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Protein

RING finger protein 112

Gene

RNF112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 98RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 112
Alternative name(s):
Brain finger protein
Zinc finger protein 179
Gene namesi
Name:RNF112
Synonyms:BFP, ZNF179
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000128482.15
HGNCiHGNC:12968 RNF112
MIMi601237 gene
neXtProtiNX_Q9ULX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7732
OpenTargetsiENSG00000128482

Polymorphism and mutation databases

BioMutaiRNF112
DMDMi378405197

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563011 – 631RING finger protein 112Add BLAST631

Proteomic databases

EPDiQ9ULX5
PaxDbiQ9ULX5
PeptideAtlasiQ9ULX5
PRIDEiQ9ULX5

PTM databases

iPTMnetiQ9ULX5
PhosphoSitePlusiQ9ULX5

Expressioni

Tissue specificityi

Predominantly expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000128482
CleanExiHS_RNF112
ExpressionAtlasiQ9ULX5 baseline and differential
GenevisibleiQ9ULX5 HS

Organism-specific databases

HPAiHPA015970

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000454919

Structurei

3D structure databases

ProteinModelPortaliQ9ULX5
SMRiQ9ULX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 397GB1/RHD3-type GAdd BLAST232

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 98RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2037 Eukaryota
KOG2177 Eukaryota
ENOG410XR6Z LUCA
GeneTreeiENSGT00390000008959
HOVERGENiHBG056662
InParanoidiQ9ULX5
OMAiARDTPVC
OrthoDBiEOG091G0GYC

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02263 GBP, 1 hit
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPALSVTS FCHRLGKRER KQSFMGNSGN SWSHTPFPKL ELGLGPQPMA
60 70 80 90 100
PRELPTCSIC LERLRDPISL DCGHDFCIRC FSTHRLPGCE PPCCPECRKI
110 120 130 140 150
CKQKRGLRSL GEKMKLLPQR PLPPALQETC PVRAEPLLLV RINASGGLIL
160 170 180 190 200
RMGAINRCLK HPLARDTPVC LLAVLGEQHS GKSFLLNHLL QGLPGLESGE
210 220 230 240 250
GGRPRGGEAS LQGCRWGANG LARGIWMWSH PFLLGKEGKK VAVFLVDTGD
260 270 280 290 300
AMSPELSRET RIKLCALTTM LSSYQILSTS QELKDTDLDY LEMFVHVAEV
310 320 330 340 350
MGKHYGMVPI QHLDLLVRDS SHPNKAGQGH VGNIFQRLSG RYPKVQELLQ
360 370 380 390 400
GKRARCCLLP APGRRRMNQG HASPGDTDDD FRHLLGAYVS DVLSAAPQHA
410 420 430 440 450
KSRCQGYWNE GRAVARGDRR LLTGQQLAQE IKNLSGWMGR TGPGFTSPDE
460 470 480 490 500
MAAQLHDLRK VEAAKREFEE YVRQQDVATK RIFSALRVLP DTMRNLLSTQ
510 520 530 540 550
KDAILARHGV ALLCKGRDQT LEALEAELQA TAKAFMDSYT MRFCGHLAAV
560 570 580 590 600
GGAVGAGLMG LAGGVVGAGM AAAALAAEAG MVAAGAAVGA TGAAVVGGGV
610 620 630
GAGLAATVGC MEKEEDERLL EGDREPLLQE E
Length:631
Mass (Da):68,298
Last modified:February 22, 2012 - v2
Checksum:i770C4F33B1395954
GO
Isoform 2 (identifier: Q9ULX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-374: P → PG

Show »
Length:632
Mass (Da):68,355
Checksum:iF8D294815E65ED02
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042377374P → PG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026054 mRNA Translation: BAA84698.1
AC004448 Genomic DNA No translation available.
BC053989 mRNA Translation: AAH53989.1
AF054587 Genomic DNA Translation: AAC08584.1
CCDSiCCDS58529.1 [Q9ULX5-1]
PIRiJC7155
RefSeqiNP_009079.2, NM_007148.4 [Q9ULX5-1]
UniGeneiHs.189482

Genome annotation databases

EnsembliENST00000461366; ENSP00000454919; ENSG00000128482 [Q9ULX5-1]
GeneIDi7732
KEGGihsa:7732
UCSCiuc010vyw.3 human [Q9ULX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRN112_HUMAN
AccessioniPrimary (citable) accession number: Q9ULX5
Secondary accession number(s): O60633, Q7Z5V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 22, 2012
Last modified: February 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome