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Q9ULV0

- MYO5B_HUMAN

UniProt

Q9ULV0 - MYO5B_HUMAN

Protein

Unconventional myosin-Vb

Gene

MYO5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi163 – 1708ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microfilament motor activity Source: Reactome
    3. protein binding Source: UniProtKB
    4. Rab GTPase binding Source: UniProtKB

    GO - Biological processi

    1. metabolic process Source: GOC
    2. protein transport Source: UniProtKB-KW
    3. transmembrane transport Source: Reactome
    4. vesicle-mediated transport Source: UniProtKB
    5. water transport Source: Reactome

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-Vb
    Gene namesi
    Name:MYO5B
    Synonyms:KIAA1119
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:7603. MYO5B.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. myosin complex Source: UniProtKB-KW
    4. protein complex Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Diarrhea 2, with microvillus atrophy (DIAR2) [MIM:251850]: A disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081V → G in DIAR2. 1 Publication
    VAR_054993
    Natural varianti219 – 2191R → H in DIAR2. 1 Publication
    VAR_054994
    Natural varianti656 – 6561R → C in DIAR2. 1 Publication
    VAR_054995

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1300 – 13001Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication
    Mutagenesisi1307 – 13071Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication
    Mutagenesisi1714 – 17141Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication
    Mutagenesisi1748 – 17481Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi251850. phenotype.
    Orphaneti2290. Microvillous inclusion disease.
    PharmGKBiPA31408.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18481848Unconventional myosin-VbPRO_0000123460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1446 – 14461Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULV0.
    PaxDbiQ9ULV0.
    PRIDEiQ9ULV0.

    PTM databases

    PhosphoSiteiQ9ULV0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULV0.
    BgeeiQ9ULV0.
    CleanExiHS_MYO5B.
    GenevestigatoriQ9ULV0.

    Organism-specific databases

    HPAiHPA040593.
    HPA040902.

    Interactioni

    Subunit structurei

    Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1.5 Publications

    Protein-protein interaction databases

    BioGridi110729. 10 interactions.
    IntActiQ9ULV0. 4 interactions.
    MINTiMINT-1209283.
    STRINGi9606.ENSP00000285039.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1468 – 14714
    Helixi1474 – 14763
    Helixi1477 – 14848
    Turni1485 – 14873
    Helixi1490 – 14934
    Helixi1500 – 151415
    Helixi1518 – 153821
    Turni1539 – 15413
    Helixi1543 – 156220
    Helixi1567 – 15693
    Helixi1575 – 15784
    Helixi1588 – 161326
    Helixi1614 – 16163
    Helixi1617 – 16226
    Helixi1654 – 167017
    Helixi1675 – 169925
    Helixi1701 – 17033
    Helixi1706 – 172520
    Helixi1729 – 17313
    Helixi1733 – 17364
    Helixi1738 – 17469
    Helixi1754 – 176310
    Helixi1769 – 177810
    Helixi1791 – 180010
    Turni1801 – 18033
    Helixi1831 – 18333
    Helixi1838 – 18403
    Beta strandi1845 – 18484

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4J5MX-ray2.07A1453-1848[»]
    4LNZX-ray3.11A1460-1848[»]
    4LWZX-ray2.55B/D1456-1848[»]
    4LX0X-ray2.19B/D1456-1848[»]
    ProteinModelPortaliQ9ULV0.
    SMRiQ9ULV0. Positions 5-816, 858-898, 1456-1848.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 761693Myosin motorAdd
    BLAST
    Domaini769 – 79830IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini792 – 82130IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini817 – 84832IQ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini840 – 86930IQ 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini865 – 89632IQ 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini888 – 91730IQ 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1526 – 1803278DilutePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni640 – 66223Actin-bindingSequence AnalysisAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili899 – 1266368Sequence AnalysisAdd
    BLAST
    Coiled coili1341 – 1471131Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi801 – 916116Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 dilute domain.PROSITE-ProRule annotation
    Contains 6 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000171839.
    HOVERGENiHBG052556.
    InParanoidiQ9ULV0.
    KOiK10357.
    OMAiQTMEPLI.
    OrthoDBiEOG7PK8XT.
    PhylomeDBiQ9ULV0.
    TreeFamiTF328771.

    Family and domain databases

    InterProiIPR018444. Dil_domain.
    IPR002710. Dilute.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01843. DIL. 1 hit.
    PF00612. IQ. 6 hits.
    PF00063. Myosin_head. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 6 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS51126. DILUTE. 1 hit.
    PS50096. IQ. 6 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULV0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY     50
    PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY 100
    TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM 150
    ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS 200
    PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV 250
    FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD 300
    DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS 350
    ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA 400
    RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF 450
    EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI 500
    EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII 550
    VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP 600
    ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT 650
    TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY 700
    HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA 750
    GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG 800
    HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF 850
    VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR 900
    RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV 950
    TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK 1000
    ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS 1050
    VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN 1100
    PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ 1150
    KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL 1200
    KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA 1250
    HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ 1300
    EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ 1350
    SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS 1400
    RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR 1450
    HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL 1500
    PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL 1550
    SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ 1600
    IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN 1650
    SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR 1700
    KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK 1750
    KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ 1800
    LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV 1848
    Length:1,848
    Mass (Da):213,672
    Last modified:May 18, 2010 - v3
    Checksum:i4EB8FA02F6B38707
    GO
    Isoform 2 (identifier: Q9ULV0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-859: Missing.
         1315-1340: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:963
    Mass (Da):111,759
    Checksum:i14C45F254C2AFAB5
    GO
    Isoform 3 (identifier: Q9ULV0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1430: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:418
    Mass (Da):47,983
    Checksum:iE2A61014E7DFFF90
    GO

    Sequence cautioni

    The sequence BAA86433.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101C → G.
    Corresponds to variant rs16951438 [ dbSNP | Ensembl ].
    VAR_056182
    Natural varianti108 – 1081V → G in DIAR2. 1 Publication
    VAR_054993
    Natural varianti126 – 1261T → A.2 Publications
    Corresponds to variant rs1815930 [ dbSNP | Ensembl ].
    VAR_063141
    Natural varianti219 – 2191R → H in DIAR2. 1 Publication
    VAR_054994
    Natural varianti307 – 3071K → N.
    Corresponds to variant rs17659179 [ dbSNP | Ensembl ].
    VAR_056183
    Natural varianti656 – 6561R → C in DIAR2. 1 Publication
    VAR_054995
    Natural varianti918 – 9181R → H.
    Corresponds to variant rs2298624 [ dbSNP | Ensembl ].
    VAR_056184
    Natural varianti942 – 9421K → R.
    Corresponds to variant rs2277716 [ dbSNP | Ensembl ].
    VAR_056185
    Natural varianti1055 – 10551L → LL.2 Publications
    Corresponds to variant rs72530399 [ dbSNP | Ensembl ].
    VAR_063142

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 14301430Missing in isoform 3. 1 PublicationVSP_056198Add
    BLAST
    Alternative sequencei1 – 859859Missing in isoform 2. 1 PublicationVSP_056199Add
    BLAST
    Alternative sequencei1315 – 134026Missing in isoform 2. 1 PublicationVSP_056200Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032945 mRNA. Translation: BAA86433.2. Different initiation.
    AK025336 mRNA. Translation: BAB15114.1.
    AB290160 mRNA. Translation: BAG06714.1.
    AC090227 Genomic DNA. No translation available.
    AC091044 Genomic DNA. No translation available.
    AC092705 Genomic DNA. No translation available.
    AC105224 Genomic DNA. No translation available.
    BC033527 mRNA. Translation: AAH33527.1.
    CCDSiCCDS42436.1.
    RefSeqiNP_001073936.1. NM_001080467.2.
    UniGeneiHs.720076.

    Genome annotation databases

    EnsembliENST00000285039; ENSP00000285039; ENSG00000167306.
    ENST00000324581; ENSP00000315531; ENSG00000167306.
    ENST00000592688; ENSP00000466368; ENSG00000167306.
    GeneIDi4645.
    KEGGihsa:4645.
    UCSCiuc002leb.2. human.

