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Q9ULW5

- RAB26_HUMAN

UniProt

Q9ULW5 - RAB26_HUMAN

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Protein

Ras-related protein Rab-26

Gene

RAB26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 789GTP1 Publication
Nucleotide bindingi119 – 1235GTP1 Publication
Nucleotide bindingi177 – 1804GTP1 Publication
Nucleotide bindingi207 – 2093GTP1 Publication

GO - Molecular functioni

  1. GMP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB

GO - Biological processi

  1. exocrine system development Source: UniProtKB
  2. Golgi to plasma membrane protein transport Source: UniProtKB
  3. regulated secretory pathway Source: UniProtKB
  4. regulation of exocytosis Source: UniProtKB
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:RAB26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14259. RAB26.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclesecretory vesicle membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication
Note: Not localized at the plasma membrane By similarity. Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.By similarity

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
  2. intrinsic component of plasma membrane Source: UniProtKB
  3. secretory granule membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi77 – 771T → N: Inactive, constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 2 Publications
Mutagenesisi123 – 1231Q → L: Constitutively activated. 1 Publication
Mutagenesisi177 – 1771N → I: Inactive, due to loss of GNP binding. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 1 Publication

Organism-specific databases

PharmGKBiPA34116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Ras-related protein Rab-26PRO_0000121218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi253 – 2531S-geranylgeranyl cysteineBy similarity
Lipidationi254 – 2541S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ9ULW5.
PaxDbiQ9ULW5.
PRIDEiQ9ULW5.

PTM databases

PhosphoSiteiQ9ULW5.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiQ9ULW5.
CleanExiHS_RAB26.
ExpressionAtlasiQ9ULW5. baseline and differential.
GenevestigatoriQ9ULW5.

Organism-specific databases

HPAiHPA050223.

Interactioni

Subunit structurei

Interacts with RIMS1 By similarity. Interacts with ADRA2B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRA2BP180894EBI-958239,EBI-9077302

Protein-protein interaction databases

BioGridi117364. 6 interactions.
IntActiQ9ULW5. 2 interactions.
STRINGi9606.ENSP00000210187.

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi61 – 699Combined sources
Helixi76 – 8510Combined sources
Beta strandi100 – 1089Combined sources
Beta strandi111 – 1199Combined sources
Helixi134 – 1363Combined sources
Beta strandi138 – 1458Combined sources
Helixi149 – 1535Combined sources
Helixi155 – 16511Combined sources
Beta strandi171 – 1777Combined sources
Helixi189 – 19810Combined sources
Beta strandi203 – 2053Combined sources
Turni208 – 2103Combined sources
Helixi214 – 22613Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G6BX-ray2.00A56-233[»]
ProteinModelPortaliQ9ULW5.
SMRiQ9ULW5. Positions 58-227.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULW5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi93 – 1019Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9ULW5.
KOiK07913.
OMAiNKVDSAH.
PhylomeDBiQ9ULW5.
TreeFamiTF323428.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULW5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR
60 70 80 90 100
PSLGGGVDFY DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID
110 120 130 140 150
FRNKVLDVDG VKVKLQMWDT AGQERFRSVT HAYYRDAHAL LLLYDVTNKA
160 170 180 190 200
SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD SAHERVVKRE DGEKLAKEYG
210 220 230 240 250
LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL HDYVKREGRG

ASCCRP
Length:256
Mass (Da):27,900
Last modified:March 6, 2007 - v3
Checksum:i575232F4B9E7FA7E
GO
Isoform 2 (identifier: Q9ULW5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Note: No experimental confirmation available

Show »
Length:190
Mass (Da):21,355
Checksum:i517387B7C0B3291C
GO

Sequence cautioni

The sequence BAA84707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271Q → R in AAH66913. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666Missing in isoform 2. 1 PublicationVSP_056879Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY646153 mRNA. Translation: AAU88191.1.
AK314110 mRNA. Translation: BAG36803.1.
AC009065 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85552.1.
BC066913 mRNA. Translation: AAH66913.1.
AB027137 mRNA. Translation: BAA84707.1. Different initiation.
AF498952 mRNA. Translation: AAM21100.1.
CCDSiCCDS10460.1.
RefSeqiNP_055168.2. NM_014353.4.
UniGeneiHs.3797.

Genome annotation databases

EnsembliENST00000210187; ENSP00000210187; ENSG00000167964.
GeneIDi25837.
KEGGihsa:25837.
UCSCiuc002cou.3. human.

Polymorphism databases

DMDMi134044256.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY646153 mRNA. Translation: AAU88191.1 .
AK314110 mRNA. Translation: BAG36803.1 .
AC009065 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85552.1 .
BC066913 mRNA. Translation: AAH66913.1 .
AB027137 mRNA. Translation: BAA84707.1 . Different initiation.
AF498952 mRNA. Translation: AAM21100.1 .
CCDSi CCDS10460.1.
RefSeqi NP_055168.2. NM_014353.4.
UniGenei Hs.3797.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2G6B X-ray 2.00 A 56-233 [» ]
ProteinModelPortali Q9ULW5.
SMRi Q9ULW5. Positions 58-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117364. 6 interactions.
IntActi Q9ULW5. 2 interactions.
STRINGi 9606.ENSP00000210187.

PTM databases

PhosphoSitei Q9ULW5.

Polymorphism databases

DMDMi 134044256.

Proteomic databases

MaxQBi Q9ULW5.
PaxDbi Q9ULW5.
PRIDEi Q9ULW5.

Protocols and materials databases

DNASUi 25837.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000210187 ; ENSP00000210187 ; ENSG00000167964 .
GeneIDi 25837.
KEGGi hsa:25837.
UCSCi uc002cou.3. human.

Organism-specific databases

CTDi 25837.
GeneCardsi GC16P002190.
HGNCi HGNC:14259. RAB26.
HPAi HPA050223.
MIMi 605455. gene.
neXtProti NX_Q9ULW5.
PharmGKBi PA34116.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118937.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q9ULW5.
KOi K07913.
OMAi NKVDSAH.
PhylomeDBi Q9ULW5.
TreeFami TF323428.

Miscellaneous databases

ChiTaRSi RAB26. human.
EvolutionaryTracei Q9ULW5.
GeneWikii RAB26.
GenomeRNAii 25837.
NextBioi 47147.
PROi Q9ULW5.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULW5.
CleanExi HS_RAB26.
ExpressionAtlasi Q9ULW5. baseline and differential.
Genevestigatori Q9ULW5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and characterization of human Ras-related oncogene Rab26."
    Zhu N., Xu Y., Yang J., Li R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain cortex.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  6. "cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region."
    Seki N., Yoshikawa T., Hattori A., Miyajima N., Muramatsu M., Saito T.
    J. Hum. Genet. 45:309-314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-256 (ISOFORM 1).
    Tissue: Fetal brain.
  7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-256 (ISOFORM 1).
    Tissue: Brain.
  8. "RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation."
    Tian X., Jin R.U., Bredemeyer A.J., Oates E.J., Blazewska K.M., McKenna C.E., Mills J.C.
    Mol. Cell. Biol. 30:1269-1284(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF THR-77.
  9. "Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi."
    Li C., Fan Y., Lan T.H., Lambert N.A., Wu G.
    J. Biol. Chem. 287:42784-42794(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ADRA2B, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-77; GLN-123 AND ASN-177.
  10. "Crystal structure of human RAB26 in complex with a GTP analogue."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 56-233 IN COMPLEX WITH GTP ANALOG.

Entry informationi

Entry nameiRAB26_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW5
Secondary accession number(s): B2RAA6, Q3L6K5, Q6NXS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3