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Protein

E3 ubiquitin-protein ligase HECTD1

Gene

HECTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2579Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HECTD1 (EC:2.3.2.26By similarity)
Alternative name(s):
E3 ligase for inhibin receptor
EULIR
HECT domain-containing protein 1
HECT-type E3 ubiquitin transferase HECTD1
Gene namesi
Name:HECTD1
Synonyms:KIAA1131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000092148.12
HGNCiHGNC:20157 HECTD1
neXtProtiNX_Q9ULT8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989284

Polymorphism and mutation databases

BioMutaiHECTD1
DMDMi313104227

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839451 – 2610E3 ubiquitin-protein ligase HECTD1Add BLAST2610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei631PhosphoserineCombined sources1
Modified residuei640PhosphoserineBy similarity1
Modified residuei1384PhosphoserineBy similarity1
Modified residuei1488PhosphoserineCombined sources1
Modified residuei1567PhosphoserineBy similarity1
Modified residuei1760PhosphothreonineCombined sources1
Modified residuei1772PhosphoserineCombined sources1
Modified residuei2318PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULT8
MaxQBiQ9ULT8
PaxDbiQ9ULT8
PeptideAtlasiQ9ULT8
PRIDEiQ9ULT8

PTM databases

iPTMnetiQ9ULT8
PhosphoSitePlusiQ9ULT8

Expressioni

Gene expression databases

BgeeiENSG00000092148
CleanExiHS_HECTD1
ExpressionAtlasiQ9ULT8 baseline and differential
GenevisibleiQ9ULT8 HS

Organism-specific databases

HPAiHPA002929
HPA054461

Interactioni

Subunit structurei

Interacts with IGSF1 (PubMed:12421765). Interacts (via N-terminus) with HSP90AA1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi117359, 61 interactors
DIPiDIP-31669N
IntActiQ9ULT8, 19 interactors
MINTiQ9ULT8
STRINGi9606.ENSP00000382269

Structurei

Secondary structure

12610
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1270 – 1272Combined sources3
Beta strandi1279 – 1282Combined sources4
Turni1289 – 1292Combined sources4
Beta strandi1299 – 1301Combined sources3
Beta strandi1309 – 1314Combined sources6
Turni1315 – 1317Combined sources3
Beta strandi1319 – 1325Combined sources7
Helixi1326 – 1328Combined sources3
Beta strandi1332 – 1334Combined sources3
Helixi1883 – 1886Combined sources4
Helixi1896 – 1902Combined sources7
Beta strandi1905 – 1908Combined sources4
Helixi1910 – 1920Combined sources11
Helixi1923 – 1928Combined sources6
Helixi1935 – 1941Combined sources7
Helixi1944 – 1957Combined sources14
Turni1960 – 1962Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK3NMR-A1266-1338[»]
2LC3NMR-A1879-1966[»]
3DKMX-ray1.60A1271-1341[»]
ProteinModelPortaliQ9ULT8
SMRiQ9ULT8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULT8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati395 – 424ANK 1Add BLAST30
Repeati426 – 455ANK 2Add BLAST30
Repeati459 – 491ANK 3Add BLAST33
Repeati579 – 612ANK 4Add BLAST34
Domaini1266 – 1338MIB/HERC2PROSITE-ProRule annotationAdd BLAST73
Domaini2151 – 2610HECTPROSITE-ProRule annotationAdd BLAST460

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2029 – 2103K-boxAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1350 – 1649Ser-richAdd BLAST300

Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4276 Eukaryota
COG5021 LUCA
HOGENOMiHOG000018061
HOVERGENiHBG067533
InParanoidiQ9ULT8
KOiK12231
PhylomeDBiQ9ULT8
TreeFamiTF323674

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00078 HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR012919 SUN_dom
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF07738 Sad1_UNC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00119 HECTc, 1 hit
SUPFAMiSSF159034 SSF159034, 1 hit
SSF48371 SSF48371, 3 hits
SSF48403 SSF48403, 1 hit
SSF49785 SSF49785, 1 hit
SSF56204 SSF56204, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ULT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP
60 70 80 90 100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK
110 120 130 140 150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF
160 170 180 190 200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH
210 220 230 240 250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP
260 270 280 290 300
SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS
310 320 330 340 350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP
360 370 380 390 400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL
410 420 430 440 450
NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG
460 470 480 490 500
ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT
510 520 530 540 550
NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI RKASLALIRK
560 570 580 590 600
MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII
610 620 630 640 650
RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE
660 670 680 690 700
DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG
710 720 730 740 750
KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP
760 770 780 790 800
TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF
810 820 830 840 850
TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES
860 870 880 890 900
MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL
910 920 930 940 950
KDENTISPYE MCSSGLVQAL LTVLNNSMDL DMKQDCSQLV ERINVFKTAF
960 970 980 990 1000
SENEDDESRP AVALIRKLIA VLESIERLPL HLYDTPGSTY NLQILTRRLR
1010 1020 1030 1040 1050
FRLERAPGET ALIDRTGRML KMEPLATVES LEQYLLKMVA KQWYDFDRSS
1060 1070 1080 1090 1100
FVFVRKLREG QNFIFRHQHD FDENGIIYWI GTNAKTAYEW VNPAAYGLVV
1110 1120 1130 1140 1150
VTSSEGRNLP YGRLEDILSR DNSALNCHSN DDKNAWFAID LGLWVIPSAY
1160 1170 1180 1190 1200
TLRHARGYGR SALRNWVFQV SKDGQNWTSL YTHVDDCSLN EPGSTATWPL
1210 1220 1230 1240 1250
DPPKDEKQGW RHVRIKQMGK NASGQTHYLS LSGFELYGTV NGVCEDQLGK
1260 1270 1280 1290 1300
AAKEAEANLR RQRRLVRSQV LKYMVPGARV IRGLDWKWRD QDGSPQGEGT
1310 1320 1330 1340 1350
VTGELHNGWI DVTWDAGGSN SYRMGAEGKF DLKLAPGYDP DTVASPKPVS
1360 1370 1380 1390 1400
STVSGTTQSW SSLVKNNCPD KTSAAAGSSS RKGSSSSVCS VASSSDISLG
1410 1420 1430 1440 1450
STKTERRSEI VMEHSIVSGA DVHEPIVVLS SAENVPQTEV GSSSSASTST
1460 1470 1480 1490 1500
LTAETGSENA ERKLGPDSSV RTPGESSAIS MGIVSVSSPD VSSVSELTNK
1510 1520 1530 1540 1550
EAASQRPLSS SASNRLSVSS LLAAGAPMSS SASVPNLSSR ETSSLESFVR
1560 1570 1580 1590 1600
RVANIARTNA TNNMNLSRSS SDNNTNTLGR NVMSTATSPL MGAQSFPNLT
1610 1620 1630 1640 1650
TPGTTSTVTM STSSVTSSSN VATATTVLSV GQSLSNTLTT SLTSTSSESD
1660 1670 1680 1690 1700
TGQEAEYSLY DFLDSCRAST LLAELDDDED LPEPDEEDDE NEDDNQEDQE
1710 1720 1730 1740 1750
YEEVMILRRP SLQRRAGSRS DVTHHAVTSQ LPQVPAGAGS RPIGEQEEEE
1760 1770 1780 1790 1800
