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Q9ULW6

- NP1L2_HUMAN

UniProt

Q9ULW6 - NP1L2_HUMAN

Protein

Nucleosome assembly protein 1-like 2

Gene

NAP1L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Acidic protein which may be involved in interactions with other proteins or DNA.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. nucleosome assembly Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleosome assembly protein 1-like 2
    Alternative name(s):
    Brain-specific protein, X-linked
    Gene namesi
    Name:NAP1L2
    Synonyms:BPX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:7638. NAP1L2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31440.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Nucleosome assembly protein 1-like 2PRO_0000185655Add
    BLAST

    Proteomic databases

    PaxDbiQ9ULW6.
    PRIDEiQ9ULW6.

    PTM databases

    PhosphoSiteiQ9ULW6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULW6.
    BgeeiQ9ULW6.
    CleanExiHS_NAP1L2.
    GenevestigatoriQ9ULW6.

    Organism-specific databases

    HPAiHPA057065.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q9WMX22EBI-3911716,EBI-6863748From a different organism.

    Protein-protein interaction databases

    BioGridi110755. 4 interactions.
    IntActiQ9ULW6. 2 interactions.
    MINTiMINT-150103.
    STRINGi9606.ENSP00000362616.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULW6.
    SMRiQ9ULW6. Positions 86-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi346 – 3527Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi160 – 23576Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG248175.
    HOGENOMiHOG000171827.
    HOVERGENiHBG052653.
    InParanoidiQ9ULW6.
    KOiK11280.
    OMAiWMAAIEE.
    OrthoDBiEOG73Z2T8.
    PhylomeDBiQ9ULW6.
    TreeFamiTF314349.

    Family and domain databases

    InterProiIPR002164. NAP_family.
    [Graphical view]
    PANTHERiPTHR11875. PTHR11875. 1 hit.
    PfamiPF00956. NAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ULW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE    50
    AAAGLGEEGE NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF 100
    VESLPVKVKY RVLALKKLQT RAANLESKFL REFHDIERKF AEMYQPLLEK 150
    RRQIINAIYE PTEEECEYKS DSEDCDDEEM CHEEMYGNEE GMVHEYVDED 200
    DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI PDFWLTVLKN 250
    VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE 300
    LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ 350
    KHRIWGTIRT VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI 400
    IPRSVLFFSG DALESQQEGV VREVNDAIYD KIIYDNWMAA IEEVKACCKN 450
    LEALVEDIDR 460
    Length:460
    Mass (Da):52,542
    Last modified:May 1, 2000 - v1
    Checksum:i36BE77964B5096C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31E → K in AAH26325. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027013 mRNA. Translation: BAA84706.1.
    AF136178 mRNA. Translation: AAP97268.1.
    CR457095 mRNA. Translation: CAG33376.1.
    AK316569 mRNA. Translation: BAG38158.1.
    CH471104 Genomic DNA. Translation: EAW98670.1.
    BC026325 mRNA. Translation: AAH26325.1.
    CCDSiCCDS14423.1.
    RefSeqiNP_068798.1. NM_021963.3.
    UniGeneiHs.66180.
    Hs.740565.

    Genome annotation databases

    EnsembliENST00000373517; ENSP00000362616; ENSG00000186462.
    GeneIDi4674.
    KEGGihsa:4674.
    UCSCiuc004ebi.3. human.

    Polymorphism databases

    DMDMi22256943.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027013 mRNA. Translation: BAA84706.1 .
    AF136178 mRNA. Translation: AAP97268.1 .
    CR457095 mRNA. Translation: CAG33376.1 .
    AK316569 mRNA. Translation: BAG38158.1 .
    CH471104 Genomic DNA. Translation: EAW98670.1 .
    BC026325 mRNA. Translation: AAH26325.1 .
    CCDSi CCDS14423.1.
    RefSeqi NP_068798.1. NM_021963.3.
    UniGenei Hs.66180.
    Hs.740565.

    3D structure databases

    ProteinModelPortali Q9ULW6.
    SMRi Q9ULW6. Positions 86-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110755. 4 interactions.
    IntActi Q9ULW6. 2 interactions.
    MINTi MINT-150103.
    STRINGi 9606.ENSP00000362616.

    PTM databases

    PhosphoSitei Q9ULW6.

    Polymorphism databases

    DMDMi 22256943.

    Proteomic databases

    PaxDbi Q9ULW6.
    PRIDEi Q9ULW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373517 ; ENSP00000362616 ; ENSG00000186462 .
    GeneIDi 4674.
    KEGGi hsa:4674.
    UCSCi uc004ebi.3. human.

    Organism-specific databases

    CTDi 4674.
    GeneCardsi GC0XM072348.
    HGNCi HGNC:7638. NAP1L2.
    HPAi HPA057065.
    MIMi 300026. gene.
    neXtProti NX_Q9ULW6.
    PharmGKBi PA31440.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248175.
    HOGENOMi HOG000171827.
    HOVERGENi HBG052653.
    InParanoidi Q9ULW6.
    KOi K11280.
    OMAi WMAAIEE.
    OrthoDBi EOG73Z2T8.
    PhylomeDBi Q9ULW6.
    TreeFami TF314349.

    Miscellaneous databases

    GenomeRNAii 4674.
    NextBioi 18016.
    PROi Q9ULW6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULW6.
    Bgeei Q9ULW6.
    CleanExi HS_NAP1L2.
    Genevestigatori Q9ULW6.

    Family and domain databases

    InterProi IPR002164. NAP_family.
    [Graphical view ]
    PANTHERi PTHR11875. PTHR11875. 1 hit.
    Pfami PF00956. NAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of a new human cDNA homologous to Mus musculus Bpx protein."
      Li N.G., Yu L., Zhao S.Y.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNP1L2_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULW6
    Secondary accession number(s): B2RE61, Q8TAN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3