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Q9ULT8

- HECD1_HUMAN

UniProt

Q9ULT8 - HECD1_HUMAN

Protein

E3 ubiquitin-protein ligase HECTD1

Gene

HECTD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2579 – 25791Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. metal ion binding Source: InterPro
    3. protein binding Source: UniProtKB
    4. ubiquitin-protein transferase activity Source: RefGenome

    GO - Biological processi

    1. neural tube closure Source: Ensembl
    2. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: RefGenome

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase HECTD1 (EC:6.3.2.-)
    Alternative name(s):
    E3 ligase for inhibin receptor
    EULIR
    HECT domain-containing protein 1
    Gene namesi
    Name:HECTD1
    Synonyms:KIAA1131
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20157. HECTD1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134989284.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 26102610E3 ubiquitin-protein ligase HECTD1PRO_0000083945Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei631 – 6311Phosphoserine1 Publication
    Modified residuei1488 – 14881Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULT8.
    PaxDbiQ9ULT8.
    PeptideAtlasiQ9ULT8.
    PRIDEiQ9ULT8.

    PTM databases

    PhosphoSiteiQ9ULT8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULT8.
    BgeeiQ9ULT8.
    CleanExiHS_HECTD1.
    GenevestigatoriQ9ULT8.

    Organism-specific databases

    HPAiHPA002929.

    Interactioni

    Subunit structurei

    Interacts with IGSF1.1 Publication

    Protein-protein interaction databases

    BioGridi117359. 16 interactions.
    DIPiDIP-31669N.
    IntActiQ9ULT8. 10 interactions.
    MINTiMINT-6783566.
    STRINGi9606.ENSP00000382269.

    Structurei

    Secondary structure

    1
    2610
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1270 – 12723
    Beta strandi1279 – 12824
    Turni1289 – 12924
    Beta strandi1299 – 13013
    Beta strandi1309 – 13146
    Turni1315 – 13173
    Beta strandi1319 – 13257
    Helixi1326 – 13283
    Beta strandi1332 – 13343
    Helixi1883 – 18864
    Helixi1896 – 19027
    Beta strandi1905 – 19084
    Helixi1910 – 192011
    Helixi1923 – 19286
    Helixi1935 – 19417
    Helixi1944 – 195714
    Turni1960 – 19623

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DK3NMR-A1266-1338[»]
    2LC3NMR-A1879-1966[»]
    3DKMX-ray1.60A1271-1341[»]
    ProteinModelPortaliQ9ULT8.
    SMRiQ9ULT8. Positions 1266-1338, 1879-1966.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ULT8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati395 – 42430ANK 1Add
    BLAST
    Repeati426 – 45530ANK 2Add
    BLAST
    Repeati459 – 49133ANK 3Add
    BLAST
    Repeati579 – 61234ANK 4Add
    BLAST
    Domaini1266 – 133873MIB/HERC2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2151 – 2610460HECTPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2029 – 210375K-boxAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1350 – 1649300Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPL family. K-HECT subfamily.Curated
    Contains 4 ANK repeats.PROSITE-ProRule annotation
    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
    Contains 1 MIB/HERC2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG5021.
    HOGENOMiHOG000018061.
    HOVERGENiHBG067533.
    InParanoidiQ9ULT8.
    KOiK12231.
    OMAiTKHSFTA.
    PhylomeDBiQ9ULT8.
    TreeFamiTF323674.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR008979. Galactose-bd-like.
    IPR000569. HECT.
    IPR010606. Mib_Herc2.
    IPR012919. Sad1_UNC_C.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF00632. HECT. 1 hit.
    PF06701. MIB_HERC2. 1 hit.
    PF07738. Sad1_UNC. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    SM00119. HECTc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    SSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56204. SSF56204. 4 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50237. HECT. 1 hit.
    PS51416. MIB_HERC2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ULT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP     50
    RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK 100
    ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF 150
    IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH 200
    QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP 250
    SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS 300
    ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP 350
    GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL 400
    NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG 450
    ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT 500
    NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI RKASLALIRK 550
    MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII 600
    RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE 650
    DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG 700
    KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP 750
    TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF 800
    TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES 850
    MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL 900
    KDENTISPYE MCSSGLVQAL LTVLNNSMDL DMKQDCSQLV ERINVFKTAF 950
    SENEDDESRP AVALIRKLIA VLESIERLPL HLYDTPGSTY NLQILTRRLR 1000
    FRLERAPGET ALIDRTGRML KMEPLATVES LEQYLLKMVA KQWYDFDRSS 1050
    FVFVRKLREG QNFIFRHQHD FDENGIIYWI GTNAKTAYEW VNPAAYGLVV 1100
    VTSSEGRNLP YGRLEDILSR DNSALNCHSN DDKNAWFAID LGLWVIPSAY 1150
    TLRHARGYGR SALRNWVFQV SKDGQNWTSL YTHVDDCSLN EPGSTATWPL 1200
    DPPKDEKQGW RHVRIKQMGK NASGQTHYLS LSGFELYGTV NGVCEDQLGK 1250
    AAKEAEANLR RQRRLVRSQV LKYMVPGARV IRGLDWKWRD QDGSPQGEGT 1300
    VTGELHNGWI DVTWDAGGSN SYRMGAEGKF DLKLAPGYDP DTVASPKPVS 1350
    STVSGTTQSW SSLVKNNCPD KTSAAAGSSS RKGSSSSVCS VASSSDISLG 1400
    STKTERRSEI VMEHSIVSGA DVHEPIVVLS SAENVPQTEV GSSSSASTST 1450
    LTAETGSENA ERKLGPDSSV RTPGESSAIS MGIVSVSSPD VSSVSELTNK 1500
    EAASQRPLSS SASNRLSVSS LLAAGAPMSS SASVPNLSSR ETSSLESFVR 1550
    RVANIARTNA TNNMNLSRSS SDNNTNTLGR NVMSTATSPL MGAQSFPNLT 1600
    TPGTTSTVTM STSSVTSSSN VATATTVLSV GQSLSNTLTT SLTSTSSESD 1650
    TGQEAEYSLY DFLDSCRAST LLAELDDDED LPEPDEEDDE NEDDNQEDQE 1700
    YEEVMILRRP SLQRRAGSRS DVTHHAVTSQ LPQVPAGAGS RPIGEQEEEE 1750
    YETKGGRRRT WDDDYVLKRQ FSALVPAFDP RPGRTNVQQT TDLEIPPPGT 1800
    PHSELLEEVE CTPSPRLALT LKVTGLGTTR EVELPLTNFR STIFYYVQKL 1850
    LQLSCNGNVK SDKLRRIWEP TYTIMYREMK DSDKEKENGK MGCWSIEHVE 1900
    QYLGTDELPK NDLITYLQKN ADAAFLRHWK LTGTNKSIRK NRNCSQLIAA 1950
    YKDFCEHGTK SGLNQGAIST LQSSDILNLT KEQPQAKAGN GQNSCGVEDV 2000
    LQLLRILYIV ASDPYSRISQ EDGDEQLQFT FPPDEFTSKK ITTKILQQIE 2050
    EPLALASGAL PDWCEQLTSK CPFLIPFETR QLYFTCTAFG ASRAIVWLQN 2100
    RREATVERTR TTSSVRRDDP GEFRVGRLKH ERVKVPRGES LMEWAENVMQ 2150
    IHADRKSVLE VEFLGEEGTG LGPTLEFYAL VAAEFQRTDL GAWLCDDNFP 2200
    DDESRHVDLG GGLKPPGYYV QRSCGLFTAP FPQDSDELER ITKLFHFLGI 2250
    FLAKCIQDNR LVDLPISKPF FKLMCMGDIK SNMSKLIYES RGDRDLHCTE 2300
    SQSEASTEEG HDSLSVGSFE EDSKSEFILD PPKPKPPAWF NGILTWEDFE 2350
    LVNPHRARFL KEIKDLAIKR RQILSNKGLS EDEKNTKLQE LVLKNPSGSG 2400
    PPLSIEDLGL NFQFCPSSRI YGFTAVDLKP SGEDEMITMD NAEEYVDLMF 2450
    DFCMHTGIQK QMEAFRDGFN KVFPMEKLSS FSHEEVQMIL CGNQSPSWAA 2500
    EDIINYTEPK LGYTRDSPGF LRFVRVLCGM SSDERKAFLQ FTTGCSTLPP 2550
    GGLANLHPRL TVVRKVDATD ASYPSVNTCV HYLKLPEYSS EEIMRERLLA 2600
    ATMEKGFHLN 2610
    Length:2,610
    Mass (Da):289,384
    Last modified:November 30, 2010 - v3
    Checksum:i27E56401E07E158C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti561 – 5611K → Q in AAP13073. 1 PublicationCurated
    Sequence conflicti603 – 6031L → I in AAP13073. 1 PublicationCurated
    Sequence conflicti611 – 6133FLD → YKH in AAP13073. 1 PublicationCurated
    Sequence conflicti653 – 6531K → Q in AAP13073. 1 PublicationCurated
    Sequence conflicti894 – 8941E → K in AAP13073. 1 PublicationCurated
    Sequence conflicti927 – 94418SMDLD…VERIN → VSIFRATKQKQNEVPKVILS in AAP13073. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti951 – 9511S → T in AAP13073. 1 PublicationCurated
    Sequence conflicti1281 – 12811I → T in BAA86445. (PubMed:12508121)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti656 – 6561Q → H.
    Corresponds to variant rs11620816 [ dbSNP | Ensembl ].
    VAR_059666
    Natural varianti2027 – 20271L → P.3 Publications
    Corresponds to variant rs1315794 [ dbSNP | Ensembl ].
    VAR_067707

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY254380 mRNA. Translation: AAP13073.1.
    AL121808 Genomic DNA. No translation available.
    AL136418 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65950.1.
    CH471078 Genomic DNA. Translation: EAW65952.1.
    AB032957 mRNA. Translation: BAA86445.2.
    AL110222 mRNA. Translation: CAB53681.1.
    BC011658 mRNA. Translation: AAH11658.2.
    BC063686 mRNA. Translation: AAH63686.1.
    CCDSiCCDS41939.1.
    PIRiT14761.
    RefSeqiNP_056197.3. NM_015382.3.
    XP_005267559.2. XM_005267502.2.
    UniGeneiHs.708017.

    Genome annotation databases

    EnsembliENST00000399332; ENSP00000382269; ENSG00000092148.
    ENST00000553700; ENSP00000450697; ENSG00000092148.
    GeneIDi25831.
    KEGGihsa:25831.
    UCSCiuc001wrc.1. human.

    Polymorphism databases

    DMDMi313104227.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY254380 mRNA. Translation: AAP13073.1 .
    AL121808 Genomic DNA. No translation available.
    AL136418 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65950.1 .
    CH471078 Genomic DNA. Translation: EAW65952.1 .
    AB032957 mRNA. Translation: BAA86445.2 .
    AL110222 mRNA. Translation: CAB53681.1 .
    BC011658 mRNA. Translation: AAH11658.2 .
    BC063686 mRNA. Translation: AAH63686.1 .
    CCDSi CCDS41939.1.
    PIRi T14761.
    RefSeqi NP_056197.3. NM_015382.3.
    XP_005267559.2. XM_005267502.2.
    UniGenei Hs.708017.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DK3 NMR - A 1266-1338 [» ]
    2LC3 NMR - A 1879-1966 [» ]
    3DKM X-ray 1.60 A 1271-1341 [» ]
    ProteinModelPortali Q9ULT8.
    SMRi Q9ULT8. Positions 1266-1338, 1879-1966.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117359. 16 interactions.
    DIPi DIP-31669N.
    IntActi Q9ULT8. 10 interactions.
    MINTi MINT-6783566.
    STRINGi 9606.ENSP00000382269.

    PTM databases

    PhosphoSitei Q9ULT8.

    Polymorphism databases

    DMDMi 313104227.

    Proteomic databases

    MaxQBi Q9ULT8.
    PaxDbi Q9ULT8.
    PeptideAtlasi Q9ULT8.
    PRIDEi Q9ULT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399332 ; ENSP00000382269 ; ENSG00000092148 .
    ENST00000553700 ; ENSP00000450697 ; ENSG00000092148 .
    GeneIDi 25831.
    KEGGi hsa:25831.
    UCSCi uc001wrc.1. human.

    Organism-specific databases

    CTDi 25831.
    GeneCardsi GC14M031569.
    HGNCi HGNC:20157. HECTD1.
    HPAi HPA002929.
    neXtProti NX_Q9ULT8.
    PharmGKBi PA134989284.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5021.
    HOGENOMi HOG000018061.
    HOVERGENi HBG067533.
    InParanoidi Q9ULT8.
    KOi K12231.
    OMAi TKHSFTA.
    PhylomeDBi Q9ULT8.
    TreeFami TF323674.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi HECTD1. human.
    EvolutionaryTracei Q9ULT8.
    GenomeRNAii 25831.
    NextBioi 47125.
    PROi Q9ULT8.

    Gene expression databases

    ArrayExpressi Q9ULT8.
    Bgeei Q9ULT8.
    CleanExi HS_HECTD1.
    Genevestigatori Q9ULT8.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR008979. Galactose-bd-like.
    IPR000569. HECT.
    IPR010606. Mib_Herc2.
    IPR012919. Sad1_UNC_C.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF00632. HECT. 1 hit.
    PF06701. MIB_HERC2. 1 hit.
    PF07738. Sad1_UNC. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    SM00119. HECTc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    SSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56204. SSF56204. 4 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50237. HECT. 1 hit.
    PS51416. MIB_HERC2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EULIR is an E3 ubiquitin ligase for inhibin receptor."
      Zhang H.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-2027.
    4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-2610, VARIANT PRO-2027.
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1652-2610, VARIANT PRO-2027.
      Tissue: Testis.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2091-2610.
      Tissue: Muscle and Urinary bladder.
    7. "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs."
      Nakayama M., Kikuno R., Ohara O.
      Genome Res. 12:1773-1784(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IGSF1.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Solution structure of MIB-HERC2 domain in HECT domain containing protein 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1266-1338.

    Entry informationi

    Entry nameiHECD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULT8
    Secondary accession number(s): D3DS86
    , Q6P445, Q86VJ1, Q96F34, Q9UFZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3