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Q9ULZ9

- MMP17_HUMAN

UniProt

Q9ULZ9 - MMP17_HUMAN

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Protein
Matrix metalloproteinase-17
Gene
MMP17, MT4MMP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Catalytic activityi

Cleaves pro-TNF-alpha at the 74-Ala-|-Gln-75 site.

Cofactori

Binds 1 zinc ion per subunit By similarity.
Calcium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101Zinc; in inhibited form By similarity
Metal bindingi248 – 2481Zinc; catalytic By similarity
Active sitei249 – 2491 By similarity
Metal bindingi252 – 2521Zinc; catalytic By similarity
Metal bindingi258 – 2581Zinc; catalytic By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. enzyme activator activity Source: ProtInc
  3. metalloendopeptidase activity Source: ProtInc
  4. zinc ion binding Source: ProtInc

GO - Biological processi

  1. positive regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_118682. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiM10.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-17 (EC:3.4.24.-)
Short name:
MMP-17
Alternative name(s):
Membrane-type matrix metalloproteinase 4
Short name:
MT-MMP 4
Short name:
MTMMP4
Membrane-type-4 matrix metalloproteinase
Short name:
MT4-MMP
Short name:
MT4MMP
Gene namesi
Name:MMP17
Synonyms:MT4MMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:7163. MMP17.

Subcellular locationi

Isoform Long : Cell membrane; Lipid-anchorGPI-anchor; Extracellular side. Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30875.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Propeptidei36 – 12590 By similarity
PRO_0000028818Add
BLAST
Chaini126 – 565440Matrix metalloproteinase-17
PRO_0000028819Add
BLAST
Propeptidei566 – 60338Removed in mature form Reviewed prediction
PRO_0000028820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi332 ↔ 523 By similarity
Lipidationi565 – 5651GPI-anchor amidated serine Reviewed prediction

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Zymogen

Proteomic databases

PaxDbiQ9ULZ9.
PRIDEiQ9ULZ9.

PTM databases

PhosphoSiteiQ9ULZ9.

Expressioni

Tissue specificityi

Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.

Gene expression databases

ArrayExpressiQ9ULZ9.
BgeeiQ9ULZ9.
CleanExiHS_MMP17.
GenevestigatoriQ9ULZ9.

Interactioni

Protein-protein interaction databases

BioGridi110469. 1 interaction.
STRINGi9606.ENSP00000353767.

Structurei

3D structure databases

ProteinModelPortaliQ9ULZ9.
SMRiQ9ULZ9. Positions 39-523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati333 – 37846Hemopexin 1
Add
BLAST
Repeati382 – 42746Hemopexin 2
Add
BLAST
Repeati428 – 47548Hemopexin 3
Add
BLAST
Repeati476 – 52348Hemopexin 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 1158Cysteine switch By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 1254Poly-Arg

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG295915.
HOVERGENiHBG052484.
InParanoidiQ9ULZ9.
KOiK07997.
OMAiAHNDRTY.
OrthoDBiEOG7XPZ57.
PhylomeDBiQ9ULZ9.
TreeFamiTF315428.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028726. MMP17.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF118. PTHR10201:SF118. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9ULZ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRRAARGPG PPPPGPGLSR LPLPLLLLLA LGTRGGCAAP APAPRAEDLS    50
LGVEWLSRFG YLPPADPTTG QLQTQEELSK AITAMQQFGG LEATGILDEA 100
TLALMKTPRC SLPDLPVLTQ ARRRRQAPAP TKWNKRNLSW RVRTFPRDSP 150
LGHDTVRALM YYALKVWSDI APLNFHEVAG SAADIQIDFS KADHNDGYPF 200
DGPGGTVAHA FFPGHHHTAG DTHFDDDEAW TFRSSDAHGM DLFAVAVHEF 250
GHAIGLSHVA AAHSIMRPYY QGPVGDPLRY GLPYEDKVRV WQLYGVRESV 300
SPTAQPEEPP LLPEPPDNRS SAPPRKDVPH RCSTHFDAVA QIRGEAFFFK 350
GKYFWRLTRD RHLVSLQPAQ MHRFWRGLPL HLDSVDAVYE RTSDHKIVFF 400
KGDRYWVFKD NNVEEGYPRP VSDFSLPPGG IDAAFSWAHN DRTYFFKDQL 450
YWRYDDHTRH MDPGYPAQSP LWRGVPSTLD DAMRWSDGAS YFFRGQEYWK 500
VLDGELEVAP GYPQSTARDW LVCGDSQADG SVAAGVDAAE GPRAPPGQHD 550
QSRSEDGYEV CSCTSGASSP PGAPGPLVAA TMLLLLPPLS PGALWTAAQA 600
LTL 603
Length:603
Mass (Da):66,653
Last modified:May 18, 2010 - v4
Checksum:iBB297B21973C7A0B
GO
Isoform Short (identifier: Q9ULZ9-2) [UniParc]FASTAAdd to Basket

