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Q9ULW6

- NP1L2_HUMAN

UniProt

Q9ULW6 - NP1L2_HUMAN

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Protein

Nucleosome assembly protein 1-like 2

Gene

NAP1L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acidic protein which may be involved in interactions with other proteins or DNA.By similarity

GO - Molecular functioni

  1. chromatin binding Source: Ensembl

GO - Biological processi

  1. nucleosome assembly Source: ProtInc
  2. positive regulation of histone H3-K14 acetylation Source: Ensembl
  3. positive regulation of histone H3-K9 acetylation Source: Ensembl
  4. positive regulation of neuron differentiation Source: Ensembl
  5. regulation of stem cell division Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 2
Alternative name(s):
Brain-specific protein, X-linked
Gene namesi
Name:NAP1L2
Synonyms:BPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:7638. NAP1L2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Nucleosome assembly protein 1-like 2PRO_0000185655Add
BLAST

Proteomic databases

PaxDbiQ9ULW6.
PRIDEiQ9ULW6.

PTM databases

PhosphoSiteiQ9ULW6.

Expressioni

Gene expression databases

BgeeiQ9ULW6.
CleanExiHS_NAP1L2.
ExpressionAtlasiQ9ULW6. baseline and differential.
GenevestigatoriQ9ULW6.

Organism-specific databases

HPAiHPA057065.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-3911716,EBI-6863748From a different organism.

Protein-protein interaction databases

BioGridi110755. 5 interactions.
IntActiQ9ULW6. 2 interactions.
MINTiMINT-150103.
STRINGi9606.ENSP00000362616.

Structurei

3D structure databases

ProteinModelPortaliQ9ULW6.
SMRiQ9ULW6. Positions 86-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi346 – 3527Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi160 – 23576Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG248175.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ9ULW6.
KOiK11280.
OMAiWMAAIEE.
OrthoDBiEOG73Z2T8.
PhylomeDBiQ9ULW6.
TreeFamiTF314349.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULW6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE
60 70 80 90 100
AAAGLGEEGE NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF
110 120 130 140 150
VESLPVKVKY RVLALKKLQT RAANLESKFL REFHDIERKF AEMYQPLLEK
160 170 180 190 200
RRQIINAIYE PTEEECEYKS DSEDCDDEEM CHEEMYGNEE GMVHEYVDED
210 220 230 240 250
DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI PDFWLTVLKN
260 270 280 290 300
VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE
310 320 330 340 350
LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ
360 370 380 390 400
KHRIWGTIRT VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI
410 420 430 440 450
IPRSVLFFSG DALESQQEGV VREVNDAIYD KIIYDNWMAA IEEVKACCKN
460
LEALVEDIDR
Length:460
Mass (Da):52,542
Last modified:May 1, 2000 - v1
Checksum:i36BE77964B5096C6
GO
Isoform 2 (identifier: Q9ULW6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Note: No experimental confirmation available

Show »
Length:318
Mass (Da):37,312
Checksum:iB1975362947CD836
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31E → K in AAH26325. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 142142Missing in isoform 2. 1 PublicationVSP_057064Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027013 mRNA. Translation: BAA84706.1.
AF136178 mRNA. Translation: AAP97268.1.
CR457095 mRNA. Translation: CAG33376.1.
AK303676 mRNA. Translation: BAG64673.1.
AK316569 mRNA. Translation: BAG38158.1.
AC004074 Genomic DNA. No translation available.
CH471104 Genomic DNA. Translation: EAW98670.1.
BC026325 mRNA. Translation: AAH26325.1.
CCDSiCCDS14423.1.
RefSeqiNP_068798.1. NM_021963.3.
UniGeneiHs.66180.
Hs.740565.

Genome annotation databases

EnsembliENST00000373517; ENSP00000362616; ENSG00000186462.
GeneIDi4674.
KEGGihsa:4674.
UCSCiuc004ebi.3. human.

Polymorphism databases

DMDMi22256943.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027013 mRNA. Translation: BAA84706.1 .
AF136178 mRNA. Translation: AAP97268.1 .
CR457095 mRNA. Translation: CAG33376.1 .
AK303676 mRNA. Translation: BAG64673.1 .
AK316569 mRNA. Translation: BAG38158.1 .
AC004074 Genomic DNA. No translation available.
CH471104 Genomic DNA. Translation: EAW98670.1 .
BC026325 mRNA. Translation: AAH26325.1 .
CCDSi CCDS14423.1.
RefSeqi NP_068798.1. NM_021963.3.
UniGenei Hs.66180.
Hs.740565.

3D structure databases

ProteinModelPortali Q9ULW6.
SMRi Q9ULW6. Positions 86-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110755. 5 interactions.
IntActi Q9ULW6. 2 interactions.
MINTi MINT-150103.
STRINGi 9606.ENSP00000362616.

PTM databases

PhosphoSitei Q9ULW6.

Polymorphism databases

DMDMi 22256943.

Proteomic databases

PaxDbi Q9ULW6.
PRIDEi Q9ULW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373517 ; ENSP00000362616 ; ENSG00000186462 .
GeneIDi 4674.
KEGGi hsa:4674.
UCSCi uc004ebi.3. human.

Organism-specific databases

CTDi 4674.
GeneCardsi GC0XM072348.
HGNCi HGNC:7638. NAP1L2.
HPAi HPA057065.
MIMi 300026. gene.
neXtProti NX_Q9ULW6.
PharmGKBi PA31440.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248175.
GeneTreei ENSGT00480000042668.
HOGENOMi HOG000171827.
HOVERGENi HBG052653.
InParanoidi Q9ULW6.
KOi K11280.
OMAi WMAAIEE.
OrthoDBi EOG73Z2T8.
PhylomeDBi Q9ULW6.
TreeFami TF314349.

Miscellaneous databases

GenomeRNAii 4674.
NextBioi 18016.
PROi Q9ULW6.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULW6.
CleanExi HS_NAP1L2.
ExpressionAtlasi Q9ULW6. baseline and differential.
Genevestigatori Q9ULW6.

Family and domain databases

InterProi IPR002164. NAP_family.
[Graphical view ]
PANTHERi PTHR11875. PTHR11875. 1 hit.
Pfami PF00956. NAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of a new human cDNA homologous to Mus musculus Bpx protein."
    Li N.G., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Thymus.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiNP1L2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW6
Secondary accession number(s): B2RE61, B4E161, Q8TAN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3