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Q9ULT8

- HECD1_HUMAN

UniProt

Q9ULT8 - HECD1_HUMAN

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Protein

E3 ubiquitin-protein ligase HECTD1

Gene

HECTD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2579 – 25791Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. metal ion binding Source: InterPro
  3. ubiquitin-protein transferase activity Source: RefGenome

GO - Biological processi

  1. neural tube closure Source: Ensembl
  2. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HECTD1 (EC:6.3.2.-)
Alternative name(s):
E3 ligase for inhibin receptor
EULIR
HECT domain-containing protein 1
Gene namesi
Name:HECTD1
Synonyms:KIAA1131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20157. HECTD1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26102610E3 ubiquitin-protein ligase HECTD1PRO_0000083945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei631 – 6311Phosphoserine1 Publication
Modified residuei1488 – 14881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ULT8.
PaxDbiQ9ULT8.
PeptideAtlasiQ9ULT8.
PRIDEiQ9ULT8.

PTM databases

PhosphoSiteiQ9ULT8.

Expressioni

Gene expression databases

BgeeiQ9ULT8.
CleanExiHS_HECTD1.
ExpressionAtlasiQ9ULT8. baseline and differential.
GenevestigatoriQ9ULT8.

Organism-specific databases

HPAiHPA002929.

Interactioni

Subunit structurei

Interacts with IGSF1.1 Publication

Protein-protein interaction databases

BioGridi117359. 31 interactions.
DIPiDIP-31669N.
IntActiQ9ULT8. 11 interactions.
MINTiMINT-6783566.
STRINGi9606.ENSP00000382269.

Structurei

Secondary structure

1
2610
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1270 – 12723Combined sources
Beta strandi1279 – 12824Combined sources
Turni1289 – 12924Combined sources
Beta strandi1299 – 13013Combined sources
Beta strandi1309 – 13146Combined sources
Turni1315 – 13173Combined sources
Beta strandi1319 – 13257Combined sources
Helixi1326 – 13283Combined sources
Beta strandi1332 – 13343Combined sources
Helixi1883 – 18864Combined sources
Helixi1896 – 19027Combined sources
Beta strandi1905 – 19084Combined sources
Helixi1910 – 192011Combined sources
Helixi1923 – 19286Combined sources
Helixi1935 – 19417Combined sources
Helixi1944 – 195714Combined sources
Turni1960 – 19623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DK3NMR-A1266-1338[»]
2LC3NMR-A1879-1966[»]
3DKMX-ray1.60A1271-1341[»]
ProteinModelPortaliQ9ULT8.
SMRiQ9ULT8. Positions 1266-1338, 1879-1966.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULT8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati395 – 42430ANK 1Add
BLAST
Repeati426 – 45530ANK 2Add
BLAST
Repeati459 – 49133ANK 3Add
BLAST
Repeati579 – 61234ANK 4Add
BLAST
Domaini1266 – 133873MIB/HERC2PROSITE-ProRule annotationAdd
BLAST
Domaini2151 – 2610460HECTPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2029 – 210375K-boxAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1350 – 1649300Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 1 MIB/HERC2 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG5021.
HOGENOMiHOG000018061.
HOVERGENiHBG067533.
InParanoidiQ9ULT8.
KOiK12231.
OMAiTKHSFTA.
PhylomeDBiQ9ULT8.
TreeFamiTF323674.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR008979. Galactose-bd-like.
IPR000569. HECT.
IPR010606. Mib_Herc2.
IPR012919. Sad1_UNC_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF07738. Sad1_UNC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56204. SSF56204. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP
60 70 80 90 100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK
110 120 130 140 150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF
160 170 180 190 200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH
210 220 230 240 250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP
260 270 280 290 300
SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS
310 320 330 340 350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP
360 370 380 390 400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL
410 420 430 440 450
NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG
460 470 480 490 500
ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT
510 520 530 540 550
NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI RKASLALIRK
560 570 580 590 600
MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII
610 620 630 640 650
RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE
660 670 680 690 700
DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG
710 720 730 740 750
KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP
760 770 780 790 800
TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF
810 820 830 840 850
TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES
860 870 880 890 900
MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL
910 920 930 940 950
KDENTISPYE MCSSGLVQAL LTVLNNSMDL DMKQDCSQLV ERINVFKTAF
960 970 980 990 1000
SENEDDESRP AVALIRKLIA VLESIERLPL HLYDTPGSTY NLQILTRRLR
1010 1020 1030 1040 1050
FRLERAPGET ALIDRTGRML KMEPLATVES LEQYLLKMVA KQWYDFDRSS
1060 1070 1080 1090 1100
FVFVRKLREG QNFIFRHQHD FDENGIIYWI GTNAKTAYEW VNPAAYGLVV
1110 1120 1130 1140 1150
VTSSEGRNLP YGRLEDILSR DNSALNCHSN DDKNAWFAID LGLWVIPSAY
1160 1170 1180 1190 1200
TLRHARGYGR SALRNWVFQV SKDGQNWTSL YTHVDDCSLN EPGSTATWPL
1210 1220 1230 1240 1250
DPPKDEKQGW RHVRIKQMGK NASGQTHYLS LSGFELYGTV NGVCEDQLGK
1260 1270 1280 1290 1300
AAKEAEANLR RQRRLVRSQV LKYMVPGARV IRGLDWKWRD QDGSPQGEGT
1310 1320 1330 1340 1350
VTGELHNGWI DVTWDAGGSN SYRMGAEGKF DLKLAPGYDP DTVASPKPVS
1360 1370 1380 1390 1400
STVSGTTQSW SSLVKNNCPD KTSAAAGSSS RKGSSSSVCS VASSSDISLG
1410 1420 1430 1440 1450
STKTERRSEI VMEHSIVSGA DVHEPIVVLS SAENVPQTEV GSSSSASTST
1460 1470 1480 1490 1500
LTAETGSENA ERKLGPDSSV RTPGESSAIS MGIVSVSSPD VSSVSELTNK
1510 1520 1530 1540 1550
EAASQRPLSS SASNRLSVSS LLAAGAPMSS SASVPNLSSR ETSSLESFVR
1560 1570 1580 1590 1600
RVANIARTNA TNNMNLSRSS SDNNTNTLGR NVMSTATSPL MGAQSFPNLT
1610 1620 1630 1640 1650
TPGTTSTVTM STSSVTSSSN VATATTVLSV GQSLSNTLTT SLTSTSSESD
1660 1670 1680 1690 1700
TGQEAEYSLY DFLDSCRAST LLAELDDDED LPEPDEEDDE NEDDNQEDQE
1710 1720 1730 1740 1750
YEEVMILRRP SLQRRAGSRS DVTHHAVTSQ LPQVPAGAGS RPIGEQEEEE
1760 1770 1780 1790 1800
YETKGGRRRT WDDDYVLKRQ FSALVPAFDP RPGRTNVQQT TDLEIPPPGT
1810 1820 1830 1840 1850
PHSELLEEVE CTPSPRLALT LKVTGLGTTR EVELPLTNFR STIFYYVQKL
1860 1870 1880 1890 1900
LQLSCNGNVK SDKLRRIWEP TYTIMYREMK DSDKEKENGK MGCWSIEHVE
1910 1920 1930 1940 1950
QYLGTDELPK NDLITYLQKN ADAAFLRHWK LTGTNKSIRK NRNCSQLIAA
1960 1970 1980 1990 2000
YKDFCEHGTK SGLNQGAIST LQSSDILNLT KEQPQAKAGN GQNSCGVEDV
2010 2020 2030 2040 2050
LQLLRILYIV ASDPYSRISQ EDGDEQLQFT FPPDEFTSKK ITTKILQQIE
2060 2070 2080 2090 2100
EPLALASGAL PDWCEQLTSK CPFLIPFETR QLYFTCTAFG ASRAIVWLQN
2110 2120 2130 2140 2150
RREATVERTR TTSSVRRDDP GEFRVGRLKH ERVKVPRGES LMEWAENVMQ
2160 2170 2180 2190 2200
IHADRKSVLE VEFLGEEGTG LGPTLEFYAL VAAEFQRTDL GAWLCDDNFP
2210 2220 2230 2240 2250
DDESRHVDLG GGLKPPGYYV QRSCGLFTAP FPQDSDELER ITKLFHFLGI
2260 2270 2280 2290 2300
FLAKCIQDNR LVDLPISKPF FKLMCMGDIK SNMSKLIYES RGDRDLHCTE
2310 2320 2330 2340 2350
SQSEASTEEG HDSLSVGSFE EDSKSEFILD PPKPKPPAWF NGILTWEDFE
2360 2370 2380 2390 2400
LVNPHRARFL KEIKDLAIKR RQILSNKGLS EDEKNTKLQE LVLKNPSGSG
2410 2420 2430 2440 2450
PPLSIEDLGL NFQFCPSSRI YGFTAVDLKP SGEDEMITMD NAEEYVDLMF
2460 2470 2480 2490 2500
DFCMHTGIQK QMEAFRDGFN KVFPMEKLSS FSHEEVQMIL CGNQSPSWAA
2510 2520 2530 2540 2550
EDIINYTEPK LGYTRDSPGF LRFVRVLCGM SSDERKAFLQ FTTGCSTLPP
2560 2570 2580 2590 2600
GGLANLHPRL TVVRKVDATD ASYPSVNTCV HYLKLPEYSS EEIMRERLLA
2610
ATMEKGFHLN
Length:2,610
Mass (Da):289,384
Last modified:November 30, 2010 - v3
Checksum:i27E56401E07E158C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti561 – 5611K → Q in AAP13073. 1 PublicationCurated
Sequence conflicti603 – 6031L → I in AAP13073. 1 PublicationCurated
Sequence conflicti611 – 6133FLD → YKH in AAP13073. 1 PublicationCurated
Sequence conflicti653 – 6531K → Q in AAP13073. 1 PublicationCurated
Sequence conflicti894 – 8941E → K in AAP13073. 1 PublicationCurated
Sequence conflicti927 – 94418SMDLD…VERIN → VSIFRATKQKQNEVPKVILS in AAP13073. 1 PublicationCuratedAdd
BLAST
Sequence conflicti951 – 9511S → T in AAP13073. 1 PublicationCurated
Sequence conflicti1281 – 12811I → T in BAA86445. (PubMed:12508121)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti656 – 6561Q → H.
Corresponds to variant rs11620816 [ dbSNP | Ensembl ].
VAR_059666
Natural varianti2027 – 20271L → P.3 Publications
Corresponds to variant rs1315794 [ dbSNP | Ensembl ].
VAR_067707

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254380 mRNA. Translation: AAP13073.1.
AL121808 Genomic DNA. No translation available.
AL136418 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65950.1.
CH471078 Genomic DNA. Translation: EAW65952.1.
AB032957 mRNA. Translation: BAA86445.2.
AL110222 mRNA. Translation: CAB53681.1.
BC011658 mRNA. Translation: AAH11658.2.
BC063686 mRNA. Translation: AAH63686.1.
CCDSiCCDS41939.1.
PIRiT14761.
RefSeqiNP_056197.3. NM_015382.3.
XP_005267559.2. XM_005267502.2.
UniGeneiHs.708017.

Genome annotation databases

EnsembliENST00000399332; ENSP00000382269; ENSG00000092148.
ENST00000553700; ENSP00000450697; ENSG00000092148.
GeneIDi25831.
KEGGihsa:25831.
UCSCiuc001wrc.1. human.

Polymorphism databases

DMDMi313104227.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254380 mRNA. Translation: AAP13073.1 .
AL121808 Genomic DNA. No translation available.
AL136418 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65950.1 .
CH471078 Genomic DNA. Translation: EAW65952.1 .
AB032957 mRNA. Translation: BAA86445.2 .
AL110222 mRNA. Translation: CAB53681.1 .
BC011658 mRNA. Translation: AAH11658.2 .
BC063686 mRNA. Translation: AAH63686.1 .
CCDSi CCDS41939.1.
PIRi T14761.
RefSeqi NP_056197.3. NM_015382.3.
XP_005267559.2. XM_005267502.2.
UniGenei Hs.708017.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DK3 NMR - A 1266-1338 [» ]
2LC3 NMR - A 1879-1966 [» ]
3DKM X-ray 1.60 A 1271-1341 [» ]
ProteinModelPortali Q9ULT8.
SMRi Q9ULT8. Positions 1266-1338, 1879-1966.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117359. 31 interactions.
DIPi DIP-31669N.
IntActi Q9ULT8. 11 interactions.
MINTi MINT-6783566.
STRINGi 9606.ENSP00000382269.

PTM databases

PhosphoSitei Q9ULT8.

Polymorphism databases

DMDMi 313104227.

Proteomic databases

MaxQBi Q9ULT8.
PaxDbi Q9ULT8.
PeptideAtlasi Q9ULT8.
PRIDEi Q9ULT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399332 ; ENSP00000382269 ; ENSG00000092148 .
ENST00000553700 ; ENSP00000450697 ; ENSG00000092148 .
GeneIDi 25831.
KEGGi hsa:25831.
UCSCi uc001wrc.1. human.

Organism-specific databases

CTDi 25831.
GeneCardsi GC14M031569.
HGNCi HGNC:20157. HECTD1.
HPAi HPA002929.
neXtProti NX_Q9ULT8.
PharmGKBi PA134989284.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5021.
HOGENOMi HOG000018061.
HOVERGENi HBG067533.
InParanoidi Q9ULT8.
KOi K12231.
OMAi TKHSFTA.
PhylomeDBi Q9ULT8.
TreeFami TF323674.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi HECTD1. human.
EvolutionaryTracei Q9ULT8.
GenomeRNAii 25831.
NextBioi 47125.
PROi Q9ULT8.

Gene expression databases

Bgeei Q9ULT8.
CleanExi HS_HECTD1.
ExpressionAtlasi Q9ULT8. baseline and differential.
Genevestigatori Q9ULT8.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR008979. Galactose-bd-like.
IPR000569. HECT.
IPR010606. Mib_Herc2.
IPR012919. Sad1_UNC_C.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF07738. Sad1_UNC. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
SM00119. HECTc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
SSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56204. SSF56204. 4 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EULIR is an E3 ubiquitin ligase for inhibin receptor."
    Zhang H.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-2027.
  4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-2610, VARIANT PRO-2027.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1652-2610, VARIANT PRO-2027.
    Tissue: Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2091-2610.
    Tissue: Muscle and Urinary bladder.
  7. "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs."
    Nakayama M., Kikuno R., Ohara O.
    Genome Res. 12:1773-1784(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF1.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Solution structure of MIB-HERC2 domain in HECT domain containing protein 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1266-1338.

Entry informationi

Entry nameiHECD1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULT8
Secondary accession number(s): D3DS86
, Q6P445, Q86VJ1, Q96F34, Q9UFZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3