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Protein

RNA-binding protein NOB1

Gene

NOB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mRNA degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi270 – 2701ZincBy similarity
Metal bindingi273 – 2731ZincBy similarity
Metal bindingi285 – 2851ZincBy similarity
Metal bindingi288 – 2881ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein NOB1
Alternative name(s):
Phosphorylation regulatory protein HP-10
Protein ART-4
Gene namesi
Name:NOB1
Synonyms:ART4, NOB1P, PSMD8BP1
ORF Names:MSTP158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29540. NOB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485585.

Polymorphism and mutation databases

DMDMi74753398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 412411RNA-binding protein NOB1PRO_0000233265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841PhosphoserineCombined sources
Modified residuei201 – 2011PhosphoserineCombined sources
Modified residuei325 – 3251PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULX3.
MaxQBiQ9ULX3.
PaxDbiQ9ULX3.
PeptideAtlasiQ9ULX3.
PRIDEiQ9ULX3.

PTM databases

iPTMnetiQ9ULX3.
PhosphoSiteiQ9ULX3.

Expressioni

Tissue specificityi

Detected in liver, lung, placenta, endothelial cells and spleen.2 Publications

Gene expression databases

BgeeiENSG00000141101.
CleanExiHS_ART4.
HS_NOB1.
ExpressionAtlasiQ9ULX3. baseline and differential.
GenevisibleiQ9ULX3. HS.

Organism-specific databases

HPAiHPA041522.
HPA049430.
HPA067411.

Interactioni

Subunit structurei

Interacts with UPF2.1 Publication

Protein-protein interaction databases

BioGridi118808. 36 interactions.
IntActiQ9ULX3. 11 interactions.
MINTiMINT-4533498.
STRINGi9606.ENSP00000268802.

Structurei

3D structure databases

ProteinModelPortaliQ9ULX3.
SMRiQ9ULX3. Positions 7-96, 260-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 108104PINcAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 1917Poly-Glu

Sequence similaritiesi

Belongs to the NOB1 family.Curated
Contains 1 PINc domain.Curated

Phylogenomic databases

eggNOGiKOG2463. Eukaryota.
COG1439. LUCA.
GeneTreeiENSGT00390000015857.
HOGENOMiHOG000159692.
HOVERGENiHBG057385.
InParanoidiQ9ULX3.
KOiK11883.
OMAiLHINWNR.
OrthoDBiEOG091G0C8H.
PhylomeDBiQ9ULX3.
TreeFamiTF105838.

Family and domain databases

InterProiIPR014881. NOB1_Zn-bd.
IPR002716. PIN_dom.
IPR033411. Ribonuclease_PIN.
IPR033461. WRNPLPNID.
[Graphical view]
PfamiPF08772. NOB1_Zn_bind. 1 hit.
PF17146. PIN_6. 1 hit.
PF15017. WRNPLPNID. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF144206. SSF144206. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVEHVVAD AGAFLRHAAL QDIGKNIYTI REVVTEIRDK ATRRRLAVLP
60 70 80 90 100
YELRFKEPLP EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV
110 120 130 140 150
SHLKQEPQKV KVSSSIQHPE TPLHISGFHL PYKPKPPQET EKGHSACEPE
160 170 180 190 200
NLEFSSFMFW RNPLPNIDHE LQELLIDRGE DVPSEEEEEE ENGFEDRKDD
210 220 230 240 250
SDDDGGGWIT PSNIKQIQQE LEQCDVPEDV RVGCLTTDFA MQNVLLQMGL
260 270 280 290 300
HVLAVNGMLI REARSYILRC HGCFKTTSDM SRVFCSHCGN KTLKKVSVTV
310 320 330 340 350
SDDGTLHMHF SRNPKVLNPR GLRYSLPTPK GGKYAINPHL TEDQRFPQLR
360 370 380 390 400
LSQKARQKTN VFAPDYIAGV SPFVENDISS RSATLQVRDS TLGAGRRRLN
410
PNASRKKFVK KR
Length:412
Mass (Da):46,675
Last modified:May 1, 2000 - v1
Checksum:i369680A6DCFC7CB0
GO

