKD.
OrthoDBiEOG7GJ6F3.
PhylomeDBiQ9UM19.
TreeFamiTF300009.

Miscellaneous databases

ChiTaRSiHPCAL4. human.
GeneWikiiHPCAL4.
GenomeRNAii51440.
PROiQ9UM19.

Gene expression databases

BgeeiQ9UM19.
CleanExiHS_HPCAL4.
ExpressionAtlasiQ9UM19. baseline and differential.
GenevisibleiQ9UM19. HS.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029534. VILIP-2.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF84. PTHR23055:SF84. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes."
    Kobayashi M., Sakai E., Furuta Y., Takamatsu K.
    DNA Seq. 9:171-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHPCL4_HUMAN
AccessioniPrimary (citable) accession number: Q9UM19
Secondary accession number(s): B2R5U2
, D3DPU1, Q5TG97, Q8N611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.