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Protein

C-type lectin domain family 4 member E

Gene

CLEC4E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • receptor activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166523-MONOMER.
ReactomeiR-HSA-5621480. Dectin-2 family.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member E
Alternative name(s):
C-type lectin superfamily member 9
Macrophage-inducible C-type lectin
Gene namesi
Name:CLEC4E
Synonyms:CLECSF9, MINCLE
ORF Names:UNQ218/PRO244
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14555. CLEC4E.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini41 – 219ExtracellularSequence analysisAdd BLAST179

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26253.
OpenTargetsiENSG00000166523.
PharmGKBiPA26586.

Polymorphism and mutation databases

BioMutaiCLEC4E.
DMDMi59797976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466191 – 219C-type lectin domain family 4 member EAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi80 ↔ 91PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 205PROSITE-ProRule annotation
Disulfide bondi179 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9ULY5.
PaxDbiQ9ULY5.
PeptideAtlasiQ9ULY5.
PRIDEiQ9ULY5.

PTM databases

iPTMnetiQ9ULY5.
PhosphoSitePlusiQ9ULY5.

Expressioni

Gene expression databases

BgeeiENSG00000166523.
CleanExiHS_CLEC4E.
ExpressionAtlasiQ9ULY5. baseline and differential.
GenevisibleiQ9ULY5. HS.

Organism-specific databases

HPAiHPA004935.

Interactioni

Subunit structurei

Monomer. Homodimer.1 Publication

Protein-protein interaction databases

BioGridi117639. 3 interactors.
STRINGi9606.ENSP00000299663.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi85 – 87Combined sources3
Beta strandi90 – 94Combined sources5
Helixi101 – 110Combined sources10
Helixi121 – 130Combined sources10
Beta strandi137 – 143Combined sources7
Beta strandi150 – 152Combined sources3
Beta strandi174 – 182Combined sources9
Beta strandi192 – 196Combined sources5
Beta strandi201 – 208Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WH2X-ray1.30A74-219[»]
3WH3X-ray1.32A74-219[»]
ProteinModelPortaliQ9ULY5.
SMRiQ9ULY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 206C-type lectinPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3J. Eukaryota.
ENOG410YTFW. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ9ULY5.
KOiK10059.
OMAiVKNCCPL.
OrthoDBiEOG091G0DW5.
PhylomeDBiQ9ULY5.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSKSSETQ CTERGCFSSQ MFLWTVAGIP ILFLSACFIT RCVVTFRIFQ
60 70 80 90 100
TCDEKKFQLP ENFTELSCYN YGSGSVKNCC PLNWEYFQSS CYFFSTDTIS
110 120 130 140 150
WALSLKNCSA MGAHLVVINS QEEQEFLSYK KPKMREFFIG LSDQVVEGQW
160 170 180 190 200
QWVDGTPLTK SLSFWDVGEP NNIATLEDCA TMRDSSNPRQ NWNDVTCFLN
210
YFRICEMVGI NPLNKGKSL
Length:219
Mass (Da):25,073
Last modified:May 1, 2000 - v1
Checksum:iC5D48DD7427D7FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024718 mRNA. Translation: BAA83755.1.
AY358499 mRNA. Translation: AAQ88863.1.
AK312671 mRNA. Translation: BAG35553.1.
AC092746 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88618.1.
BC000715 mRNA. Translation: AAH00715.1.
CCDSiCCDS8594.1.
RefSeqiNP_055173.1. NM_014358.3.
UniGeneiHs.236516.

Genome annotation databases

EnsembliENST00000299663; ENSP00000299663; ENSG00000166523.
GeneIDi26253.
KEGGihsa:26253.
UCSCiuc001quo.2. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mincle

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024718 mRNA. Translation: BAA83755.1.
AY358499 mRNA. Translation: AAQ88863.1.
AK312671 mRNA. Translation: BAG35553.1.
AC092746 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88618.1.
BC000715 mRNA. Translation: AAH00715.1.
CCDSiCCDS8594.1.
RefSeqiNP_055173.1. NM_014358.3.
UniGeneiHs.236516.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WH2X-ray1.30A74-219[»]
3WH3X-ray1.32A74-219[»]
ProteinModelPortaliQ9ULY5.
SMRiQ9ULY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117639. 3 interactors.
STRINGi9606.ENSP00000299663.

PTM databases

iPTMnetiQ9ULY5.
PhosphoSitePlusiQ9ULY5.

Polymorphism and mutation databases

BioMutaiCLEC4E.
DMDMi59797976.

Proteomic databases

EPDiQ9ULY5.
PaxDbiQ9ULY5.
PeptideAtlasiQ9ULY5.
PRIDEiQ9ULY5.

Protocols and materials databases

DNASUi26253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299663; ENSP00000299663; ENSG00000166523.
GeneIDi26253.
KEGGihsa:26253.
UCSCiuc001quo.2. human.

Organism-specific databases

CTDi26253.
DisGeNETi26253.
GeneCardsiCLEC4E.
HGNCiHGNC:14555. CLEC4E.
HPAiHPA004935.
MIMi609962. gene.
neXtProtiNX_Q9ULY5.
OpenTargetsiENSG00000166523.
PharmGKBiPA26586.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS3J. Eukaryota.
ENOG410YTFW. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ9ULY5.
KOiK10059.
OMAiVKNCCPL.
OrthoDBiEOG091G0DW5.
PhylomeDBiQ9ULY5.
TreeFamiTF333341.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166523-MONOMER.
ReactomeiR-HSA-5621480. Dectin-2 family.

Miscellaneous databases

GenomeRNAii26253.
PROiQ9ULY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166523.
CleanExiHS_CLEC4E.
ExpressionAtlasiQ9ULY5. baseline and differential.
GenevisibleiQ9ULY5. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC4E_HUMAN
AccessioniPrimary (citable) accession number: Q9ULY5
Secondary accession number(s): B2R6Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.