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Q9ULW5

- RAB26_HUMAN

UniProt

Q9ULW5 - RAB26_HUMAN

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Protein
Ras-related protein Rab-26
Gene
RAB26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 789GTP
Nucleotide bindingi119 – 1235GTP
Nucleotide bindingi177 – 1804GTP
Nucleotide bindingi207 – 2093GTP

GO - Molecular functioni

  1. GMP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. Golgi to plasma membrane protein transport Source: UniProtKB
  2. exocrine system development Source: UniProtKB
  3. regulated secretory pathway Source: UniProtKB
  4. regulation of exocytosis Source: UniProtKB
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:RAB26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14259. RAB26.

Subcellular locationi

Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesiclesecretory vesicle membrane; Lipid-anchor; Cytoplasmic side Inferred
Note: Not localized at the plasma membrane By similarity. Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.1 Publication

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
  2. intrinsic component of plasma membrane Source: UniProtKB
  3. secretory granule membrane Source: UniProtKB
  4. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi77 – 771T → N: Inactive, constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 2 Publications
Mutagenesisi123 – 1231Q → L: Constitutively activated. 1 Publication
Mutagenesisi177 – 1771N → I: Inactive, due to loss of GNP binding. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 1 Publication

Organism-specific databases

PharmGKBiPA34116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Ras-related protein Rab-26
PRO_0000121218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi253 – 2531S-geranylgeranyl cysteine By similarity
Lipidationi254 – 2541S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ9ULW5.
PRIDEiQ9ULW5.

PTM databases

PhosphoSiteiQ9ULW5.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

ArrayExpressiQ9ULW5.
BgeeiQ9ULW5.
CleanExiHS_RAB26.
GenevestigatoriQ9ULW5.

Organism-specific databases

HPAiHPA050223.

Interactioni

Subunit structurei

Interacts with RIMS1 By similarity. Interacts with ADRA2B.1 Publication

Protein-protein interaction databases

BioGridi117364. 6 interactions.
IntActiQ9ULW5. 1 interaction.
STRINGi9606.ENSP00000210187.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi61 – 699
Helixi76 – 8510
Beta strandi100 – 1089
Beta strandi111 – 1199
Helixi134 – 1363
Beta strandi138 – 1458
Helixi149 – 1535
Helixi155 – 16511
Beta strandi171 – 1777
Helixi189 – 19810
Beta strandi203 – 2053
Turni208 – 2103
Helixi214 – 22613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G6BX-ray2.00A56-233[»]
ProteinModelPortaliQ9ULW5.
SMRiQ9ULW5. Positions 58-227.

Miscellaneous databases

EvolutionaryTraceiQ9ULW5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi93 – 1019Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9ULW5.
KOiK07913.
OMAiNKVDSAH.
PhylomeDBiQ9ULW5.
TreeFamiTF323428.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULW5-1 [UniParc]FASTAAdd to Basket

« Hide

MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR    50
PSLGGGVDFY DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID 100
FRNKVLDVDG VKVKLQMWDT AGQERFRSVT HAYYRDAHAL LLLYDVTNKA 150
SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD SAHERVVKRE DGEKLAKEYG 200
LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL HDYVKREGRG 250
ASCCRP 256
Length:256
Mass (Da):27,900
Last modified:March 6, 2007 - v3
Checksum:i575232F4B9E7FA7E
GO

Sequence cautioni

The sequence BAA84707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271Q → R in AAH66913. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY646153 mRNA. Translation: AAU88191.1.
AC009065 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85552.1.
BC066913 mRNA. Translation: AAH66913.1.
AB027137 mRNA. Translation: BAA84707.1. Different initiation.
AF498952 mRNA. Translation: AAM21100.1.
CCDSiCCDS10460.1.
RefSeqiNP_055168.2. NM_014353.4.
UniGeneiHs.3797.

Genome annotation databases

EnsembliENST00000210187; ENSP00000210187; ENSG00000167964.
GeneIDi25837.
KEGGihsa:25837.
UCSCiuc002cou.3. human.

Polymorphism databases

DMDMi134044256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY646153 mRNA. Translation: AAU88191.1 .
AC009065 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85552.1 .
BC066913 mRNA. Translation: AAH66913.1 .
AB027137 mRNA. Translation: BAA84707.1 . Different initiation.
AF498952 mRNA. Translation: AAM21100.1 .
CCDSi CCDS10460.1.
RefSeqi NP_055168.2. NM_014353.4.
UniGenei Hs.3797.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2G6B X-ray 2.00 A 56-233 [» ]
ProteinModelPortali Q9ULW5.
SMRi Q9ULW5. Positions 58-227.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117364. 6 interactions.
IntActi Q9ULW5. 1 interaction.
STRINGi 9606.ENSP00000210187.

PTM databases

PhosphoSitei Q9ULW5.

Polymorphism databases

DMDMi 134044256.

Proteomic databases

PaxDbi Q9ULW5.
PRIDEi Q9ULW5.

Protocols and materials databases

DNASUi 25837.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000210187 ; ENSP00000210187 ; ENSG00000167964 .
GeneIDi 25837.
KEGGi hsa:25837.
UCSCi uc002cou.3. human.

Organism-specific databases

CTDi 25837.
GeneCardsi GC16P002190.
HGNCi HGNC:14259. RAB26.
HPAi HPA050223.
MIMi 605455. gene.
neXtProti NX_Q9ULW5.
PharmGKBi PA34116.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q9ULW5.
KOi K07913.
OMAi NKVDSAH.
PhylomeDBi Q9ULW5.
TreeFami TF323428.

Miscellaneous databases

ChiTaRSi RAB26. human.
EvolutionaryTracei Q9ULW5.
GeneWikii RAB26.
GenomeRNAii 25837.
NextBioi 47147.
PROi Q9ULW5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ULW5.
Bgeei Q9ULW5.
CleanExi HS_RAB26.
Genevestigatori Q9ULW5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and characterization of human Ras-related oncogene Rab26."
    Zhu N., Xu Y., Yang J., Li R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  5. "cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region."
    Seki N., Yoshikawa T., Hattori A., Miyajima N., Muramatsu M., Saito T.
    J. Hum. Genet. 45:309-314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-256.
    Tissue: Fetal brain.
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-256.
    Tissue: Brain.
  7. "RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation."
    Tian X., Jin R.U., Bredemeyer A.J., Oates E.J., Blazewska K.M., McKenna C.E., Mills J.C.
    Mol. Cell. Biol. 30:1269-1284(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF THR-77.
  8. "Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi."
    Li C., Fan Y., Lan T.H., Lambert N.A., Wu G.
    J. Biol. Chem. 287:42784-42794(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ADRA2B, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-77; GLN-123 AND ASN-177.
  9. "Crystal structure of human RAB26 in complex with a GTP analogue."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 56-233 IN COMPLEX WITH GTP ANALOG.

Entry informationi

Entry nameiRAB26_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW5
Secondary accession number(s): Q3L6K5, Q6NXS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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