Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleosome assembly protein 1-like 2

Gene

NAP1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acidic protein which may be involved in interactions with other proteins or DNA.By similarity

Caution

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 2
Alternative name(s):
Brain-specific protein, X-linked
Gene namesi
Name:NAP1L2
Synonyms:BPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000186462.8
HGNCiHGNC:7638 NAP1L2
MIMi300026 gene
neXtProtiNX_Q9ULW6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186462
PharmGKBiPA31440

Polymorphism and mutation databases

BioMutaiNAP1L2
DMDMi22256943

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856551 – 460Nucleosome assembly protein 1-like 2Add BLAST460

Proteomic databases

EPDiQ9ULW6
PaxDbiQ9ULW6
PeptideAtlasiQ9ULW6
PRIDEiQ9ULW6

PTM databases

iPTMnetiQ9ULW6
PhosphoSitePlusiQ9ULW6

Expressioni

Gene expression databases

BgeeiENSG00000186462
CleanExiHS_NAP1L2
GenevisibleiQ9ULW6 HS

Organism-specific databases

HPAiHPA054050
HPA057065

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-3911716,EBI-6863748From Hepatitis C virus genotype 1b (isolate Con1).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1107554 interactors.
IntActiQ9ULW6 10 interactors.
STRINGi9606.ENSP00000362616

Structurei

3D structure databases

ProteinModelPortaliQ9ULW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi346 – 352Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 235Glu-rich (acidic)Add BLAST76

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ9ULW6
KOiK11280
OMAiWMAAIEE
OrthoDBiEOG091G0HVV
PhylomeDBiQ9ULW6
TreeFamiTF314349

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESENRKEL SESSQEEAGN QIMVEGLGEH LERGEDAAAG LGDDGKCGEE
60 70 80 90 100
AAAGLGEEGE NGEDTAAGSG EDGKKGGDTD EDSEADRPKG LIGYVLDTDF
110 120 130 140 150
VESLPVKVKY RVLALKKLQT RAANLESKFL REFHDIERKF AEMYQPLLEK
160 170 180 190 200
RRQIINAIYE PTEEECEYKS DSEDCDDEEM CHEEMYGNEE GMVHEYVDED
210 220 230 240 250
DGYEDYYYDY AVEEEEEEEE EDDIEATGEE NKEEEDPKGI PDFWLTVLKN
260 270 280 290 300
VDTLTPLIKK YDEPILKLLT DIKVKLSDPG EPLSFTLEFH FKPNEYFKNE
310 320 330 340 350
LLTKTYVLKS KLAYYDPHPY RGTAIEYSTG CEIDWNEGKN VTLKTIKKKQ
360 370 380 390 400
KHRIWGTIRT VTEDFPKDSF FNFFSPHGIT SNGRDGNDDF LLGHNLRTYI
410 420 430 440 450
IPRSVLFFSG DALESQQEGV VREVNDAIYD KIIYDNWMAA IEEVKACCKN
460
LEALVEDIDR
Length:460
Mass (Da):52,542
Last modified:May 1, 2000 - v1
Checksum:i36BE77964B5096C6
GO
Isoform 2 (identifier: Q9ULW6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):37,312
Checksum:iB1975362947CD836
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3E → K in AAH26325 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0570641 – 142Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027013 mRNA Translation: BAA84706.1
AF136178 mRNA Translation: AAP97268.1
CR457095 mRNA Translation: CAG33376.1
AK303676 mRNA Translation: BAG64673.1
AK316569 mRNA Translation: BAG38158.1
AC004074 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98670.1
BC026325 mRNA Translation: AAH26325.1
CCDSiCCDS14423.1 [Q9ULW6-1]
RefSeqiNP_068798.1, NM_021963.3 [Q9ULW6-1]
UniGeneiHs.66180
Hs.740565

Genome annotation databases

EnsembliENST00000373517; ENSP00000362616; ENSG00000186462 [Q9ULW6-1]
GeneIDi4674
KEGGihsa:4674
UCSCiuc004ebi.4 human [Q9ULW6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNP1L2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW6
Secondary accession number(s): B2RE61, B4E161, Q8TAN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome