Q9ULW2 (FZD10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Frizzled-10
Short name=Fz-10
Short name=hFz10

Alternative name(s):
FzE7
CD_antigen=CD350

Gene names

Name:

FZD10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Domain	Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity. The FZ domain is involved in binding with Wnt ligands By similarity.
Post-translational modification	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome gonad development Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of Rho GTPase activity Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB non-canonical Wnt receptor signaling pathway via JNK cascade Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL positive regulation of JUN kinase activity Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL positive regulation of Rac GTPase activity Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL regulation of actin cytoskeleton organization Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL vasculature development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cell projection Inferred from Biological aspect of Ancestor. Source: RefGenome cell surface Inferred from direct assay PubMed 18271942. Source: BHF-UCL cytoplasm Inferred from direct assay PubMed 16007199. Source: BHF-UCL integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW PDZ domain binding Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt-activated receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt-protein binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 581	561	Frizzled-10		PRO_0000013005
Regions
	Topological domain	21 – 225	205	Extracellular Potential
	Transmembrane	226 – 246	21	Helical; Name=1; Potential
	Topological domain	247 – 262	16	Cytoplasmic Potential
	Transmembrane	263 – 283	21	Helical; Name=2; Potential
	Topological domain	284 – 311	28	Extracellular Potential
	Transmembrane	312 – 332	21	Helical; Name=3; Potential
	Topological domain	333 – 351	19	Cytoplasmic Potential
	Transmembrane	352 – 372	21	Helical; Name=4; Potential
	Topological domain	373 – 393	21	Extracellular Potential
	Transmembrane	394 – 414	21	Helical; Name=5; Potential
	Topological domain	415 – 443	29	Cytoplasmic Potential
	Transmembrane	444 – 464	21	Helical; Name=6; Potential
	Topological domain	465 – 502	38	Extracellular Potential
	Transmembrane	503 – 523	21	Helical; Name=7; Potential
	Topological domain	524 – 581	58	Cytoplasmic Potential
	Domain	29 – 150	122	FZ
	Motif	526 – 531	6	Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
	Motif	579 – 581	3	PDZ-binding
Amino acid modifications
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	485	1	N-linked (GlcNAc...) Potential
	Disulfide bond	34 ↔ 95		By similarity
	Disulfide bond	42 ↔ 88		By similarity
	Disulfide bond	79 ↔ 117		By similarity
	Disulfide bond	106 ↔ 147		By similarity
	Disulfide bond	110 ↔ 134		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ULW2 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E9B7E51FA7C87B26	FASTA	581	65,336
	10 20 30 40 50 60 MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT RMPNLMGHEN 70 80 90 100 110 120 QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS TPIPACRVMC EQARLKCSPI 130 140 150 160 170 180 MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH 190 200 210 220 230 240 PLKDGGPGRG GCDNPGKFHH VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF 250 260 270 280 290 300 SSAFTVLTFL IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI 310 320 330 340 350 360 QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN SSYFHLAAWA 370 380 390 400 410 420 IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI PLACYLVIGT SFILSGFVAL 430 440 450 460 470 480 FHIRRVMKTG GENTDKLEKL MVRIGLFSVL YTVPATCVIA CYFYERLNMD YWKILAAQHK 490 500 510 520 530 540 CKMNNQTKTL DCLMAASIPA VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK 550 560 570 580 KKSRRKPASV ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family." Koike J., Takagi A., Miwa T., Hirai M., Terada M., Katoh M. Biochem. Biophys. Res. Commun. 262:39-43(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney and Fetal lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals." Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K. Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-325. Tissue: Esophageal carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB027464 mRNA. Translation: BAA84093.1. BC074997 mRNA. Translation: AAH74997.1. BC074998 mRNA. Translation: AAH74998.1.
IPI	IPI00026973.
PIR	JC7086.
RefSeq	NP_009128.1. NM_007197.3.
UniGene	Hs.31664. Hs.733275.
3D structure databases
ProteinModelPortal	Q9ULW2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000229030.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	17433091.
Proteomic databases
PaxDb	Q9ULW2.
PRIDE	Q9ULW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229030; ENSP00000229030; ENSG00000111432.
GeneID	11211.
KEGG	hsa:11211.
UCSC	uc001uii.3. human.
Organism-specific databases
CTD	11211.
GeneCards	GC12P130648.
HGNC	HGNC:4039. FZD10.
HPA	HPA014484. HPA014485.
MIM	606147. gene.
neXtProt	NX_Q9ULW2.
PharmGKB	PA28456.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG257258.
HOGENOM	HOG000233236.
HOVERGEN	HBG006977.
InParanoid	Q9ULW2.
KO	K02842.
OMA	LQSWQNV.
OrthoDB	EOG4C2H93.
PhylomeDB	Q9ULW2.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9ULW2.
Bgee	Q9ULW2.
CleanEx	HS_FZD10.
Genevestigator	Q9ULW2.
GermOnline	ENSG00000111432. Homo sapiens.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR000539. Frizzled. IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR026549. FZD10. IPR017981. GPCR_2-like. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF24. PTHR11309:SF24. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11211.
NextBio	42667.
SOURCE	Search...

Entry information

Entry name

FZD10_HUMAN

Accession

Primary (citable) accession number: Q9ULW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.