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Q9ULX9

- MAFF_HUMAN

UniProt

Q9ULX9 - MAFF_HUMAN

Protein

Transcription factor MafF

Gene

MAFF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. in utero embryonic development Source: Ensembl
    3. parturition Source: ProtInc
    4. regulation of epidermal cell differentiation Source: Ensembl
    5. skeletal muscle cell differentiation Source: Ensembl
    6. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Stress response, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiQ9ULX9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor MafF
    Alternative name(s):
    U-Maf
    V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
    Gene namesi
    Name:MAFF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:6780. MAFF.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30538.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Transcription factor MafFPRO_0000076497Add
    BLAST

    Proteomic databases

    MaxQBiQ9ULX9.
    PaxDbiQ9ULX9.
    PRIDEiQ9ULX9.

    PTM databases

    PhosphoSiteiQ9ULX9.

    Expressioni

    Tissue specificityi

    Expressed in the term myometrium and kidney.

    Inductioni

    By oxidative stress.1 Publication

    Gene expression databases

    ArrayExpressiQ9ULX9.
    BgeeiQ9ULX9.
    CleanExiHS_MAFF.
    GenevestigatoriQ9ULX9.

    Organism-specific databases

    HPAiCAB025341.

    Interactioni

    Subunit structurei

    Monomer and homo- or heterodimer. Interacts with MIP.1 Publication

    Protein-protein interaction databases

    BioGridi117264. 25 interactions.
    IntActiQ9ULX9. 4 interactions.
    MINTiMINT-1413410.
    STRINGi9606.ENSP00000345393.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULX9.
    SMRiQ9ULX9. Positions 24-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 11464bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 7626Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni79 – 9315Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Maf subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG315640.
    HOGENOMiHOG000045475.
    HOVERGENiHBG001725.
    InParanoidiQ9ULX9.
    KOiK09037.
    OMAiHGPASCS.
    OrthoDBiEOG7BGHMQ.
    PhylomeDBiQ9ULX9.
    TreeFamiTF325689.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view]
    PANTHERiPTHR10129. PTHR10129. 1 hit.
    PfamiPF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULX9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT    50
    RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM 100
    RLELDALRGK CEALQGFARS VAAARGPATL VAPASVITIV KSTPGSGSGP 150
    AHGPDPAHGP ASCS 164
    Length:164
    Mass (Da):17,760
    Last modified:June 20, 2002 - v2
    Checksum:iFC34D9FF317E5EE1
    GO
    Isoform 2 (identifier: Q9ULX9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:135
    Mass (Da):14,569
    Checksum:i54E949F996CCE45A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161G → A in BAA86871. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929Missing in isoform 2. 1 PublicationVSP_043029Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025247 mRNA. Translation: BAA86871.1.
    AJ010857 mRNA. Translation: CAB52435.1.
    AK002001 mRNA. Translation: BAA92029.1.
    AK300932 mRNA. Translation: BAG62561.1.
    AL021977 Genomic DNA. Translation: CAB45266.1.
    BC015037 mRNA. Translation: AAH15037.1.
    BC067751 mRNA. Translation: AAH67751.1.
    CCDSiCCDS13968.1. [Q9ULX9-1]
    CCDS54528.1. [Q9ULX9-2]
    PIRiJC7112.
    RefSeqiNP_001155044.1. NM_001161572.1. [Q9ULX9-1]
    NP_001155045.1. NM_001161573.1. [Q9ULX9-1]
    NP_001155046.1. NM_001161574.1. [Q9ULX9-2]
    NP_036455.1. NM_012323.3. [Q9ULX9-1]
    UniGeneiHs.517617.

