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Protein

Unconventional myosin-Vb

Gene

MYO5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi163 – 1708ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microfilament motor activity Source: Reactome
  3. Rab GTPase binding Source: UniProtKB

GO - Biological processi

  1. endosome localization Source: UniProtKB
  2. metabolic process Source: GOC
  3. protein transport Source: UniProtKB-KW
  4. renal water homeostasis Source: Reactome
  5. transmembrane transport Source: Reactome
  6. vesicle-mediated transport Source: UniProtKB
  7. water transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Vb
Gene namesi
Name:MYO5B
Synonyms:KIAA1119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:7603. MYO5B.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. apical cortex Source: UniProtKB
  2. cytoplasmic vesicle membrane Source: Reactome
  3. extracellular vesicular exosome Source: UniProtKB
  4. myosin complex Source: UniProtKB-KW
  5. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Diarrhea 2, with microvillus atrophy (DIAR2)6 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.

See also OMIM:251850
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081V → G in DIAR2. 1 Publication
VAR_054993
Natural varianti143 – 1431A → E in DIAR2. 1 Publication
VAR_071649
Natural varianti168 – 1681G → R in DIAR2. 1 Publication
VAR_071650
Natural varianti219 – 2191R → H in DIAR2. 1 Publication
VAR_054994
Natural varianti316 – 3161G → R in DIAR2. 1 Publication
VAR_071651
Natural varianti401 – 4011R → H in DIAR2. 1 Publication
VAR_071652
Natural varianti435 – 4351G → R in DIAR2. 1 Publication
VAR_071653
Natural varianti456 – 4561N → S in DIAR2. 1 Publication
VAR_071654
Natural varianti514 – 5141C → R in DIAR2. 1 Publication
VAR_071655
Natural varianti538 – 5381F → S in DIAR2; enterocytes display disruption of cell polarity when associated with variant P-550; enterocytes display mislocalized apical and basolateral transporter proteins when associated with variant P-550; enterocytes display altered distribution of certain endosomal/lysosomal constituents including Rab GTPases when associated with variant P-550. 1 Publication
VAR_072814
Natural varianti550 – 5501I → F in DIAR2; enterocytes display disruption of cell polarity when associated with variant S-538; enterocytes display mislocalized apical and basolateral transporter proteins when associated with variant S-538; enterocytes display altered distribution of certain endosomal/lysosomal constituents including Rab GTPases when associated with variant S-538. 1 Publication
VAR_072815
Natural varianti656 – 6561R → C in DIAR2. 1 Publication
VAR_054995
Natural varianti660 – 6601P → L in DIAR2; found within Navajo populations; alterations in junctional composition of enterocytes; loss of polarity in basolateral and apical compartments of enterocytes; causes the motor to move slowly along F-actin; loss of apical brush border in cells at the villus tips; formation of microvillus inclusions in cells at the villus tips. 3 Publications
VAR_071656
Natural varianti1556 – 15561L → R in DIAR2. 1 Publication
VAR_071657

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1300 – 13001Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication
Mutagenesisi1307 – 13071Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication
Mutagenesisi1714 – 17141Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication
Mutagenesisi1748 – 17481Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi251850. phenotype.
Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA31408.

Polymorphism and mutation databases

BioMutaiMYO5B.
DMDMi296439293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18481848Unconventional myosin-VbPRO_0000123460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1446 – 14461Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9ULV0.
PaxDbiQ9ULV0.
PRIDEiQ9ULV0.

PTM databases

PhosphoSiteiQ9ULV0.

Expressioni

Gene expression databases

BgeeiQ9ULV0.
CleanExiHS_MYO5B.
ExpressionAtlasiQ9ULV0. baseline and differential.
GenevestigatoriQ9ULV0.

Organism-specific databases

HPAiHPA040593.
HPA040902.

Interactioni

Subunit structurei

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-311356,EBI-10187270
BNIP2Q129825EBI-311356,EBI-752094
TCF4P158843EBI-311356,EBI-533224
TRIM54Q9BYV23EBI-311356,EBI-2130429

