Q9ULV3 (CIZ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cip1-interacting zinc finger protein

Alternative name(s):
CDKN1A-interacting zinc finger protein 1
Nuclear protein NP94
Zinc finger protein 356

Gene names

Name:	CIZ1
Synonyms:	LSFR1, NP94, ZNF356

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	898 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate the subcellular localization of CIP/WAF1.
Subunit structure	Interacts with CIP/WAF1.
Subcellular location	Nucleus.
Involvement in disease	Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.
Sequence similarities	Contains 1 matrin-type zinc finger.
Sequence caution	The sequence AAF23231.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAF37882.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Dystonia
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	maintenance of nucleus location Inferred from electronic annotation. Source: Compara positive regulation of DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Traceable author statement Ref.1. Source: ProtInc
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SH3BP4	Q9P0V3	2	EBI-2652948,EBI-1049513

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULV3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULV3-2)

Also known as: NP94B;

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     197-201: Missing.

Isoform 3 (identifier: Q9ULV3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     377-432: Missing.

Isoform 4 (identifier: Q9ULV3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     377-432: Missing.

Isoform 5 (identifier: Q9ULV3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 898	898	Cip1-interacting zinc finger protein		PRO_0000089776
Regions
	Zinc finger	799 – 830	32	Matrin-type
	Compositional bias	4 – 44	41	Gln-rich
	Compositional bias	276 – 470	195	Gln-rich
	Compositional bias	741 – 761	21	Glu-rich
Amino acid modifications
	Modified residue	567	1	Phosphothreonine Ref.10
Natural variations
	Alternative sequence	1 – 101	101	Missing in isoform 5.		VSP_044729
	Alternative sequence	97 – 120	24	Missing in isoform 2 and isoform 3.		VSP_004164
	Alternative sequence	197 – 201	5	Missing in isoform 2.		VSP_004165
	Alternative sequence	377 – 432	56	Missing in isoform 3 and isoform 4.		VSP_039894
	Natural variant	47	1	P → S Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. Ref.12		VAR_067971
	Natural variant	50	1	P → L. Ref.12		VAR_067972
	Natural variant	219	1	A → T. Ref.2 Corresponds to variant rs45588035 [ dbSNP | Ensembl ].		VAR_056820
	Natural variant	264	1	S → G Probable disease-associated mutation found in a family with adult onset primary cervical dystonia; exonic splicing enhancer mutation resulting in altered CIZ1 splicing pattern. Ref.12		VAR_067973
	Natural variant	370	1	E → G. Ref.2 Corresponds to variant rs45554035 [ dbSNP | Ensembl ].		VAR_063105
	Natural variant	394	1	Q → E. Ref.12		VAR_067974
	Natural variant	577	1	S → F. Ref.12		VAR_067975
	Natural variant	578	1	S → F. Ref.2 Corresponds to variant rs12334 [ dbSNP | Ensembl ].		VAR_056821
	Natural variant	638	1	V → M. Ref.2 Ref.3 Corresponds to variant rs11549266 [ dbSNP | Ensembl ].		VAR_056822
	Natural variant	672	1	R → M Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. Ref.12		VAR_067976
	Natural variant	847	1	R → Q. Ref.2 Corresponds to variant rs11549260 [ dbSNP | Ensembl ].		VAR_063106
Experimental info
	Sequence conflict	9	1	Missing in AAF23231. Ref.7
	Sequence conflict	35	1	L → S in AAF23231. Ref.7
	Sequence conflict	101	1	A → V in BAB14750. Ref.3
	Sequence conflict	232	1	P → L in BAA85783. Ref.1
	Sequence conflict	500	1	G → S in AAF37882. Ref.7
	Sequence conflict	549	1	K → E in BAG64643. Ref.3
	Sequence conflict	555	1	S → G in BAA85783. Ref.1
	Sequence conflict	568	1	P → L in AAF23231. Ref.7
	Sequence conflict	634	1	S → P in AAF23231. Ref.7
	Sequence conflict	677	1	K → R in AAF37882. Ref.7
	Sequence conflict	678	1	I → V in BAB14750. Ref.3
	Sequence conflict	682	1	S → P in BAB14750. Ref.3
	Sequence conflict	698	1	R → L in CAB44346. Ref.8
	Sequence conflict	735	1	D → G in AAF23231. Ref.7
	Sequence conflict	757	1	E → K in BAB14750. Ref.3
	Sequence conflict	810	1	S → N in AAF37882. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 5E14389E81A146F1	FASTA	898	100,045
	10 20 30 40 50 60 MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP LPMAVSRGLP 70 80 90 100 110 120 PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGLDQF AMPPATYDTA GLTMPTATLG 130 140 150 160 170 180 NLRGYGMASP GLAAPSLTPP QLATPNLQQF FPQATRQSLL GPPPVGVPMN PSQFNLSGRN 190 200 210 220 230 240 PQKQARTSSS TTPNRKDSSS QTMPVEDKSD PPEGSEEAAE PRMDTPEDQD LPPCPEDIAK 250 260 270 280 290 300 EKRTPAPEPE PCEASELPAK RLRSSEEPTE KEPPGQLQVK AQPQARMTVP KQTQTPDLLP 310 320 330 340 350 360 EALEAQVLPR FQPRVLQVQA QVQSQTQPRI PSTDTQVQPK LQKQAQTQTS PEHLVLQQKQ 370 380 390 400 410 420 VQPQLQQEAE PQKQVQPQVQ PQAHSQGPRQ VQLQQEAEPL KQVQPQVQPQ AHSQPPRQVQ 430 440 450 460 470 480 LQLQKQVQTQ TYPQVHTQAQ PSVQPQEHPP AQVSVQPPEQ THEQPHTQPQ VSLLAPEQTP 490 500 510 520 530 540 VVVHVCGLEM PPDAVEAGGG MEKTLPEPVG TQVSMEEIQN ESACGLDVGE CENRAREMPG 550 560 570 580 590 600 VWGAGGSLKV TILQSSDSRA FSTVPLTPVP RPSDSVSSTP AATSTPSKQA LQFFCYICKA 610 620 630 640 650 660 SCSSQQEFQD HMSEPQHQQR LGEIQHMSQA CLLSLLPVPR DVLETEDEEP PPRRWCNTCQ 670 680 690 700 710 720 LYYMGDLIQH RRTQDHKIAK QSLRPFCTVC NRYFKTPRKF VEHVKSQGHK DKAKELKSLE 730 740 750 760 770 780 KEIAGQDEDH FITVDAVGCF EGDEEEEEDD EDEEEIEVEE ELCKQVRSRD ISREEWKGSE 790 800 810 820 830 840 TYSPNTAYGV DFLVPVMGYI CRICHKFYHS NSGAQLSHCK SLGHFENLQK YKAAKNPSPT 850 860 870 880 890 TRPVSRRCAI NARNALTALF TSSGRPPSQP NTQDKTPSKV TARPSQPPLP RRSTRLKT
	Isoform 2 (NP94B) [UniParc]. Checksum: ACCB3ABBE6A91F03	FASTA	869	97,075
	10 20 30 40 50 60 MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP LPMAVSRGLP 70 80 90 100 110 120 PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGNLRG YGMASPGLAA PSLTPPQLAT 130 140 150 160 170 180 PNLQQFFPQA TRQSLLGPPP VGVPMNPSQF NLSGRNPQKQ ARTSSSTTPN RKTMPVEDKS 190 200 210 220 230 240 DPPEGSEEAA EPRMDTPEDQ DLPPCPEDIA KEKRTPAPEP EPCEASELPA KRLRSSEEPT 250 260 270 280 290 300 EKEPPGQLQV KAQPQARMTV PKQTQTPDLL PEALEAQVLP RFQPRVLQVQ AQVQSQTQPR 310 320 330 340 350 360 IPSTDTQVQP KLQKQAQTQT SPEHLVLQQK QVQPQLQQEA EPQKQVQPQV QPQAHSQGPR 370 380 390 400 410 420 QVQLQQEAEP LKQVQPQVQP QAHSQPPRQV QLQLQKQVQT QTYPQVHTQA QPSVQPQEHP 430 440 450 460 470 480 PAQVSVQPPE QTHEQPHTQP QVSLLAPEQT PVVVHVCGLE MPPDAVEAGG GMEKTLPEPV 490 500 510 520 530 540 GTQVSMEEIQ NESACGLDVG ECENRAREMP GVWGAGGSLK VTILQSSDSR AFSTVPLTPV 550 560 570 580 590 600 PRPSDSVSST PAATSTPSKQ ALQFFCYICK ASCSSQQEFQ DHMSEPQHQQ RLGEIQHMSQ 610 620 630 640 650 660 ACLLSLLPVP RDVLETEDEE PPPRRWCNTC QLYYMGDLIQ HRRTQDHKIA KQSLRPFCTV 670 680 690 700 710 720 CNRYFKTPRK FVEHVKSQGH KDKAKELKSL EKEIAGQDED HFITVDAVGC FEGDEEEEED 730 740 750 760 770 780 DEDEEEIEVE EELCKQVRSR DISREEWKGS ETYSPNTAYG VDFLVPVMGY ICRICHKFYH 790 800 810 820 830 840 SNSGAQLSHC KSLGHFENLQ KYKAAKNPSP TTRPVSRRCA INARNALTAL FTSSGRPPSQ 850 860 PNTQDKTPSK VTARPSQPPL PRRSTRLKT
	Isoform 3 [UniParc]. Checksum: 28DBDF0FB222820E	FASTA	818	91,153
	10 20 30 40 50 60 MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP LPMAVSRGLP 70 80 90 100 110 120 PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGNLRG YGMASPGLAA PSLTPPQLAT 130 140 150 160 170 180 PNLQQFFPQA TRQSLLGPPP VGVPMNPSQF NLSGRNPQKQ ARTSSSTTPN RKDSSSQTMP 190 200 210 220 230 240 VEDKSDPPEG SEEAAEPRMD TPEDQDLPPC PEDIAKEKRT PAPEPEPCEA SELPAKRLRS 250 260 270 280 290 300 SEEPTEKEPP GQLQVKAQPQ ARMTVPKQTQ TPDLLPEALE AQVLPRFQPR VLQVQAQVQS 310 320 330 340 350 360 QTQPRIPSTD TQVQPKLQKQ AQTQTSPEHL VLQQKQVQPQ LQQEAEPQKQ VQPQVHTQAQ 370 380 390 400 410 420 PSVQPQEHPP AQVSVQPPEQ THEQPHTQPQ VSLLAPEQTP VVVHVCGLEM PPDAVEAGGG 430 440 450 460 470 480 MEKTLPEPVG TQVSMEEIQN ESACGLDVGE CENRAREMPG VWGAGGSLKV TILQSSDSRA 490 500 510 520 530 540 FSTVPLTPVP RPSDSVSSTP AATSTPSKQA LQFFCYICKA SCSSQQEFQD HMSEPQHQQR 550 560 570 580 590 600 LGEIQHMSQA CLLSLLPVPR DVLETEDEEP PPRRWCNTCQ LYYMGDLIQH RRTQDHKIAK 610 620 630 640 650 660 QSLRPFCTVC NRYFKTPRKF VEHVKSQGHK DKAKELKSLE KEIAGQDEDH FITVDAVGCF 670 680 690 700 710 720 EGDEEEEEDD EDEEEIEVEE ELCKQVRSRD ISREEWKGSE TYSPNTAYGV DFLVPVMGYI 730 740 750 760 770 780 CRICHKFYHS NSGAQLSHCK SLGHFENLQK YKAAKNPSPT TRPVSRRCAI NARNALTALF 790 800 810 TSSGRPPSQP NTQDKTPSKV TARPSQPPLP RRSTRLKT
	Isoform 4 [UniParc]. Checksum: C799C715E082C006	FASTA	842	93,619
	10 20 30 40 50 60 MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP LPMAVSRGLP 70 80 90 100 110 120 PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGLDQF AMPPATYDTA GLTMPTATLG 130 140 150 160 170 180 NLRGYGMASP GLAAPSLTPP QLATPNLQQF FPQATRQSLL GPPPVGVPMN PSQFNLSGRN 190 200 210 220 230 240 PQKQARTSSS TTPNRKDSSS QTMPVEDKSD PPEGSEEAAE PRMDTPEDQD LPPCPEDIAK 250 260 270 280 290 300 EKRTPAPEPE PCEASELPAK RLRSSEEPTE KEPPGQLQVK AQPQARMTVP KQTQTPDLLP 310 320 330 340 350 360 EALEAQVLPR FQPRVLQVQA QVQSQTQPRI PSTDTQVQPK LQKQAQTQTS PEHLVLQQKQ 370 380 390 400 410 420 VQPQLQQEAE PQKQVQPQVH TQAQPSVQPQ EHPPAQVSVQ PPEQTHEQPH TQPQVSLLAP 430 440 450 460 470 480 EQTPVVVHVC GLEMPPDAVE AGGGMEKTLP EPVGTQVSME EIQNESACGL DVGECENRAR 490 500 510 520 530 540 EMPGVWGAGG SLKVTILQSS DSRAFSTVPL TPVPRPSDSV SSTPAATSTP SKQALQFFCY 550 560 570 580 590 600 ICKASCSSQQ EFQDHMSEPQ HQQRLGEIQH MSQACLLSLL PVPRDVLETE DEEPPPRRWC 610 620 630 640 650 660 NTCQLYYMGD LIQHRRTQDH KIAKQSLRPF CTVCNRYFKT PRKFVEHVKS QGHKDKAKEL 670 680 690 700 710 720 KSLEKEIAGQ DEDHFITVDA VGCFEGDEEE EEDDEDEEEI EVEEELCKQV RSRDISREEW 730 740 750 760 770 780 KGSETYSPNT AYGVDFLVPV MGYICRICHK FYHSNSGAQL SHCKSLGHFE NLQKYKAAKN 790 800 810 820 830 840 PSPTTRPVSR RCAINARNAL TALFTSSGRP PSQPNTQDKT PSKVTARPSQ PPLPRRSTRL KT
	Isoform 5 [UniParc]. Checksum: 1C3805A4CFAC8864	FASTA	797	88,520
	10 20 30 40 50 60 MPPATYDTAG LTMPTATLGN LRGYGMASPG LAAPSLTPPQ LATPNLQQFF PQATRQSLLG 70 80 90 100 110 120 PPPVGVPMNP SQFNLSGRNP QKQARTSSST TPNRKDSSSQ TMPVEDKSDP PEGSEEAAEP 130 140 150 160 170 180 RMDTPEDQDL PPCPEDIAKE KRTPAPEPEP CEASELPAKR LRSSEEPTEK EPPGQLQVKA 190 200 210 220 230 240 QPQARMTVPK QTQTPDLLPE ALEAQVLPRF QPRVLQVQAQ VQSQTQPRIP STDTQVQPKL 250 260 270 280 290 300 QKQAQTQTSP EHLVLQQKQV QPQLQQEAEP QKQVQPQVQP QAHSQGPRQV QLQQEAEPLK 310 320 330 340 350 360 QVQPQVQPQA HSQPPRQVQL QLQKQVQTQT YPQVHTQAQP SVQPQEHPPA QVSVQPPEQT 370 380 390 400 410 420 HEQPHTQPQV SLLAPEQTPV VVHVCGLEMP PDAVEAGGGM EKTLPEPVGT QVSMEEIQNE 430 440 450 460 470 480 SACGLDVGEC ENRAREMPGV WGAGGSLKVT ILQSSDSRAF STVPLTPVPR PSDSVSSTPA 490 500 510 520 530 540 ATSTPSKQAL QFFCYICKAS CSSQQEFQDH MSEPQHQQRL GEIQHMSQAC LLSLLPVPRD 550 560 570 580 590 600 VLETEDEEPP PRRWCNTCQL YYMGDLIQHR RTQDHKIAKQ SLRPFCTVCN RYFKTPRKFV 610 620 630 640 650 660 EHVKSQGHKD KAKELKSLEK EIAGQDEDHF ITVDAVGCFE GDEEEEEDDE DEEEIEVEEE 670 680 690 700 710 720 LCKQVRSRDI SREEWKGSET YSPNTAYGVD FLVPVMGYIC RICHKFYHSN SGAQLSHCKS 730 740 750 760 770 780 LGHFENLQKY KAAKNPSPTT RPVSRRCAIN ARNALTALFT SSGRPPSQPN TQDKTPSKVT 790 ARPSQPPLPR RSTRLKT