    Genome annotation databases

    EnsembliENST00000338483; ENSP00000345393; ENSG00000185022. [Q9ULX9-1]
    ENST00000407965; ENSP00000384094; ENSG00000185022. [Q9ULX9-1]
    ENST00000426621; ENSP00000388882; ENSG00000185022. [Q9ULX9-1]
    ENST00000538320; ENSP00000442060; ENSG00000185022. [Q9ULX9-1]
    ENST00000538999; ENSP00000441482; ENSG00000185022. [Q9ULX9-2]
    GeneIDi23764.
    KEGGihsa:23764.
    UCSCiuc003avc.3. human. [Q9ULX9-1]

    Polymorphism databases

    DMDMi21542145.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025247 mRNA. Translation: BAA86871.1 .
    AJ010857 mRNA. Translation: CAB52435.1 .
    AK002001 mRNA. Translation: BAA92029.1 .
    AK300932 mRNA. Translation: BAG62561.1 .
    AL021977 Genomic DNA. Translation: CAB45266.1 .
    BC015037 mRNA. Translation: AAH15037.1 .
    BC067751 mRNA. Translation: AAH67751.1 .
    CCDSi CCDS13968.1. [Q9ULX9-1 ]
    CCDS54528.1. [Q9ULX9-2 ]
    PIRi JC7112.
    RefSeqi NP_001155044.1. NM_001161572.1. [Q9ULX9-1 ]
    NP_001155045.1. NM_001161573.1. [Q9ULX9-1 ]
    NP_001155046.1. NM_001161574.1. [Q9ULX9-2 ]
    NP_036455.1. NM_012323.3. [Q9ULX9-1 ]
    UniGenei Hs.517617.

    3D structure databases

    ProteinModelPortali Q9ULX9.
    SMRi Q9ULX9. Positions 24-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117264. 25 interactions.
    IntActi Q9ULX9. 4 interactions.
    MINTi MINT-1413410.
    STRINGi 9606.ENSP00000345393.

    PTM databases

    PhosphoSitei Q9ULX9.

    Polymorphism databases

    DMDMi 21542145.

    Proteomic databases

    MaxQBi Q9ULX9.
    PaxDbi Q9ULX9.
    PRIDEi Q9ULX9.

    Protocols and materials databases

    DNASUi 23764.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338483 ; ENSP00000345393 ; ENSG00000185022 . [Q9ULX9-1 ]
    ENST00000407965 ; ENSP00000384094 ; ENSG00000185022 . [Q9ULX9-1 ]
    ENST00000426621 ; ENSP00000388882 ; ENSG00000185022 . [Q9ULX9-1 ]
    ENST00000538320 ; ENSP00000442060 ; ENSG00000185022 . [Q9ULX9-1 ]
    ENST00000538999 ; ENSP00000441482 ; ENSG00000185022 . [Q9ULX9-2 ]
    GeneIDi 23764.
    KEGGi hsa:23764.
    UCSCi uc003avc.3. human. [Q9ULX9-1 ]

    Organism-specific databases

    CTDi 23764.
    GeneCardsi GC22P038597.
    HGNCi HGNC:6780. MAFF.
    HPAi CAB025341.
    MIMi 604877. gene.
    neXtProti NX_Q9ULX9.
    PharmGKBi PA30538.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315640.
    HOGENOMi HOG000045475.
    HOVERGENi HBG001725.
    InParanoidi Q9ULX9.
    KOi K09037.
    OMAi HGPASCS.
    OrthoDBi EOG7BGHMQ.
    PhylomeDBi Q9ULX9.
    TreeFami TF325689.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinki Q9ULX9.

    Miscellaneous databases

    ChiTaRSi MAFF. human.
    GeneWikii MAFF_(gene).
    GenomeRNAii 23764.
    NextBioi 46719.
    PROi Q9ULX9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULX9.
    Bgeei Q9ULX9.
    CleanExi HS_MAFF.
    Genevestigatori Q9ULX9.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view ]
    PANTHERi PTHR10129. PTHR10129. 1 hit.
    Pfami PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium."
      Kimura T., Ivell R., Rust W., Mizumoto Y., Ogita K., Kusui C., Matsumura Y., Azuma C., Murata Y.
      Biochem. Biophys. Res. Commun. 264:86-92(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Term myometrium.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Small intestine.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Skin.
    5. "Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators."
      Moran J.A., Dahl E.L., Mulcahy R.T.
      Biochem. J. 361:371-377(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "The novel human gene MIP functions as a co-activator of hMafF."
      Ye X., Li Y., Huang Q., Yu Y., Yuan H., Wang P., Wan D., Gu J., Huo K., Li Y.-Y., Lu H.
      Arch. Biochem. Biophys. 449:87-93(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MIP.

    Entry informationi

    Entry nameiMAFF_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULX9
    Secondary accession number(s): B4DV49, Q9Y525
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3