Protein-protein interaction databases

BioGridi110729. 19 interactions.
IntActiQ9ULV0. 8 interactions.
MINTiMINT-1209283.
STRINGi9606.ENSP00000285039.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1468 – 14714Combined sources
Helixi1474 – 14763Combined sources
Helixi1477 – 14848Combined sources
Turni1485 – 14873Combined sources
Helixi1490 – 14934Combined sources
Helixi1500 – 151415Combined sources
Helixi1518 – 153821Combined sources
Turni1539 – 15413Combined sources
Helixi1543 – 156220Combined sources
Helixi1567 – 15693Combined sources
Helixi1575 – 15784Combined sources
Helixi1588 – 161326Combined sources
Helixi1614 – 16163Combined sources
Helixi1617 – 16226Combined sources
Helixi1654 – 167017Combined sources
Helixi1675 – 169925Combined sources
Helixi1701 – 17033Combined sources
Helixi1706 – 172520Combined sources
Helixi1729 – 17313Combined sources
Helixi1733 – 17364Combined sources
Helixi1738 – 17469Combined sources
Helixi1754 – 176310Combined sources
Helixi1769 – 177810Combined sources
Helixi1791 – 180010Combined sources
Turni1801 – 18033Combined sources
Helixi1831 – 18333Combined sources
Helixi1838 – 18403Combined sources
Beta strandi1845 – 18484Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J5MX-ray2.07A1453-1848[»]
4LNZX-ray3.11A1460-1848[»]
4LWZX-ray2.55B/D1456-1848[»]
4LX0X-ray2.19B/D1456-1848[»]
ProteinModelPortaliQ9ULV0.
SMRiQ9ULV0. Positions 5-816, 1456-1848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 761693Myosin motorAdd
BLAST
Domaini769 – 79830IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini792 – 82130IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini817 – 84832IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini840 – 86930IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini865 – 89632IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini888 – 91730IQ 6PROSITE-ProRule annotationAdd
BLAST
Domaini1526 – 1803278DilutePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni640 – 66223Actin-bindingSequence AnalysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili899 – 1266368Sequence AnalysisAdd
BLAST
Coiled coili1341 – 1471131Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi801 – 916116Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00780000121876.
HOGENOMiHOG000152631.
HOVERGENiHBG052556.
InParanoidiQ9ULV0.
KOiK10357.
OMAiYMINAVT.
OrthoDBiEOG7PK8XT.
PhylomeDBiQ9ULV0.
TreeFamiTF328771.

Family and domain databases

InterProiIPR018444. Dil_domain.
IPR002710. Dilute.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY
60 70 80 90 100
PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS
210 220 230 240 250
PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV
260 270 280 290 300
FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD
310 320 330 340 350
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS
360 370 380 390 400
ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA
410 420 430 440 450
RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF
460 470 480 490 500
EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI
510 520 530 540 550
EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII
560 570 580 590 600
VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP
610 620 630 640 650
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT
660 670 680 690 700
TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY
710 720 730 740 750
HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA
760 770 780 790 800
GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG
810 820 830 840 850
HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF
860 870 880 890 900
VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR
910 920 930 940 950
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV
960 970 980 990 1000
TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK
1010 1020 1030 1040 1050
ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS
1060 1070 1080 1090 1100
VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN
1110 1120 1130 1140 1150
PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ
1160 1170 1180 1190 1200
KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL
1210 1220 1230 1240 1250
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA
1260 1270 1280 1290 1300
HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ
1310 1320 1330 1340 1350
EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ
1360 1370 1380 1390 1400
SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS
1410 1420 1430 1440 1450
RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR
1460 1470 1480 1490 1500
HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL
1510 1520 1530 1540 1550
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL
1560 1570 1580 1590 1600
SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ
1610 1620 1630 1640 1650
IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN
1660 1670 1680 1690 1700
SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR
1710 1720 1730 1740 1750
KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK
1760 1770 1780 1790 1800
KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ
1810 1820 1830 1840
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV
Length:1,848
Mass (Da):213,672
Last modified:May 18, 2010 - v3
Checksum:i4EB8FA02F6B38707
GO
Isoform 2 (identifier: Q9ULV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-859: Missing.
     1315-1340: Missing.

Note: No experimental confirmation available.

Show »
Length:963
Mass (Da):111,759
Checksum:i14C45F254C2AFAB5
GO
Isoform 3 (identifier: Q9ULV0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.

Note: No experimental confirmation available. Contains a N-acetylmethionine at position 1.1 Publication

Show »
Length:418
Mass (Da):47,983
Checksum:iE2A61014E7DFFF90
GO

Sequence cautioni

The sequence BAA86433.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101C → G.
Corresponds to variant rs16951438 [ dbSNP | Ensembl ].
VAR_056182
Natural varianti108 – 1081V → G in DIAR2. 1 Publication
VAR_054993
Natural varianti126 – 1261T → A.2 Publications
Corresponds to variant rs1815930 [ dbSNP | Ensembl ].
VAR_063141
Natural varianti143 – 1431A → E in DIAR2. 1 Publication
VAR_071649
Natural varianti168 – 1681G → R in DIAR2. 1 Publication
VAR_071650
Natural varianti219 – 2191R → H in DIAR2. 1 Publication
VAR_054994
Natural varianti307 – 3071K → N.
Corresponds to variant rs17659179 [ dbSNP | Ensembl ].
VAR_056183
Natural varianti316 – 3161G → R in DIAR2. 1 Publication
VAR_071651
Natural varianti401 – 4011R → H in DIAR2. 1 Publication
VAR_071652
Natural varianti435 – 4351G → R in DIAR2. 1 Publication
VAR_071653
Natural varianti456 – 4561N → S in DIAR2. 1 Publication
VAR_071654
Natural varianti514 – 5141C → R in DIAR2. 1 Publication
VAR_071655
Natural varianti538 – 5381F → S in DIAR2; enterocytes display disruption of cell polarity when associated with variant P-550; enterocytes display mislocalized apical and basolateral transporter proteins when associated with variant P-550; enterocytes display altered distribution of certain endosomal/lysosomal constituents including Rab GTPases when associated with variant P-550. 1 Publication
VAR_072814
Natural varianti550 – 5501I → F in DIAR2; enterocytes display disruption of cell polarity when associated with variant S-538; enterocytes display mislocalized apical and basolateral transporter proteins when associated with variant S-538; enterocytes display altered distribution of certain endosomal/lysosomal constituents including Rab GTPases when associated with variant S-538. 1 Publication
VAR_072815
Natural varianti656 – 6561R → C in DIAR2. 1 Publication
VAR_054995
Natural varianti660 – 6601P → L in DIAR2; found within Navajo populations; alterations in junctional composition of enterocytes; loss of polarity in basolateral and apical compartments of enterocytes; causes the motor to move slowly along F-actin; loss of apical brush border in cells at the villus tips; formation of microvillus inclusions in cells at the villus tips. 3 Publications
VAR_071656
Natural varianti918 – 9181R → H.
Corresponds to variant rs2298624 [ dbSNP | Ensembl ].
VAR_056184
Natural varianti942 – 9421K → R.
Corresponds to variant rs2277716 [ dbSNP | Ensembl ].
VAR_056185
Natural varianti1055 – 10551L → LL.2 Publications
Corresponds to variant rs72530399 [ dbSNP | Ensembl ].
VAR_063142
Natural varianti1556 – 15561L → R in DIAR2. 1 Publication
VAR_071657
Natural varianti1688 – 16881M → V.1 Publication
VAR_071658

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14301430Missing in isoform 3. 1 PublicationVSP_056198Add
BLAST
Alternative sequencei1 – 859859Missing in isoform 2. 1 PublicationVSP_056199Add
BLAST
Alternative sequencei1315 – 134026Missing in isoform 2. 1 PublicationVSP_056200Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA. Translation: BAA86433.2. Different initiation.
AK025336 mRNA. Translation: BAB15114.1.
AB290160 mRNA. Translation: BAG06714.1.
AC090227 Genomic DNA. No translation available.
AC091044 Genomic DNA. No translation available.
AC092705 Genomic DNA. No translation available.
AC105224 Genomic DNA. No translation available.
BC033527 mRNA. Translation: AAH33527.1.
CCDSiCCDS42436.1. [Q9ULV0-1]
RefSeqiNP_001073936.1. NM_001080467.2. [Q9ULV0-1]
UniGeneiHs.720076.

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306. [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306. [Q9ULV0-3]
GeneIDi4645.
KEGGihsa:4645.
UCSCiuc002ldz.3. human.
uc002lea.2. human.
uc002leb.2. human. [Q9ULV0-1]

Polymorphism and mutation databases

BioMutaiMYO5B.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA. Translation: BAA86433.2. Different initiation.
AK025336 mRNA. Translation: BAB15114.1.
AB290160 mRNA. Translation: BAG06714.1.
AC090227 Genomic DNA. No translation available.
AC091044 Genomic DNA. No translation available.
AC092705 Genomic DNA. No translation available.
AC105224 Genomic DNA. No translation available.
BC033527 mRNA. Translation: AAH33527.1.
CCDSiCCDS42436.1. [Q9ULV0-1]
RefSeqiNP_001073936.1. NM_001080467.2. [Q9ULV0-1]
UniGeneiHs.720076.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J5MX-ray2.07A1453-1848[»]
4LNZX-ray3.11A1460-1848[»]
4LWZX-ray2.55B/D1456-1848[»]
4LX0X-ray2.19B/D1456-1848[»]
ProteinModelPortaliQ9ULV0.
SMRiQ9ULV0. Positions 5-816, 1456-1848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110729. 19 interactions.
IntActiQ9ULV0. 8 interactions.
MINTiMINT-1209283.
STRINGi9606.ENSP00000285039.

PTM databases

PhosphoSiteiQ9ULV0.

Polymorphism and mutation databases

BioMutaiMYO5B.
DMDMi296439293.

Proteomic databases

MaxQBiQ9ULV0.
PaxDbiQ9ULV0.
PRIDEiQ9ULV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306. [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306. [Q9ULV0-3]
GeneIDi4645.
KEGGihsa:4645.
UCSCiuc002ldz.3. human.
uc002lea.2. human.
uc002leb.2. human. [Q9ULV0-1]

Organism-specific databases

CTDi4645.
GeneCardsiGC18M047349.
H-InvDBHIX0014446.
HGNCiHGNC:7603. MYO5B.
HPAiHPA040593.
HPA040902.
MIMi251850. phenotype.
606540. gene.
neXtProtiNX_Q9ULV0.
Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA31408.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00780000121876.
HOGENOMiHOG000152631.
HOVERGENiHBG052556.
InParanoidiQ9ULV0.
KOiK10357.
OMAiYMINAVT.
OrthoDBiEOG7PK8XT.
PhylomeDBiQ9ULV0.
TreeFamiTF328771.

Enzyme and pathway databases

ReactomeiREACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

ChiTaRSiMYO5B. human.
GeneWikiiMYO5B.
GenomeRNAii4645.
NextBioi17900.
PROiQ9ULV0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULV0.
CleanExiHS_MYO5B.
ExpressionAtlasiQ9ULV0. baseline and differential.
GenevestigatoriQ9ULV0.

Family and domain databases

InterProiIPR018444. Dil_domain.
IPR002710. Dilute.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-126 AND LEU-1055 INS.
    Tissue: Brain.
  2. Ohara O., Nagase T., Yamakawa H., Kikuno R.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO N-TERMINUS AND 918.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  4. "Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins."
    Yamakawa H., Kikuno R.F., Nagase T., Ohara O.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-126 AND LEU-1055 INS.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon.
  7. Cited for: INTERACTION WITH RAB11FIP2.
  8. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
    Yan Q., Sun W., Kujala P., Lotfi Y., Vida T.A., Bean A.J.
    Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CART COMPLEX.
  9. "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells."
    Swiatecka-Urban A., Talebian L., Kanno E., Moreau-Marquis S., Coutermarsh B., Hansen K., Karlson K.H., Barnaby R., Cheney R.E., Langford G.M., Fukuda M., Stanton B.A.
    J. Biol. Chem. 282:23725-23736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAB11A, IDENTIFICATION IN A COMPLEX WITH RAB11A AND CFTR.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface."
    Chu B.-B., Ge L., Xie C., Zhao Y., Miao H.-H., Wang J., Li B.-L., Song B.-L.
    J. Biol. Chem. 284:22481-22490(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NPC1L1.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: FUNCTION, VARIANTS DIAR2 ARG-316; SER-456; ARG-514 AND LEU-660, VARIANT VAL-1688.
  14. "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization."
    Roland J.T., Bryant D.M., Datta A., Itzen A., Mostov K.E., Goldenring J.R.
    Proc. Natl. Acad. Sci. U.S.A. 108:2789-2794(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAB11A AND RAB8A, MUTAGENESIS OF GLN-1300; TYR-1307; TYR-1714 AND GLN-1748.
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Navajo microvillous inclusion disease is due to a mutation in MYO5B."
    Erickson R.P., Larson-Thome K., Valenzuela R.K., Whitaker S.E., Shub M.D.
    Am. J. Med. Genet. A 146A:3117-3119(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DIAR2 LEU-660.
  17. Cited for: VARIANTS DIAR2 GLY-108; HIS-219 AND CYS-656.
  18. Cited for: VARIANTS DIAR2 GLU-143; ARG-168; HIS-401; ARG-435 AND ARG-1556.
  19. "Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity."
    Thoeni C.E., Vogel G.F., Tancevski I., Geley S., Lechner S., Pfaller K., Hess M.W., Muller T., Janecke A.R., Avitzur Y., Muise A., Cutz E., Huber L.A.
    Traffic 15:22-42(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS DIAR2 SER-538 AND PHE-550.
  20. "Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease."
    Knowles B.C., Roland J.T., Krishnan M., Tyska M.J., Lapierre L.A., Dickman P.S., Goldenring J.R., Shub M.D.
    J. Clin. Invest. 124:2947-2962(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DIAR2 LEU-660, CHARACTERIZATION OF VARIANT DIAR2 LEU-660.

Entry informationi

Entry nameiMYO5B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULV0
Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.