References

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[1]	"Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1." Mitsui K., Matsumoto A., Ohtsuka S., Ohtsubo M., Yoshimura A. Biochem. Biophys. Res. Commun. 264:457-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	NIEHS SNPs program Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-219; GLY-370; PHE-578; MET-638 AND GLN-847.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5), VARIANT MET-638. Tissue: Testis and Thymus.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lymph.
[7]	"Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC." Warder D.E., Keherly M.J. J. Biomed. Sci. 10:406-417(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-898 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 50-898 (ISOFORM 2). Tissue: Medulloblastoma.
[8]	"Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes." Gilley J., Fried M. Hum. Mol. Genet. 8:1313-1320(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 649-898.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-567, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Mutations in CIZ1 cause adult onset primary cervical dystonia." Xiao J., Uitti R.J., Zhao Y., Vemula S.R., Perlmutter J.S., Wszolek Z.K., Maraganore D.M., Auburger G., Leube B., Lehnhoff K., Ledoux M.S. Ann. Neurol. 71:458-469(2012) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN ADULT ONSET PRIMARY CERVICAL DYSTONIA, VARIANTS SER-47; LEU-50; GLY-264; GLU-394; PHE-577 AND MET-672.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030835 mRNA. Translation: BAA85783.1. EF467915 Genomic DNA. Translation: ABO43037.1. AK023978 mRNA. Translation: BAB14750.1. AK292713 mRNA. Translation: BAF85402.1. AK303636 mRNA. Translation: BAG64643.1. AK316393 mRNA. Translation: BAH14764.1. AL590708 Genomic DNA. Translation: CAI13828.1. AL590708 Genomic DNA. Translation: CAI13829.1. AL590708 Genomic DNA. Translation: CAI13831.1. CH471090 Genomic DNA. Translation: EAW87752.1. CH471090 Genomic DNA. Translation: EAW87753.1. CH471090 Genomic DNA. Translation: EAW87754.1. BC021163 mRNA. Translation: AAH21163.1. AF159027 mRNA. Translation: AAF23231.1. Different initiation. AF234161 mRNA. Translation: AAF37882.1. Different initiation. Y17453 Genomic DNA. Translation: CAB44346.1. Y17454 Genomic DNA. Translation: CAB44347.1.
IPI	IPI00183425. IPI00220051. IPI00329602. IPI00551026. IPI01013233.
RefSeq	NP_001124487.1. NM_001131015.1. NP_001124488.1. NM_001131016.1. NP_001124489.1. NM_001131017.1. NP_001124490.1. NM_001131018.1. NP_001244904.1. NM_001257975.1. NP_001244905.1. NM_001257976.1. NP_036259.2. NM_012127.2.
UniGene	Hs.212395.
3D structure databases
ProteinModelPortal	Q9ULV3.
SMR	Q9ULV3. Positions 590-623, 656-706, 799-835.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULV3. 7 interactions.
STRING	9606.ENSP00000362029.
PTM databases
PhosphoSite	Q9ULV3.
Polymorphism databases
DMDM	296434448.
Proteomic databases
PaxDb	Q9ULV3.
PRIDE	Q9ULV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325721; ENSP00000320374; ENSG00000148337. ENST00000372938; ENSP00000362029; ENSG00000148337. ENST00000372948; ENSP00000362039; ENSG00000148337. ENST00000372954; ENSP00000362045; ENSG00000148337. ENST00000393608; ENSP00000377232; ENSG00000148337. ENST00000541172; ENSP00000445057; ENSG00000148337.
GeneID	25792.
KEGG	hsa:25792.
UCSC	uc004bts.3. human. uc004btt.3. human. uc004btu.3. human. uc004btw.3. human.
Organism-specific databases
CTD	25792.
GeneCards	GC09M130929.
HGNC	HGNC:16744. CIZ1.
MIM	611420. gene.
neXtProt	NX_Q9ULV3.
PharmGKB	PA134883336.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70338.
HOVERGEN	HBG002558.
InParanoid	Q9ULV3.
OrthoDB	EOG4320ZW.
PhylomeDB	Q9ULV3.
Gene expression databases
ArrayExpress	Q9ULV3.
Bgee	Q9ULV3.
CleanEx	HS_CIZ1.
Genevestigator	Q9ULV3.
GermOnline	ENSG00000148337. Homo sapiens.
Family and domain databases
InterPro	IPR026811. CIZ1. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR022755. Znf_C2H2_jaz. IPR000690. Znf_C2H2_matrin. IPR003604. Znf_U1. [Graphical view]
PANTHER	PTHR15491:SF3. PTHR15491:SF3. 1 hit.
Pfam	PF12171. zf-C2H2_jaz. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. SM00451. ZnF_U1. 3 hits. [Graphical view]
PROSITE	PS50171. ZF_MATRIN. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 2 hits. Uncertain. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CIZ1. human.
GenomeRNAi	25792.
NextBio	46965.
SOURCE	Search...

Entry information

Entry name

CIZ1_HUMAN

Accession

Primary (citable) accession number: Q9ULV3
Secondary accession number(s): A8K9J8 , B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.