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Q9ULW6 (NP1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleosome assembly protein 1-like 2
Alternative name(s):
Brain-specific protein, X-linked
Gene names
Name:NAP1L2
Synonyms:BPX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acidic protein which may be involved in interactions with other proteins or DNA By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the nucleosome assembly protein (NAP) family.

Ontologies

Keywords
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnucleosome assembly

Traceable author statement PubMed 8789438. Source: ProtInc

   Cellular_componentnucleus

Traceable author statement PubMed 8789438. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9WMX22EBI-3911716,EBI-6863748From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Nucleosome assembly protein 1-like 2
PRO_0000185655

Regions

Motif346 – 3527Nuclear localization signal Potential
Compositional bias160 – 23576Glu-rich (acidic)

Experimental info

Sequence conflict31E → K in AAH26325. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9ULW6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 36BE77964B5096C6

FASTA46052,542
        10         20         30         40         50         60 
MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE AAAGLGEEGE 

        70         80         90        100        110        120 
NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF VESLPVKVKY RVLALKKLQT 

       130        140        150        160        170        180 
RAANLESKFL REFHDIERKF AEMYQPLLEK RRQIINAIYE PTEEECEYKS DSEDCDDEEM 

       190        200        210        220        230        240 
CHEEMYGNEE GMVHEYVDED DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI 

       250        260        270        280        290        300 
PDFWLTVLKN VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE 

       310        320        330        340        350        360 
LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ KHRIWGTIRT 

       370        380        390        400        410        420 
VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI IPRSVLFFSG DALESQQEGV 

       430        440        450        460 
VREVNDAIYD KIIYDNWMAA IEEVKACCKN LEALVEDIDR 

« Hide

References

« Hide 'large scale' references
[1]Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of a new human cDNA homologous to Mus musculus Bpx protein."
Li N.G., Yu L., Zhao S.Y.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027013 mRNA. Translation: BAA84706.1.
AF136178 mRNA. Translation: AAP97268.1.
CR457095 mRNA. Translation: CAG33376.1.
AK316569 mRNA. Translation: BAG38158.1.
CH471104 Genomic DNA. Translation: EAW98670.1.
BC026325 mRNA. Translation: AAH26325.1.
RefSeqNP_068798.1. NM_021963.3.
UniGeneHs.66180.
Hs.740565.

3D structure databases

ProteinModelPortalQ9ULW6.
SMRQ9ULW6. Positions 86-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110755. 4 interactions.
IntActQ9ULW6. 2 interactions.
MINTMINT-150103.
STRING9606.ENSP00000362616.

PTM databases

PhosphoSiteQ9ULW6.

Polymorphism databases

DMDM22256943.

Proteomic databases

PaxDbQ9ULW6.
PRIDEQ9ULW6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373517; ENSP00000362616; ENSG00000186462.
GeneID4674.
KEGGhsa:4674.
UCSCuc004ebi.3. human.

Organism-specific databases

CTD4674.
GeneCardsGC0XM072348.
HGNCHGNC:7638. NAP1L2.
HPAHPA057065.
MIM300026. gene.
neXtProtNX_Q9ULW6.
PharmGKBPA31440.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248175.
HOGENOMHOG000171827.
HOVERGENHBG052653.
InParanoidQ9ULW6.
KOK11280.
OMAWMAAIEE.
OrthoDBEOG73Z2T8.
PhylomeDBQ9ULW6.
TreeFamTF314349.

Gene expression databases

ArrayExpressQ9ULW6.
BgeeQ9ULW6.
CleanExHS_NAP1L2.
GenevestigatorQ9ULW6.

Family and domain databases

InterProIPR002164. NAP_family.
[Graphical view]
PANTHERPTHR11875. PTHR11875. 1 hit.
PfamPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4674.
NextBio18016.
PROQ9ULW6.
SOURCESearch...

Entry information

Entry nameNP1L2_HUMAN
AccessionPrimary (citable) accession number: Q9ULW6
Secondary accession number(s): B2RE61, Q8TAN6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM