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Q9ULW2

- FZD10_HUMAN

UniProt

Q9ULW2 - FZD10_HUMAN

Protein

Frizzled-10

Gene

FZD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. protein binding Source: UniProtKB
    4. Wnt-activated receptor activity Source: RefGenome
    5. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. brain development Source: RefGenome
    2. canonical Wnt signaling pathway Source: RefGenome
    3. cellular response to retinoic acid Source: UniProtKB
    4. gonad development Source: RefGenome
    5. negative regulation of Rho GTPase activity Source: BHF-UCL
    6. neuron differentiation Source: UniProtKB
    7. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
    8. positive regulation of JUN kinase activity Source: BHF-UCL
    9. positive regulation of Rac GTPase activity Source: BHF-UCL
    10. regulation of actin cytoskeleton organization Source: BHF-UCL
    11. vasculature development Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-10
    Short name:
    Fz-10
    Short name:
    hFz10
    Alternative name(s):
    FzE7
    CD_antigen: CD350
    Gene namesi
    Name:FZD10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4039. FZD10.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell projection Source: RefGenome
    2. cell surface Source: BHF-UCL
    3. cytoplasm Source: BHF-UCL
    4. integral component of plasma membrane Source: ProtInc
    5. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28456.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 581561Frizzled-10PRO_0000013005Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 95PROSITE-ProRule annotation
    Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi79 ↔ 117PROSITE-ProRule annotation
    Disulfide bondi106 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi110 ↔ 134PROSITE-ProRule annotation
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9ULW2.
    PRIDEiQ9ULW2.

    Expressioni

    Tissue specificityi

    Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.

    Gene expression databases

    ArrayExpressiQ9ULW2.
    BgeeiQ9ULW2.
    CleanExiHS_FZD10.
    GenevestigatoriQ9ULW2.

    Organism-specific databases

    HPAiHPA014484.
    HPA014485.

    Interactioni

    Subunit structurei

    Interacts with MYOC.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HILPDAQ9Y5L22EBI-8803802,EBI-8803836

    Protein-protein interaction databases

    BioGridi116380. 1 interaction.
    IntActiQ9ULW2. 1 interaction.
    STRINGi9606.ENSP00000229030.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULW2.
    SMRiQ9ULW2. Positions 34-150, 193-537.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 225205ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini247 – 26216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 31128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 35119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini373 – 39321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini415 – 44329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini465 – 50238ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini524 – 58158CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei226 – 24621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei503 – 52321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 150122FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi526 – 5316Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi579 – 5813PDZ-binding

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiQ9ULW2.
    KOiK02842.
    OMAiQSWQNVC.
    OrthoDBiEOG7M3J01.
    PhylomeDBiQ9ULW2.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ULW2-1 [UniParc]FASTAAdd to Basket

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    MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT    50
    RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS 100
    TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA 150
    PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH 200
    VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF SSAFTVLTFL 250
    IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI 300
    QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN 350
    SSYFHLAAWA IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI 400
    PLACYLVIGT SFILSGFVAL FHIRRVMKTG GENTDKLEKL MVRIGLFSVL 450
    YTVPATCVIA CYFYERLNMD YWKILAAQHK CKMNNQTKTL DCLMAASIPA 500
    VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK KKSRRKPASV 550
    ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V 581
    Length:581
    Mass (Da):65,336
    Last modified:May 1, 2000 - v1
    Checksum:iE9B7E51FA7C87B26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027464 mRNA. Translation: BAA84093.1.
    BC074997 mRNA. Translation: AAH74997.1.
    BC074998 mRNA. Translation: AAH74998.1.
    CCDSiCCDS9267.1.
    PIRiJC7086.
    RefSeqiNP_009128.1. NM_007197.3.
    UniGeneiHs.31664.
    Hs.733275.

    Genome annotation databases

    EnsembliENST00000229030; ENSP00000229030; ENSG00000111432.
    GeneIDi11211.
    KEGGihsa:11211.
    UCSCiuc001uii.3. human.

    Polymorphism databases

    DMDMi17433091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027464 mRNA. Translation: BAA84093.1 .
    BC074997 mRNA. Translation: AAH74997.1 .
    BC074998 mRNA. Translation: AAH74998.1 .
    CCDSi CCDS9267.1.
    PIRi JC7086.
    RefSeqi NP_009128.1. NM_007197.3.
    UniGenei Hs.31664.
    Hs.733275.

    3D structure databases

    ProteinModelPortali Q9ULW2.
    SMRi Q9ULW2. Positions 34-150, 193-537.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116380. 1 interaction.
    IntActi Q9ULW2. 1 interaction.
    STRINGi 9606.ENSP00000229030.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 17433091.

    Proteomic databases

    PaxDbi Q9ULW2.
    PRIDEi Q9ULW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229030 ; ENSP00000229030 ; ENSG00000111432 .
    GeneIDi 11211.
    KEGGi hsa:11211.
    UCSCi uc001uii.3. human.

    Organism-specific databases

    CTDi 11211.
    GeneCardsi GC12P130648.
    HGNCi HGNC:4039. FZD10.
    HPAi HPA014484.
    HPA014485.
    MIMi 606147. gene.
    neXtProti NX_Q9ULW2.
    PharmGKBi PA28456.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257258.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi Q9ULW2.
    KOi K02842.
    OMAi QSWQNVC.
    OrthoDBi EOG7M3J01.
    PhylomeDBi Q9ULW2.
    TreeFami TF317907.

    Enzyme and pathway databases

    Reactomei REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GeneWikii FZD10.
    GenomeRNAii 11211.
    NextBioi 42667.
    PROi Q9ULW2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULW2.
    Bgeei Q9ULW2.
    CleanExi HS_FZD10.
    Genevestigatori Q9ULW2.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family."
      Koike J., Takagi A., Miwa T., Hirai M., Terada M., Katoh M.
      Biochem. Biophys. Res. Commun. 262:39-43(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal kidney and Fetal lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
      Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
      Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-325.
      Tissue: Esophageal carcinoma.
    4. Cited for: INTERACTION WITH MYOC.

    Entry informationi

    Entry nameiFZD10_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3