    Polymorphism databases

    DMDMi296439293.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032945 mRNA. Translation: BAA86433.2 . Different initiation.
    AK025336 mRNA. Translation: BAB15114.1 .
    AB290160 mRNA. Translation: BAG06714.1 .
    AC090227 Genomic DNA. No translation available.
    AC091044 Genomic DNA. No translation available.
    AC092705 Genomic DNA. No translation available.
    AC105224 Genomic DNA. No translation available.
    BC033527 mRNA. Translation: AAH33527.1 .
    CCDSi CCDS42436.1.
    RefSeqi NP_001073936.1. NM_001080467.2.
    UniGenei Hs.720076.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4J5M X-ray 2.07 A 1453-1848 [» ]
    4LNZ X-ray 3.11 A 1460-1848 [» ]
    4LWZ X-ray 2.55 B/D 1456-1848 [» ]
    4LX0 X-ray 2.19 B/D 1456-1848 [» ]
    ProteinModelPortali Q9ULV0.
    SMRi Q9ULV0. Positions 5-816, 858-898, 1456-1848.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110729. 10 interactions.
    IntActi Q9ULV0. 4 interactions.
    MINTi MINT-1209283.
    STRINGi 9606.ENSP00000285039.

    PTM databases

    PhosphoSitei Q9ULV0.

    Polymorphism databases

    DMDMi 296439293.

    Proteomic databases

    MaxQBi Q9ULV0.
    PaxDbi Q9ULV0.
    PRIDEi Q9ULV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285039 ; ENSP00000285039 ; ENSG00000167306 .
    ENST00000324581 ; ENSP00000315531 ; ENSG00000167306 .
    ENST00000592688 ; ENSP00000466368 ; ENSG00000167306 .
    GeneIDi 4645.
    KEGGi hsa:4645.
    UCSCi uc002leb.2. human.

    Organism-specific databases

    CTDi 4645.
    GeneCardsi GC18M047349.
    H-InvDB HIX0014446.
    HGNCi HGNC:7603. MYO5B.
    HPAi HPA040593.
    HPA040902.
    MIMi 251850. phenotype.
    606540. gene.
    neXtProti NX_Q9ULV0.
    Orphaneti 2290. Microvillous inclusion disease.
    PharmGKBi PA31408.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000171839.
    HOVERGENi HBG052556.
    InParanoidi Q9ULV0.
    KOi K10357.
    OMAi QTMEPLI.
    OrthoDBi EOG7PK8XT.
    PhylomeDBi Q9ULV0.
    TreeFami TF328771.

    Enzyme and pathway databases

    Reactomei REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    ChiTaRSi MYO5B. human.
    GeneWikii MYO5B.
    GenomeRNAii 4645.
    NextBioi 17900.
    PROi Q9ULV0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULV0.
    Bgeei Q9ULV0.
    CleanExi HS_MYO5B.
    Genevestigatori Q9ULV0.

    Family and domain databases

    InterProi IPR018444. Dil_domain.
    IPR002710. Dilute.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01843. DIL. 1 hit.
    PF00612. IQ. 6 hits.
    PF00063. Myosin_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 6 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS51126. DILUTE. 1 hit.
    PS50096. IQ. 6 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-126 AND LEU-1055 INS.
      Tissue: Brain.
    2. Ohara O., Nagase T., Yamakawa H., Kikuno R.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO N-TERMINUS AND 918.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    4. "Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins."
      Yamakawa H., Kikuno R.F., Nagase T., Ohara O.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-126 AND LEU-1055 INS.
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Colon.
    7. Cited for: INTERACTION WITH RAB11FIP2.
    8. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
      Yan Q., Sun W., Kujala P., Lotfi Y., Vida T.A., Bean A.J.
      Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CART COMPLEX.
    9. "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells."
      Swiatecka-Urban A., Talebian L., Kanno E., Moreau-Marquis S., Coutermarsh B., Hansen K., Karlson K.H., Barnaby R., Cheney R.E., Langford G.M., Fukuda M., Stanton B.A.
      J. Biol. Chem. 282:23725-23736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAB11A, IDENTIFICATION IN A COMPLEX WITH RAB11A AND CFTR.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface."
      Chu B.-B., Ge L., Xie C., Zhao Y., Miao H.-H., Wang J., Li B.-L., Song B.-L.
      J. Biol. Chem. 284:22481-22490(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NPC1L1.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization."
      Roland J.T., Bryant D.M., Datta A., Itzen A., Mostov K.E., Goldenring J.R.
      Proc. Natl. Acad. Sci. U.S.A. 108:2789-2794(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAB11A AND RAB8A, MUTAGENESIS OF GLN-1300; TYR-1307; TYR-1714 AND GLN-1748.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: VARIANTS DIAR2 GLY-108; HIS-219 AND CYS-656.

    Entry informationi

    Entry nameiMYO5B_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULV0
    Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3