YETKGGRRRT WDDDYVLKRQ FSALVPAFDP RPGRTNVQQT TDLEIPPPGT
1810 1820 1830 1840 1850
PHSELLEEVE CTPSPRLALT LKVTGLGTTR EVELPLTNFR STIFYYVQKL
1860 1870 1880 1890 1900
LQLSCNGNVK SDKLRRIWEP TYTIMYREMK DSDKEKENGK MGCWSIEHVE
1910 1920 1930 1940 1950
QYLGTDELPK NDLITYLQKN ADAAFLRHWK LTGTNKSIRK NRNCSQLIAA
1960 1970 1980 1990 2000
YKDFCEHGTK SGLNQGAIST LQSSDILNLT KEQPQAKAGN GQNSCGVEDV
2010 2020 2030 2040 2050
LQLLRILYIV ASDPYSRISQ EDGDEQLQFT FPPDEFTSKK ITTKILQQIE
2060 2070 2080 2090 2100
EPLALASGAL PDWCEQLTSK CPFLIPFETR QLYFTCTAFG ASRAIVWLQN
2110 2120 2130 2140 2150
RREATVERTR TTSSVRRDDP GEFRVGRLKH ERVKVPRGES LMEWAENVMQ
2160 2170 2180 2190 2200
IHADRKSVLE VEFLGEEGTG LGPTLEFYAL VAAEFQRTDL GAWLCDDNFP
2210 2220 2230 2240 2250
DDESRHVDLG GGLKPPGYYV QRSCGLFTAP FPQDSDELER ITKLFHFLGI
2260 2270 2280 2290 2300
FLAKCIQDNR LVDLPISKPF FKLMCMGDIK SNMSKLIYES RGDRDLHCTE
2310 2320 2330 2340 2350
SQSEASTEEG HDSLSVGSFE EDSKSEFILD PPKPKPPAWF NGILTWEDFE
2360 2370 2380 2390 2400
LVNPHRARFL KEIKDLAIKR RQILSNKGLS EDEKNTKLQE LVLKNPSGSG
2410 2420 2430 2440 2450
PPLSIEDLGL NFQFCPSSRI YGFTAVDLKP SGEDEMITMD NAEEYVDLMF
2460 2470 2480 2490 2500
DFCMHTGIQK QMEAFRDGFN KVFPMEKLSS FSHEEVQMIL CGNQSPSWAA
2510 2520 2530 2540 2550
EDIINYTEPK LGYTRDSPGF LRFVRVLCGM SSDERKAFLQ FTTGCSTLPP
2560 2570 2580 2590 2600
GGLANLHPRL TVVRKVDATD ASYPSVNTCV HYLKLPEYSS EEIMRERLLA
2610
ATMEKGFHLN
Length:2,610
Mass (Da):289,384
Last modified:November 30, 2010 - v3
Checksum:i27E56401E07E158C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti561K → Q in AAP13073 (Ref. 1) Curated1
Sequence conflicti603L → I in AAP13073 (Ref. 1) Curated1
Sequence conflicti611 – 613FLD → YKH in AAP13073 (Ref. 1) Curated3
Sequence conflicti653K → Q in AAP13073 (Ref. 1) Curated1
Sequence conflicti894E → K in AAP13073 (Ref. 1) Curated1
Sequence conflicti927 – 944SMDLD…VERIN → VSIFRATKQKQNEVPKVILS in AAP13073 (Ref. 1) CuratedAdd BLAST18
Sequence conflicti951S → T in AAP13073 (Ref. 1) Curated1
Sequence conflicti1281I → T in BAA86445 (PubMed:12508121).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059666656Q → H. Corresponds to variant dbSNP:rs11620816Ensembl.1
Natural variantiVAR_0677072027L → P3 PublicationsCorresponds to variant dbSNP:rs1315794Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254380 mRNA Translation: AAP13073.1
AL121808 Genomic DNA No translation available.
AL136418 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65950.1
CH471078 Genomic DNA Translation: EAW65952.1
AB032957 mRNA Translation: BAA86445.2
AL110222 mRNA Translation: CAB53681.1
BC011658 mRNA Translation: AAH11658.2
BC063686 mRNA Translation: AAH63686.1
CCDSiCCDS41939.1
PIRiT14761
RefSeqiNP_056197.3, NM_015382.3
XP_005267559.2, XM_005267502.2
UniGeneiHs.708017

Genome annotation databases

EnsembliENST00000399332; ENSP00000382269; ENSG00000092148
ENST00000553700; ENSP00000450697; ENSG00000092148
GeneIDi25831
KEGGihsa:25831
UCSCiuc001wrc.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHECD1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULT8
Secondary accession number(s): D3DS86
, Q6P445, Q86VJ1, Q96F34, Q9UFZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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