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Q9ULV3

- CIZ1_HUMAN

UniProt

Q9ULV3 - CIZ1_HUMAN

Protein

Cip1-interacting zinc finger protein

Gene

CIZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May regulate the subcellular localization of CIP/WAF1.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri799 – 83032Matrin-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. protein binding Source: IntAct
    3. zinc ion binding Source: ProtInc

    GO - Biological processi

    1. maintenance of protein location in nucleus Source: Ensembl
    2. positive regulation of DNA-dependent DNA replication initiation Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cip1-interacting zinc finger protein
    Alternative name(s):
    CDKN1A-interacting zinc finger protein 1
    Nuclear protein NP94
    Zinc finger protein 356
    Gene namesi
    Name:CIZ1
    Synonyms:LSFR1, NP94, ZNF356
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16744. CIZ1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.

    Keywords - Diseasei

    Disease mutation, Dystonia

    Organism-specific databases

    PharmGKBiPA134883336.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 898898Cip1-interacting zinc finger proteinPRO_0000089776Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei567 – 5671Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULV3.
    PaxDbiQ9ULV3.
    PRIDEiQ9ULV3.

    PTM databases

    PhosphoSiteiQ9ULV3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULV3.
    BgeeiQ9ULV3.
    CleanExiHS_CIZ1.
    GenevestigatoriQ9ULV3.

    Organism-specific databases

    HPAiHPA020380.
    HPA020384.
    HPA020387.

    Interactioni

    Subunit structurei

    Interacts with CIP/WAF1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SH3BP4Q9P0V32EBI-2652948,EBI-1049513

    Protein-protein interaction databases

    BioGridi117325. 9 interactions.
    IntActiQ9ULV3. 7 interactions.
    STRINGi9606.ENSP00000362029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULV3.
    SMRiQ9ULV3. Positions 655-706.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 4441Gln-richAdd
    BLAST
    Compositional biasi276 – 470195Gln-richAdd
    BLAST
    Compositional biasi741 – 76121Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri799 – 83032Matrin-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG70338.
    HOVERGENiHBG002558.
    InParanoidiQ9ULV3.
    OrthoDBiEOG75F4G0.
    PhylomeDBiQ9ULV3.
    TreeFamiTF332388.

    Family and domain databases

    InterProiIPR026811. CIZ1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR000690. Znf_C2H2_matrin.
    IPR003604. Znf_U1.
    [Graphical view]
    PANTHERiPTHR15491:SF9. PTHR15491:SF9. 1 hit.
    PfamiPF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    SM00451. ZnF_U1. 3 hits.
    [Graphical view]
    PROSITEiPS50171. ZF_MATRIN. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULV3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP    50
    LPMAVSRGLP PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGLDQF 100
    AMPPATYDTA GLTMPTATLG NLRGYGMASP GLAAPSLTPP QLATPNLQQF 150
    FPQATRQSLL GPPPVGVPMN PSQFNLSGRN PQKQARTSSS TTPNRKDSSS 200
    QTMPVEDKSD PPEGSEEAAE PRMDTPEDQD LPPCPEDIAK EKRTPAPEPE 250
    PCEASELPAK RLRSSEEPTE KEPPGQLQVK AQPQARMTVP KQTQTPDLLP 300
    EALEAQVLPR FQPRVLQVQA QVQSQTQPRI PSTDTQVQPK LQKQAQTQTS 350
    PEHLVLQQKQ VQPQLQQEAE PQKQVQPQVQ PQAHSQGPRQ VQLQQEAEPL 400
    KQVQPQVQPQ AHSQPPRQVQ LQLQKQVQTQ TYPQVHTQAQ PSVQPQEHPP 450
    AQVSVQPPEQ THEQPHTQPQ VSLLAPEQTP VVVHVCGLEM PPDAVEAGGG 500
    MEKTLPEPVG TQVSMEEIQN ESACGLDVGE CENRAREMPG VWGAGGSLKV 550
    TILQSSDSRA FSTVPLTPVP RPSDSVSSTP AATSTPSKQA LQFFCYICKA 600
    SCSSQQEFQD HMSEPQHQQR LGEIQHMSQA CLLSLLPVPR DVLETEDEEP 650
    PPRRWCNTCQ LYYMGDLIQH RRTQDHKIAK QSLRPFCTVC NRYFKTPRKF 700
    VEHVKSQGHK DKAKELKSLE KEIAGQDEDH FITVDAVGCF EGDEEEEEDD 750
    EDEEEIEVEE ELCKQVRSRD ISREEWKGSE TYSPNTAYGV DFLVPVMGYI 800
    CRICHKFYHS NSGAQLSHCK SLGHFENLQK YKAAKNPSPT TRPVSRRCAI 850
    NARNALTALF TSSGRPPSQP NTQDKTPSKV TARPSQPPLP RRSTRLKT 898
    Length:898
    Mass (Da):100,045
    Last modified:May 18, 2010 - v2
    Checksum:i5E14389E81A146F1
    GO
    Isoform 2 (identifier: Q9ULV3-2) [UniParc]FASTAAdd to Basket

    Also known as: NP94B

    The sequence of this isoform differs from the canonical sequence as follows:
         97-120: Missing.
         197-201: Missing.

    Show »
    Length:869
    Mass (Da):97,075
    Checksum:iACCB3ABBE6A91F03
    GO
    Isoform 3 (identifier: Q9ULV3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-120: Missing.
         377-432: Missing.

    Show »
    Length:818
    Mass (Da):91,153
    Checksum:i28DBDF0FB222820E
    GO
    Isoform 4 (identifier: Q9ULV3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         377-432: Missing.

    Show »
    Length:842
    Mass (Da):93,619
    Checksum:iC799C715E082C006
    GO
    Isoform 5 (identifier: Q9ULV3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-101: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:797
    Mass (Da):88,520
    Checksum:i1C3805A4CFAC8864
    GO

    Sequence cautioni

    The sequence AAF23231.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAF37882.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91Missing in AAF23231. (PubMed:12824700)Curated
    Sequence conflicti35 – 351L → S in AAF23231. (PubMed:12824700)Curated
    Sequence conflicti101 – 1011A → V in BAB14750. (PubMed:14702039)Curated
    Sequence conflicti232 – 2321P → L in BAA85783. (PubMed:10529385)Curated
    Sequence conflicti500 – 5001G → S in AAF37882. (PubMed:12824700)Curated
    Sequence conflicti549 – 5491K → E in BAG64643. (PubMed:14702039)Curated
    Sequence conflicti555 – 5551S → G in BAA85783. (PubMed:10529385)Curated
    Sequence conflicti568 – 5681P → L in AAF23231. (PubMed:12824700)Curated
    Sequence conflicti634 – 6341S → P in AAF23231. (PubMed:12824700)Curated
    Sequence conflicti677 – 6771K → R in AAF37882. (PubMed:12824700)Curated
    Sequence conflicti678 – 6781I → V in BAB14750. (PubMed:14702039)Curated
    Sequence conflicti682 – 6821S → P in BAB14750. (PubMed:14702039)Curated
    Sequence conflicti698 – 6981R → L in CAB44346. (PubMed:10369878)Curated
    Sequence conflicti735 – 7351D → G in AAF23231. (PubMed:12824700)Curated
    Sequence conflicti757 – 7571E → K in BAB14750. (PubMed:14702039)Curated
    Sequence conflicti810 – 8101S → N in AAF37882. (PubMed:12824700)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471P → S Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. 1 Publication
    VAR_067971
    Natural varianti50 – 501P → L.1 Publication
    VAR_067972
    Natural varianti219 – 2191A → T.1 Publication
    Corresponds to variant rs45588035 [ dbSNP | Ensembl ].
    VAR_056820
    Natural varianti264 – 2641S → G Probable disease-associated mutation found in a family with adult onset primary cervical dystonia; exonic splicing enhancer mutation resulting in altered CIZ1 splicing pattern. 1 Publication
    VAR_067973
    Natural varianti370 – 3701E → G.1 Publication
    Corresponds to variant rs45554035 [ dbSNP | Ensembl ].
    VAR_063105
    Natural varianti394 – 3941Q → E.1 Publication
    VAR_067974
    Natural varianti577 – 5771S → F.1 Publication
    VAR_067975
    Natural varianti578 – 5781S → F.1 Publication
    Corresponds to variant rs12334 [ dbSNP | Ensembl ].
    VAR_056821
    Natural varianti638 – 6381V → M.2 Publications
    Corresponds to variant rs11549266 [ dbSNP | Ensembl ].
    VAR_056822
    Natural varianti672 – 6721R → M Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. 1 Publication
    VAR_067976
    Natural varianti847 – 8471R → Q.1 Publication
    Corresponds to variant rs11549260 [ dbSNP | Ensembl ].
    VAR_063106

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 101101Missing in isoform 5. 1 PublicationVSP_044729Add
    BLAST
    Alternative sequencei97 – 12024Missing in isoform 2 and isoform 3. 2 PublicationsVSP_004164Add
    BLAST
    Alternative sequencei197 – 2015Missing in isoform 2. 1 PublicationVSP_004165
    Alternative sequencei377 – 43256Missing in isoform 3 and isoform 4. 2 PublicationsVSP_039894Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030835 mRNA. Translation: BAA85783.1.
    EF467915 Genomic DNA. Translation: ABO43037.1.
    AK023978 mRNA. Translation: BAB14750.1.
    AK292713 mRNA. Translation: BAF85402.1.
    AK303636 mRNA. Translation: BAG64643.1.
    AK316393 mRNA. Translation: BAH14764.1.
    AL590708 Genomic DNA. Translation: CAI13828.1.
    AL590708 Genomic DNA. Translation: CAI13829.1.
    AL590708 Genomic DNA. Translation: CAI13831.1.
    CH471090 Genomic DNA. Translation: EAW87752.1.
    CH471090 Genomic DNA. Translation: EAW87753.1.
    CH471090 Genomic DNA. Translation: EAW87754.1.
    BC021163 mRNA. Translation: AAH21163.1.
    AF159027 mRNA. Translation: AAF23231.1. Different initiation.
    AF234161 mRNA. Translation: AAF37882.1. Different initiation.
    Y17453 Genomic DNA. Translation: CAB44346.1.
    Y17454 Genomic DNA. Translation: CAB44347.1.
    CCDSiCCDS48033.1. [Q9ULV3-3]
    CCDS48034.1. [Q9ULV3-4]
    CCDS59147.1. [Q9ULV3-5]
    CCDS6894.1. [Q9ULV3-1]
    RefSeqiNP_001124487.1. NM_001131015.1. [Q9ULV3-4]
    NP_001124488.1. NM_001131016.1. [Q9ULV3-1]
    NP_001124489.1. NM_001131017.1.
    NP_001124490.1. NM_001131018.1. [Q9ULV3-3]
    NP_001244904.1. NM_001257975.1.
    NP_001244905.1. NM_001257976.1. [Q9ULV3-5]
    NP_036259.2. NM_012127.2. [Q9ULV3-1]
    UniGeneiHs.212395.

    Genome annotation databases

    EnsembliENST00000372938; ENSP00000362029; ENSG00000148337. [Q9ULV3-1]
    ENST00000372948; ENSP00000362039; ENSG00000148337. [Q9ULV3-4]
    ENST00000372954; ENSP00000362045; ENSG00000148337. [Q9ULV3-3]
    ENST00000393608; ENSP00000377232; ENSG00000148337. [Q9ULV3-1]
    GeneIDi25792.
    KEGGihsa:25792.
    UCSCiuc004bts.3. human. [Q9ULV3-2]
    uc004btt.3. human. [Q9ULV3-1]
    uc004btu.3. human. [Q9ULV3-3]
    uc004btw.3. human. [Q9ULV3-4]

    Polymorphism databases

    DMDMi296434448.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030835 mRNA. Translation: BAA85783.1 .
    EF467915 Genomic DNA. Translation: ABO43037.1 .
    AK023978 mRNA. Translation: BAB14750.1 .
    AK292713 mRNA. Translation: BAF85402.1 .
    AK303636 mRNA. Translation: BAG64643.1 .
    AK316393 mRNA. Translation: BAH14764.1 .
    AL590708 Genomic DNA. Translation: CAI13828.1 .
    AL590708 Genomic DNA. Translation: CAI13829.1 .
    AL590708 Genomic DNA. Translation: CAI13831.1 .
    CH471090 Genomic DNA. Translation: EAW87752.1 .
    CH471090 Genomic DNA. Translation: EAW87753.1 .
    CH471090 Genomic DNA. Translation: EAW87754.1 .
    BC021163 mRNA. Translation: AAH21163.1 .
    AF159027 mRNA. Translation: AAF23231.1 . Different initiation.
    AF234161 mRNA. Translation: AAF37882.1 . Different initiation.
    Y17453 Genomic DNA. Translation: CAB44346.1 .
    Y17454 Genomic DNA. Translation: CAB44347.1 .
    CCDSi CCDS48033.1. [Q9ULV3-3 ]
    CCDS48034.1. [Q9ULV3-4 ]
    CCDS59147.1. [Q9ULV3-5 ]
    CCDS6894.1. [Q9ULV3-1 ]
    RefSeqi NP_001124487.1. NM_001131015.1. [Q9ULV3-4 ]
    NP_001124488.1. NM_001131016.1. [Q9ULV3-1 ]
    NP_001124489.1. NM_001131017.1.
    NP_001124490.1. NM_001131018.1. [Q9ULV3-3 ]
    NP_001244904.1. NM_001257975.1.
    NP_001244905.1. NM_001257976.1. [Q9ULV3-5 ]
    NP_036259.2. NM_012127.2. [Q9ULV3-1 ]
    UniGenei Hs.212395.

