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Protein

Unconventional myosin-Vb

Gene

MYO5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi163 – 170ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microfilament motor activity Source: Reactome
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • endosome localization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • renal water homeostasis Source: Reactome
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167306-MONOMER.
ReactomeiR-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Vb
Gene namesi
Name:MYO5B
Synonyms:KIAA1119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:7603. MYO5B.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • apical cortex Source: UniProtKB
  • cytoplasmic vesicle membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Diarrhea 2, with microvillus atrophy (DIAR2)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
See also OMIM:251850
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054993108V → G in DIAR2. 1 PublicationCorresponds to variant rs121908103dbSNPEnsembl.1
Natural variantiVAR_071649143A → E in DIAR2. 1 Publication1
Natural variantiVAR_071650168G → R in DIAR2. 1 Publication1
Natural variantiVAR_054994219R → H in DIAR2. 1 Publication1
Natural variantiVAR_071651316G → R in DIAR2. 1 PublicationCorresponds to variant rs753558336dbSNPEnsembl.1
Natural variantiVAR_071652401R → H in DIAR2. 1 Publication1
Natural variantiVAR_071653435G → R in DIAR2. 1 Publication1
Natural variantiVAR_071654456N → S in DIAR2. 1 Publication1
Natural variantiVAR_071655514C → R in DIAR2. 1 Publication1
Natural variantiVAR_072814538F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_072815550I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_054995656R → C in DIAR2. 1 PublicationCorresponds to variant rs121908105dbSNPEnsembl.1
Natural variantiVAR_071656660P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant rs121908106dbSNPEnsembl.1
Natural variantiVAR_0716571556L → R in DIAR2. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1300Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication1
Mutagenesisi1307Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication1
Mutagenesisi1714Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication1
Mutagenesisi1748Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4645.
MalaCardsiMYO5B.
MIMi251850. phenotype.
OpenTargetsiENSG00000167306.
Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA31408.

Polymorphism and mutation databases

BioMutaiMYO5B.
DMDMi296439293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234601 – 1848Unconventional myosin-VbAdd BLAST1848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1446PhosphoserineCombined sources1
Isoform 3 (identifier: Q9ULV0-3)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ULV0.
PaxDbiQ9ULV0.
PeptideAtlasiQ9ULV0.
PRIDEiQ9ULV0.

PTM databases

iPTMnetiQ9ULV0.
PhosphoSitePlusiQ9ULV0.
SwissPalmiQ9ULV0.

Expressioni

Gene expression databases

BgeeiENSG00000167306.
CleanExiHS_MYO5B.
ExpressionAtlasiQ9ULV0. baseline and differential.
GenevisibleiQ9ULV0. HS.

Organism-specific databases

HPAiHPA040593.
HPA040902.

Interactioni

Subunit structurei

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-311356,EBI-10187270
BNIP2Q129825EBI-311356,EBI-752094
TCF4P158843EBI-311356,EBI-533224
TRIM54Q9BYV23EBI-311356,EBI-2130429

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110729. 48 interactors.
IntActiQ9ULV0. 27 interactors.
MINTiMINT-1209283.
STRINGi9606.ENSP00000285039.

Structurei

Secondary structure

11848
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1468 – 1471Combined sources4
Helixi1474 – 1476Combined sources3
Helixi1477 – 1484Combined sources8
Turni1485 – 1487Combined sources3
Helixi1490 – 1493Combined sources4
Helixi1500 – 1514Combined sources15
Helixi1518 – 1538Combined sources21
Turni1539 – 1541Combined sources3
Helixi1543 – 1562Combined sources20
Helixi1567 – 1569Combined sources3
Helixi1575 – 1578Combined sources4
Helixi1588 – 1613Combined sources26
Helixi1614 – 1616Combined sources3
Helixi1617 – 1622Combined sources6
Helixi1654 – 1670Combined sources17
Helixi1675 – 1699Combined sources25
Helixi1701 – 1703Combined sources3
Helixi1706 – 1725Combined sources20
Helixi1729 – 1731Combined sources3
Helixi1733 – 1736Combined sources4
Helixi1738 – 1746Combined sources9
Helixi1754 – 1763Combined sources10
Helixi1769 – 1778Combined sources10
Helixi1791 – 1800Combined sources10
Turni1801 – 1803Combined sources3
Helixi1831 – 1833Combined sources3
Helixi1838 – 1840Combined sources3
Beta strandi1845 – 1848Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J5MX-ray2.07A1453-1848[»]
4LNZX-ray3.11A1460-1848[»]
4LWZX-ray2.55B/D1456-1848[»]
4LX0X-ray2.19B/D1456-1848[»]
ProteinModelPortaliQ9ULV0.
SMRiQ9ULV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 761Myosin motorAdd BLAST693
Domaini769 – 798IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini792 – 821IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini817 – 848IQ 3PROSITE-ProRule annotationAdd BLAST32
Domaini840 – 869IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini865 – 896IQ 5PROSITE-ProRule annotationAdd BLAST32
Domaini888 – 917IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1526 – 1803DilutePROSITE-ProRule annotationAdd BLAST278

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni640 – 662Actin-bindingSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili899 – 1266Sequence analysisAdd BLAST368
Coiled coili1341 – 1471Sequence analysisAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi801 – 916Arg-richAdd BLAST116

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000152631.
HOVERGENiHBG052556.
InParanoidiQ9ULV0.
KOiK10357.
OMAiYMINAVT.
OrthoDBiEOG091G0G93.
PhylomeDBiQ9ULV0.
TreeFamiTF328771.

Family and domain databases

InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY
60 70 80 90 100
PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS
210 220 230 240 250
PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV
260 270 280 290 300
FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD
310 320 330 340 350
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS
360 370 380 390 400
ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA
410 420 430 440 450
RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF
460 470 480 490 500
EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI
510 520 530 540 550
EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII
560 570 580 590 600
VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP
610 620 630 640 650
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT
660 670 680 690 700
TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY
710 720 730 740 750
HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA
760 770 780 790 800
GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG
810 820 830 840 850
HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF
860 870 880 890 900
VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR
910 920 930 940 950
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV
960 970 980 990 1000
TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK
1010 1020 1030 1040 1050
ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS
1060 1070 1080 1090 1100
VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN
1110 1120 1130 1140 1150
PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ
1160 1170 1180 1190 1200
KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL
1210 1220 1230 1240 1250
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA
1260 1270 1280 1290 1300
HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ
1310 1320 1330 1340 1350
EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ
1360 1370 1380 1390 1400
SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS
1410 1420 1430 1440 1450
RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR
1460 1470 1480 1490 1500
HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL
1510 1520 1530 1540 1550
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL
1560 1570 1580 1590 1600
SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ
1610 1620 1630 1640 1650
IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN
1660 1670 1680 1690 1700
SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR
1710 1720 1730 1740 1750
KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK
1760 1770 1780 1790 1800
KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ
1810 1820 1830 1840
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV
Length:1,848
Mass (Da):213,672
Last modified:May 18, 2010 - v3
Checksum:i4EB8FA02F6B38707
GO
Isoform 2 (identifier: Q9ULV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-859: Missing.
     1315-1340: Missing.

Note: No experimental confirmation available.
Show »
Length:963
Mass (Da):111,759
Checksum:i14C45F254C2AFAB5
GO
Isoform 3 (identifier: Q9ULV0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:418
Mass (Da):47,983
Checksum:iE2A61014E7DFFF90
GO

Sequence cautioni

The sequence BAA86433 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05618210C → G.Corresponds to variant rs16951438dbSNPEnsembl.1
Natural variantiVAR_054993108V → G in DIAR2. 1 PublicationCorresponds to variant rs121908103dbSNPEnsembl.1
Natural variantiVAR_063141126T → A.2 PublicationsCorresponds to variant rs1815930dbSNPEnsembl.1
Natural variantiVAR_071649143A → E in DIAR2. 1 Publication1
Natural variantiVAR_071650168G → R in DIAR2. 1 Publication1
Natural variantiVAR_054994219R → H in DIAR2. 1 Publication1
Natural variantiVAR_056183307K → N.Corresponds to variant rs17659179dbSNPEnsembl.1
Natural variantiVAR_071651316G → R in DIAR2. 1 PublicationCorresponds to variant rs753558336dbSNPEnsembl.1
Natural variantiVAR_071652401R → H in DIAR2. 1 Publication1
Natural variantiVAR_071653435G → R in DIAR2. 1 Publication1
Natural variantiVAR_071654456N → S in DIAR2. 1 Publication1
Natural variantiVAR_071655514C → R in DIAR2. 1 Publication1
Natural variantiVAR_072814538F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_072815550I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_054995656R → C in DIAR2. 1 PublicationCorresponds to variant rs121908105dbSNPEnsembl.1
Natural variantiVAR_071656660P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant rs121908106dbSNPEnsembl.1
Natural variantiVAR_056184918R → H.Corresponds to variant rs2298624dbSNPEnsembl.1
Natural variantiVAR_056185942K → R.Corresponds to variant rs2277716dbSNPEnsembl.1
Natural variantiVAR_0631421055L → LL.2 PublicationsCorresponds to variant rs72530399dbSNPEnsembl.1
Natural variantiVAR_0716571556L → R in DIAR2. 1 Publication1
Natural variantiVAR_0716581688M → V.1 PublicationCorresponds to variant rs112417235dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561981 – 1430Missing in isoform 3. 1 PublicationAdd BLAST1430
Alternative sequenceiVSP_0561991 – 859Missing in isoform 2. 1 PublicationAdd BLAST859
Alternative sequenceiVSP_0562001315 – 1340Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA. Translation: BAA86433.2. Different initiation.
AK025336 mRNA. Translation: BAB15114.1.
AB290160 mRNA. Translation: BAG06714.1.
AC090227 Genomic DNA. No translation available.
AC091044 Genomic DNA. No translation available.
AC092705 Genomic DNA. No translation available.
AC105224 Genomic DNA. No translation available.
BC033527 mRNA. Translation: AAH33527.1.
CCDSiCCDS42436.1. [Q9ULV0-1]
RefSeqiNP_001073936.1. NM_001080467.2. [Q9ULV0-1]
UniGeneiHs.720076.

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306. [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306. [Q9ULV0-3]
GeneIDi4645.
KEGGihsa:4645.
UCSCiuc002ldz.4. human. [Q9ULV0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA. Translation: BAA86433.2. Different initiation.
AK025336 mRNA. Translation: BAB15114.1.
AB290160 mRNA. Translation: BAG06714.1.
AC090227 Genomic DNA. No translation available.
AC091044 Genomic DNA. No translation available.
AC092705 Genomic DNA. No translation available.
AC105224 Genomic DNA. No translation available.
BC033527 mRNA. Translation: AAH33527.1.
CCDSiCCDS42436.1. [Q9ULV0-1]
RefSeqiNP_001073936.1. NM_001080467.2. [Q9ULV0-1]
UniGeneiHs.720076.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J5MX-ray2.07A1453-1848[»]
4LNZX-ray3.11A1460-1848[»]
4LWZX-ray2.55B/D1456-1848[»]
4LX0X-ray2.19B/D1456-1848[»]
ProteinModelPortaliQ9ULV0.
SMRiQ9ULV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110729. 48 interactors.
IntActiQ9ULV0. 27 interactors.
MINTiMINT-1209283.
STRINGi9606.ENSP00000285039.

PTM databases

iPTMnetiQ9ULV0.
PhosphoSitePlusiQ9ULV0.
SwissPalmiQ9ULV0.

Polymorphism and mutation databases

BioMutaiMYO5B.
DMDMi296439293.

Proteomic databases

EPDiQ9ULV0.
PaxDbiQ9ULV0.
PeptideAtlasiQ9ULV0.
PRIDEiQ9ULV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306. [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306. [Q9ULV0-3]
GeneIDi4645.
KEGGihsa:4645.
UCSCiuc002ldz.4. human. [Q9ULV0-1]

Organism-specific databases

CTDi4645.
DisGeNETi4645.
GeneCardsiMYO5B.
H-InvDBHIX0014446.
HGNCiHGNC:7603. MYO5B.
HPAiHPA040593.
HPA040902.
MalaCardsiMYO5B.
MIMi251850. phenotype.
606540. gene.
neXtProtiNX_Q9ULV0.
OpenTargetsiENSG00000167306.
Orphaneti2290. Microvillus inclusion disease.
PharmGKBiPA31408.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000152631.
HOVERGENiHBG052556.
InParanoidiQ9ULV0.
KOiK10357.
OMAiYMINAVT.
OrthoDBiEOG091G0G93.
PhylomeDBiQ9ULV0.
TreeFamiTF328771.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167306-MONOMER.
ReactomeiR-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

ChiTaRSiMYO5B. human.
GeneWikiiMYO5B.
GenomeRNAii4645.
PROiQ9ULV0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167306.
CleanExiHS_MYO5B.
ExpressionAtlasiQ9ULV0. baseline and differential.
GenevisibleiQ9ULV0. HS.

Family and domain databases

InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 6 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 6 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULV0
Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.