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Protein

RNA-binding protein NOB1

Gene

NOB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mRNA degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi270ZincBy similarity1
Metal bindingi273ZincBy similarity1
Metal bindingi285ZincBy similarity1
Metal bindingi288ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein NOB1
Alternative name(s):
Phosphorylation regulatory protein HP-10
Protein ART-4
Gene namesi
Name:NOB1
Synonyms:ART4, NOB1P, PSMD8BP1
ORF Names:MSTP158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000141101.12
HGNCiHGNC:29540 NOB1
MIMi613586 gene
neXtProtiNX_Q9ULX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi28987
OpenTargetsiENSG00000141101
PharmGKBiPA143485585

Polymorphism and mutation databases

DMDMi74753398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002332652 – 412RNA-binding protein NOB1Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULX3
MaxQBiQ9ULX3
PaxDbiQ9ULX3
PeptideAtlasiQ9ULX3
PRIDEiQ9ULX3

PTM databases

iPTMnetiQ9ULX3
PhosphoSitePlusiQ9ULX3

Expressioni

Tissue specificityi

Detected in liver, lung, placenta, endothelial cells and spleen.2 Publications

Gene expression databases

BgeeiENSG00000141101
CleanExiHS_ART4
HS_NOB1
ExpressionAtlasiQ9ULX3 baseline and differential
GenevisibleiQ9ULX3 HS

Organism-specific databases

HPAiHPA041522
HPA049430
HPA067411

Interactioni

Subunit structurei

Interacts with UPF2.1 Publication

Protein-protein interaction databases

BioGridi118808, 39 interactors
IntActiQ9ULX3, 14 interactors
STRINGi9606.ENSP00000268802

Structurei

3D structure databases

ProteinModelPortaliQ9ULX3
SMRiQ9ULX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 108PINcAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Poly-Glu7

Sequence similaritiesi

Belongs to the NOB1 family.Curated

Phylogenomic databases

eggNOGiKOG2463 Eukaryota
COG1439 LUCA
GeneTreeiENSGT00390000015857
HOGENOMiHOG000159692
HOVERGENiHBG057385
InParanoidiQ9ULX3
KOiK11883
OMAiPHLTEDQ
OrthoDBiEOG091G0C8H
PhylomeDBiQ9ULX3
TreeFamiTF105838

Family and domain databases

Gene3Di3.30.40.120, 1 hit
InterProiView protein in InterPro
IPR017117 Nob1_euk
IPR036283 NOB1_Zf-like_sf
IPR014881 NOB1_Zn-bd
IPR002716 PIN_dom
IPR033411 Ribonuclease_PIN
IPR033461 WRNPLPNID
PfamiView protein in Pfam
PF08772 NOB1_Zn_bind, 1 hit
PF17146 PIN_6, 1 hit
PF15017 WRNPLPNID, 1 hit
PIRSFiPIRSF037125 D-site_20S_pre-rRNA_nuclease, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF144206 SSF144206, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVEHVVAD AGAFLRHAAL QDIGKNIYTI REVVTEIRDK ATRRRLAVLP
60 70 80 90 100
YELRFKEPLP EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV
110 120 130 140 150
SHLKQEPQKV KVSSSIQHPE TPLHISGFHL PYKPKPPQET EKGHSACEPE
160 170 180 190 200
NLEFSSFMFW RNPLPNIDHE LQELLIDRGE DVPSEEEEEE ENGFEDRKDD
210 220 230 240 250
SDDDGGGWIT PSNIKQIQQE LEQCDVPEDV RVGCLTTDFA MQNVLLQMGL
260 270 280 290 300
HVLAVNGMLI REARSYILRC HGCFKTTSDM SRVFCSHCGN KTLKKVSVTV
310 320 330 340 350
SDDGTLHMHF SRNPKVLNPR GLRYSLPTPK GGKYAINPHL TEDQRFPQLR
360 370 380 390 400
LSQKARQKTN VFAPDYIAGV SPFVENDISS RSATLQVRDS TLGAGRRRLN
410
PNASRKKFVK KR
Length:412
Mass (Da):46,675
Last modified:May 1, 2000 - v1
Checksum:i369680A6DCFC7CB0
GO

Sequence cautioni

The sequence AAQ13705 differs from that shown. Reason: Frameshift at position 393.Curated
The sequence BAA91473 differs from that shown. Reason: Frameshift at position 87.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408F → L in AAQ13705 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050287231R → Q1 PublicationCorresponds to variant dbSNP:rs3811348Ensembl.1
Natural variantiVAR_050288366Y → F. Corresponds to variant dbSNP:rs1075935Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026125 mRNA Translation: BAA86961.1
AY487344 mRNA Translation: AAR85357.1
AK001028 mRNA Translation: BAA91473.1 Frameshift.
BC000050 mRNA Translation: AAH00050.2
BC064630 mRNA Translation: AAH64630.1
AF190161 mRNA Translation: AAQ13705.1 Frameshift.
CCDSiCCDS10884.1
PIRiA61382
RefSeqiNP_054781.1, NM_014062.2
UniGeneiHs.271695

Genome annotation databases

EnsembliENST00000268802; ENSP00000268802; ENSG00000141101
GeneIDi28987
KEGGihsa:28987
UCSCiuc002exs.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOB1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULX3
Secondary accession number(s): Q7L6B7
, Q7M4M4, Q7Z4B5, Q9NWB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health