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Protein

Ras-related protein Rab-26

Gene

RAB26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 78GTP1 Publication9
Nucleotide bindingi119 – 123GTP1 Publication5
Nucleotide bindingi177 – 180GTP1 Publication4
Nucleotide bindingi207 – 209GTP1 Publication3

GO - Molecular functioni

  • GMP binding Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • exocrine system development Source: UniProtKB
  • Golgi to plasma membrane protein transport Source: UniProtKB
  • regulated exocytosis Source: UniProtKB
  • regulation of exocytosis Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167964-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:RAB26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14259. RAB26.

Subcellular locationi

  • Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication
  • Cytoplasmic vesiclesecretory vesicle membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication

  • Note: Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77T → N: Inactive, constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 2 Publications1
Mutagenesisi123Q → L: Constitutively activated. 1 Publication1
Mutagenesisi177N → I: Inactive, due to loss of GNP binding. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000167964.
PharmGKBiPA34116.

Polymorphism and mutation databases

BioMutaiRAB26.
DMDMi134044256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212181 – 256Ras-related protein Rab-26Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi253S-geranylgeranyl cysteineBy similarity1
Lipidationi254S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ9ULW5.
PeptideAtlasiQ9ULW5.
PRIDEiQ9ULW5.

PTM databases

iPTMnetiQ9ULW5.
PhosphoSitePlusiQ9ULW5.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSG00000167964.
CleanExiHS_RAB26.
ExpressionAtlasiQ9ULW5. baseline and differential.
GenevisibleiQ9ULW5. HS.

Organism-specific databases

HPAiHPA050223.

Interactioni

Subunit structurei

Interacts with RIMS1 (By similarity). Interacts with ADRA2B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRA2BP180894EBI-958239,EBI-9077302

Protein-protein interaction databases

BioGridi117364. 3 interactors.
IntActiQ9ULW5. 3 interactors.
STRINGi9606.ENSP00000210187.

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi61 – 69Combined sources9
Helixi76 – 85Combined sources10
Beta strandi100 – 108Combined sources9
Beta strandi111 – 119Combined sources9
Helixi134 – 136Combined sources3
Beta strandi138 – 145Combined sources8
Helixi149 – 153Combined sources5
Helixi155 – 165Combined sources11
Beta strandi171 – 177Combined sources7
Helixi189 – 198Combined sources10
Beta strandi203 – 205Combined sources3
Turni208 – 210Combined sources3
Helixi214 – 226Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6BX-ray2.00A56-233[»]
ProteinModelPortaliQ9ULW5.
SMRiQ9ULW5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULW5.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi93 – 101Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083. Eukaryota.
ENOG410Z9H6. LUCA.
GeneTreeiENSGT00860000133675.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9ULW5.
KOiK07913.
OMAiNKVDSAH.
OrthoDBiEOG091G0JXU.
PhylomeDBiQ9ULW5.
TreeFamiTF323428.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR
60 70 80 90 100
PSLGGGVDFY DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID
110 120 130 140 150
FRNKVLDVDG VKVKLQMWDT AGQERFRSVT HAYYRDAHAL LLLYDVTNKA
160 170 180 190 200
SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD SAHERVVKRE DGEKLAKEYG
210 220 230 240 250
LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL HDYVKREGRG

ASCCRP
Length:256
Mass (Da):27,900
Last modified:March 6, 2007 - v3
Checksum:i575232F4B9E7FA7E
GO
Isoform 2 (identifier: Q9ULW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,355
Checksum:i517387B7C0B3291C
GO

Sequence cautioni

The sequence BAA84707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227Q → R in AAH66913 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568791 – 66Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646153 mRNA. Translation: AAU88191.1.
AK314110 mRNA. Translation: BAG36803.1.
AC009065 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85552.1.
BC066913 mRNA. Translation: AAH66913.1.
AB027137 mRNA. Translation: BAA84707.1. Different initiation.
AF498952 mRNA. Translation: AAM21100.1.
CCDSiCCDS10460.1. [Q9ULW5-1]
CCDS76806.1. [Q9ULW5-2]
RefSeqiNP_001294982.1. NM_001308053.1. [Q9ULW5-2]
NP_055168.2. NM_014353.4. [Q9ULW5-1]
UniGeneiHs.3797.

Genome annotation databases

EnsembliENST00000210187; ENSP00000210187; ENSG00000167964. [Q9ULW5-1]
ENST00000541451; ENSP00000441580; ENSG00000167964. [Q9ULW5-2]
GeneIDi25837.
KEGGihsa:25837.
UCSCiuc002cou.4. human. [Q9ULW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646153 mRNA. Translation: AAU88191.1.
AK314110 mRNA. Translation: BAG36803.1.
AC009065 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85552.1.
BC066913 mRNA. Translation: AAH66913.1.
AB027137 mRNA. Translation: BAA84707.1. Different initiation.
AF498952 mRNA. Translation: AAM21100.1.
CCDSiCCDS10460.1. [Q9ULW5-1]
CCDS76806.1. [Q9ULW5-2]
RefSeqiNP_001294982.1. NM_001308053.1. [Q9ULW5-2]
NP_055168.2. NM_014353.4. [Q9ULW5-1]
UniGeneiHs.3797.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6BX-ray2.00A56-233[»]
ProteinModelPortaliQ9ULW5.
SMRiQ9ULW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117364. 3 interactors.
IntActiQ9ULW5. 3 interactors.
STRINGi9606.ENSP00000210187.

PTM databases

iPTMnetiQ9ULW5.
PhosphoSitePlusiQ9ULW5.

Polymorphism and mutation databases

BioMutaiRAB26.
DMDMi134044256.

Proteomic databases

PaxDbiQ9ULW5.
PeptideAtlasiQ9ULW5.
PRIDEiQ9ULW5.

Protocols and materials databases

DNASUi25837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000210187; ENSP00000210187; ENSG00000167964. [Q9ULW5-1]
ENST00000541451; ENSP00000441580; ENSG00000167964. [Q9ULW5-2]
GeneIDi25837.
KEGGihsa:25837.
UCSCiuc002cou.4. human. [Q9ULW5-1]

Organism-specific databases

CTDi25837.
GeneCardsiRAB26.
HGNCiHGNC:14259. RAB26.
HPAiHPA050223.
MIMi605455. gene.
neXtProtiNX_Q9ULW5.
OpenTargetsiENSG00000167964.
PharmGKBiPA34116.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0083. Eukaryota.
ENOG410Z9H6. LUCA.
GeneTreeiENSGT00860000133675.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9ULW5.
KOiK07913.
OMAiNKVDSAH.
OrthoDBiEOG091G0JXU.
PhylomeDBiQ9ULW5.
TreeFamiTF323428.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167964-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9ULW5.
GeneWikiiRAB26.
GenomeRNAii25837.
PROiQ9ULW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167964.
CleanExiHS_RAB26.
ExpressionAtlasiQ9ULW5. baseline and differential.
GenevisibleiQ9ULW5. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB26_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW5
Secondary accession number(s): B2RAA6, Q3L6K5, Q6NXS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 160 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.