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Protein

Transcription factor MafF

Gene

MAFF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846).3 Publications

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: Reactome
  • in utero embryonic development Source: Ensembl
  • parturition Source: ProtInc
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of epidermal cell differentiation Source: Ensembl
  • skeletal muscle cell differentiation Source: Ensembl
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiQ9ULX9
SIGNORiQ9ULX9

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafF
Alternative name(s):
U-Maf
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
Gene namesi
Name:MAFF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000185022.11
HGNCiHGNC:6780 MAFF
MIMi604877 gene
neXtProtiNX_Q9ULX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23764
OpenTargetsiENSG00000185022
PharmGKBiPA30538

Polymorphism and mutation databases

BioMutaiMAFF
DMDMi21542145

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764971 – 164Transcription factor MafFAdd BLAST164

Proteomic databases

EPDiQ9ULX9
PaxDbiQ9ULX9
PeptideAtlasiQ9ULX9
PRIDEiQ9ULX9

PTM databases

iPTMnetiQ9ULX9
PhosphoSitePlusiQ9ULX9

Expressioni

Tissue specificityi

Expressed in the term myometrium and kidney.

Inductioni

By oxidative stress.1 Publication

Gene expression databases

BgeeiENSG00000185022
CleanExiHS_MAFF
ExpressionAtlasiQ9ULX9 baseline and differential
GenevisibleiQ9ULX9 HS

Organism-specific databases

HPAiCAB025341
HPA055371

Interactioni

Subunit structurei

Monomer and homo- or heterodimer. Interacts with MIP (PubMed:16549056). Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2L1/NRF1 (PubMed:8932385).2 Publications

Protein-protein interaction databases

BioGridi117264, 35 interactors
IntActiQ9ULX9, 6 interactors
MINTiQ9ULX9
STRINGi9606.ENSP00000345393

Structurei

3D structure databases

ProteinModelPortaliQ9ULX9
SMRiQ9ULX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiKOG4196 Eukaryota
ENOG41102C7 LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000045475
HOVERGENiHBG001725
InParanoidiQ9ULX9
KOiK09037
OMAiNRQLKLR
OrthoDBiEOG091G0H46
PhylomeDBiQ9ULX9
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR033531 MafF
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF25 PTHR10129:SF25, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM
110 120 130 140 150
RLELDALRGK CEALQGFARS VAAARGPATL VAPASVITIV KSTPGSGSGP
160
AHGPDPAHGP ASCS
Length:164
Mass (Da):17,760
Last modified:June 20, 2002 - v2
Checksum:iFC34D9FF317E5EE1
GO
Isoform 2 (identifier: Q9ULX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,569
Checksum:i54E949F996CCE45A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116G → A in BAA86871 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430291 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025247 mRNA Translation: BAA86871.1
AJ010857 mRNA Translation: CAB52435.1
AK002001 mRNA Translation: BAA92029.1
AK300932 mRNA Translation: BAG62561.1
AL021977 Genomic DNA No translation available.
BC015037 mRNA Translation: AAH15037.1
BC067751 mRNA Translation: AAH67751.1
CCDSiCCDS13968.1 [Q9ULX9-1]
CCDS54528.1 [Q9ULX9-2]
PIRiJC7112
RefSeqiNP_001155044.1, NM_001161572.1 [Q9ULX9-1]
NP_001155045.1, NM_001161573.1 [Q9ULX9-1]
NP_001155046.1, NM_001161574.1 [Q9ULX9-2]
NP_036455.1, NM_012323.3 [Q9ULX9-1]
UniGeneiHs.517617

Genome annotation databases

EnsembliENST00000338483; ENSP00000345393; ENSG00000185022 [Q9ULX9-1]
ENST00000407965; ENSP00000384094; ENSG00000185022 [Q9ULX9-1]
ENST00000426621; ENSP00000388882; ENSG00000185022 [Q9ULX9-1]
ENST00000538320; ENSP00000442060; ENSG00000185022 [Q9ULX9-1]
ENST00000538999; ENSP00000441482; ENSG00000185022 [Q9ULX9-2]
GeneIDi23764
KEGGihsa:23764
UCSCiuc003avc.4 human [Q9ULX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAFF_HUMAN
AccessioniPrimary (citable) accession number: Q9ULX9
Secondary accession number(s): B4DV49, Q9Y525
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: March 28, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health