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Protein

Transcription factor MafF

Gene

MAFF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32119-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiQ9ULX9.
SIGNORiQ9ULX9.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafF
Alternative name(s):
U-Maf
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
Gene namesi
Name:MAFF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6780. MAFF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23764.
OpenTargetsiENSG00000185022.
PharmGKBiPA30538.

Polymorphism and mutation databases

BioMutaiMAFF.
DMDMi21542145.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764971 – 164Transcription factor MafFAdd BLAST164

Proteomic databases

EPDiQ9ULX9.
PaxDbiQ9ULX9.
PeptideAtlasiQ9ULX9.
PRIDEiQ9ULX9.

PTM databases

iPTMnetiQ9ULX9.
PhosphoSitePlusiQ9ULX9.

Expressioni

Tissue specificityi

Expressed in the term myometrium and kidney.

Inductioni

By oxidative stress.1 Publication

Gene expression databases

BgeeiENSG00000185022.
CleanExiHS_MAFF.
ExpressionAtlasiQ9ULX9. baseline and differential.
GenevisibleiQ9ULX9. HS.

Organism-specific databases

HPAiCAB025341.
HPA055371.

Interactioni

Subunit structurei

Monomer and homo- or heterodimer. Interacts with MIP.1 Publication

Protein-protein interaction databases

BioGridi117264. 34 interactors.
IntActiQ9ULX9. 6 interactors.
MINTiMINT-1413410.
STRINGi9606.ENSP00000345393.

Structurei

3D structure databases

ProteinModelPortaliQ9ULX9.
SMRiQ9ULX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG41102C7. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiQ9ULX9.
KOiK09037.
OMAiHGPASCS.
OrthoDBiEOG091G0H46.
PhylomeDBiQ9ULX9.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR033531. MafF.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF25. PTHR10129:SF25. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM
110 120 130 140 150
RLELDALRGK CEALQGFARS VAAARGPATL VAPASVITIV KSTPGSGSGP
160
AHGPDPAHGP ASCS
Length:164
Mass (Da):17,760
Last modified:June 20, 2002 - v2
Checksum:iFC34D9FF317E5EE1
GO
Isoform 2 (identifier: Q9ULX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,569
Checksum:i54E949F996CCE45A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116G → A in BAA86871 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430291 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025247 mRNA. Translation: BAA86871.1.
AJ010857 mRNA. Translation: CAB52435.1.
AK002001 mRNA. Translation: BAA92029.1.
AK300932 mRNA. Translation: BAG62561.1.
AL021977 Genomic DNA. Translation: CAB45266.1.
BC015037 mRNA. Translation: AAH15037.1.
BC067751 mRNA. Translation: AAH67751.1.
CCDSiCCDS13968.1. [Q9ULX9-1]
CCDS54528.1. [Q9ULX9-2]
PIRiJC7112.
RefSeqiNP_001155044.1. NM_001161572.1. [Q9ULX9-1]
NP_001155045.1. NM_001161573.1. [Q9ULX9-1]
NP_001155046.1. NM_001161574.1. [Q9ULX9-2]
NP_036455.1. NM_012323.3. [Q9ULX9-1]
UniGeneiHs.517617.

Genome annotation databases

EnsembliENST00000338483; ENSP00000345393; ENSG00000185022. [Q9ULX9-1]
ENST00000407965; ENSP00000384094; ENSG00000185022. [Q9ULX9-1]
ENST00000426621; ENSP00000388882; ENSG00000185022. [Q9ULX9-1]
ENST00000538320; ENSP00000442060; ENSG00000185022. [Q9ULX9-1]
ENST00000538999; ENSP00000441482; ENSG00000185022. [Q9ULX9-2]
GeneIDi23764.
KEGGihsa:23764.
UCSCiuc003avc.4. human. [Q9ULX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025247 mRNA. Translation: BAA86871.1.
AJ010857 mRNA. Translation: CAB52435.1.
AK002001 mRNA. Translation: BAA92029.1.
AK300932 mRNA. Translation: BAG62561.1.
AL021977 Genomic DNA. Translation: CAB45266.1.
BC015037 mRNA. Translation: AAH15037.1.
BC067751 mRNA. Translation: AAH67751.1.
CCDSiCCDS13968.1. [Q9ULX9-1]
CCDS54528.1. [Q9ULX9-2]
PIRiJC7112.
RefSeqiNP_001155044.1. NM_001161572.1. [Q9ULX9-1]
NP_001155045.1. NM_001161573.1. [Q9ULX9-1]
NP_001155046.1. NM_001161574.1. [Q9ULX9-2]
NP_036455.1. NM_012323.3. [Q9ULX9-1]
UniGeneiHs.517617.

3D structure databases

ProteinModelPortaliQ9ULX9.
SMRiQ9ULX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117264. 34 interactors.
IntActiQ9ULX9. 6 interactors.
MINTiMINT-1413410.
STRINGi9606.ENSP00000345393.

PTM databases

iPTMnetiQ9ULX9.
PhosphoSitePlusiQ9ULX9.

Polymorphism and mutation databases

BioMutaiMAFF.
DMDMi21542145.

Proteomic databases

EPDiQ9ULX9.
PaxDbiQ9ULX9.
PeptideAtlasiQ9ULX9.
PRIDEiQ9ULX9.

Protocols and materials databases

DNASUi23764.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338483; ENSP00000345393; ENSG00000185022. [Q9ULX9-1]
ENST00000407965; ENSP00000384094; ENSG00000185022. [Q9ULX9-1]
ENST00000426621; ENSP00000388882; ENSG00000185022. [Q9ULX9-1]
ENST00000538320; ENSP00000442060; ENSG00000185022. [Q9ULX9-1]
ENST00000538999; ENSP00000441482; ENSG00000185022. [Q9ULX9-2]
GeneIDi23764.
KEGGihsa:23764.
UCSCiuc003avc.4. human. [Q9ULX9-1]

Organism-specific databases

CTDi23764.
DisGeNETi23764.
GeneCardsiMAFF.
HGNCiHGNC:6780. MAFF.
HPAiCAB025341.
HPA055371.
MIMi604877. gene.
neXtProtiNX_Q9ULX9.
OpenTargetsiENSG00000185022.
PharmGKBiPA30538.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG41102C7. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiQ9ULX9.
KOiK09037.
OMAiHGPASCS.
OrthoDBiEOG091G0H46.
PhylomeDBiQ9ULX9.
TreeFamiTF325689.

Enzyme and pathway databases

BioCyciZFISH:G66-32119-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiQ9ULX9.
SIGNORiQ9ULX9.

Miscellaneous databases

ChiTaRSiMAFF. human.
GeneWikiiMAFF_(gene).
GenomeRNAii23764.
PROiQ9ULX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185022.
CleanExiHS_MAFF.
ExpressionAtlasiQ9ULX9. baseline and differential.
GenevisibleiQ9ULX9. HS.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR033531. MafF.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF25. PTHR10129:SF25. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAFF_HUMAN
AccessioniPrimary (citable) accession number: Q9ULX9
Secondary accession number(s): B4DV49, Q9Y525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.