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Protein

Anaphase-promoting complex subunit 10

Gene

ANAPC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-HSA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-HSA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-HSA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-HSA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-HSA-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-HSA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-HSA-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-HSA-176412. Phosphorylation of the APC/C.
R-HSA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ9UM13.
SIGNORiQ9UM13.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 10
Short name:
APC10
Alternative name(s):
Cyclosome subunit 10
Gene namesi
Name:ANAPC10
Synonyms:APC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164162.12.
HGNCiHGNC:24077. ANAPC10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10393.
OpenTargetsiENSG00000164162.
PharmGKBiPA134938672.

Polymorphism and mutation databases

BioMutaiANAPC10.
DMDMi34395509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001740112 – 185Anaphase-promoting complex subunit 10Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei169N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UM13.
MaxQBiQ9UM13.
PaxDbiQ9UM13.
PeptideAtlasiQ9UM13.
PRIDEiQ9UM13.

PTM databases

iPTMnetiQ9UM13.
PhosphoSitePlusiQ9UM13.

Expressioni

Gene expression databases

BgeeiENSG00000164162.
CleanExiHS_ANAPC10.
ExpressionAtlasiQ9UM13. baseline and differential.
GenevisibleiQ9UM13. HS.

Organism-specific databases

HPAiHPA044547.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa (PubMed:25043029). The C-terminus of APC10 binds to CDC27/APC3 (PubMed:11524682). Interacts with PIWIL1; interaction only takes place when PIWIL1 binds piRNA (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi115665. 47 interactors.
CORUMiQ9UM13.
DIPiDIP-39885N.
ELMiQ9UM13.
IntActiQ9UM13. 23 interactors.
MINTiMINT-3082419.
STRINGi9606.ENSP00000310071.

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 18Combined sources6
Beta strandi21 – 24Combined sources4
Helixi26 – 28Combined sources3
Beta strandi29 – 34Combined sources6
Helixi43 – 46Combined sources4
Beta strandi58 – 74Combined sources17
Beta strandi76 – 82Combined sources7
Helixi83 – 86Combined sources4
Helixi87 – 89Combined sources3
Beta strandi90 – 101Combined sources12
Beta strandi106 – 112Combined sources7
Beta strandi117 – 123Combined sources7
Beta strandi129 – 144Combined sources16
Helixi145 – 147Combined sources3
Beta strandi155 – 161Combined sources7
Beta strandi166 – 170Combined sources5
Helixi176 – 180Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JHJX-ray1.60A2-172[»]
4UI9electron microscopy3.60L2-185[»]
5A31electron microscopy4.30L1-185[»]
5G04electron microscopy4.00L1-185[»]
5G05electron microscopy3.40L1-185[»]
5KHRelectron microscopy6.10L1-185[»]
5KHUelectron microscopy4.80L1-185[»]
5L9Telectron microscopy6.40L1-185[»]
5L9Uelectron microscopy6.40L1-185[»]
5LCWelectron microscopy4.00L1-185[»]
ProteinModelPortaliQ9UM13.
SMRiQ9UM13.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UM13.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 185DOCPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the APC10 family.Curated

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
GeneTreeiENSGT00390000013722.
HOGENOMiHOG000241616.
HOVERGENiHBG050528.
InParanoidiQ9UM13.
KOiK03357.
OMAiTFWHSDG.
OrthoDBiEOG091G0MB2.
PhylomeDBiQ9UM13.
TreeFamiTF105446.

Family and domain databases

CDDicd08366. APC10. 1 hit.
Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR016901. APC10/Doc1.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
PANTHERiPTHR12936. PTHR12936. 1 hit.
PfamiView protein in Pfam
PF03256. ANAPC10. 1 hit.
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiView protein in SMART
SM01337. APC10. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiView protein in PROSITE
PS51284. DOC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UM13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL
60 70 80 90 100
ETYWQSDGSQ PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN
110 120 130 140 150
NFHNLQEIRQ LELVEPSGWI HVPLTDNHKK PTRTFMIQIA VLANHQNGRD
160 170 180
THMRQIKIYT PVEESSIGKF PRCTTIDFMM YRSIR
Length:185
Mass (Da):21,252
Last modified:May 1, 2000 - v1
Checksum:iACA7F245B3861FF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6K → R in AAD30527 (PubMed:10318877).Curated1
Sequence conflicti134T → S in CAB45705 (PubMed:11230166).Curated1
Sequence conflicti146Q → L in CAB45705 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02520046R → Q1 PublicationCorresponds to variant dbSNP:rs35257136Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132794 mRNA. Translation: AAD30527.1.
AB012109 mRNA. Translation: BAA86953.1.
AL080090 mRNA. Translation: CAB45705.1.
DQ304649 Genomic DNA. Translation: ABB96248.1.
CH471056 Genomic DNA. Translation: EAX05050.1.
CH471056 Genomic DNA. Translation: EAX05051.1.
BC005217 mRNA. Translation: AAH05217.1.
CCDSiCCDS43273.1.
PIRiT12476.
RefSeqiNP_001243635.1. NM_001256706.1.
NP_001243636.1. NM_001256707.1.
NP_001243637.1. NM_001256708.1.
NP_001243638.1. NM_001256709.1.
NP_001243639.1. NM_001256710.1.
NP_001305296.1. NM_001318367.1.
NP_055700.2. NM_014885.4.
XP_011529826.1. XM_011531524.2.
UniGeneiHs.480876.

Genome annotation databases

EnsembliENST00000309439; ENSP00000310071; ENSG00000164162.
ENST00000451299; ENSP00000403891; ENSG00000164162.
ENST00000507656; ENSP00000423995; ENSG00000164162.
ENST00000613466; ENSP00000478501; ENSG00000164162.
GeneIDi10393.
KEGGihsa:10393.
UCSCiuc003iju.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPC10_HUMAN
AccessioniPrimary (citable) accession number: Q9UM13
Secondary accession number(s): D3DNZ7
, Q2V500, Q9UG51, Q9Y5R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families