Q9ULW6 (NP1L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleosome assembly protein 1-like 2

Alternative name(s):
Brain-specific protein, X-linked

Gene names

Name:	NAP1L2
Synonyms:	BPX

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acidic protein which may be involved in interactions with other proteins or DNA By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the nucleosome assembly protein (NAP) family.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleosome assembly Traceable author statement PubMed 8789438. Source: ProtInc
Cellular_component	nucleus Traceable author statement PubMed 8789438. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Nucleosome assembly protein 1-like 2		PRO_0000185655
Regions
	Motif	346 – 352	7	Nuclear localization signal Potential
	Compositional bias	160 – 235	76	Glu-rich (acidic)
Experimental info
	Sequence conflict	3	1	E → K in AAH26325. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q9ULW6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 36BE77964B5096C6	FASTA	460	52,542
	10 20 30 40 50 60 MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE AAAGLGEEGE 70 80 90 100 110 120 NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF VESLPVKVKY RVLALKKLQT 130 140 150 160 170 180 RAANLESKFL REFHDIERKF AEMYQPLLEK RRQIINAIYE PTEEECEYKS DSEDCDDEEM 190 200 210 220 230 240 CHEEMYGNEE GMVHEYVDED DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI 250 260 270 280 290 300 PDFWLTVLKN VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE 310 320 330 340 350 360 LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ KHRIWGTIRT 370 380 390 400 410 420 VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI IPRSVLFFSG DALESQQEGV 430 440 450 460 VREVNDAIYD KIIYDNWMAA IEEVKACCKN LEALVEDIDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of a new human cDNA homologous to Mus musculus Bpx protein." Li N.G., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB027013 mRNA. Translation: BAA84706.1. AF136178 mRNA. Translation: AAP97268.1. CR457095 mRNA. Translation: CAG33376.1. AK316569 mRNA. Translation: BAG38158.1. CH471104 Genomic DNA. Translation: EAW98670.1. BC026325 mRNA. Translation: AAH26325.1.
IPI	IPI00030392.
RefSeq	NP_068798.1. NM_021963.3.
UniGene	Hs.66180. Hs.740565.
3D structure databases
ProteinModelPortal	Q9ULW6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULW6. 1 interaction.
MINT	MINT-150103.
STRING	9606.ENSP00000362616.
PTM databases
PhosphoSite	Q9ULW6.
Polymorphism databases
DMDM	22256943.
Proteomic databases
PaxDb	Q9ULW6.
PRIDE	Q9ULW6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373517; ENSP00000362616; ENSG00000186462.
GeneID	4674.
KEGG	hsa:4674.
UCSC	uc004ebi.3. human.
Organism-specific databases
CTD	4674.
GeneCards	GC0XM072348.
HGNC	HGNC:7638. NAP1L2.
MIM	300026. gene.
neXtProt	NX_Q9ULW6.
PharmGKB	PA31440.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG248175.
HOGENOM	HOG000171827.
HOVERGEN	HBG052653.
InParanoid	Q9ULW6.
KO	K11280.
OMA	WMAAIEE.
OrthoDB	EOG4MKNGJ.
PhylomeDB	Q9ULW6.
Gene expression databases
ArrayExpress	Q9ULW6.
Bgee	Q9ULW6.
CleanEx	HS_NAP1L2.
Genevestigator	Q9ULW6.
GermOnline	ENSG00000186462. Homo sapiens.
Family and domain databases
InterPro	IPR002164. NAP_family. [Graphical view]
PANTHER	PTHR11875. PTHR11875. 1 hit.
Pfam	PF00956. NAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4674.
NextBio	18016.
SOURCE	Search...

Entry information

Entry name

NP1L2_HUMAN

Accession

Primary (citable) accession number: Q9ULW6
Secondary accession number(s): B2RE61, Q8TAN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.