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Q9ULW2

- FZD10_HUMAN

UniProt

Q9ULW2 - FZD10_HUMAN

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Protein

Frizzled-10

Gene

FZD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: RefGenome

GO - Biological processi

  1. brain development Source: RefGenome
  2. canonical Wnt signaling pathway Source: RefGenome
  3. cellular response to retinoic acid Source: UniProtKB
  4. gonad development Source: RefGenome
  5. negative regulation of Rho GTPase activity Source: BHF-UCL
  6. neuron differentiation Source: UniProtKB
  7. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
  8. positive regulation of JUN kinase activity Source: BHF-UCL
  9. positive regulation of Rac GTPase activity Source: BHF-UCL
  10. regulation of actin cytoskeleton organization Source: BHF-UCL
  11. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Short name:
hFz10
Alternative name(s):
FzE7
CD_antigen: CD350
Gene namesi
Name:FZD10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4039. FZD10.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 225205ExtracellularSequence AnalysisAdd
BLAST
Transmembranei226 – 24621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini247 – 26216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini284 – 31128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini333 – 35119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei352 – 37221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini373 – 39321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei394 – 41421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini415 – 44329CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei444 – 46421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini465 – 50238ExtracellularSequence AnalysisAdd
BLAST
Transmembranei503 – 52321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini524 – 58158CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: RefGenome
  2. cell surface Source: BHF-UCL
  3. cytoplasm Source: BHF-UCL
  4. integral component of plasma membrane Source: ProtInc
  5. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 581561Frizzled-10PRO_0000013005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 95PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi79 ↔ 117PROSITE-ProRule annotation
Disulfide bondi106 ↔ 147PROSITE-ProRule annotation
Disulfide bondi110 ↔ 134PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9ULW2.
PaxDbiQ9ULW2.
PRIDEiQ9ULW2.

Expressioni

Tissue specificityi

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.

Gene expression databases

BgeeiQ9ULW2.
CleanExiHS_FZD10.
ExpressionAtlasiQ9ULW2. baseline and differential.
GenevestigatoriQ9ULW2.

Organism-specific databases

HPAiHPA014484.
HPA014485.

Interactioni

Subunit structurei

Interacts with MYOC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HILPDAQ9Y5L22EBI-8803802,EBI-8803836

Protein-protein interaction databases

BioGridi116380. 1 interaction.
IntActiQ9ULW2. 1 interaction.
STRINGi9606.ENSP00000229030.

Structurei

3D structure databases

ProteinModelPortaliQ9ULW2.
SMRiQ9ULW2. Positions 34-150, 193-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 150122FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi526 – 5316Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
Motifi579 – 5813PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ9ULW2.
KOiK02842.
OMAiQSWQNVC.
OrthoDBiEOG7M3J01.
PhylomeDBiQ9ULW2.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT
60 70 80 90 100
RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS
110 120 130 140 150
TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA
160 170 180 190 200
PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH
210 220 230 240 250
VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF SSAFTVLTFL
260 270 280 290 300
IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI
310 320 330 340 350
QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN
360 370 380 390 400
SSYFHLAAWA IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI
410 420 430 440 450
PLACYLVIGT SFILSGFVAL FHIRRVMKTG GENTDKLEKL MVRIGLFSVL
460 470 480 490 500
YTVPATCVIA CYFYERLNMD YWKILAAQHK CKMNNQTKTL DCLMAASIPA
510 520 530 540 550
VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK KKSRRKPASV
560 570 580
ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V
Length:581
Mass (Da):65,336
Last modified:May 1, 2000 - v1
Checksum:iE9B7E51FA7C87B26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027464 mRNA. Translation: BAA84093.1.
BC074997 mRNA. Translation: AAH74997.1.
BC074998 mRNA. Translation: AAH74998.1.
CCDSiCCDS9267.1.
PIRiJC7086.
RefSeqiNP_009128.1. NM_007197.3.
UniGeneiHs.31664.
Hs.733275.

Genome annotation databases

EnsembliENST00000229030; ENSP00000229030; ENSG00000111432.
GeneIDi11211.
KEGGihsa:11211.
UCSCiuc001uii.3. human.

Polymorphism databases

DMDMi17433091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027464 mRNA. Translation: BAA84093.1 .
BC074997 mRNA. Translation: AAH74997.1 .
BC074998 mRNA. Translation: AAH74998.1 .
CCDSi CCDS9267.1.
PIRi JC7086.
RefSeqi NP_009128.1. NM_007197.3.
UniGenei Hs.31664.
Hs.733275.

3D structure databases

ProteinModelPortali Q9ULW2.
SMRi Q9ULW2. Positions 34-150, 193-537.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116380. 1 interaction.
IntActi Q9ULW2. 1 interaction.
STRINGi 9606.ENSP00000229030.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 17433091.

Proteomic databases

MaxQBi Q9ULW2.
PaxDbi Q9ULW2.
PRIDEi Q9ULW2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229030 ; ENSP00000229030 ; ENSG00000111432 .
GeneIDi 11211.
KEGGi hsa:11211.
UCSCi uc001uii.3. human.

Organism-specific databases

CTDi 11211.
GeneCardsi GC12P130648.
HGNCi HGNC:4039. FZD10.
HPAi HPA014484.
HPA014485.
MIMi 606147. gene.
neXtProti NX_Q9ULW2.
PharmGKBi PA28456.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi Q9ULW2.
KOi K02842.
OMAi QSWQNVC.
OrthoDBi EOG7M3J01.
PhylomeDBi Q9ULW2.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

GeneWikii FZD10.
GenomeRNAii 11211.
NextBioi 42667.
PROi Q9ULW2.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULW2.
CleanExi HS_FZD10.
ExpressionAtlasi Q9ULW2. baseline and differential.
Genevestigatori Q9ULW2.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family."
    Koike J., Takagi A., Miwa T., Hirai M., Terada M., Katoh M.
    Biochem. Biophys. Res. Commun. 262:39-43(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal kidney and Fetal lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
    Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
    Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-325.
    Tissue: Esophageal carcinoma.
  4. Cited for: INTERACTION WITH MYOC.

Entry informationi

Entry nameiFZD10_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3