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Protein

Activator of basal transcription 1

Gene

ABT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of basal transcription 1
Short name:
hABT1
Alternative name(s):
Basal transcriptional activator
Gene namesi
Name:ABT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146109.4.
HGNCiHGNC:17369. ABT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29777.
OpenTargetsiENSG00000146109.
PharmGKBiPA38451.

Polymorphism and mutation databases

BioMutaiABT1.
DMDMi74753396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331681 – 272Activator of basal transcription 1Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ULW3.
MaxQBiQ9ULW3.
PaxDbiQ9ULW3.
PeptideAtlasiQ9ULW3.
PRIDEiQ9ULW3.

PTM databases

iPTMnetiQ9ULW3.
PhosphoSitePlusiQ9ULW3.

Expressioni

Gene expression databases

BgeeiENSG00000146109.
CleanExiHS_ABT1.
ExpressionAtlasiQ9ULW3. baseline and differential.
GenevisibleiQ9ULW3. HS.

Interactioni

Subunit structurei

Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118909. 33 interactors.
IntActiQ9ULW3. 20 interactors.
MINTiMINT-3082379.
STRINGi9606.ENSP00000274849.

Structurei

3D structure databases

ProteinModelPortaliQ9ULW3.
SMRiQ9ULW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 142RRMAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili161 – 191Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 94Poly-Ala5

Sequence similaritiesi

Belongs to the ESF2/ABP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3152. Eukaryota.
ENOG4111JJV. LUCA.
GeneTreeiENSGT00390000002062.
HOGENOMiHOG000242500.
HOVERGENiHBG057308.
InParanoidiQ9ULW3.
KOiK14785.
OMAiLSGFKWV.
OrthoDBiEOG091G0G6C.
PhylomeDBiQ9ULW3.
TreeFamiTF314506.

Family and domain databases

CDDicd12263. RRM_ABT1_like. 1 hit.
InterProiView protein in InterPro
IPR034353. ABT1/ESF2_RRM.
IPR000504. RRM_dom.
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ULW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEESEKAA TEQEPLEGTE QTLDAEEEQE ESEEAACGSK KRVVPGIVYL
60 70 80 90 100
GHIPPRFRPL HVRNLLSAYG EVGRVFFQAE DRFVRRKKKA AAAAGGKKRS
110 120 130 140 150
YTKDYTEGWV EFRDKRIAKR VAASLHNTPM GARRRSPFRY DLWNLKYLHR
160 170 180 190 200
FTWSHLSEHL AFERQVRRQR LRAEVAQAKR ETDFYLQSVE RGQRFLAADG
210 220 230 240 250
DPARPDGSWT FAQRPTEQEL RARKAARPGG RERARLATAQ DKARSNKGLL
260 270
ARIFGAPPPS ESMEGPSLVR DS
Length:272
Mass (Da):31,079
Last modified:May 1, 2000 - v1
Checksum:iFB9B44192C16BD8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027258 mRNA. Translation: BAA86886.1.
AL513548 Genomic DNA. No translation available.
BC048812 mRNA. Translation: AAH48812.1.
BC066313 mRNA. Translation: AAH66313.1.
CCDSiCCDS4616.1.
RefSeqiNP_037507.1. NM_013375.3.
UniGeneiHs.254406.

Genome annotation databases

EnsembliENST00000274849; ENSP00000274849; ENSG00000146109.
GeneIDi29777.
KEGGihsa:29777.
UCSCiuc003nii.4. human.

Similar proteinsi

Entry informationi

Entry nameiABT1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families