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Q9ULW5

- RAB26_HUMAN

UniProt

Q9ULW5 - RAB26_HUMAN

Protein

Ras-related protein Rab-26

Gene

RAB26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 789GTP
    Nucleotide bindingi119 – 1235GTP
    Nucleotide bindingi177 – 1804GTP
    Nucleotide bindingi207 – 2093GTP

    GO - Molecular functioni

    1. GMP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB

    GO - Biological processi

    1. exocrine system development Source: UniProtKB
    2. Golgi to plasma membrane protein transport Source: UniProtKB
    3. regulated secretory pathway Source: UniProtKB
    4. regulation of exocytosis Source: UniProtKB
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-26
    Gene namesi
    Name:RAB26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14259. RAB26.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclesecretory vesicle membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication
    Note: Not localized at the plasma membrane By similarity. Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.By similarity

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB
    2. intrinsic component of plasma membrane Source: UniProtKB
    3. secretory granule membrane Source: UniProtKB
    4. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi77 – 771T → N: Inactive, constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 2 Publications
    Mutagenesisi123 – 1231Q → L: Constitutively activated. 1 Publication
    Mutagenesisi177 – 1771N → I: Inactive, due to loss of GNP binding. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 1 Publication

    Organism-specific databases

    PharmGKBiPA34116.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Ras-related protein Rab-26PRO_0000121218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi253 – 2531S-geranylgeranyl cysteineBy similarity
    Lipidationi254 – 2541S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    PaxDbiQ9ULW5.
    PRIDEiQ9ULW5.

    PTM databases

    PhosphoSiteiQ9ULW5.

    Expressioni

    Tissue specificityi

    Predominantly expressed in brain.

    Gene expression databases

    ArrayExpressiQ9ULW5.
    BgeeiQ9ULW5.
    CleanExiHS_RAB26.
    GenevestigatoriQ9ULW5.

    Organism-specific databases

    HPAiHPA050223.

    Interactioni

    Subunit structurei

    Interacts with RIMS1 By similarity. Interacts with ADRA2B.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ADRA2BP180894EBI-958239,EBI-9077302

    Protein-protein interaction databases

    BioGridi117364. 6 interactions.
    IntActiQ9ULW5. 2 interactions.
    STRINGi9606.ENSP00000210187.

    Structurei

    Secondary structure

    1
    256
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi61 – 699
    Helixi76 – 8510
    Beta strandi100 – 1089
    Beta strandi111 – 1199
    Helixi134 – 1363
    Beta strandi138 – 1458
    Helixi149 – 1535
    Helixi155 – 16511
    Beta strandi171 – 1777
    Helixi189 – 19810
    Beta strandi203 – 2053
    Turni208 – 2103
    Helixi214 – 22613

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2G6BX-ray2.00A56-233[»]
    ProteinModelPortaliQ9ULW5.
    SMRiQ9ULW5. Positions 58-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ULW5.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi93 – 1019Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ9ULW5.
    KOiK07913.
    OMAiNKVDSAH.
    PhylomeDBiQ9ULW5.
    TreeFamiTF323428.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ULW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR    50
    PSLGGGVDFY DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID 100
    FRNKVLDVDG VKVKLQMWDT AGQERFRSVT HAYYRDAHAL LLLYDVTNKA 150
    SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD SAHERVVKRE DGEKLAKEYG 200
    LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL HDYVKREGRG 250
    ASCCRP 256
    Length:256
    Mass (Da):27,900
    Last modified:March 6, 2007 - v3
    Checksum:i575232F4B9E7FA7E
    GO

    Sequence cautioni

    The sequence BAA84707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271Q → R in AAH66913. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY646153 mRNA. Translation: AAU88191.1.
    AC009065 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85552.1.
    BC066913 mRNA. Translation: AAH66913.1.
    AB027137 mRNA. Translation: BAA84707.1. Different initiation.
    AF498952 mRNA. Translation: AAM21100.1.
    CCDSiCCDS10460.1.
    RefSeqiNP_055168.2. NM_014353.4.
    UniGeneiHs.3797.

    Genome annotation databases

    EnsembliENST00000210187; ENSP00000210187; ENSG00000167964.
    GeneIDi25837.
    KEGGihsa:25837.
    UCSCiuc002cou.3. human.

    Polymorphism databases

    DMDMi134044256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY646153 mRNA. Translation: AAU88191.1 .
    AC009065 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85552.1 .
    BC066913 mRNA. Translation: AAH66913.1 .
    AB027137 mRNA. Translation: BAA84707.1 . Different initiation.
    AF498952 mRNA. Translation: AAM21100.1 .
    CCDSi CCDS10460.1.
    RefSeqi NP_055168.2. NM_014353.4.
    UniGenei Hs.3797.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2G6B X-ray 2.00 A 56-233 [» ]
    ProteinModelPortali Q9ULW5.
    SMRi Q9ULW5. Positions 58-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117364. 6 interactions.
    IntActi Q9ULW5. 2 interactions.
    STRINGi 9606.ENSP00000210187.

    PTM databases

    PhosphoSitei Q9ULW5.

    Polymorphism databases

    DMDMi 134044256.

    Proteomic databases

    PaxDbi Q9ULW5.
    PRIDEi Q9ULW5.

    Protocols and materials databases

    DNASUi 25837.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000210187 ; ENSP00000210187 ; ENSG00000167964 .
    GeneIDi 25837.
    KEGGi hsa:25837.
    UCSCi uc002cou.3. human.

    Organism-specific databases

    CTDi 25837.
    GeneCardsi GC16P002190.
    HGNCi HGNC:14259. RAB26.
    HPAi HPA050223.
    MIMi 605455. gene.
    neXtProti NX_Q9ULW5.
    PharmGKBi PA34116.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q9ULW5.
    KOi K07913.
    OMAi NKVDSAH.
    PhylomeDBi Q9ULW5.
    TreeFami TF323428.

    Miscellaneous databases

    ChiTaRSi RAB26. human.
    EvolutionaryTracei Q9ULW5.
    GeneWikii RAB26.
    GenomeRNAii 25837.
    NextBioi 47147.
    PROi Q9ULW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULW5.
    Bgeei Q9ULW5.
    CleanExi HS_RAB26.
    Genevestigatori Q9ULW5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and characterization of human Ras-related oncogene Rab26."
      Zhu N., Xu Y., Yang J., Li R.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    5. "cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region."
      Seki N., Yoshikawa T., Hattori A., Miyajima N., Muramatsu M., Saito T.
      J. Hum. Genet. 45:309-314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-256.
      Tissue: Fetal brain.
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-256.
      Tissue: Brain.
    7. "RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation."
      Tian X., Jin R.U., Bredemeyer A.J., Oates E.J., Blazewska K.M., McKenna C.E., Mills J.C.
      Mol. Cell. Biol. 30:1269-1284(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF THR-77.
    8. "Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi."
      Li C., Fan Y., Lan T.H., Lambert N.A., Wu G.
      J. Biol. Chem. 287:42784-42794(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ADRA2B, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-77; GLN-123 AND ASN-177.
    9. "Crystal structure of human RAB26 in complex with a GTP analogue."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 56-233 IN COMPLEX WITH GTP ANALOG.

    Entry informationi

    Entry nameiRAB26_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULW5
    Secondary accession number(s): Q3L6K5, Q6NXS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3