ID   NP1L2_HUMAN             Reviewed;         460 AA.
AC   Q9ULW6; B2RE61; B4E161; Q8TAN6;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=Nucleosome assembly protein 1-like 2;
DE   AltName: Full=Brain-specific protein, X-linked;
GN   Name=NAP1L2; Synonyms=BPX;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N.,
RA   Saito T.;
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Li N.G., Yu L., Zhao S.Y.;
RT   "Cloning of a new human cDNA homologous to Mus musculus Bpx protein.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Kidney, and Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acidic protein which may be involved in interactions with
CC       other proteins or DNA. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9ULW6; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-3911716, EBI-10749669;
CC       Q9ULW6; Q8N715: CCDC185; NbExp=3; IntAct=EBI-3911716, EBI-740814;
CC       Q9ULW6; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-3911716, EBI-399105;
CC       Q9ULW6; Q8TBF8: FAM81A; NbExp=3; IntAct=EBI-3911716, EBI-11993062;
CC       Q9ULW6; P42858: HTT; NbExp=3; IntAct=EBI-3911716, EBI-466029;
CC       Q9ULW6; O95198: KLHL2; NbExp=3; IntAct=EBI-3911716, EBI-746999;
CC       Q9ULW6; Q96HR3: MED30; NbExp=3; IntAct=EBI-3911716, EBI-394659;
CC       Q9ULW6; P55209: NAP1L1; NbExp=3; IntAct=EBI-3911716, EBI-356392;
CC       Q9ULW6; Q99457: NAP1L3; NbExp=3; IntAct=EBI-3911716, EBI-8645631;
CC       Q9ULW6; Q96NT1: NAP1L5; NbExp=5; IntAct=EBI-3911716, EBI-713627;
CC       Q9ULW6; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-3911716, EBI-1105153;
CC       Q9ULW6; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-3911716, EBI-748391;
CC       Q9ULW6; O60239: SH3BP5; NbExp=3; IntAct=EBI-3911716, EBI-624860;
CC       Q9ULW6; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-3911716, EBI-11952721;
CC       Q9ULW6; PRO_0000037551 [Q9WMX2]; Xeno; NbExp=2; IntAct=EBI-3911716, EBI-6863748;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ULW6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ULW6-2; Sequence=VSP_057064;
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
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DR   EMBL; AB027013; BAA84706.1; -; mRNA.
DR   EMBL; AF136178; AAP97268.1; -; mRNA.
DR   EMBL; CR457095; CAG33376.1; -; mRNA.
DR   EMBL; AK303676; BAG64673.1; -; mRNA.
DR   EMBL; AK316569; BAG38158.1; -; mRNA.
DR   EMBL; AC004074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471104; EAW98670.1; -; Genomic_DNA.
DR   EMBL; BC026325; AAH26325.1; -; mRNA.
DR   CCDS; CCDS14423.1; -. [Q9ULW6-1]
DR   RefSeq; NP_068798.1; NM_021963.3. [Q9ULW6-1]
DR   AlphaFoldDB; Q9ULW6; -.
DR   SMR; Q9ULW6; -.
DR   BioGRID; 110755; 37.
DR   IntAct; Q9ULW6; 21.
DR   STRING; 9606.ENSP00000362616; -.
DR   iPTMnet; Q9ULW6; -.
DR   PhosphoSitePlus; Q9ULW6; -.
DR   BioMuta; NAP1L2; -.
DR   DMDM; 22256943; -.
DR   EPD; Q9ULW6; -.
DR   jPOST; Q9ULW6; -.
DR   MassIVE; Q9ULW6; -.
DR   PaxDb; 9606-ENSP00000362616; -.
DR   PeptideAtlas; Q9ULW6; -.
DR   ProteomicsDB; 5729; -.
DR   ProteomicsDB; 85143; -. [Q9ULW6-1]
DR   Antibodypedia; 27991; 155 antibodies from 20 providers.
DR   DNASU; 4674; -.
DR   Ensembl; ENST00000373517.4; ENSP00000362616.3; ENSG00000186462.9. [Q9ULW6-1]
DR   GeneID; 4674; -.
DR   KEGG; hsa:4674; -.
DR   MANE-Select; ENST00000373517.4; ENSP00000362616.3; NM_021963.4; NP_068798.1.
DR   UCSC; uc004ebi.4; human. [Q9ULW6-1]
DR   AGR; HGNC:7638; -.
DR   CTD; 4674; -.
DR   DisGeNET; 4674; -.
DR   GeneCards; NAP1L2; -.
DR   HGNC; HGNC:7638; NAP1L2.
DR   HPA; ENSG00000186462; Tissue enriched (brain).
DR   MIM; 300026; gene.
DR   neXtProt; NX_Q9ULW6; -.
DR   OpenTargets; ENSG00000186462; -.
DR   PharmGKB; PA31440; -.
DR   VEuPathDB; HostDB:ENSG00000186462; -.
DR   eggNOG; KOG1507; Eukaryota.
DR   GeneTree; ENSGT00940000163372; -.
DR   HOGENOM; CLU_038841_3_1_1; -.
DR   InParanoid; Q9ULW6; -.
DR   OMA; WMAAIEE; -.
DR   OrthoDB; 25866at2759; -.
DR   PhylomeDB; Q9ULW6; -.
DR   TreeFam; TF314349; -.
DR   PathwayCommons; Q9ULW6; -.
DR   SignaLink; Q9ULW6; -.
DR   BioGRID-ORCS; 4674; 9 hits in 772 CRISPR screens.
DR   GenomeRNAi; 4674; -.
DR   Pharos; Q9ULW6; Tbio.
DR   PRO; PR:Q9ULW6; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q9ULW6; Protein.
DR   Bgee; ENSG00000186462; Expressed in endothelial cell and 168 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0035034; F:histone acetyltransferase regulator activity; IEA:Ensembl.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR   GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:2000035; P:regulation of stem cell division; IEA:Ensembl.
DR   Gene3D; 1.20.5.1500; -; 1.
DR   Gene3D; 3.30.1120.90; Nucleosome assembly protein; 1.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875:SF36; NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 2; 1.
DR   PANTHER; PTHR11875; TESTIS-SPECIFIC Y-ENCODED PROTEIN; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; NAP-like; 1.
DR   Genevisible; Q9ULW6; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Nucleus; Reference proteome.
FT   CHAIN           1..460
FT                   /note="Nucleosome assembly protein 1-like 2"
FT                   /id="PRO_0000185655"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           346..352
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..230
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..142
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_057064"
FT   CONFLICT        3
FT                   /note="E -> K (in Ref. 7; AAH26325)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   460 AA;  52542 MW;  36BE77964B5096C6 CRC64;
     MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE AAAGLGEEGE
     NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF VESLPVKVKY RVLALKKLQT
     RAANLESKFL REFHDIERKF AEMYQPLLEK RRQIINAIYE PTEEECEYKS DSEDCDDEEM
     CHEEMYGNEE GMVHEYVDED DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI
     PDFWLTVLKN VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE
     LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ KHRIWGTIRT
     VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI IPRSVLFFSG DALESQQEGV
     VREVNDAIYD KIIYDNWMAA IEEVKACCKN LEALVEDIDR
//