Sequence cautioni

The sequence AAQ13705 differs from that shown. Reason: Frameshift at position 393. Curated
The sequence BAA91473 differs from that shown. Reason: Frameshift at position 87. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti408 – 4081F → L in AAQ13705 (Ref. 6) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti231 – 2311R → Q.1 Publication
Corresponds to variant rs3811348 [ dbSNP | Ensembl ].
VAR_050287
Natural varianti366 – 3661Y → F.
Corresponds to variant rs1075935 [ dbSNP | Ensembl ].
VAR_050288

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026125 mRNA. Translation: BAA86961.1.
AY487344 mRNA. Translation: AAR85357.1.
AK001028 mRNA. Translation: BAA91473.1. Frameshift.
BC000050 mRNA. Translation: AAH00050.2.
BC064630 mRNA. Translation: AAH64630.1.
AF190161 mRNA. Translation: AAQ13705.1. Frameshift.
CCDSiCCDS10884.1.
PIRiA61382.
RefSeqiNP_054781.1. NM_014062.2.
UniGeneiHs.271695.

Genome annotation databases

EnsembliENST00000268802; ENSP00000268802; ENSG00000141101.
GeneIDi28987.
KEGGihsa:28987.
UCSCiuc002exs.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026125 mRNA. Translation: BAA86961.1.
AY487344 mRNA. Translation: AAR85357.1.
AK001028 mRNA. Translation: BAA91473.1. Frameshift.
BC000050 mRNA. Translation: AAH00050.2.
BC064630 mRNA. Translation: AAH64630.1.
AF190161 mRNA. Translation: AAQ13705.1. Frameshift.
CCDSiCCDS10884.1.
PIRiA61382.
RefSeqiNP_054781.1. NM_014062.2.
UniGeneiHs.271695.

3D structure databases

ProteinModelPortaliQ9ULX3.
SMRiQ9ULX3. Positions 7-96, 260-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118808. 36 interactions.
IntActiQ9ULX3. 11 interactions.
MINTiMINT-4533498.
STRINGi9606.ENSP00000268802.

PTM databases

iPTMnetiQ9ULX3.
PhosphoSiteiQ9ULX3.

Polymorphism and mutation databases

DMDMi74753398.

Proteomic databases

EPDiQ9ULX3.
MaxQBiQ9ULX3.
PaxDbiQ9ULX3.
PeptideAtlasiQ9ULX3.
PRIDEiQ9ULX3.

Protocols and materials databases

DNASUi28987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268802; ENSP00000268802; ENSG00000141101.
GeneIDi28987.
KEGGihsa:28987.
UCSCiuc002exs.5. human.

Organism-specific databases

CTDi28987.
GeneCardsiNOB1.
HGNCiHGNC:29540. NOB1.
HPAiHPA041522.
HPA049430.
HPA067411.
MIMi613586. gene.
neXtProtiNX_Q9ULX3.
PharmGKBiPA143485585.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2463. Eukaryota.
COG1439. LUCA.
GeneTreeiENSGT00390000015857.
HOGENOMiHOG000159692.
HOVERGENiHBG057385.
InParanoidiQ9ULX3.
KOiK11883.
OMAiLHINWNR.
OrthoDBiEOG091G0C8H.
PhylomeDBiQ9ULX3.
TreeFamiTF105838.

Enzyme and pathway databases

ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiNOB1. human.
GeneWikiiNOB1.
GenomeRNAii28987.
PROiQ9ULX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141101.
CleanExiHS_ART4.
HS_NOB1.
ExpressionAtlasiQ9ULX3. baseline and differential.
GenevisibleiQ9ULX3. HS.

Family and domain databases

InterProiIPR014881. NOB1_Zn-bd.
IPR002716. PIN_dom.
IPR033411. Ribonuclease_PIN.
IPR033461. WRNPLPNID.
[Graphical view]
PfamiPF08772. NOB1_Zn_bind. 1 hit.
PF17146. PIN_6. 1 hit.
PF15017. WRNPLPNID. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF144206. SSF144206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOB1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULX3
Secondary accession number(s): Q7L6B7
, Q7M4M4, Q7Z4B5, Q9NWB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.