    3D structure databases

    ProteinModelPortali Q9ULV3.
    SMRi Q9ULV3. Positions 655-706.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117325. 9 interactions.
    IntActi Q9ULV3. 7 interactions.
    STRINGi 9606.ENSP00000362029.

    PTM databases

    PhosphoSitei Q9ULV3.

    Polymorphism databases

    DMDMi 296434448.

    Proteomic databases

    MaxQBi Q9ULV3.
    PaxDbi Q9ULV3.
    PRIDEi Q9ULV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372938 ; ENSP00000362029 ; ENSG00000148337 . [Q9ULV3-1 ]
    ENST00000372948 ; ENSP00000362039 ; ENSG00000148337 . [Q9ULV3-4 ]
    ENST00000372954 ; ENSP00000362045 ; ENSG00000148337 . [Q9ULV3-3 ]
    ENST00000393608 ; ENSP00000377232 ; ENSG00000148337 . [Q9ULV3-1 ]
    GeneIDi 25792.
    KEGGi hsa:25792.
    UCSCi uc004bts.3. human. [Q9ULV3-2 ]
    uc004btt.3. human. [Q9ULV3-1 ]
    uc004btu.3. human. [Q9ULV3-3 ]
    uc004btw.3. human. [Q9ULV3-4 ]

    Organism-specific databases

    CTDi 25792.
    GeneCardsi GC09M130929.
    HGNCi HGNC:16744. CIZ1.
    HPAi HPA020380.
    HPA020384.
    HPA020387.
    MIMi 611420. gene.
    neXtProti NX_Q9ULV3.
    PharmGKBi PA134883336.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70338.
    HOVERGENi HBG002558.
    InParanoidi Q9ULV3.
    OrthoDBi EOG75F4G0.
    PhylomeDBi Q9ULV3.
    TreeFami TF332388.

    Miscellaneous databases

    ChiTaRSi CIZ1. human.
    GeneWikii CIZ1.
    GenomeRNAii 25792.
    NextBioi 46965.
    PROi Q9ULV3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULV3.
    Bgeei Q9ULV3.
    CleanExi HS_CIZ1.
    Genevestigatori Q9ULV3.

    Family and domain databases

    InterProi IPR026811. CIZ1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR000690. Znf_C2H2_matrin.
    IPR003604. Znf_U1.
    [Graphical view ]
    PANTHERi PTHR15491:SF9. PTHR15491:SF9. 1 hit.
    Pfami PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    SM00451. ZnF_U1. 3 hits.
    [Graphical view ]
    PROSITEi PS50171. ZF_MATRIN. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1."
      Mitsui K., Matsumoto A., Ohtsuka S., Ohtsubo M., Yoshimura A.
      Biochem. Biophys. Res. Commun. 264:457-464(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. NIEHS SNPs program
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-219; GLY-370; PHE-578; MET-638 AND GLN-847.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5), VARIANT MET-638.
      Tissue: Testis and Thymus.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Lymph.
    7. "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC."
      Warder D.E., Keherly M.J.
      J. Biomed. Sci. 10:406-417(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-898 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 50-898 (ISOFORM 2).
      Tissue: Medulloblastoma.
    8. "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes."
      Gilley J., Fried M.
      Hum. Mol. Genet. 8:1313-1320(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 649-898.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-567, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: POSSIBLE INVOLVEMENT IN ADULT ONSET PRIMARY CERVICAL DYSTONIA, VARIANTS SER-47; LEU-50; GLY-264; GLU-394; PHE-577 AND MET-672.

    Entry informationi

    Entry nameiCIZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULV3
    Secondary accession number(s): A8K9J8
    , B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3