##gff-version 3 Q9ULV8 UniProtKB Chain 1 474 . . . ID=PRO_0000055866;Note=E3 ubiquitin-protein ligase CBL-C Q9ULV8 UniProtKB Domain 7 321 . . . Note=Cbl-PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00839 Q9ULV8 UniProtKB Zinc finger 351 390 . . . Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175 Q9ULV8 UniProtKB Region 7 145 . . . Note=4H Q9ULV8 UniProtKB Region 146 218 . . . Note=EF-hand-like Q9ULV8 UniProtKB Region 219 321 . . . Note=SH2-like Q9ULV8 UniProtKB Region 322 350 . . . Note=Linker Q9ULV8 UniProtKB Region 351 474 . . . Note=Interaction with RET;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18753381;Dbxref=PMID:18753381 Q9ULV8 UniProtKB Region 409 474 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULV8 UniProtKB Compositional bias 431 447 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULV8 UniProtKB Binding site 199 199 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22681 Q9ULV8 UniProtKB Binding site 201 201 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22681 Q9ULV8 UniProtKB Binding site 210 210 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22681 Q9ULV8 UniProtKB Binding site 264 264 . . . . Q9ULV8 UniProtKB Modified residue 341 341 . . . Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:20525694,PMID:23145173 Q9ULV8 UniProtKB Alternative sequence 261 306 . . . ID=VSP_005732;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10362357;Dbxref=PMID:10362357 Q9ULV8 UniProtKB Natural variant 405 405 . . . ID=VAR_018298;Note=H->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10362357,ECO:0000269|PubMed:10571044;Dbxref=dbSNP:rs3208856,PMID:10362357,PMID:10571044 Q9ULV8 UniProtKB Mutagenesis 244 244 . . . Note=Abolishes interaction with EGFR. Decreases interaction with SRC and abolishes SRC ubiquitination. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 244 244 . . . Note=No effect on interaction with EGFR and SRC as well as on SRC ubiquitination. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 264 264 . . . Note=Abolishes interaction with EGFR. Decreases interaction with SRC and abolishes SRC ubiquitination. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 265 265 . . . Note=Enhances interaction with EGFR and SRC as well as SRC ubiquitination. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 266 266 . . . Note=Decreases interactions with EGFR and SRC as well as SRC ubiquitination. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 268 268 . . . Note=Abolishes interaction with EGFR. Decreases interaction with and ubiquitination of SRC. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22888118;Dbxref=PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 276 276 . . . Note=No effect on interaction with RET. Binds slightly to SRC%2C this interaction is independent of SRC phosphorylation. Strongly decreases SRC ubiquitination. Abolishes interaction with EGFR. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:18753381,ECO:0000269|PubMed:22888118;Dbxref=PMID:14661060,PMID:18753381,PMID:22888118 Q9ULV8 UniProtKB Mutagenesis 341 341 . . . Note=Induces E3 activity and autoubiquitination. Releases ubiquitin-conjugating enzyme E2 UBE2D2 faster. Y->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:20525694,PMID:23145173 Q9ULV8 UniProtKB Mutagenesis 341 341 . . . Note=Abolishes activation by EGF stimulation and enhancement by TGFB1I1 of E3 activity. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:20525694,PMID:23145173 Q9ULV8 UniProtKB Mutagenesis 341 341 . . . Note=Abolishes E3 activity. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:20525694,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:20525694,PMID:23145173 Q9ULV8 UniProtKB Mutagenesis 351 351 . . . Note=No effect on TGFB1I1 and SRC interactions. Abolishes SRC ubiquitination. Abolishes interaction with TGFB1I1%3B when associated with A-366. Abolishes interaction with RET and inhibition of RET degradation. C->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:18753381,ECO:0000269|PubMed:23145173;Dbxref=PMID:14661060,PMID:18753381,PMID:23145173 Q9ULV8 UniProtKB Mutagenesis 366 366 . . . Note=Abolishes interaction with TGFB1I1. Abolishes interaction with TGFB1I1%3B when associated with A-351. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23145173;Dbxref=PMID:23145173 Q9ULV8 UniProtKB Sequence conflict 234 234 . . . Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9ULV8 UniProtKB Sequence conflict 413 413 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9ULV8 UniProtKB Helix 13 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 40 42 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3OP0 Q9ULV8 UniProtKB Helix 44 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 64 66 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 76 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 100 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3OP0 Q9ULV8 UniProtKB Helix 108 111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3OP0 Q9ULV8 UniProtKB Helix 116 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 140 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Turn 146 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 154 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 168 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 172 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Turn 180 182 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 189 198 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 203 207 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 208 217 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 221 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 224 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 238 241 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRQ Q9ULV8 UniProtKB Helix 244 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 252 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 260 265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 267 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 273 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Beta strand 284 287 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 294 303 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VRP Q9ULV8 UniProtKB Helix 320 323 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3OP0