Also known as: Puente

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:519
Mass (Da):57,938
Checksum:iEB74B32E8A7619C3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform Short.
VSP_005456Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231L → LLPL in BAA82707. 1 Publication
Sequence conflicti23 – 231L → LLPL in CAA61753. 1 Publication
Sequence conflicti182 – 1821A → T in BAA82707. 1 Publication
Sequence conflicti182 – 1821A → T in CAA61753. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021225 mRNA. Translation: BAA82707.2.
X89576 mRNA. Translation: CAA61753.1.
AC131009 Genomic DNA. No translation available.
CCDSiCCDS31927.1. [Q9ULZ9-1]
RefSeqiNP_057239.4. NM_016155.4. [Q9ULZ9-1]
UniGeneiHs.709245.

Genome annotation databases

EnsembliENST00000360564; ENSP00000353767; ENSG00000198598. [Q9ULZ9-1]
ENST00000535291; ENSP00000441106; ENSG00000198598. [Q9ULZ9-2]
GeneIDi4326.
KEGGihsa:4326.
UCSCiuc001ujc.1. human. [Q9ULZ9-1]

Polymorphism databases

DMDMi296439485.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021225 mRNA. Translation: BAA82707.2 .
X89576 mRNA. Translation: CAA61753.1 .
AC131009 Genomic DNA. No translation available.
CCDSi CCDS31927.1. [Q9ULZ9-1 ]
RefSeqi NP_057239.4. NM_016155.4. [Q9ULZ9-1 ]
UniGenei Hs.709245.

3D structure databases

ProteinModelPortali Q9ULZ9.
SMRi Q9ULZ9. Positions 39-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110469. 1 interaction.
STRINGi 9606.ENSP00000353767.

Chemistry

ChEMBLi CHEMBL2937.

Protein family/group databases

MEROPSi M10.017.

PTM databases

PhosphoSitei Q9ULZ9.

Polymorphism databases

DMDMi 296439485.

Proteomic databases

PaxDbi Q9ULZ9.
PRIDEi Q9ULZ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360564 ; ENSP00000353767 ; ENSG00000198598 . [Q9ULZ9-1 ]
ENST00000535291 ; ENSP00000441106 ; ENSG00000198598 . [Q9ULZ9-2 ]
GeneIDi 4326.
KEGGi hsa:4326.
UCSCi uc001ujc.1. human. [Q9ULZ9-1 ]

Organism-specific databases

CTDi 4326.
GeneCardsi GC12P132312.
H-InvDB HIX0036662.
HGNCi HGNC:7163. MMP17.
MIMi 602285. gene.
neXtProti NX_Q9ULZ9.
PharmGKBi PA30875.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295915.
HOVERGENi HBG052484.
InParanoidi Q9ULZ9.
KOi K07997.
OMAi AHNDRTY.
OrthoDBi EOG7XPZ57.
PhylomeDBi Q9ULZ9.
TreeFami TF315428.

Enzyme and pathway databases

Reactomei REACT_118682. Activation of Matrix Metalloproteinases.

Miscellaneous databases

GeneWikii MMP17.
GenomeRNAii 4326.
NextBioi 17023.
PROi Q9ULZ9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ULZ9.
Bgeei Q9ULZ9.
CleanExi HS_MMP17.
Genevestigatori Q9ULZ9.

Family and domain databases

Gene3Di 2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028726. MMP17.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
PANTHERi PTHR10201:SF118. PTHR10201:SF118. 1 hit.
Pfami PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEi PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts."
    Kajita M., Kinoh H., Ito N., Takamura A., Itoh Y., Okada A., Sato H., Seiki M.
    FEBS Lett. 457:353-356(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: Monocytic leukemia.
  2. Seiki M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 41; 44; 202-207; 221 AND 225.
  3. "Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma."
    Puente X.S., Pendas A.M., Llano E., Velasco G., Lopez-Otin C.
    Cancer Res. 56:944-949(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Mammary carcinoma.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain."
    Wang Y., Johnson A.R., Ye Q.-Z., Dyer R.D.
    J. Biol. Chem. 274:33043-33049(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-299, CHARACTERIZATION.
  6. "Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase."
    Itoh Y., Kajita M., Kinoh H., Mori H., Okada A., Seiki M.
    J. Biol. Chem. 274:34260-34266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR.
  7. "Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase."
    Kolkenbrock H., Essers L., Ulbrich N., Will H.
    Biol. Chem. 380:1103-1108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiMMP17_HUMAN
AccessioniPrimary (citable) accession number: Q9ULZ9
Secondary accession number(s): Q14850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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