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Q9ULZ2 (STAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal-transducing adaptor protein 1

Short name=STAP-1
Alternative name(s):
BCR downstream-signaling protein 1
Docking protein BRDG1
Stem cell adaptor protein 1
Gene names
Name:STAP1
Synonyms:BRDG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. Ref.1

Subunit structure

Interacts with KIT and CSF1R By similarity. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner. Ref.5

Subcellular location

Nucleus. Cytoplasm. Mitochondrion Ref.5.

Post-translational modification

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT By similarity. Ref.1

Sequence similarities

Contains 1 PH domain.

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Signal-transducing adaptor protein 1
PRO_0000072237

Regions

Domain25 – 12197PH
Domain177 – 280104SH2

Amino acid modifications

Modified residue1681Phosphotyrosine By similarity

Secondary structure

......................................... 295
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9ULZ2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8C242AC5C61038E0

FASTA29534,291
        10         20         30         40         50         60 
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR GTTLFFYTDK 

        70         80         90        100        110        120 
KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT 

       130        140        150        160        170        180 
ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY 

       190        200        210        220        230        240 
TVSRKEATEM LQKNPSLGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL 

       250        260        270        280        290 
EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase."
Ohya K., Kajigaya S., Kitanaka A., Yoshida K., Miyazato A., Yamashita Y., Yamanaka T., Ikeda U., Shimada K., Ozawa K., Mano H.
Proc. Natl. Acad. Sci. U.S.A. 96:11976-11981(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION BY TEC.
Tissue: Hematopoietic.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell.
[5]"S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."
Djouder N., Metzler S.C., Schmidt A., Wirbelauer C., Gstaiger M., Aebersold R., Hess D., Krek W.
Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH URI1, SUBCELLULAR LOCATION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Solution structure of the PH domain of human docking protein BRDG1."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 16-151.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023483 mRNA. Translation: BAA85311.1.
AK313676 mRNA. Translation: BAG36427.1.
CH471057 Genomic DNA. Translation: EAX05547.1.
BC014958 mRNA. Translation: AAH14958.1.
CCDSCCDS3515.1.
RefSeqNP_036240.1. NM_012108.2.
XP_006714238.1. XM_006714175.1.
UniGeneHs.435579.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1X1FNMR-A16-151[»]
3MAZX-ray1.90A167-285[»]
ProteinModelPortalQ9ULZ2.
SMRQ9ULZ2. Positions 16-156, 171-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117619. 6 interactions.
IntActQ9ULZ2. 6 interactions.
MINTMINT-8098930.
STRING9606.ENSP00000265404.

PTM databases

PhosphoSiteQ9ULZ2.

Polymorphism databases

DMDM62511239.

Proteomic databases

MaxQBQ9ULZ2.
PaxDbQ9ULZ2.
PeptideAtlasQ9ULZ2.
PRIDEQ9ULZ2.

Protocols and materials databases

DNASU26228.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265404; ENSP00000265404; ENSG00000035720.
ENST00000396225; ENSP00000379527; ENSG00000035720.
GeneID26228.
KEGGhsa:26228.
UCSCuc003hde.4. human.

Organism-specific databases

CTD26228.
GeneCardsGC04P068424.
HGNCHGNC:24133. STAP1.
HPAHPA038529.
MIM604298. gene.
neXtProtNX_Q9ULZ2.
PharmGKBPA162404948.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47666.
HOGENOMHOG000234375.
HOVERGENHBG062262.
InParanoidQ9ULZ2.
OMAPMPACFY.
OrthoDBEOG79KPFP.
PhylomeDBQ9ULZ2.
TreeFamTF332087.

Enzyme and pathway databases

SignaLinkQ9ULZ2.

Gene expression databases

BgeeQ9ULZ2.
CleanExHS_STAP1.
GenevestigatorQ9ULZ2.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000980. SH2.
[Graphical view]
PfamPF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9ULZ2.
GeneWikiSTAP1.
GenomeRNAi26228.
NextBio48387.
PROQ9ULZ2.
SOURCESearch...

Entry information

Entry nameSTAP1_HUMAN
AccessionPrimary (citable) accession number: Q9ULZ2
Secondary accession number(s): B2R980
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM