Q9ULW3 (ABT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activator of basal transcription 1
Short name=hABT1

Alternative name(s):
Basal transcriptional activator

Gene names

Name:

ABT1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes By similarity.
Subunit structure	Interacts with ESF1/ABTAP By similarity. Interacts with IGHMBP2. Ref.5
Subcellular location	Nucleus By similarity. Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the ESF2/ABP1 family. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Ligand	DNA-binding RNA-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro transcription coactivator activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Activator of basal transcription 1		PRO_0000233168
Regions
	Domain	46 – 142	97	RRM
	Coiled coil	161 – 191	31	Potential
	Compositional bias	90 – 94	5	Poly-Ala
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9ULW3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FB9B44192C16BD8A	FASTA	272	31,079
	10 20 30 40 50 60 MEAEESEKAA TEQEPLEGTE QTLDAEEEQE ESEEAACGSK KRVVPGIVYL GHIPPRFRPL 70 80 90 100 110 120 HVRNLLSAYG EVGRVFFQAE DRFVRRKKKA AAAAGGKKRS YTKDYTEGWV EFRDKRIAKR 130 140 150 160 170 180 VAASLHNTPM GARRRSPFRY DLWNLKYLHR FTWSHLSEHL AFERQVRRQR LRAEVAQAKR 190 200 210 220 230 240 ETDFYLQSVE RGQRFLAADG DPARPDGSWT FAQRPTEQEL RARKAARPGG RERARLATAQ 250 260 270 DKARSNKGLL ARIFGAPPPS ESMEGPSLVR DS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth." Oda T., Kayukawa K., Hagiwara H., Yudate H.T., Masuho Y., Murakami Y., Tamura T.-A., Muramatsu M.-A. Mol. Cell. Biol. 20:1407-1418(2000) [PubMed: 10648625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum and Testis.
[4]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery." de Planell-Saguer M., Schroeder D.G., Rodicio M.C., Cox G.A., Mourelatos Z. Hum. Mol. Genet. 18:2115-2126(2009) [PubMed: 19299493] [Abstract] Cited for: INTERACTION WITH IGHMBP2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB027258 mRNA. Translation: BAA86886.1. AL513548 Genomic DNA. Translation: CAC40824.1. BC048812 mRNA. Translation: AAH48812.1. BC066313 mRNA. Translation: AAH66313.1.
IPI	IPI00002938.
RefSeq	NP_037507.1. NM_013375.3.
UniGene	Hs.254406.
3D structure databases
ProteinModelPortal	Q9ULW3.
SMR	Q9ULW3. Positions 46-134.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULW3. 1 interaction.
STRING	Q9ULW3.
PTM databases
PhosphoSite	Q9ULW3.
Polymorphism databases
DMDM	74753396.
Proteomic databases
PRIDE	Q9ULW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274849; ENSP00000274849; ENSG00000146109.
GeneID	29777.
KEGG	hsa:29777.
UCSC	uc003nii.1. human.
Organism-specific databases
CTD	29777.
GeneCards	GC06P026597.
H-InvDB	HIX0025006.
HGNC	HGNC:17369. ABT1.
neXtProt	NX_Q9ULW3.
PharmGKB	PA38451.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05113.
GeneTree	ENSGT00390000002062.
HOGENOM	HBG716559.
HOVERGEN	HBG057308.
InParanoid	Q9ULW3.
OMA	WNIRYLS.
OrthoDB	EOG4S1T7W.
PhylomeDB	Q9ULW3.
Gene expression databases
ArrayExpress	Q9ULW3.
Bgee	Q9ULW3.
CleanEx	HS_ABT1.
Genevestigator	Q9ULW3.
GermOnline	ENSG00000146109. Homo sapiens.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
KO	K14785.
PROSITE	PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	52298.

Entry information

Entry name

ABT1_HUMAN

Accession

Primary (citable) accession number: Q9ULW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.