Reviewed, UniProtKB/Swiss-Prot Q9ULW3 (ABT1_HUMAN)

Names and origin

Protein names

Recommended name:
    Activator of basal transcription 1
      Short name=hABT1
Alternative name(s):
    Basal transcriptional activator

Gene names

Name:

ABT1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes By similarity.
Subunit structure	Interacts with ESF1/ABTAP By similarity. Interacts with IGHMBP2.
Subcellular location	Nucleus By similarity. Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the ESF2/ABP1 family. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Ligand	DNA-binding RNA-binding
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW general RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc transcription coactivator activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Activator of basal transcription 1		PRO_0000233168
Regions
	Domain	46 – 142	97	RRM
	Coiled coil	161 – 191	31	Potential
	Compositional bias	90 – 94	5	Poly-Ala
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine

Sequences

	Sequence		Length	Mass (Da)
	Q9ULW3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FB9B44192C16BD8A	FASTA	272	31,079
	10 20 30 40 50 60 MEAEESEKAA TEQEPLEGTE QTLDAEEEQE ESEEAACGSK KRVVPGIVYL GHIPPRFRPL 70 80 90 100 110 120 HVRNLLSAYG EVGRVFFQAE DRFVRRKKKA AAAAGGKKRS YTKDYTEGWV EFRDKRIAKR 130 140 150 160 170 180 VAASLHNTPM GARRRSPFRY DLWNLKYLHR FTWSHLSEHL AFERQVRRQR LRAEVAQAKR 190 200 210 220 230 240 ETDFYLQSVE RGQRFLAADG DPARPDGSWT FAQRPTEQEL RARKAARPGG RERARLATAQ 250 260 270 DKARSNKGLL ARIFGAPPPS ESMEGPSLVR DS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth." Oda T., Kayukawa K., Hagiwara H., Yudate H.T., Masuho Y., Murakami Y., Tamura T.-A., Muramatsu M.-A. Mol. Cell. Biol. 20:1407-1418(2000) [PubMed: 10648625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum and Testis.
[4]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY.
[5]	"Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery." de Planell-Saguer M., Schroeder D.G., Rodicio M.C., Cox G.A., Mourelatos Z. Hum. Mol. Genet. 18:2115-2126(2009) [PubMed: 19299493] [Abstract] Cited for: INTERACTION WITH IGHMBP2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB027258 mRNA. Translation: BAA86886.1. AL513548 Genomic DNA. Translation: CAC40824.1. BC048812 mRNA. Translation: AAH48812.1. BC066313 mRNA. Translation: AAH66313.1.
IPI	IPI00002938.
RefSeq	NP_037507.1.
UniGene	Hs.254406
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ULW3.
PTM databases
PhosphoSite	Q9ULW3.
Proteomic databases
PRIDE	Q9ULW3.
Genome annotation databases
Ensembl	ENST00000274849; ENSP00000274849; ENSG00000146109; Homo sapiens. [Genome view]
GeneID	29777.
KEGG	hsa:29777.
UCSC	uc003nii.1. human.
Organism-specific databases
CTD	29777.
GeneCards	GC06P026705.
H-InvDB	HIX0025006.
HGNC	HGNC:17369. ABT1.
PharmGKB	PA38451.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9ULW3.
HOVERGEN	Q9ULW3.
OMA	WNIRYLS
OrthoDB	EOG98PQ5K
Gene expression databases
ArrayExpress	Q9ULW3.
Bgee	Q9ULW3.
CleanEx	HS_ABT1.
Genevestigator	Q9ULW3.
GermOnline	ENSG00000146109. Homo sapiens.
Family and domain databases
PROSITE	PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	52298.

Entry information

Entry name

ABT1_HUMAN

Accession

Primary (citable) accession number: Q9ULW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.