Q9ULW5 (RAB26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-26

Gene names

Name:

RAB26

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side By similarity.
Tissue specificity	Predominantly expressed in brain.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.
Sequence caution	The sequence BAA84707.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	exocrine system development Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of exocytosis Inferred from sequence or structural similarity. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intrinsic to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	GTP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 256

256

Ras-related protein Rab-26

PRO_0000121218

Regions

Nucleotide binding

70 – 78

9

GTP

Nucleotide binding

119 – 123

5

GTP

Nucleotide binding

177 – 180

4

GTP

Nucleotide binding

207 – 209

3

GTP

Motif

93 – 101

9

Effector region By similarity

Amino acid modifications

Lipidation

253

1

S-geranylgeranyl cysteine By similarity

Lipidation

254

1

S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict

227

1

Q → R in AAH66913. Ref.2

Secondary structure

1

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256

Helix Strand Turn

Details...

Beta strand

61 – 69

9

Helix

76 – 85

10

Beta strand

100 – 108

9

Beta strand

111 – 119

9

Helix

134 – 136

3

Beta strand

138 – 145

8

Helix

149 – 153

5

Helix

155 – 165

11

Beta strand

171 – 177

7

Helix

189 – 198

10

Beta strand

203 – 205

3

Turn

208 – 210

3

Helix

214 – 226

13

Sequences

	Sequence		Length	Mass (Da)
	Q9ULW5 [UniParc]. Last modified March 6, 2007. Version 3. Checksum: 575232F4B9E7FA7E	FASTA	256	27,900
	10 20 30 40 50 60 MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR PSLGGGVDFY 70 80 90 100 110 120 DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID FRNKVLDVDG VKVKLQMWDT 130 140 150 160 170 180 AGQERFRSVT HAYYRDAHAL LLLYDVTNKA SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD 190 200 210 220 230 240 SAHERVVKRE DGEKLAKEYG LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL 250 HDYVKREGRG ASCCRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[3]	"cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region." Seki N., Yoshikawa T., Hattori A., Miyajima N., Muramatsu M., Saito T. J. Hum. Genet. 45:309-314(2000) [PubMed: 11043516] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-256. Tissue: Fetal brain.
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-256. Tissue: Brain.
[5]	"Crystal structure of human RAB26 in complex with a GTP analogue." Structural genomics consortium (SGC) Submitted (FEB-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 56-233 IN COMPLEX WITH GTP ANALOG.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC009065 Genomic DNA. No translation available.
BC066913 mRNA. Translation: AAH66913.1.
AB027137 mRNA. Translation: BAA84707.1. Different initiation.
AF498952 mRNA. Translation: AAM21100.1.

IPI

IPI00419883.

RefSeq

NP_055168.2. NM_014353.4.

UniGene

Hs.3797.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2G6B	X-ray	2.00	A	56-233	[»]

ProteinModelPortal

Q9ULW5.

SMR

Q9ULW5. Positions 58-254.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9ULW5. 1 interaction.

STRING

Q9ULW5.

Polymorphism databases

DMDM

134044256.

Proteomic databases

PRIDE

Q9ULW5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000210187; ENSP00000210187; ENSG00000167964.

GeneID

25837.

KEGG

hsa:25837.

UCSC

uc002cou.1. human.

Organism-specific databases

CTD

25837.

GeneCards

GC16P002198.

H-InvDB

HIX0038522.

HGNC

HGNC:14259. RAB26.

MIM

605455. gene.

neXtProt

NX_Q9ULW5.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00600000084225.

HOGENOM

HBG745225.

HOVERGEN

HBG009351.

InParanoid

Q9ULW5.

OMA

HERVVKR.

OrthoDB

EOG4VMFG9.

PhylomeDB

Q9ULW5.

Gene expression databases

ArrayExpress

Q9ULW5.

Bgee

Q9ULW5.

CleanEx

HS_RAB26.

Genevestigator

Q9ULW5.

GermOnline

ENSG00000167964. Homo sapiens.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]

KO

K07913.

Pfam

PF00071. Ras. 1 hit.
[Graphical view]

PRINTS

PR00449. RASTRNSFRMNG.

SMART

SM00175. RAB. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. Small_GTP. 1 hit.

PROSITE

PS51419. RAB. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

47147.

SOURCE

Search...

Entry information

Entry name

RAB26_HUMAN

Accession

Primary (citable) accession number: Q9ULW5
Secondary accession number(s): Q6NXS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	March 6, 2007
Last modified:	January 25, 2012
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.