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Q9ULW8

- PADI3_HUMAN

UniProt

Q9ULW8 - PADI3_HUMAN

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Protein

Protein-arginine deiminase type-3

Gene

PADI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

Calcium.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein-arginine deiminase activity Source: ProtInc

GO - Biological processi

  1. protein citrullination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciMetaCyc:HS06944-MONOMER.
BRENDAi3.5.3.15. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene namesi
Name:PADI3
Synonyms:PDI3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18337. PADI3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Protein-arginine deiminase type-3PRO_0000220029Add
BLAST

Proteomic databases

MaxQBiQ9ULW8.
PaxDbiQ9ULW8.
PeptideAtlasiQ9ULW8.
PRIDEiQ9ULW8.

PTM databases

PhosphoSiteiQ9ULW8.

Expressioni

Tissue specificityi

Hair follicles, and epidermis at very low levels.

Gene expression databases

BgeeiQ9ULW8.
CleanExiHS_PADI3.
GenevestigatoriQ9ULW8.

Organism-specific databases

HPAiHPA043739.

Interactioni

Protein-protein interaction databases

BioGridi119686. 6 interactions.
STRINGi9606.ENSP00000364609.

Structurei

3D structure databases

ProteinModelPortaliQ9ULW8.
SMRiQ9ULW8. Positions 6-664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiNOG42085.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9ULW8.
KOiK01481.
OMAiMSLQRIV.
OrthoDBiEOG7P5T09.
PhylomeDBiQ9ULW8.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ULW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLQRIVRVS LEHPTSAVCV AGVETLVDIY GSVPEGTEMF EVYGTPGVDI
60 70 80 90 100
YISPNMERGR ERADTRRWRF DATLEIIVVM NSPSNDLNDS HVQISYHSSH
110 120 130 140 150
EPLPLAYAVL YLTCVDISLD CDLNCEGRQD RNFVDKRQWV WGPSGYGGIL
160 170 180 190 200
LVNCDRDDPS CDVQDNCDQH VHCLQDLEDM SVMVLRTQGP AALFDDHKLV
210 220 230 240 250
LHTSSYDAKR AQVFHICGPE DVCEAYRHVL GQDKVSYEVP RLHGDEERFF
260 270 280 290 300
VEGLSFPDAG FTGLISFHVT LLDDSNEDFS ASPIFTDTVV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CRVRNNTCFV DAVAELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYVQAP HKTLPVVFDS PRNGELQDFP YKRILGPDFG YVTREPRDRS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSSGR RVTQVVRDFL
460 470 480 490 500
HAQKVQPPVE LFVDWLAVGH VDEFLSFVPA PDGKGFRMLL ASPGACFKLF
510 520 530 540 550
QEKQKCGHGR ALLFQGVVDD EQVKTISINQ VLSNKDLINY NKFVQSCIDW
560 570 580 590 600
NREVLKRELG LAECDIIDIP QLFKTERKKA TAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGC CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
CRKPFSFKWW NMVP
Length:664
Mass (Da):74,743
Last modified:December 21, 2004 - v2
Checksum:i90C22A50BF6FD480
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti480 – 4801A → V in BAA85974. (PubMed:11069618)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521I → V.
Corresponds to variant rs3750300 [ dbSNP | Ensembl ].
VAR_020462
Natural varianti171 – 1711V → M.
Corresponds to variant rs2272629 [ dbSNP | Ensembl ].
VAR_020463
Natural varianti509 – 5091G → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035502
Natural varianti582 – 5821A → T.
Corresponds to variant rs34097903 [ dbSNP | Ensembl ].
VAR_053558
Natural varianti618 – 6181R → Q.
Corresponds to variant rs35624745 [ dbSNP | Ensembl ].
VAR_053559

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026831 mRNA. Translation: BAA85974.1.
AJ549502 Genomic DNA. Translation: CAE47742.1.
AL590644 Genomic DNA. Translation: CAH73166.1.
BC041592 mRNA. Translation: AAH41592.1.
BC109091 mRNA. Translation: AAI09092.1.
BC109092 mRNA. Translation: AAI09093.1.
CCDSiCCDS179.1.
RefSeqiNP_057317.2. NM_016233.2.
UniGeneiHs.149195.

Genome annotation databases

EnsembliENST00000375460; ENSP00000364609; ENSG00000142619.
GeneIDi51702.
KEGGihsa:51702.
UCSCiuc001bai.3. human.

Polymorphism databases

DMDMi56757696.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026831 mRNA. Translation: BAA85974.1 .
AJ549502 Genomic DNA. Translation: CAE47742.1 .
AL590644 Genomic DNA. Translation: CAH73166.1 .
BC041592 mRNA. Translation: AAH41592.1 .
BC109091 mRNA. Translation: AAI09092.1 .
BC109092 mRNA. Translation: AAI09093.1 .
CCDSi CCDS179.1.
RefSeqi NP_057317.2. NM_016233.2.
UniGenei Hs.149195.

3D structure databases

ProteinModelPortali Q9ULW8.
SMRi Q9ULW8. Positions 6-664.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119686. 6 interactions.
STRINGi 9606.ENSP00000364609.

Chemistry

BindingDBi Q9ULW8.
ChEMBLi CHEMBL1909488.
DrugBanki DB00155. L-Citrulline.

PTM databases

PhosphoSitei Q9ULW8.

Polymorphism databases

DMDMi 56757696.

Proteomic databases

MaxQBi Q9ULW8.
PaxDbi Q9ULW8.
PeptideAtlasi Q9ULW8.
PRIDEi Q9ULW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375460 ; ENSP00000364609 ; ENSG00000142619 .
GeneIDi 51702.
KEGGi hsa:51702.
UCSCi uc001bai.3. human.

Organism-specific databases

CTDi 51702.
GeneCardsi GC01P017575.
HGNCi HGNC:18337. PADI3.
HPAi HPA043739.
MIMi 606755. gene.
neXtProti NX_Q9ULW8.
PharmGKBi PA32901.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42085.
GeneTreei ENSGT00390000008680.
HOGENOMi HOG000220908.
HOVERGENi HBG053016.
InParanoidi Q9ULW8.
KOi K01481.
OMAi MSLQRIV.
OrthoDBi EOG7P5T09.
PhylomeDBi Q9ULW8.
TreeFami TF331952.

Enzyme and pathway databases

BioCyci MetaCyc:HS06944-MONOMER.
BRENDAi 3.5.3.15. 2681.

Miscellaneous databases

GeneWikii PADI3.
GenomeRNAii 51702.
NextBioi 55728.
PROi Q9ULW8.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULW8.
CleanExi HS_PADI3.
Genevestigatori Q9ULW8.

Family and domain databases

InterProi IPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
IPR016296. Protein-arginine_deiminase_sub.
[Graphical view ]
PANTHERi PTHR10837. PTHR10837. 1 hit.
Pfami PF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMi SSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin."
    Kanno T., Kawada A., Yamanouchi J., Yosida-Noro C., Yoshiki A., Shiraiwa M., Kusakabe M., Manabe M., Tezuka T., Takahara H.
    J. Invest. Dermatol. 115:813-823(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Keratinocyte.
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
    Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
    Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-509.

Entry informationi

Entry nameiPADI3_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW8
Secondary accession number(s): Q58EY7, Q70SX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3