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Reviewed, UniProtKB/Swiss-Prot Q9ULV8 (CBLC_HUMAN)

Last modified June 16, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Signal transduction protein CBL-C
Alternative name(s):
    SH3-binding protein CBL-C
    CBL-3
    RING finger protein 57
Gene names
Name: CBLC
Synonyms: CBL3, RNF57
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Regulator of EGFR mediated signal transduction.

Subunit structure

Interacts with a restricted range of SH3 domain proteins.

Subcellular location

Nucleus Potential.

Tissue specificity

Ubiquitous.

Domain

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.

Post-translational modification

Phosphorylated on tyrosines by EGFR. Ref.4

Miscellaneous

This protein has one functional calcium-binding site By similarity.

Sequence similarities

Contains 1 CBL N-terminal domain.

Contains 2 EF-hand-like domains.

Contains 1 RING-type zinc finger.

Contains 1 SH2 domain.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q9ULV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q9ULV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     261-306: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Signal transduction protein CBL-C
PRO_0000055866

Regions

Domain8 – 327320CBL N-terminal
Domain182 – 1909EF-hand-like 1
Domain199 – 21012EF-hand-like 2
Domain237 – 31175SH2; atypical
Zinc finger351 – 39040RING-type
Region8 – 1471404H
Region312 – 35039Linker
Motif89 – 924Nuclear localization signal Potential

Sites

Binding site2641Phosphotyrosine By similarity

Amino acid modifications

Modified residue401Phosphoserine Ref.4

Natural variations

Alternative sequence261 – 30646Missing in isoform Short.
VSP_005732
Natural variant4051H → Y: dbSNP rs3208856. Ref.1 Ref.2
VAR_018298

Experimental info

Sequence conflict2341N → T in BAA86298. Ref.1
Sequence conflict4131S → P in AAH28915. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified February 6, 2007. Version 3.
Checksum: 202634AEDE434544

FASTA47452,456
        10         20         30         40         50         60 
MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH 

        70         80         90        100        110        120 
SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ 

       130        140        150        160        170        180 
LAKLAIIFSH MHAELHALFP GGKYCGHMYQ LTKAPAHTFW RESCGARCVL PWAEFESLLG 

       190        200        210        220        230        240 
TCHPVEPGCT ALALRTTIDL TCSGHVSIFE FDVFTRLFQP WPTLLKNWQL LAVNHPGYMA 

       250        260        270        280        290        300 
FLTYDEVQER LQACRDKPGS YIFRPSCTRL GQWAIGYVSS DGSILQTIPA NKPLSQVLLE 

       310        320        330        340        350        360 
GQKDGFYLYP DGKTHNPDLT ELGQAEPQQR IHVSEEQLQL YWAMDSTFEL CKICAESNKD 

       370        380        390        400        410        420 
VKIEPCGHLL CSCCLAAWQH SDSQTCPFCR CEIKGWEAVS IYQFHGQATA EDSGNSSDQE 

       430        440        450        460        470 
GRELELGQVP LSAPPLPPRP DLPPRKPRNA QPKVRLLKGN SPPAALGPQD PAPA

« Hide

Isoform Short.

Checksum: 7070EDF530032CA0
Show »

FASTA42847,418

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References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel cbl-family gene, cbl-c."
Kim M., Tezuka T., Suzuki Y., Sugano S., Hirai M., Yamamoto T.
Gene 239:145-154(1999) [PubMed: 10571044] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT TYR-405.
[2]"cbl-3: a new mammalian cbl family protein."
Keane M.M., Ettenberg S.A., Nau M.M., Banerjee P., Cuello M., Penninger J., Lipkowitz S.
Oncogene 18:3365-3375(1999) [PubMed: 10362357] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), VARIANT TYR-405.
Tissue: Pancreatic adenocarcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Tissue: Skin.
[4]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, MASS SPECTROMETRY.
Tissue: Epithelium.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AB028645 mRNA. Translation: BAA86298.1.
AF117646 mRNA. Translation: AAD34341.1.
AF117647 mRNA. Translation: AAD34342.1.
BC028915 mRNA. Translation: AAH28915.1.
IPIIPI00008459.
IPI00220418.
RefSeqNP_001124324.1.
NP_036248.3.
UniGeneHs.466907

3D structure databases

HSSPHSSP built from PDB template 1FBV based on UniProtKB P22681.
ModBaseSearch...

PTM databases

PhosphoSiteQ9ULV8.

Proteomic databases

PRIDEQ9ULV8.

Genome annotation databases

EnsemblENSG00000142273. Homo sapiens. [Contig view]
GeneID23624.
KEGGhsa:23624.
NMPDRfig|9606.3.peg.16655.

Organism-specific databases

GeneCardsGC19P049972.
H-InvDBHIX0015212.
HGNCHGNC:15961. CBLC.
HPACAB008087.
MIM608453. gene.
PharmGKBPA26117.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9ULV8.
HOVERGENQ9ULV8.
OMAQ9ULV8. SINTIFH.

Gene expression databases

ArrayExpressQ9ULV8.
BgeeQ9ULV8.
CleanExHS_CBLC.
GermOnlineENSG00000142273. Homo sapiens.

Family and domain databases

InterProIPR014741. Adaptor_Cbl_EF_Hand-like.
IPR003153. Adaptor_Cbl_N.
IPR014742. Adaptor_Cbl_SH2-like.
IPR011992. EF-Hand_type.
IPR000980. SH2.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
Gene3DG3DSA:1.20.930.20. Adaptor_Cbl_N. 1 hit.
G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
G3DSA:3.30.505.10. SH2. 1 hit.
PfamPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
PROSITEPS50001. SH2. False negative.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio46378.
SOURCESearch...

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Entry information

Entry nameCBLC_HUMAN
AccessionPrimary (citable) accession number: Q9ULV8
Secondary accession number(s): Q8N1E5, Q9Y5Z2, Q9Y5Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 6, 2007
Last modified: June 16, 2009
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents