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Protein

RING finger protein 112

Gene

RNF112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 98RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: InterPro
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 112
Alternative name(s):
Brain finger protein
Zinc finger protein 179
Gene namesi
Name:RNF112
Synonyms:BFP, ZNF179
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12968. RNF112.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7732.
OpenTargetsiENSG00000128482.

Polymorphism and mutation databases

BioMutaiRNF112.
DMDMi378405197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563011 – 631RING finger protein 112Add BLAST631

Proteomic databases

PaxDbiQ9ULX5.
PRIDEiQ9ULX5.

PTM databases

iPTMnetiQ9ULX5.
PhosphoSitePlusiQ9ULX5.

Expressioni

Tissue specificityi

Predominantly expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000128482.
CleanExiHS_RNF112.
ExpressionAtlasiQ9ULX5. baseline and differential.
GenevisibleiQ9ULX5. HS.

Organism-specific databases

HPAiHPA015970.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000454919.

Structurei

3D structure databases

ProteinModelPortaliQ9ULX5.
SMRiQ9ULX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 397GB1/RHD3-type GAdd BLAST232

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 98RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
KOG2177. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOVERGENiHBG056662.
InParanoidiQ9ULX5.
OMAiMGAINRC.
OrthoDBiEOG091G0GYC.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPALSVTS FCHRLGKRER KQSFMGNSGN SWSHTPFPKL ELGLGPQPMA
60 70 80 90 100
PRELPTCSIC LERLRDPISL DCGHDFCIRC FSTHRLPGCE PPCCPECRKI
110 120 130 140 150
CKQKRGLRSL GEKMKLLPQR PLPPALQETC PVRAEPLLLV RINASGGLIL
160 170 180 190 200
RMGAINRCLK HPLARDTPVC LLAVLGEQHS GKSFLLNHLL QGLPGLESGE
210 220 230 240 250
GGRPRGGEAS LQGCRWGANG LARGIWMWSH PFLLGKEGKK VAVFLVDTGD
260 270 280 290 300
AMSPELSRET RIKLCALTTM LSSYQILSTS QELKDTDLDY LEMFVHVAEV
310 320 330 340 350
MGKHYGMVPI QHLDLLVRDS SHPNKAGQGH VGNIFQRLSG RYPKVQELLQ
360 370 380 390 400
GKRARCCLLP APGRRRMNQG HASPGDTDDD FRHLLGAYVS DVLSAAPQHA
410 420 430 440 450
KSRCQGYWNE GRAVARGDRR LLTGQQLAQE IKNLSGWMGR TGPGFTSPDE
460 470 480 490 500
MAAQLHDLRK VEAAKREFEE YVRQQDVATK RIFSALRVLP DTMRNLLSTQ
510 520 530 540 550
KDAILARHGV ALLCKGRDQT LEALEAELQA TAKAFMDSYT MRFCGHLAAV
560 570 580 590 600
GGAVGAGLMG LAGGVVGAGM AAAALAAEAG MVAAGAAVGA TGAAVVGGGV
610 620 630
GAGLAATVGC MEKEEDERLL EGDREPLLQE E
Length:631
Mass (Da):68,298
Last modified:February 22, 2012 - v2
Checksum:i770C4F33B1395954
GO
Isoform 2 (identifier: Q9ULX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-374: P → PG

Show »
Length:632
Mass (Da):68,355
Checksum:iF8D294815E65ED02
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042377374P → PG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026054 mRNA. Translation: BAA84698.1.
AC004448 Genomic DNA. No translation available.
BC053989 mRNA. Translation: AAH53989.1.
AF054587 Genomic DNA. Translation: AAC08584.1.
CCDSiCCDS58529.1. [Q9ULX5-1]
PIRiJC7155.
RefSeqiNP_009079.2. NM_007148.4. [Q9ULX5-1]
UniGeneiHs.189482.

Genome annotation databases

EnsembliENST00000461366; ENSP00000454919; ENSG00000128482. [Q9ULX5-1]
GeneIDi7732.
KEGGihsa:7732.
UCSCiuc010vyw.3. human. [Q9ULX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026054 mRNA. Translation: BAA84698.1.
AC004448 Genomic DNA. No translation available.
BC053989 mRNA. Translation: AAH53989.1.
AF054587 Genomic DNA. Translation: AAC08584.1.
CCDSiCCDS58529.1. [Q9ULX5-1]
PIRiJC7155.
RefSeqiNP_009079.2. NM_007148.4. [Q9ULX5-1]
UniGeneiHs.189482.

3D structure databases

ProteinModelPortaliQ9ULX5.
SMRiQ9ULX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000454919.

PTM databases

iPTMnetiQ9ULX5.
PhosphoSitePlusiQ9ULX5.

Polymorphism and mutation databases

BioMutaiRNF112.
DMDMi378405197.

Proteomic databases

PaxDbiQ9ULX5.
PRIDEiQ9ULX5.

Protocols and materials databases

DNASUi7732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000461366; ENSP00000454919; ENSG00000128482. [Q9ULX5-1]
GeneIDi7732.
KEGGihsa:7732.
UCSCiuc010vyw.3. human. [Q9ULX5-1]

Organism-specific databases

CTDi7732.
DisGeNETi7732.
GeneCardsiRNF112.
HGNCiHGNC:12968. RNF112.
HPAiHPA015970.
MIMi601237. gene.
neXtProtiNX_Q9ULX5.
OpenTargetsiENSG00000128482.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
KOG2177. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOVERGENiHBG056662.
InParanoidiQ9ULX5.
OMAiMGAINRC.
OrthoDBiEOG091G0GYC.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128482-MONOMER.

Miscellaneous databases

ChiTaRSiRNF112. human.
GenomeRNAii7732.
PROiQ9ULX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128482.
CleanExiHS_RNF112.
ExpressionAtlasiQ9ULX5. baseline and differential.
GenevisibleiQ9ULX5. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN112_HUMAN
AccessioniPrimary (citable) accession number: Q9ULX5
Secondary accession number(s): O60633, Q7Z5V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 22, 2012
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.