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Protein

Signal-transducing adaptor protein 1

Gene

STAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.1 Publication

GO - Molecular functioni

  • phospholipid binding Source: BHF-UCL
  • phosphotyrosine binding Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: BHF-UCL
  • transmembrane receptor protein tyrosine kinase adaptor activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000035720-MONOMER.
SignaLinkiQ9ULZ2.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transducing adaptor protein 1
Short name:
STAP-1
Alternative name(s):
BCR downstream-signaling protein 1
Docking protein BRDG1
Stem cell adaptor protein 1
Gene namesi
Name:STAP1
Synonyms:BRDG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24133. STAP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26228.
OpenTargetsiENSG00000035720.
PharmGKBiPA162404948.

Polymorphism and mutation databases

BioMutaiSTAP1.
DMDMi62511239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722371 – 295Signal-transducing adaptor protein 1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULZ2.
MaxQBiQ9ULZ2.
PaxDbiQ9ULZ2.
PeptideAtlasiQ9ULZ2.
PRIDEiQ9ULZ2.
TopDownProteomicsiQ9ULZ2.

PTM databases

iPTMnetiQ9ULZ2.
PhosphoSitePlusiQ9ULZ2.

Expressioni

Gene expression databases

BgeeiENSG00000035720.
CleanExiHS_STAP1.
ExpressionAtlasiQ9ULZ2. baseline and differential.
GenevisibleiQ9ULZ2. HS.

Organism-specific databases

HPAiHPA038529.

Interactioni

Subunit structurei

Interacts with KIT and CSF1R (By similarity). Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5JPT65EBI-6083058,EBI-10244213
ARP102752EBI-6083058,EBI-608057
FAM134CQ86VR25EBI-6083058,EBI-10192441
GAB1Q134803EBI-6083058,EBI-517684
KITP107213EBI-6083058,EBI-1379503
METP085813EBI-6083058,EBI-1039152
SH3KBP1Q96B974EBI-6083058,EBI-346595

GO - Molecular functioni

  • phosphotyrosine binding Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: BHF-UCL
  • transmembrane receptor protein tyrosine kinase adaptor activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi117619. 7 interactors.
IntActiQ9ULZ2. 8 interactors.
MINTiMINT-8098930.
STRINGi9606.ENSP00000265404.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Beta strandi26 – 35Combined sources10
Beta strandi43 – 50Combined sources8
Beta strandi53 – 58Combined sources6
Beta strandi66 – 68Combined sources3
Beta strandi76 – 79Combined sources4
Beta strandi89 – 93Combined sources5
Beta strandi99 – 102Combined sources4
Helixi106 – 121Combined sources16
Helixi132 – 149Combined sources18
Helixi184 – 193Combined sources10
Helixi195 – 197Combined sources3
Beta strandi199 – 204Combined sources6
Beta strandi208 – 217Combined sources10
Beta strandi219 – 221Combined sources3
Beta strandi223 – 232Combined sources10
Beta strandi235 – 238Combined sources4
Beta strandi240 – 242Combined sources3
Beta strandi244 – 248Combined sources5
Helixi249 – 259Combined sources11
Turni260 – 262Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1FNMR-A16-151[»]
3MAZX-ray1.90A167-285[»]
ProteinModelPortaliQ9ULZ2.
SMRiQ9ULZ2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULZ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 121PHPROSITE-ProRule annotationAdd BLAST97
Domaini177 – 280SH2PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGPX. Eukaryota.
ENOG4111PK4. LUCA.
GeneTreeiENSGT00530000063841.
HOGENOMiHOG000234375.
HOVERGENiHBG062262.
InParanoidiQ9ULZ2.
OMAiPRRIFQE.
OrthoDBiEOG091G0929.
PhylomeDBiQ9ULZ2.
TreeFamiTF332087.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000980. SH2.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR
60 70 80 90 100
GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ
110 120 130 140 150
LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI
160 170 180 190 200
ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM
210 220 230 240 250
ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF
260 270 280 290
SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA
Length:295
Mass (Da):34,291
Last modified:May 1, 2000 - v1
Checksum:i8C242AC5C61038E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023483 mRNA. Translation: BAA85311.1.
AK313676 mRNA. Translation: BAG36427.1.
CH471057 Genomic DNA. Translation: EAX05547.1.
BC014958 mRNA. Translation: AAH14958.1.
CCDSiCCDS3515.1.
RefSeqiNP_001304698.1. NM_001317769.1.
NP_036240.1. NM_012108.3.
UniGeneiHs.435579.

Genome annotation databases

EnsembliENST00000265404; ENSP00000265404; ENSG00000035720.
ENST00000396225; ENSP00000379527; ENSG00000035720.
GeneIDi26228.
KEGGihsa:26228.
UCSCiuc003hde.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023483 mRNA. Translation: BAA85311.1.
AK313676 mRNA. Translation: BAG36427.1.
CH471057 Genomic DNA. Translation: EAX05547.1.
BC014958 mRNA. Translation: AAH14958.1.
CCDSiCCDS3515.1.
RefSeqiNP_001304698.1. NM_001317769.1.
NP_036240.1. NM_012108.3.
UniGeneiHs.435579.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1FNMR-A16-151[»]
3MAZX-ray1.90A167-285[»]
ProteinModelPortaliQ9ULZ2.
SMRiQ9ULZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117619. 7 interactors.
IntActiQ9ULZ2. 8 interactors.
MINTiMINT-8098930.
STRINGi9606.ENSP00000265404.

PTM databases

iPTMnetiQ9ULZ2.
PhosphoSitePlusiQ9ULZ2.

Polymorphism and mutation databases

BioMutaiSTAP1.
DMDMi62511239.

Proteomic databases

EPDiQ9ULZ2.
MaxQBiQ9ULZ2.
PaxDbiQ9ULZ2.
PeptideAtlasiQ9ULZ2.
PRIDEiQ9ULZ2.
TopDownProteomicsiQ9ULZ2.

Protocols and materials databases

DNASUi26228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265404; ENSP00000265404; ENSG00000035720.
ENST00000396225; ENSP00000379527; ENSG00000035720.
GeneIDi26228.
KEGGihsa:26228.
UCSCiuc003hde.4. human.

Organism-specific databases

CTDi26228.
DisGeNETi26228.
GeneCardsiSTAP1.
HGNCiHGNC:24133. STAP1.
HPAiHPA038529.
MIMi604298. gene.
neXtProtiNX_Q9ULZ2.
OpenTargetsiENSG00000035720.
PharmGKBiPA162404948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPX. Eukaryota.
ENOG4111PK4. LUCA.
GeneTreeiENSGT00530000063841.
HOGENOMiHOG000234375.
HOVERGENiHBG062262.
InParanoidiQ9ULZ2.
OMAiPRRIFQE.
OrthoDBiEOG091G0929.
PhylomeDBiQ9ULZ2.
TreeFamiTF332087.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000035720-MONOMER.
SignaLinkiQ9ULZ2.

Miscellaneous databases

EvolutionaryTraceiQ9ULZ2.
GeneWikiiSTAP1.
GenomeRNAii26228.
PROiQ9ULZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000035720.
CleanExiHS_STAP1.
ExpressionAtlasiQ9ULZ2. baseline and differential.
GenevisibleiQ9ULZ2. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000980. SH2.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULZ2
Secondary accession number(s): B2R980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.