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Q9ULW2 (FZD10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Frizzled-10

Short name=Fz-10
Short name=hFz10
Alternative name(s):
FzE7
CD_antigen=CD350
Gene names
Name:FZD10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subunit structure

Interacts with MYOC. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Post-translational modification

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

gonad development

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of Rho GTPase activity

Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

non-canonical Wnt signaling pathway via JNK cascade

Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL

positive regulation of JUN kinase activity

Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL

positive regulation of Rac GTPase activity

Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL

regulation of actin cytoskeleton organization

Inferred from mutant phenotype PubMed 19137009. Source: BHF-UCL

vasculature development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcell projection

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell surface

Inferred from direct assay PubMed 18271942. Source: BHF-UCL

cytoplasm

Inferred from direct assay PubMed 16007199. Source: BHF-UCL

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

PDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein binding

Inferred from physical interaction Ref.4. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HILPDAQ9Y5L22EBI-8803802,EBI-8803836

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 581561Frizzled-10
PRO_0000013005

Regions

Topological domain21 – 225205Extracellular Potential
Transmembrane226 – 24621Helical; Name=1; Potential
Topological domain247 – 26216Cytoplasmic Potential
Transmembrane263 – 28321Helical; Name=2; Potential
Topological domain284 – 31128Extracellular Potential
Transmembrane312 – 33221Helical; Name=3; Potential
Topological domain333 – 35119Cytoplasmic Potential
Transmembrane352 – 37221Helical; Name=4; Potential
Topological domain373 – 39321Extracellular Potential
Transmembrane394 – 41421Helical; Name=5; Potential
Topological domain415 – 44329Cytoplasmic Potential
Transmembrane444 – 46421Helical; Name=6; Potential
Topological domain465 – 50238Extracellular Potential
Transmembrane503 – 52321Helical; Name=7; Potential
Topological domain524 – 58158Cytoplasmic Potential
Domain29 – 150122FZ
Motif526 – 5316Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motif579 – 5813PDZ-binding

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation4851N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 95 By similarity
Disulfide bond42 ↔ 88 By similarity
Disulfide bond79 ↔ 117 By similarity
Disulfide bond106 ↔ 147 By similarity
Disulfide bond110 ↔ 134 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ULW2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E9B7E51FA7C87B26

FASTA58165,336
        10         20         30         40         50         60 
MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT RMPNLMGHEN 

        70         80         90        100        110        120 
QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS TPIPACRVMC EQARLKCSPI 

       130        140        150        160        170        180 
MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH 

       190        200        210        220        230        240 
PLKDGGPGRG GCDNPGKFHH VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF 

       250        260        270        280        290        300 
SSAFTVLTFL IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI 

       310        320        330        340        350        360 
QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN SSYFHLAAWA 

       370        380        390        400        410        420 
IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI PLACYLVIGT SFILSGFVAL 

       430        440        450        460        470        480 
FHIRRVMKTG GENTDKLEKL MVRIGLFSVL YTVPATCVIA CYFYERLNMD YWKILAAQHK 

       490        500        510        520        530        540 
CKMNNQTKTL DCLMAASIPA VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK 

       550        560        570        580 
KKSRRKPASV ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family."
Koike J., Takagi A., Miwa T., Hirai M., Terada M., Katoh M.
Biochem. Biophys. Res. Commun. 262:39-43(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal kidney and Fetal lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-325.
Tissue: Esophageal carcinoma.
[4]"Myocilin is a modulator of Wnt signaling."
Kwon H.S., Lee H.S., Ji Y., Rubin J.S., Tomarev S.I.
Mol. Cell. Biol. 29:2139-2154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYOC.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027464 mRNA. Translation: BAA84093.1.
BC074997 mRNA. Translation: AAH74997.1.
BC074998 mRNA. Translation: AAH74998.1.
CCDSCCDS9267.1.
PIRJC7086.
RefSeqNP_009128.1. NM_007197.3.
UniGeneHs.31664.
Hs.733275.

3D structure databases

ProteinModelPortalQ9ULW2.
SMRQ9ULW2. Positions 34-150, 193-537.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116380. 1 interaction.
IntActQ9ULW2. 1 interaction.
STRING9606.ENSP00000229030.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM17433091.

Proteomic databases

PaxDbQ9ULW2.
PRIDEQ9ULW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229030; ENSP00000229030; ENSG00000111432.
GeneID11211.
KEGGhsa:11211.
UCSCuc001uii.3. human.

Organism-specific databases

CTD11211.
GeneCardsGC12P130648.
HGNCHGNC:4039. FZD10.
HPAHPA014484.
HPA014485.
MIM606147. gene.
neXtProtNX_Q9ULW2.
PharmGKBPA28456.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257258.
HOGENOMHOG000233236.
HOVERGENHBG006977.
InParanoidQ9ULW2.
KOK02842.
OMAQSWQNVC.
OrthoDBEOG7M3J01.
PhylomeDBQ9ULW2.
TreeFamTF317907.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9ULW2.
BgeeQ9ULW2.
CleanExHS_FZD10.
GenevestigatorQ9ULW2.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFZD10.
GenomeRNAi11211.
NextBio42667.
PROQ9ULW2.
SOURCESearch...

Entry information

Entry nameFZD10_HUMAN
AccessionPrimary (citable) accession number: Q9ULW2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries